Synthesis and cyclooxygenase inhibitory activities of some N-acylhydrazone derivatives of isoxazolo[4,5-d]pyridazin-4(5H)-ones

European Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2010, Pages 2345-2352

  Ünsal Tan, Oya ^a,b   Özden, Kevser ^a   Rauk, Arvi ^b   Balkan, Ayla ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b UNIVERSITY OF CALGARY   (Canada)

Author keywords

Cyclooxygenase enzymes; Docking; Isoxazolo 4,5 d pyridazin 4(5H) one; N Acylhydrazone

Indexed keywords

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HYDRAZIDE DERIVATIVE; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N' (2 CHLOROBENZYLIDENE) 2 [7 BENZYL 3 METHYL 4 OXOISOZOLO[4,5 D]PYRIDAZIN 4(5H)YL]ACETOHYDRAZIDE; N' (2 FLUOROBENZYLIDENE) 2 [7 BENZYL 3 METHYL 4 OXOISOXAZOLO[4,5 D]PYRIDAZIN 4(5H)YL]ACETOHYDRAZIDE; N' (3 FLUOROBENZYLIDENE) 2 [7 BENZYL 3 METHYL 4 OXOISOXAZOLO[4,5 D]PYRIDAZIN 4(5H) YL]ACETOHYDRAZIDE; N' (3 TRIFLUOROMETHYLBENZYLIDENE) 2 [7 BENZYL 3 METHYL 4 OXOISOXAZOLO [4,5 D]PYRIDAZIN 4(5H)YL]ACETOHYDRAZIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HYDROPHOBICITY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MELTING POINT; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; HUMANS; HYDRAZONES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRIDAZINES;

EID: 77950866644     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.02.012     Document Type: Article

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