메뉴 건너뛰기




Volumn 146, Issue 1, 2014, Pages

MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression

Author keywords

miRNA mRNA Interaction; Oncogene; Pancreatic Cancer; Tumorigenesis

Indexed keywords

ANTINEOPLASTIC AGENT; ATELOCOLLAGEN; MICRORNA; MICRORNA 21; MICRORNA 21 INHIBITOR; MICRORNA 23A; MICRORNA 23A INHIBITOR; MICRORNA 27A; MICRORNA 27A INHIBITOR; UNCLASSIFIED DRUG;

EID: 84890708492     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.10.010     Document Type: Article
Times cited : (149)

References (79)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • R. Siegel, E. Ward, and O. Brawley Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths CA Cancer J Clin 61 2011 212 236
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3
  • 3
    • 84865249073 scopus 로고    scopus 로고
    • Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure
    • C.R. Ferrone, R. Pieretti-Vanmarcke, and J.P. Bloom Pancreatic ductal adenocarcinoma: long-term survival does not equal cure Surgery 152 Suppl 1 2012 S43 S49
    • (2012) Surgery , vol.152 , Issue.SUPPL. 1
    • Ferrone, C.R.1    Pieretti-Vanmarcke, R.2    Bloom, J.P.3
  • 5
    • 77951964981 scopus 로고    scopus 로고
    • Posttranscriptional regulation of microRNA biogenesis in animals
    • H. Siomi, and M.C. Siomi Posttranscriptional regulation of microRNA biogenesis in animals Mol Cell 38 2010 323 332
    • (2010) Mol Cell , vol.38 , pp. 323-332
    • Siomi, H.1    Siomi, M.C.2
  • 6
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - MicroRNAs with a role in cancer
    • A. Esquela-Kerscher, and F.J. Slack Oncomirs - microRNAs with a role in cancer Nat Rev Cancer 6 2006 259 269
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 7
    • 84867740278 scopus 로고    scopus 로고
    • MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics
    • H. Xia, and K.M. Hui MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics Cancer Gene Ther 19 2012 723 730
    • (2012) Cancer Gene Ther , vol.19 , pp. 723-730
    • Xia, H.1    Hui, K.M.2
  • 8
    • 33846188098 scopus 로고    scopus 로고
    • MicroRNAs as oncogenes and tumor suppressors
    • B. Zhang, X. Pan, and G.P. Cobb microRNAs as oncogenes and tumor suppressors Dev Biol 302 2007 1 12
    • (2007) Dev Biol , vol.302 , pp. 1-12
    • Zhang, B.1    Pan, X.2    Cobb, G.P.3
  • 9
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • G.A. Calin, and C.M. Croce MicroRNA signatures in human cancers Nat Rev Cancer 6 2006 857 866
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 10
    • 58049219002 scopus 로고    scopus 로고
    • MicroRNAs as biomarkers and therapeutic drugs in human cancer
    • M. Osaki, F. Takeshita, and T. Ochiya MicroRNAs as biomarkers and therapeutic drugs in human cancer Biomarkers 13 2008 658 670
    • (2008) Biomarkers , vol.13 , pp. 658-670
    • Osaki, M.1    Takeshita, F.2    Ochiya, T.3
  • 11
    • 34247862190 scopus 로고    scopus 로고
    • MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis
    • M. Bloomston, W.L. Frankel, and F. Petrocca MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis JAMA 297 2007 1901 1908
    • (2007) JAMA , vol.297 , pp. 1901-1908
    • Bloomston, M.1    Frankel, W.L.2    Petrocca, F.3
  • 12
    • 73449134501 scopus 로고    scopus 로고
    • Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumours associates with poorer survival
    • T. Greither, L. Grochola, and A. Udelnow Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumours associates with poorer survival Int J Cancer 126 2010 73 80
    • (2010) Int J Cancer , vol.126 , pp. 73-80
    • Greither, T.1    Grochola, L.2    Udelnow, A.3
  • 13
    • 84855996930 scopus 로고    scopus 로고
    • MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma
    • N.B. Jamieson, D.C. Morran, and J.P. Morton MicroRNA molecular profiles associated with diagnosis, clinicopathologic criteria, and overall survival in patients with resectable pancreatic ductal adenocarcinoma Clin Cancer Res 18 2012 534 545
    • (2012) Clin Cancer Res , vol.18 , pp. 534-545
    • Jamieson, N.B.1    Morran, D.C.2    Morton, J.P.3
  • 14
    • 84863278019 scopus 로고    scopus 로고
    • Integrative survival-based molecular profiling of human pancreatic cancer
    • T.R. Donahue, L.M. Tran, and R. Hill Integrative survival-based molecular profiling of human pancreatic cancer Clin Cancer Res 18 2012 1352 1363
    • (2012) Clin Cancer Res , vol.18 , pp. 1352-1363
    • Donahue, T.R.1    Tran, L.M.2    Hill, R.3
  • 15
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: Correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • E. Giovannetti, N. Funel, and G.J. Peters MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity Cancer Res 70 2010 4528 4538
    • (2010) Cancer Res , vol.70 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3
  • 16
    • 80053923978 scopus 로고    scopus 로고
    • Prognostic role of microRNA-21 in various carcinomas: A systematic review and meta-analysis
    • X. Fu, Y. Han, and Y. Wu Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis Eur J Clin Invest 41 2011 1245 1253
    • (2011) Eur J Clin Invest , vol.41 , pp. 1245-1253
    • Fu, X.1    Han, Y.2    Wu, Y.3
  • 17
    • 84857468335 scopus 로고    scopus 로고
    • MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors
    • L.R. Jiao, A.E. Frampton, and J. Jacob MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors PLoS One 7 2012 e32068
    • (2012) PLoS One , vol.7 , pp. 32068
    • Jiao, L.R.1    Frampton, A.E.2    Jacob, J.3
  • 18
    • 77957948990 scopus 로고    scopus 로고
    • MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
    • M. Yihui, Y. Shuangni, and Z. Wugan miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2 Cancer Lett 298 2010 150 158
    • (2010) Cancer Lett , vol.298 , pp. 150-158
    • Yihui, M.1    Shuangni, Y.2    Wugan, Z.3
  • 19
    • 80052445088 scopus 로고    scopus 로고
    • MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma
    • M. Preis, T.B. Gardner, and S.R. Gordon MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma Clin Cancer Res 17 2011 5812 5821
    • (2011) Clin Cancer Res , vol.17 , pp. 5812-5821
    • Preis, M.1    Gardner, T.B.2    Gordon, S.R.3
  • 20
    • 0036544755 scopus 로고    scopus 로고
    • Micro RNAs are complementary to 3[prime] UTR sequence motifs that mediate negative post-transcriptional regulation
    • E.C. Lai Micro RNAs are complementary to 3[prime] UTR sequence motifs that mediate negative post-transcriptional regulation Nat Genet 30 2002 363 364
    • (2002) Nat Genet , vol.30 , pp. 363-364
    • Lai, E.C.1
  • 21
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • D. Betel, A. Koppal, and P. Agius Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites Genome Biol 11 2010 R90
    • (2010) Genome Biol , vol.11 , pp. 90
    • Betel, D.1    Koppal, A.2    Agius, P.3
  • 22
    • 79959918202 scopus 로고    scopus 로고
    • Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis
    • X. Ma, M. Kumar, and S.N. Choudhury Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis Proc Natl Acad Sci U S A 108 2011 10144 10149
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 10144-10149
    • Ma, X.1    Kumar, M.2    Choudhury, S.N.3
  • 23
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • A.L. Kasinski, and F.J. Slack Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy Nat Rev Cancer 11 2011 849 864
    • (2011) Nat Rev Cancer , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 24
    • 84866536570 scopus 로고    scopus 로고
    • Tumor infiltration in the medial resection margin predicts survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma
    • Y. Zhang, A.E. Frampton, and P. Cohen Tumor infiltration in the medial resection margin predicts survival after pancreaticoduodenectomy for pancreatic ductal adenocarcinoma J Gastrointest Surg 16 2012 1875 1882
    • (2012) J Gastrointest Surg , vol.16 , pp. 1875-1882
    • Zhang, Y.1    Frampton, A.E.2    Cohen, P.3
  • 25
    • 84857383269 scopus 로고    scopus 로고
    • DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma
    • G. Zhang, A. Schetter, and P. He DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma PLoS One 7 2012 e31507
    • (2012) PLoS One , vol.7 , pp. 31507
    • Zhang, G.1    Schetter, A.2    He, P.3
  • 26
    • 84867071711 scopus 로고    scopus 로고
    • Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101
    • A.M. Qazi, O. Gruzdyn, and A. Semaan Restoration of E-cadherin expression in pancreatic ductal adenocarcinoma treated with microRNA-101 Surgery 152 2012 704 713
    • (2012) Surgery , vol.152 , pp. 704-713
    • Qazi, A.M.1    Gruzdyn, O.2    Semaan, A.3
  • 27
    • 46049085405 scopus 로고    scopus 로고
    • Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
    • N. Funel, E. Giovannetti, and M. Del Chiaro Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma Lab Invest 88 2008 773 784
    • (2008) Lab Invest , vol.88 , pp. 773-784
    • Funel, N.1    Giovannetti, E.2    Del Chiaro, M.3
  • 28
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • H. Guo, N.T. Ingolia, and J.S. Weissman Mammalian microRNAs predominantly act to decrease target mRNA levels Nature 466 2010 835 840
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3
  • 29
    • 49949116902 scopus 로고    scopus 로고
    • The impact of microRNAs on protein output
    • D. Baek, J. Villen, and C. Shin The impact of microRNAs on protein output Nature 455 2008 64 71
    • (2008) Nature , vol.455 , pp. 64-71
    • Baek, D.1    Villen, J.2    Shin, C.3
  • 30
    • 84855356095 scopus 로고    scopus 로고
    • Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma
    • Y. Nagao, M. Hisaoka, and A. Matsuyama Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma Mod Pathol 25 2012 112 121
    • (2012) Mod Pathol , vol.25 , pp. 112-121
    • Nagao, Y.1    Hisaoka, M.2    Matsuyama, A.3
  • 31
    • 78650211014 scopus 로고    scopus 로고
    • Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer
    • S. Ali, K. Almhanna, and W. Chen Differentially expressed miRNAs in the plasma may provide a molecular signature for aggressive pancreatic cancer Am J Transl Res 3 2011 28 47
    • (2011) Am J Transl Res , vol.3 , pp. 28-47
    • Ali, S.1    Almhanna, K.2    Chen, W.3
  • 32
    • 77954934314 scopus 로고    scopus 로고
    • Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: Role of microRNA-27a
    • I. Jutooru, G. Chadalapaka, and M. Abdelrahim Methyl 2-cyano-3,12- dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a Mol Pharmacol 78 2010 226 236
    • (2010) Mol Pharmacol , vol.78 , pp. 226-236
    • Jutooru, I.1    Chadalapaka, G.2    Abdelrahim, M.3
  • 33
    • 77957948990 scopus 로고    scopus 로고
    • MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
    • Y. Ma, S. Yu, and W. Zhao miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2 Cancer Lett 298 2010 150 158
    • (2010) Cancer Lett , vol.298 , pp. 150-158
    • Ma, Y.1    Yu, S.2    Zhao, W.3
  • 34
    • 54249096193 scopus 로고    scopus 로고
    • MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths
    • D. Sayed, S. Rane, and J. Lypowy MicroRNA-21 targets Sprouty2 and promotes cellular outgrowths Mol Biol Cell 19 2008 3272 3282
    • (2008) Mol Biol Cell , vol.19 , pp. 3272-3282
    • Sayed, D.1    Rane, S.2    Lypowy, J.3
  • 35
    • 84870261155 scopus 로고    scopus 로고
    • LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
    • D. Chen, Y. Sun, and Y. Wei LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker Nat Med 18 2012 1511 1517
    • (2012) Nat Med , vol.18 , pp. 1511-1517
    • Chen, D.1    Sun, Y.2    Wei, Y.3
  • 36
    • 84867403952 scopus 로고    scopus 로고
    • MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer
    • S. Ali, H. Saleh, and S. Sethi MicroRNA profiling of diagnostic needle aspirates from patients with pancreatic cancer Br J Cancer 107 2012 1354 1360
    • (2012) Br J Cancer , vol.107 , pp. 1354-1360
    • Ali, S.1    Saleh, H.2    Sethi, S.3
  • 37
    • 80052707802 scopus 로고    scopus 로고
    • Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer
    • N. Funel, E. Giovannetti, and L.E. Pollina Critical role of laser microdissection for genetic, epigenetic and proteomic analyses in pancreatic cancer Expert Rev Mol Diagn 11 2011 695 701
    • (2011) Expert Rev Mol Diagn , vol.11 , pp. 695-701
    • Funel, N.1    Giovannetti, E.2    Pollina, L.E.3
  • 38
    • 77954959329 scopus 로고    scopus 로고
    • Biobanking of human pancreas cancer tissue: Impact of ex-vivo procurement times on RNA quality
    • U. Rudloff, U. Bhanot, and W. Gerald Biobanking of human pancreas cancer tissue: impact of ex-vivo procurement times on RNA quality Ann Surg Oncol 17 2010 2229 2236
    • (2010) Ann Surg Oncol , vol.17 , pp. 2229-2236
    • Rudloff, U.1    Bhanot, U.2    Gerald, W.3
  • 39
    • 45249111019 scopus 로고    scopus 로고
    • Affymetrix Whole-Transcript Human Gene 1.0 ST array is highly concordant with standard 3′ expression arrays
    • S. Pradervand, A. Paillusson, and J. Thomas Affymetrix Whole-Transcript Human Gene 1.0 ST array is highly concordant with standard 3′ expression arrays Biotechniques 44 2008 759 762
    • (2008) Biotechniques , vol.44 , pp. 759-762
    • Pradervand, S.1    Paillusson, A.2    Thomas, J.3
  • 40
    • 40449100030 scopus 로고    scopus 로고
    • Direct multiplexed measurement of gene expression with color-coded probe pairs
    • G.K. Geiss, R.E. Bumgarner, and B. Birditt Direct multiplexed measurement of gene expression with color-coded probe pairs Nat Biotechnol 26 2008 317 325
    • (2008) Nat Biotechnol , vol.26 , pp. 317-325
    • Geiss, G.K.1    Bumgarner, R.E.2    Birditt, B.3
  • 41
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: A practical and powerful approach to multiple testing
    • Y. Benjamini, and Y. Hochberg Controlling the false discovery rate: a practical and powerful approach to multiple testing J R Stat Soc 57 1995 289 300
    • (1995) J R Stat Soc , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 42
    • 60549109896 scopus 로고    scopus 로고
    • Regularized gene selection in cancer microarray meta-analysis
    • S. Ma, and J. Huang Regularized gene selection in cancer microarray meta-analysis BMC Bioinform 10 2009 1
    • (2009) BMC Bioinform , vol.10 , pp. 1
    • Ma, S.1    Huang, J.2
  • 43
    • 65449141024 scopus 로고    scopus 로고
    • A compendium of potential biomarkers of pancreatic cancer
    • H.C. Harsha, K. Kandasamy, and P. Ranganathan A compendium of potential biomarkers of pancreatic cancer PLoS Med 6 2009 e1000046
    • (2009) PLoS Med , vol.6 , pp. 1000046
    • Harsha, H.C.1    Kandasamy, K.2    Ranganathan, P.3
  • 44
    • 23744510853 scopus 로고    scopus 로고
    • Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes
    • R. Grutzmann, H. Boriss, and O. Ammerpohl Meta-analysis of microarray data on pancreatic cancer defines a set of commonly dysregulated genes Oncogene 24 2005 5079 5088
    • (2005) Oncogene , vol.24 , pp. 5079-5088
    • Grutzmann, R.1    Boriss, H.2    Ammerpohl, O.3
  • 45
    • 84555188294 scopus 로고    scopus 로고
    • Using the bioconductor gene answers package to interpret gene lists
    • J. Wang, A.C. Tan, T. Tian, Humana Press New York
    • G. Feng, P. Shaw, and S.T. Rosen Using the bioconductor gene answers package to interpret gene lists J. Wang, A.C. Tan, T. Tian, Next Generation Microarray Bioinformatics Vol 802 2012 Humana Press New York 101 112
    • (2012) Next Generation Microarray Bioinformatics , vol.802 VOL , pp. 101-112
    • Feng, G.1    Shaw, P.2    Rosen, S.T.3
  • 46
    • 75549090213 scopus 로고    scopus 로고
    • KEGG for representation and analysis of molecular networks involving diseases and drugs
    • M. Kanehisa, S. Goto, and M. Furumichi KEGG for representation and analysis of molecular networks involving diseases and drugs Nucleic Acids Res 38 2010 D355 D360
    • (2010) Nucleic Acids Res , vol.38
    • Kanehisa, M.1    Goto, S.2    Furumichi, M.3
  • 47
    • 0034069495 scopus 로고    scopus 로고
    • Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium
    • M. Ashburner, C.A. Ball, and J.A. Blake Gene ontology: tool for the unification of biology. The Gene Ontology Consortium Nat Genet 25 2000 25 29
    • (2000) Nat Genet , vol.25 , pp. 25-29
    • Ashburner, M.1    Ball, C.A.2    Blake, J.A.3
  • 48
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 49
    • 68449101067 scopus 로고    scopus 로고
    • Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt
    • S. Durinck, P.T. Spellman, and E. Birney Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt Nat Protocols 4 2009 1184 1191
    • (2009) Nat Protocols , vol.4 , pp. 1184-1191
    • Durinck, S.1    Spellman, P.T.2    Birney, E.3
  • 50
    • 77955963884 scopus 로고    scopus 로고
    • Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites
    • D. Betel, A. Koppal, and P. Agius Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites Genome Biol 11 2010 R90
    • (2010) Genome Biol , vol.11 , pp. 90
    • Betel, D.1    Koppal, A.2    Agius, P.3
  • 51
    • 77957948990 scopus 로고    scopus 로고
    • MiR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2
    • Y. Ma, S. Yu, and W. Zhao miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2 Cancer Lett 298 2010 150 158
    • (2010) Cancer Lett , vol.298 , pp. 150-158
    • Ma, Y.1    Yu, S.2    Zhao, W.3
  • 52
    • 0038459055 scopus 로고    scopus 로고
    • A comprehensive characterization of pancreatic ductal carcinoma cell lines: Towards the establishment of an in vitro research platform
    • B. Sipos, S. Moser, and H. Kalthoff A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform Virchows Arch 442 2003 444 452
    • (2003) Virchows Arch , vol.442 , pp. 444-452
    • Sipos, B.1    Moser, S.2    Kalthoff, H.3
  • 53
    • 46049085405 scopus 로고    scopus 로고
    • Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
    • N. Funel, E. Giovannetti, and M. Del Chiaro Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma Lab Invest 88 2008 773 784
    • (2008) Lab Invest , vol.88 , pp. 773-784
    • Funel, N.1    Giovannetti, E.2    Del Chiaro, M.3
  • 54
    • 80054902331 scopus 로고    scopus 로고
    • Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma
    • Z. Hamidov, A. Altendorf-Hofmann, and Y. Chen Reduced expression of desmocollin 2 is an independent prognostic biomarker for shorter patients survival in pancreatic ductal adenocarcinoma J Clin Pathol 64 2011 990 994
    • (2011) J Clin Pathol , vol.64 , pp. 990-994
    • Hamidov, Z.1    Altendorf-Hofmann, A.2    Chen, Y.3
  • 55
    • 84855311144 scopus 로고    scopus 로고
    • EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: Analysis of data from the phase 3 FLEX study
    • R. Pirker, J.R. Pereira, and J. von Pawel EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study Lancet Oncol 13 2012 33 42
    • (2012) Lancet Oncol , vol.13 , pp. 33-42
    • Pirker, R.1    Pereira, J.R.2    Von Pawel, J.3
  • 56
    • 84869090783 scopus 로고    scopus 로고
    • A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation
    • J.J.M. Eekels, A.O. Pasternak, and A.M. Schut A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation Gene Ther 19 2012 1058 1064
    • (2012) Gene Ther , vol.19 , pp. 1058-1064
    • Eekels, J.J.M.1    Pasternak, A.O.2    Schut, A.M.3
  • 57
    • 78349258515 scopus 로고    scopus 로고
    • Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model
    • I. Takigami, T. Ohno, and Y. Kitade Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model Int J Cancer 128 2011 216 226
    • (2011) Int J Cancer , vol.128 , pp. 216-226
    • Takigami, I.1    Ohno, T.2    Kitade, Y.3
  • 58
    • 3242733298 scopus 로고    scopus 로고
    • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    • Y. Minakuchi, F. Takeshita, and N. Kosaka Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo Nucleic Acids Res 32 2004 e109
    • (2004) Nucleic Acids Res , vol.32 , pp. 109
    • Minakuchi, Y.1    Takeshita, F.2    Kosaka, N.3
  • 59
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • H. Tazawa, N. Tsuchiya, and M. Izumiya Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells Proc Natl Acad Sci 104 2007 15472 15477
    • (2007) Proc Natl Acad Sci , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3
  • 60
    • 1642377561 scopus 로고    scopus 로고
    • ONCOMINE: A cancer microarray database and integrated data-mining platform
    • D.R. Rhodes, J. Yu, and K. Shanker ONCOMINE: a cancer microarray database and integrated data-mining platform Neoplasia 6 2004 1 6
    • (2004) Neoplasia , vol.6 , pp. 1-6
    • Rhodes, D.R.1    Yu, J.2    Shanker, K.3
  • 61
    • 78651339534 scopus 로고    scopus 로고
    • NCBI GEO: Archive for functional genomics data sets - 10 years on
    • T. Barrett, D.B. Troup, and S.E. Wilhite NCBI GEO: archive for functional genomics data sets - 10 years on Nucleic Acids Res 39 2011 D1005 D1010
    • (2011) Nucleic Acids Res , vol.39
    • Barrett, T.1    Troup, D.B.2    Wilhite, S.E.3
  • 62
    • 84857383269 scopus 로고    scopus 로고
    • DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma
    • G. Zhang, A. Schetter, and P. He DPEP1 inhibits tumor cell invasiveness, enhances chemosensitivity and predicts clinical outcome in pancreatic ductal adenocarcinoma PLoS One 7 2012 e31507
    • (2012) PLoS One , vol.7 , pp. 31507
    • Zhang, G.1    Schetter, A.2    He, P.3
  • 63
    • 0033598712 scopus 로고    scopus 로고
    • Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation
    • J.L. Cmarik, H. Min, and G. Hegamyer Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation Proc Natl Acad Sci U S A 96 1999 14037 14042
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14037-14042
    • Cmarik, J.L.1    Min, H.2    Hegamyer, G.3
  • 64
    • 84855356095 scopus 로고    scopus 로고
    • Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma
    • Y. Nagao, M. Hisaoka, and A. Matsuyama Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma Mod Pathol 25 2012 112 121
    • (2012) Mod Pathol , vol.25 , pp. 112-121
    • Nagao, Y.1    Hisaoka, M.2    Matsuyama, A.3
  • 65
    • 78751582064 scopus 로고    scopus 로고
    • Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma
    • I. Bhatti, A. Lee, and V. James Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma J Gastrointest Surg 15 2011 199 208
    • (2011) J Gastrointest Surg , vol.15 , pp. 199-208
    • Bhatti, I.1    Lee, A.2    James, V.3
  • 66
    • 47549109566 scopus 로고    scopus 로고
    • MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
    • Z. Lu, M. Liu, and V. Stribinskis MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene Oncogene 27 2008 4373 4379
    • (2008) Oncogene , vol.27 , pp. 4373-4379
    • Lu, Z.1    Liu, M.2    Stribinskis, V.3
  • 67
    • 0033976110 scopus 로고    scopus 로고
    • Arrest of G1-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription
    • D. Guardavaccaro, G. Corrente, and F. Covone Arrest of G1-S progression by the p53-inducible gene PC3 is Rb dependent and relies on the inhibition of cyclin D1 transcription Mol Cell Biol 20 2000 1797 1815
    • (2000) Mol Cell Biol , vol.20 , pp. 1797-1815
    • Guardavaccaro, D.1    Corrente, G.2    Covone, F.3
  • 68
    • 30944459963 scopus 로고    scopus 로고
    • A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation
    • A.D. Boiko, S. Porteous, and O.V. Razorenova A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation Genes Dev 20 2006 236 252
    • (2006) Genes Dev , vol.20 , pp. 236-252
    • Boiko, A.D.1    Porteous, S.2    Razorenova, O.V.3
  • 69
    • 84867881542 scopus 로고    scopus 로고
    • Tumorigenesis: Pushing pancreatic cancer to take off
    • S. Seton-Rogers Tumorigenesis: pushing pancreatic cancer to take off Nat Rev Cancer 12 2012 739
    • (2012) Nat Rev Cancer , vol.12 , pp. 739
    • Seton-Rogers, S.1
  • 70
    • 84868109838 scopus 로고    scopus 로고
    • Toward a combinatorial nature of microRNA regulation in human cells
    • O. Balaga, Y. Friedman, and M. Linial Toward a combinatorial nature of microRNA regulation in human cells Nucleic Acids Res 40 2012 9404 9416
    • (2012) Nucleic Acids Res , vol.40 , pp. 9404-9416
    • Balaga, O.1    Friedman, Y.2    Linial, M.3
  • 71
    • 70350785179 scopus 로고    scopus 로고
    • Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
    • S. Gao, C. Alarcon, and G. Sapkota Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling Mol Cell 36 2009 457 468
    • (2009) Mol Cell , vol.36 , pp. 457-468
    • Gao, S.1    Alarcon, C.2    Sapkota, G.3
  • 72
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • V. Ellenrieder, S.F. Hendler, and W. Boeck Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation Cancer Res 61 2001 4222 4228
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3
  • 73
    • 36248989248 scopus 로고    scopus 로고
    • The Nedd4-like family of E3 ubiquitin ligases and cancer
    • C. Chen, and L. Matesic The Nedd4-like family of E3 ubiquitin ligases and cancer Cancer Metast Rev 26 2007 587 604
    • (2007) Cancer Metast Rev , vol.26 , pp. 587-604
    • Chen, C.1    Matesic, L.2
  • 74
    • 84869867065 scopus 로고    scopus 로고
    • Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient
    • C. Gao, L. Pang, and C. Ren Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient Med Oncol 29 2012 1733 1738
    • (2012) Med Oncol , vol.29 , pp. 1733-1738
    • Gao, C.1    Pang, L.2    Ren, C.3
  • 75
    • 79952810954 scopus 로고    scopus 로고
    • Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer
    • T. Takeuchi, Y. Adachi, and T. Nagayama Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase the invasive activity of gallbladder cancer Int J Exp Pathol 92 2011 79 86
    • (2011) Int J Exp Pathol , vol.92 , pp. 79-86
    • Takeuchi, T.1    Adachi, Y.2    Nagayama, T.3
  • 76
    • 63049116201 scopus 로고    scopus 로고
    • Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia
    • X.Y. Hu, Y.M. Xu, and Q. Fu Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia Eur J Surg Oncol 35 2009 527 531
    • (2009) Eur J Surg Oncol , vol.35 , pp. 527-531
    • Hu, X.Y.1    Xu, Y.M.2    Fu, Q.3
  • 77
    • 84863250974 scopus 로고    scopus 로고
    • Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma
    • S. He, J. Deng, and G. Li Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma Jpn J Clin Oncol 42 2012 196 201
    • (2012) Jpn J Clin Oncol , vol.42 , pp. 196-201
    • He, S.1    Deng, J.2    Li, G.3
  • 78
    • 23744458086 scopus 로고    scopus 로고
    • Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
    • A. Siepel, G. Bejerano, and J.S. Pedersen Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes Genome Res 15 2005 1034 1050
    • (2005) Genome Res , vol.15 , pp. 1034-1050
    • Siepel, A.1    Bejerano, G.2    Pedersen, J.S.3
  • 79
    • 79551587720 scopus 로고    scopus 로고
    • Cytoscape 2.8: New features for data integration and network visualization
    • M.E. Smoot, K. Ono, and J. Ruscheinski Cytoscape 2.8: new features for data integration and network visualization Bioinformatics 27 2011 431 432
    • (2011) Bioinformatics , vol.27 , pp. 431-432
    • Smoot, M.E.1    Ono, K.2    Ruscheinski, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.