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Volumn , Issue , 2009, Pages 577-589

In Utero Transplantation

Author keywords

Clinical experience with IU HCT; Diseases with selective advantage for normal cells; Donor cell source; Fetal hematopoietic environment; Fetal immunologic tolerance; In utero transplantation; IU HCT currently in its early stages of development; Maternal and fetal risk; Strategies for successful in utero HSC transplantation

Indexed keywords


EID: 84890702658     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444303537.ch40     Document Type: Chapter
Times cited : (1)

References (124)
  • 1
    • 0025644451 scopus 로고
    • Fetal surgery
    • Harrison MR. Fetal surgery. West J Med 1990; 153: 648.
    • (1990) West J Med , vol.153 , pp. 648
    • Harrison, M.R.1
  • 2
    • 0027365075 scopus 로고
    • Intrauterine transfusion with red cells and platelets
    • Moise KJ, Jr. Intrauterine transfusion with red cells and platelets. West J Med 1993; 159: 318-24.
    • (1993) West J Med , vol.159 , pp. 318-324
    • Moise Jr., K.J.1
  • 4
    • 0000658958 scopus 로고
    • Immunogenetic consequences of vascular anastomoses between bovine cattle twins
    • Owen RD. Immunogenetic consequences of vascular anastomoses between bovine cattle twins. Science 1945; 102: 400-1.
    • (1945) Science , vol.102 , pp. 400-401
    • Owen, R.D.1
  • 5
    • 84966146209 scopus 로고
    • The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle
    • Anderson D, Billingham R, Lampkin G, Medawar P. The use of skin grafting to distinguish between monozygotic and dizygotic twins in cattle. Heredity 1951; 5: 379-97.
    • (1951) Heredity , vol.5 , pp. 379-397
    • Anderson, D.1    Billingham, R.2    Lampkin, G.3    Medawar, P.4
  • 6
    • 0007604145 scopus 로고
    • The acquired immunity concept in kidney homotransplantation
    • Simonsen M. The acquired immunity concept in kidney homotransplantation. Ann N Y Acad Sci 1955; 59: 448-52.
    • (1955) Ann N Y Acad Sci , vol.59 , pp. 448-452
    • Simonsen, M.1
  • 7
    • 0021994589 scopus 로고
    • A naturally occurring bone-marrow-chimeric primate I. Integrity of its immune system
    • Picus J, Aldrich WR, Letvin NL. A naturally occurring bone-marrow-chimeric primate. I. Integrity of its immune system. Transplantation 1985; 39: 297-303.
    • (1985) Transplantation , vol.39 , pp. 297-303
    • Picus, J.1    Aldrich, W.R.2    Letvin, N.L.3
  • 8
    • 0030023611 scopus 로고    scopus 로고
    • Blood group chimerism in human multiple births is not rare
    • van Dijk B, Bommsma D, de Man A. Blood group chimerism in human multiple births is not rare. Am J Med Genet 1996; 61: 264-8.
    • (1996) Am J Med Genet , vol.61 , pp. 264-268
    • van Dijk, B.1    Bommsma, D.2    de Man, A.3
  • 9
    • 0017736997 scopus 로고
    • Chimerism in humans
    • Gill T. Chimerism in humans. Transplant Proc 1977; 9: 1423-31.
    • (1977) Transplant Proc , vol.9 , pp. 1423-1431
    • Gill, T.1
  • 11
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham R, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172: 603-7.
    • (1953) Nature , vol.172 , pp. 603-607
    • Billingham, R.1    Brent, L.2    Medawar, P.B.3
  • 12
    • 0029440221 scopus 로고
    • Central tolerance of T cells
    • Sprent J. Central tolerance of T cells. Int Rev Immunol 1995; 13: 95-105.
    • (1995) Int Rev Immunol , vol.13 , pp. 95-105
    • Sprent, J.1
  • 14
    • 0023740145 scopus 로고
    • Early events in human T cell ontogeny Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues
    • Haynes BF, Martin ME, Kay HH, Kurtzberg J. Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues. J Exp Med 1988; 168: 1061-80.
    • (1988) J Exp Med , vol.168 , pp. 1061-1080
    • Haynes, B.F.1    Martin, M.E.2    Kay, H.H.3    Kurtzberg, J.4
  • 15
    • 1842631137 scopus 로고    scopus 로고
    • Developing a new paradigm for thymus organogenesis
    • Blackburn CC, Manley NR. Developing a new paradigm for thymus organogenesis. Nat Rev Immunol 2004; 4: 278-89.
    • (2004) Nat Rev Immunol , vol.4 , pp. 278-289
    • Blackburn, C.C.1    Manley, N.R.2
  • 16
    • 0024339411 scopus 로고
    • Developmental biology of T cell receptors
    • Strominger JL. Developmental biology of T cell receptors. Science 1989; 244: 943-50.
    • (1989) Science , vol.244 , pp. 943-950
    • Strominger, J.L.1
  • 17
    • 0034235795 scopus 로고    scopus 로고
    • T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity
    • Sandberg JK, Franksson L, Sundback J et al. T cell tolerance based on avidity thresholds rather than complete deletion allows maintenance of maximal repertoire diversity. J Immunol 2000; 165: 25-33.
    • (2000) J Immunol , vol.165 , pp. 25-33
    • Sandberg, J.K.1    Franksson, L.2    Sundback, J.3
  • 19
    • 0036533552 scopus 로고    scopus 로고
    • Autoreactive T cells revealed in the normal repertoire: escape from negative selection and peripheral tolerance
    • Yan J, Mamula MJ. Autoreactive T cells revealed in the normal repertoire: escape from negative selection and peripheral tolerance. J Immunol 2002; 168: 3188-94.
    • (2002) J Immunol , vol.168 , pp. 3188-3194
    • Yan, J.1    Mamula, M.J.2
  • 20
    • 0025036420 scopus 로고
    • Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice
    • Yui K, Komori S, Katsumata M, Siegel RM, Greene MI. Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice. Proc Natl Acad Sci U S A 1990; 87: 7135-9.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 7135-7139
    • Yui, K.1    Komori, S.2    Katsumata, M.3    Siegel, R.M.4    Greene, M.I.5
  • 21
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25) Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155: 1151-64.
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 22
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • Takahashi T, Tagami T, Yamazaki S et al. Immunologic self-tolerance maintained by CD25(+) CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med 2000; 192: 303-10.
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3
  • 23
    • 0036682932 scopus 로고    scopus 로고
    • Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion
    • Hayashi S, Peranteau WH, Shaaban AF, Flake AW. Complete allogeneic hematopoietic chimerism achieved by a combined strategy of in utero hematopoietic stem cell transplantation and postnatal donor lymphocyte infusion. Blood 2002; 100: 804-12.
    • (2002) Blood , vol.100 , pp. 804-812
    • Hayashi, S.1    Peranteau, W.H.2    Shaaban, A.F.3    Flake, A.W.4
  • 24
    • 0344173225 scopus 로고    scopus 로고
    • In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy
    • Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces tolerance by a combination of clonal deletion and anergy. J Pediatr Surg 1999; 34: 726-30.
    • (1999) J Pediatr Surg , vol.34 , pp. 726-730
    • Kim, H.B.1    Shaaban, A.F.2    Milner, R.3    Fichter, C.4    Flake, A.W.5
  • 25
    • 33846894104 scopus 로고    scopus 로고
    • Evidence for an immune barrier after in utero hematopoietic-cell transplantation
    • Peranteau WH, Endo M, Adibe OO, Flake AW. Evidence for an immune barrier after in utero hematopoietic-cell transplantation. Blood 2007; 109: 1331-3.
    • (2007) Blood , vol.109 , pp. 1331-1333
    • Peranteau, W.H.1    Endo, M.2    Adibe, O.O.3    Flake, A.W.4
  • 27
    • 0033806003 scopus 로고    scopus 로고
    • Microchimerism does not induce tolerance after in utero transplantation and may lead to the development of alloreactivity
    • Carrier E, Gilpin E, Lee TH, Busch MP, Zanetti M. Microchimerism does not induce tolerance after in utero transplantation and may lead to the development of alloreactivity. J Lab Clin Med 2000; 136: 224-35.
    • (2000) J Lab Clin Med , vol.136 , pp. 224-235
    • Carrier, E.1    Gilpin, E.2    Lee, T.H.3    Busch, M.P.4    Zanetti, M.5
  • 28
    • 0000931394 scopus 로고
    • Embryonic aspects of haemopoiesis
    • Neuberger A, Tatum EL, editors. Amsterdam: North-Holland Publishing
    • Metcalf D, Moore MAS. Embryonic aspects of haemopoiesis. In: Neuberger A, Tatum EL, editors. Haemopoietic Cells. Vol. 24. Amsterdam: North-Holland Publishing; 1971. Chapter 4.
    • (1971) Haemopoietic Cells , vol.24
    • Metcalf, D.1    Moore, M.A.S.2
  • 30
    • 34547194164 scopus 로고    scopus 로고
    • The regulatory role of the stromal microenvironment in fetal hematopoietic ontogeny
    • Badillo AT, Flake AW. The regulatory role of the stromal microenvironment in fetal hematopoietic ontogeny. Stem Cell Rev 2007; 2: 241-6.
    • (2007) Stem Cell Rev , vol.2 , pp. 241-246
    • Badillo, A.T.1    Flake, A.W.2
  • 31
    • 0027492416 scopus 로고
    • Liverderived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow
    • Zanjani ED, Ascensao JL, Tavassoli M. Liverderived fetal hematopoietic stem cells selectively and preferentially home to the fetal bone marrow. Blood 1993; 81: 399-404.
    • (1993) Blood , vol.81 , pp. 399-404
    • Zanjani, E.D.1    Ascensao, J.L.2    Tavassoli, M.3
  • 32
    • 0345624487 scopus 로고    scopus 로고
    • A kinetic model for homing and migration of prenatally transplanted marrow
    • Shaaban AF, Kim HB, Milner R, Flake AW. A kinetic model for homing and migration of prenatally transplanted marrow. Blood 1999; 94: 3251-7.
    • (1999) Blood , vol.94 , pp. 3251-3257
    • Shaaban, A.F.1    Kim, H.B.2    Milner, R.3    Flake, A.W.4
  • 33
    • 33845483092 scopus 로고    scopus 로고
    • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation
    • Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 2006; 108: 4268-74.
    • (2006) Blood , vol.108 , pp. 4268-4274
    • Peranteau, W.H.1    Endo, M.2    Adibe, O.O.3    Merchant, A.4    Zoltick, P.W.5    Flake, A.W.6
  • 34
    • 0022534779 scopus 로고
    • Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras
    • Flake AW, Harrison MR, Adzick NS, Zanjani ED. Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras. Science 1986; 233: 776-8.
    • (1986) Science , vol.233 , pp. 776-778
    • Flake, A.W.1    Harrison, M.R.2    Adzick, N.S.3    Zanjani, E.D.4
  • 36
    • 0030964445 scopus 로고    scopus 로고
    • Cellular therapy New trends and controversies in fetal diagnosis and therapy
    • Flake A, Zanjani E. Cellular therapy. New trends and controversies in fetal diagnosis and therapy. Obstet Gynecol Clin N Am 1997; 24: 159-77.
    • (1997) Obstet Gynecol Clin N Am , vol.24 , pp. 159-177
    • Flake, A.1    Zanjani, E.2
  • 37
    • 16644383495 scopus 로고    scopus 로고
    • Reconstitution of hematopoiesis following intrauterine transplantation of stem cells
    • Javazon EH, Merchant AM, Danzer E, Flake AW. Reconstitution of hematopoiesis following intrauterine transplantation of stem cells. Methods Mol Med 2005; 105: 81-94.
    • (2005) Methods Mol Med , vol.105 , pp. 81-94
    • Javazon, E.H.1    Merchant, A.M.2    Danzer, E.3    Flake, A.W.4
  • 39
    • 0028856705 scopus 로고
    • Fetal liver cell transplantation for the creation of lymphohematopoietic chimerism in fetal baboons
    • Shields LE, Bryant EM, Easterling TR, Andrews RG. Fetal liver cell transplantation for the creation of lymphohematopoietic chimerism in fetal baboons. Am J Obstet Gynecol 1995; 173: 1157-60.
    • (1995) Am J Obstet Gynecol , vol.173 , pp. 1157-1160
    • Shields, L.E.1    Bryant, E.M.2    Easterling, T.R.3    Andrews, R.G.4
  • 40
    • 21644470170 scopus 로고    scopus 로고
    • The use of CD 34(+) mobilized peripheral blood as a donor cell source does not improve chimerism after in utero hematopoietic stem cell transplantation in nonhuman primates
    • Shields LE, Gaur L, Delio P et al. The use of CD 34(+) mobilized peripheral blood as a donor cell source does not improve chimerism after in utero hematopoietic stem cell transplantation in nonhuman primates. J Med Primatol 2005; 34: 201-8.
    • (2005) J Med Primatol , vol.34 , pp. 201-208
    • Shields, L.E.1    Gaur, L.2    Delio, P.3
  • 41
    • 4444266178 scopus 로고    scopus 로고
    • Fetal immune suppression as adjunctive therapy for in utero hematopoietic stem cell transplantation in nonhuman primates
    • Shields LE, Gaur L, Delio P, Potter J, Sieverkropp A, Andrews RG. Fetal immune suppression as adjunctive therapy for in utero hematopoietic stem cell transplantation in nonhuman primates. Stem Cells 2004; 22: 759-69.
    • (2004) Stem Cells , vol.22 , pp. 759-769
    • Shields, L.E.1    Gaur, L.2    Delio, P.3    Potter, J.4    Sieverkropp, A.5    Andrews, R.G.6
  • 42
    • 0038700536 scopus 로고    scopus 로고
    • In utero hematopoietic stem cell transplantation in nonhuman primates: the role of T cells
    • Shields LE, Gaur LK, Gough M, Potter J, Sieverkropp A, Andrews RG. In utero hematopoietic stem cell transplantation in nonhuman primates: the role of T cells. Stem Cells 2003; 21: 304-14.
    • (2003) Stem Cells , vol.21 , pp. 304-314
    • Shields, L.E.1    Gaur, L.K.2    Gough, M.3    Potter, J.4    Sieverkropp, A.5    Andrews, R.G.6
  • 43
    • 0030038665 scopus 로고    scopus 로고
    • Long-term engraftment following in utero T cell-depleted parental marrow transplantation into fetal rhesus monkeys
    • Cowan MJ, Tarantal AF, Capper J, Harrison M, Garovoy M. Long-term engraftment following in utero T cell-depleted parental marrow transplantation into fetal rhesus monkeys. Bone Marrow Transplant 1996; 17: 1157-65.
    • (1996) Bone Marrow Transplant , vol.17 , pp. 1157-1165
    • Cowan, M.J.1    Tarantal, A.F.2    Capper, J.3    Harrison, M.4    Garovoy, M.5
  • 44
    • 18644366949 scopus 로고    scopus 로고
    • In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in swine
    • Lee PW, Cina RA, Randolph MA et al. In utero bone marrow transplantation induces kidney allograft tolerance across a full major histocompatibility complex barrier in swine. Transplantation 2005; 79: 1084-90.
    • (2005) Transplantation , vol.79 , pp. 1084-1090
    • Lee, P.W.1    Cina, R.A.2    Randolph, M.A.3
  • 45
    • 13844318519 scopus 로고    scopus 로고
    • Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs
    • Lee PW, Cina RA, Randolph MA et al. Stable multilineage chimerism across full MHC barriers without graft-versus-host disease following in utero bone marrow transplantation in pigs. Exp Hematol 2005; 33: 371-9.
    • (2005) Exp Hematol , vol.33 , pp. 371-379
    • Lee, P.W.1    Cina, R.A.2    Randolph, M.A.3
  • 46
    • 0035177557 scopus 로고    scopus 로고
    • In utero hematopoietic stem cell transplantation: a caprine model for prenatal therapy in inherited metabolic diseases
    • Lovell KL, Kraemer SA, Leipprandt JR et al. In utero hematopoietic stem cell transplantation: a caprine model for prenatal therapy in inherited metabolic diseases. Fetal Diagn Ther 2001; 16: 13-17.
    • (2001) Fetal Diagn Ther , vol.16 , pp. 13-17
    • Lovell, K.L.1    Kraemer, S.A.2    Leipprandt, J.R.3
  • 47
    • 0035046437 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras
    • Oppenheim SM, Muench MO, Gutierrez-Adan A et al. Hematopoietic stem cell transplantation in utero produces sheep-goat chimeras. Blood Cells Mol Dis 2001; 27: 296-308.
    • (2001) Blood Cells Mol Dis , vol.27 , pp. 296-308
    • Oppenheim, S.M.1    Muench, M.O.2    Gutierrez-Adan, A.3
  • 48
    • 2342428325 scopus 로고    scopus 로고
    • In utero hematopoietic stem cell transplantation with haploidentical donor adult bone marrow in a canine model
    • Blakemore K, Hattenburg C, Stetten G et al. In utero hematopoietic stem cell transplantation with haploidentical donor adult bone marrow in a canine model. Am J Obstet Gynecol 2004; 190: 960-73.
    • (2004) Am J Obstet Gynecol , vol.190 , pp. 960-973
    • Blakemore, K.1    Hattenburg, C.2    Stetten, G.3
  • 49
    • 0032998358 scopus 로고    scopus 로고
    • Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses
    • Omori F, Lutzko C, Abrams-Ogg A et al. Adoptive transfer of genetically modified human hematopoietic stem cells into preimmune canine fetuses. Exp Hematol 1999; 27: 242-9.
    • (1999) Exp Hematol , vol.27 , pp. 242-249
    • Omori, F.1    Lutzko, C.2    Abrams-Ogg, A.3
  • 50
    • 0033559722 scopus 로고    scopus 로고
    • Genetically corrected autologous stem cells engraft, but host immune responses limit their utility in canine alpha-L-iduronidase deficiency
    • Lutzko C, Kruth S, Abrams-Ogg AC et al. Genetically corrected autologous stem cells engraft, but host immune responses limit their utility in canine alpha-L-iduronidase deficiency. Blood 1999; 93: 1895-905.
    • (1999) Blood , vol.93 , pp. 1895-1905
    • Lutzko, C.1    Kruth, S.2    Abrams-Ogg, A.C.3
  • 51
    • 34247141337 scopus 로고    scopus 로고
    • Use of T-cell antibodies for donor dosaging in a canine model of in utero hematopoietic stem cell transplantation
    • Petersen SM, Gendelman M, Murphy KM et al. Use of T-cell antibodies for donor dosaging in a canine model of in utero hematopoietic stem cell transplantation. Fetal Diagn Ther 2007; 22: 175-9.
    • (2007) Fetal Diagn Ther , vol.22 , pp. 175-179
    • Petersen, S.M.1    Gendelman, M.2    Murphy, K.M.3
  • 52
    • 0025073709 scopus 로고
    • In utero transplantation of hematopoietic stem cells in sheep: the role of T cells in engraftment and graft-versus-host disease
    • Crombleholme TM, Harrison MR, Zanjani ED. In utero transplantation of hematopoietic stem cells in sheep: the role of T cells in engraftment and graft-versus-host disease. J Pediatr Surg 1990; 25: 885-92.
    • (1990) J Pediatr Surg , vol.25 , pp. 885-892
    • Crombleholme, T.M.1    Harrison, M.R.2    Zanjani, E.D.3
  • 53
    • 0344524500 scopus 로고
    • Prevention of genetic anemias in mice by microinjection of normal hematopoietic cells into the fetal placenta
    • Fleischman R, Mintz B. Prevention of genetic anemias in mice by microinjection of normal hematopoietic cells into the fetal placenta. Proc Natl Acad Sci U S A 1979; 76: 5736-40.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 5736-5740
    • Fleischman, R.1    Mintz, B.2
  • 54
    • 0024280901 scopus 로고
    • The dominant- white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler EN, Ryan MA, Housman DE. The dominant- white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 1988; 55: 185-92.
    • (1988) Cell , vol.55 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 55
    • 0021722705 scopus 로고
    • Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts
    • Mintz B, Anthony K, Litwin S. Monoclonal derivation of mouse myeloid and lymphoid lineages from totipotent hematopoietic stem cells experimentally engrafted in fetal hosts. Proc Natl Acad Sci U S A 1984; 81: 7835-9.
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 7835-7839
    • Mintz, B.1    Anthony, K.2    Litwin, S.3
  • 56
    • 0028825086 scopus 로고
    • In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities
    • Blazar BR, Taylor PA, Vallera DA. In utero transfer of adult bone marrow cells into recipients with severe combined immunodeficiency disorder yields lymphoid progeny with T- and B-cell functional capabilities. Blood 1995; 86: 4353-66.
    • (1995) Blood , vol.86 , pp. 4353-4366
    • Blazar, B.R.1    Taylor, P.A.2    Vallera, D.A.3
  • 57
    • 0033215518 scopus 로고    scopus 로고
    • In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers
    • Flake AW, Zanjani ED. In utero hematopoietic stem cell transplantation: ontogenic opportunities and biologic barriers. Blood 1999; 94: 2179-91.
    • (1999) Blood , vol.94 , pp. 2179-2191
    • Flake, A.W.1    Zanjani, E.D.2
  • 58
    • 0028845439 scopus 로고
    • Induction of tolerance in nondefective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells
    • Carrier E, Lee TH, Busch MP, Cowan MJ. Induction of tolerance in nondefective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells. Blood 1995; 86: 4681-90.
    • (1995) Blood , vol.86 , pp. 4681-4690
    • Carrier, E.1    Lee, T.H.2    Busch, M.P.3    Cowan, M.J.4
  • 59
    • 0028928897 scopus 로고
    • Adult bone marrow-derived pluripotent hematopoietic stem cells are engraftable when transferred in utero into moderately anemic fetal recipients
    • Blazar BR, Taylor PA, Vallera DA. Adult bone marrow-derived pluripotent hematopoietic stem cells are engraftable when transferred in utero into moderately anemic fetal recipients. Blood 1995; 85: 833-41.
    • (1995) Blood , vol.85 , pp. 833-841
    • Blazar, B.R.1    Taylor, P.A.2    Vallera, D.A.3
  • 60
    • 0031927365 scopus 로고    scopus 로고
    • Microchimerism and tolerance after in utero bone marrow transplantation in mice
    • Kim HB, Shaaban AF, Yang EY, Liechty KW, Flake AW. Microchimerism and tolerance after in utero bone marrow transplantation in mice. J Surg Res 1998; 77: 1-5.
    • (1998) J Surg Res , vol.77 , pp. 1-5
    • Kim, H.B.1    Shaaban, A.F.2    Yang, E.Y.3    Liechty, K.W.4    Flake, A.W.5
  • 61
    • 0026740372 scopus 로고
    • Hemopoietic chimerism in rodents transplanted in utero with fetal human hemopoietic cells
    • Pallavicini MG, Flake AW, Madden D et al. Hemopoietic chimerism in rodents transplanted in utero with fetal human hemopoietic cells. Transplant Proc 1992; 24: 542-3.
    • (1992) Transplant Proc , vol.24 , pp. 542-543
    • Pallavicini, M.G.1    Flake, A.W.2    Madden, D.3
  • 62
    • 0030860153 scopus 로고    scopus 로고
    • Sustained multilineage engraftment of allogeneic hematopoietic stem cells in NOD/SCID mice after in utero transplantation
    • Archer DR, Turner CW, Yeager AM, Fleming WH. Sustained multilineage engraftment of allogeneic hematopoietic stem cells in NOD/SCID mice after in utero transplantation. Blood 1997; 90: 3222-9.
    • (1997) Blood , vol.90 , pp. 3222-3229
    • Archer, D.R.1    Turner, C.W.2    Yeager, A.M.3    Fleming, W.H.4
  • 63
    • 0032533265 scopus 로고    scopus 로고
    • Engraftment of severe combined immune defi- cient mice receiving allogeneic bone marrow via in utero or postnatal transfer
    • Blazer BR, Taylor PA, McElmurry R et al. Engraftment of severe combined immune defi- cient mice receiving allogeneic bone marrow via in utero or postnatal transfer. Blood 1998; 92: 3949-59.
    • (1998) Blood , vol.92 , pp. 3949-3959
    • Blazer, B.R.1    Taylor, P.A.2    McElmurry, R.3
  • 64
    • 0037114177 scopus 로고    scopus 로고
    • Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells
    • Christopherson KW, 2nd, Hangoc G, Broxmeyer HE. Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells. J Immunol 2002; 169: 7000-8.
    • (2002) J Immunol , vol.169 , pp. 7000-7008
    • Christopherson II, K.W.1    Hangoc, G.2    Broxmeyer, H.E.3
  • 65
    • 4043117769 scopus 로고    scopus 로고
    • Modulation of hematopoietic stem cell homing and engraftment by CD26
    • Christopherson KW, Hangoc G, Mantel CR, Broxmeyer HE. Modulation of hematopoietic stem cell homing and engraftment by CD26. Science 2004; 305: 1000-3.
    • (2004) Science , vol.305 , pp. 1000-1003
    • Christopherson, K.W.1    Hangoc, G.2    Mantel, C.R.3    Broxmeyer, H.E.4
  • 66
    • 33845483092 scopus 로고    scopus 로고
    • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation
    • Peranteau WH, Endo M, Adibe OO, Merchant A, Zoltick PW, Flake AW. CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. Blood 2006; 108: 4268-74.
    • (2006) Blood , vol.108 , pp. 4268-4274
    • Peranteau, W.H.1    Endo, M.2    Adibe, O.O.3    Merchant, A.4    Zoltick, P.W.5    Flake, A.W.6
  • 67
    • 0037105589 scopus 로고    scopus 로고
    • High level allogeneic chimerism achieved by prenatal tolerance induction and postnatal non-myeloablative bone marrow transplantation
    • Peranteau WF, Hayashi S, Hsieh M, Shaaban AF, Flake AW. High level allogeneic chimerism achieved by prenatal tolerance induction and postnatal non-myeloablative bone marrow transplantation. Blood 2002; 100: 2225-34.
    • (2002) Blood , vol.100 , pp. 2225-2234
    • Peranteau, W.F.1    Hayashi, S.2    Hsieh, M.3    Shaaban, A.F.4    Flake, A.W.5
  • 68
    • 33644909853 scopus 로고    scopus 로고
    • Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation
    • Ashizuka S, Peranteau WH, Hayashi S, Flake AW. Busulfan-conditioned bone marrow transplantation results in high-level allogeneic chimerism in mice made tolerant by in utero hematopoietic cell transplantation. Exp Hematol 2006; 34: 359-68.
    • (2006) Exp Hematol , vol.34 , pp. 359-368
    • Ashizuka, S.1    Peranteau, W.H.2    Hayashi, S.3    Flake, A.W.4
  • 69
    • 0026717362 scopus 로고
    • Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero
    • Zanjani ED, Pallavicini MG, Flake AW et al. Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero. J Clin Invest 1992; 89: 1178-88.
    • (1992) J Clin Invest , vol.89 , pp. 1178-1188
    • Zanjani, E.D.1    Pallavicini, M.G.2    Flake, A.W.3
  • 70
    • 0028221579 scopus 로고
    • Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep
    • Zanjani ED, Flake AW, Rice H, Hedrick M, Tavassoli M. Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep. J Clin Invest 1994; 93: 1051-5.
    • (1994) J Clin Invest , vol.93 , pp. 1051-1055
    • Zanjani, E.D.1    Flake, A.W.2    Rice, H.3    Hedrick, M.4    Tavassoli, M.5
  • 71
    • 0000100498 scopus 로고    scopus 로고
    • High-level allogeneic hematopoietic chimerism following prenatal stem cell transplantation requires negative selection of donor thymocytes mediated by host antigen presentation cells
    • Shaaban AF, Milner R, Kim HB, Flake AW. High-level allogeneic hematopoietic chimerism following prenatal stem cell transplantation requires negative selection of donor thymocytes mediated by host antigen presentation cells. Exp Hematol 1999; 27(Suppl 1): 347.
    • (1999) Exp Hematol , vol.27 , Issue.SUPPL.. 1 , pp. 347
    • Shaaban, A.F.1    Milner, R.2    Kim, H.B.3    Flake, A.W.4
  • 72
    • 0344173225 scopus 로고    scopus 로고
    • In utero bone marrow transplantation induces donor-specific tolerance by a combination of clonal deletion and clonal anergy
    • 729-730
    • Kim HB, Shaaban AF, Milner R, Fichter C, Flake AW. In utero bone marrow transplantation induces donor-specific tolerance by a combination of clonal deletion and clonal anergy. J Pediatr Surg 1999; 34: 726-9; discussion 729-30.
    • (1999) J Pediatr Surg , vol.34 , pp. 726-729
    • Kim, H.B.1    Shaaban, A.F.2    Milner, R.3    Fichter, C.4    Flake, A.W.5
  • 73
    • 0033134088 scopus 로고    scopus 로고
    • Postnatal booster injections increase engraftment after in utero stem cell transplantation
    • Milner R, Shaaban A, Kim HB, Fichter C, Flake AW. Postnatal booster injections increase engraftment after in utero stem cell transplantation. J Surg Res 1999; 83: 44-7.
    • (1999) J Surg Res , vol.83 , pp. 44-47
    • Milner, R.1    Shaaban, A.2    Kim, H.B.3    Fichter, C.4    Flake, A.W.5
  • 74
    • 0027451062 scopus 로고
    • In utero engraftment of fully H-2-incompatible versus congenic adult bone marrow transferred into nonanemic or anemic murine fetal recipients
    • Howson-Jan K, Matloub YH, Vallera DA, Blazar BR. In utero engraftment of fully H-2-incompatible versus congenic adult bone marrow transferred into nonanemic or anemic murine fetal recipients. Transplantation 1993; 56: 709-16.
    • (1993) Transplantation , vol.56 , pp. 709-716
    • Howson-Jan, K.1    Matloub, Y.H.2    Vallera, D.A.3    Blazar, B.R.4
  • 75
    • 0342981447 scopus 로고    scopus 로고
    • Recruitment of engrafted donor cells postnatally into the blood with cytokines after in utero transplantation in mice
    • Carrier E, Lee TH, Busch MP, Cowan MJ. Recruitment of engrafted donor cells postnatally into the blood with cytokines after in utero transplantation in mice. Transplantation 1997; 64: 627-33.
    • (1997) Transplantation , vol.64 , pp. 627-633
    • Carrier, E.1    Lee, T.H.2    Busch, M.P.3    Cowan, M.J.4
  • 76
    • 0032836513 scopus 로고    scopus 로고
    • Co-transplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cell in utero
    • Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED. Co-transplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cell in utero. Exp Hematol 1999; 27: 1569-75.
    • (1999) Exp Hematol , vol.27 , pp. 1569-1575
    • Almeida-Porada, G.1    Flake, A.W.2    Glimp, H.A.3    Zanjani, E.D.4
  • 77
    • 0034210222 scopus 로고    scopus 로고
    • Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
    • Almeida-Porada G, Porada CD, Tran N, Zanjani ED. Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 2000; 95: 3620-7.
    • (2000) Blood , vol.95 , pp. 3620-3627
    • Almeida-Porada, G.1    Porada, C.D.2    Tran, N.3    Zanjani, E.D.4
  • 78
    • 0018763412 scopus 로고
    • Transplantation of murine bone marrow without prior host irradiation
    • Brecher G, Tjio JH, Haley JE, Narla J, Beal SL. Transplantation of murine bone marrow without prior host irradiation. Blood Cells 1979; 5: 237-46.
    • (1979) Blood Cells , vol.5 , pp. 237-246
    • Brecher, G.1    Tjio, J.H.2    Haley, J.E.3    Narla, J.4    Beal, S.L.5
  • 79
    • 0027263351 scopus 로고
    • Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice
    • Stewart FM, Crittenden RB, Lowry PA, Pearson- White S, Quesenberry PJ. Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice. Blood 1993; 81: 2566-71.
    • (1993) Blood , vol.81 , pp. 2566-2571
    • Stewart, F.M.1    Crittenden, R.B.2    Lowry, P.A.3    Pearson-White, S.4    Quesenberry, P.J.5
  • 80
    • 0034971850 scopus 로고    scopus 로고
    • Non-myeloablative allogeneic stem cell transplantation focusing on immunotherapy of life-threatening malignant and nonmalignant diseases
    • Slavin S, Nagler A, Shapira M, Panigrahi S, Samuel S, Or A. Non-myeloablative allogeneic stem cell transplantation focusing on immunotherapy of life-threatening malignant and nonmalignant diseases. Crit Rev Oncol Hematol 2001; 39: 25-9.
    • (2001) Crit Rev Oncol Hematol , vol.39 , pp. 25-29
    • Slavin, S.1    Nagler, A.2    Shapira, M.3    Panigrahi, S.4    Samuel, S.5    Or, A.6
  • 81
    • 0033594552 scopus 로고    scopus 로고
    • Mixed lymphohaemopoietic chimerism and graft-versuslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation [see comments]
    • Sykes M, Preffer F, McAfee S et al. Mixed lymphohaemopoietic chimerism and graft-versuslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation [see comments]. Lancet 1999; 353: 1755-9.
    • (1999) Lancet , vol.353 , pp. 1755-1759
    • Sykes, M.1    Preffer, F.2    McAfee, S.3
  • 83
    • 0034753753 scopus 로고    scopus 로고
    • Prenatal intervention: ethical considerations for life-threatening and non-life-threatening anomalies
    • Flake AW. Prenatal intervention: ethical considerations for life-threatening and non-life-threatening anomalies. Semin Pediatr Surg 2001; 10: 212-21.
    • (2001) Semin Pediatr Surg , vol.10 , pp. 212-221
    • Flake, A.W.1
  • 84
    • 0026729428 scopus 로고
    • Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses
    • Zanjani ED, Ascensao JL, Harrison MR, Tavassoli M. Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses. Blood 1992; 79: 3045-9.
    • (1992) Blood , vol.79 , pp. 3045-3049
    • Zanjani, E.D.1    Ascensao, J.L.2    Harrison, M.R.3    Tavassoli, M.4
  • 85
    • 84890737310 scopus 로고    scopus 로고
    • Fetal liver is a superior donor source for the engraftment of prenatally transplanted allogeneic hematopoietic stem cells
    • Abstract 320
    • Shaaban AF, Milner R, Kim HB, Flake AW. Fetal liver is a superior donor source for the engraftment of prenatally transplanted allogeneic hematopoietic stem cells. Exp Hematol 1999; 27(Suppl 1): 121, Abstract 320.
    • Exp Hematol 1999 , vol.27 , Issue.SUPPL. 1 , pp. 121
    • Shaaban, A.F.1    Milner, R.2    Kim, H.B.3    Flake, A.W.4
  • 86
    • 0027247597 scopus 로고
    • Bacterial and fungal contamination of human fetal liver collected transvaginally for hematopoietic stem cell transplantation
    • Rice HE, Hedrick MH, Flake AW, Donegan E, Harrison MR. Bacterial and fungal contamination of human fetal liver collected transvaginally for hematopoietic stem cell transplantation. Fetal Diagn Ther 1993; 8: 74-8.
    • (1993) Fetal Diagn Ther , vol.8 , pp. 74-78
    • Rice, H.E.1    Hedrick, M.H.2    Flake, A.W.3    Donegan, E.4    Harrison, M.R.5
  • 87
    • 0025887814 scopus 로고
    • Hematopoietic chimerism in sheep and nonhuman primates by in utero transplantation of fetal hematopoietic stem cells
    • Zanjani ED, Mackintosh FR, Harrison MR. Hematopoietic chimerism in sheep and nonhuman primates by in utero transplantation of fetal hematopoietic stem cells. Blood Cells 1991; 17: 349-63.
    • (1991) Blood Cells , vol.17 , pp. 349-363
    • Zanjani, E.D.1    Mackintosh, F.R.2    Harrison, M.R.3
  • 88
    • 17744383751 scopus 로고    scopus 로고
    • Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease
    • Muench MO, Rae J, Barcena A et al. Transplantation of a fetus with paternal Thy-1(+)CD34(+)cells for chronic granulomatous disease. Bone Marrow Transplant 2001; 27: 355-64.
    • (2001) Bone Marrow Transplant , vol.27 , pp. 355-364
    • Muench, M.O.1    Rae, J.2    Barcena, A.3
  • 89
    • 1542297360 scopus 로고    scopus 로고
    • Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes
    • Hayashi S, Hsieh M, Peranteau WH, Ashizuka S, Flake AW. Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes. Exp Hematol 2004; 32: 290-9.
    • (2004) Exp Hematol , vol.32 , pp. 290-299
    • Hayashi, S.1    Hsieh, M.2    Peranteau, W.H.3    Ashizuka, S.4    Flake, A.W.5
  • 90
    • 0036884262 scopus 로고    scopus 로고
    • Multilineage engraftment with minimal graft-versushost disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice
    • Bhattacharyya S, Chawla A, Smith K et al. Multilineage engraftment with minimal graft-versushost disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice. J Immunol 2002; 169: 6133-40.
    • (2002) J Immunol , vol.169 , pp. 6133-6140
    • Bhattacharyya, S.1    Chawla, A.2    Smith, K.3
  • 91
    • 0024522992 scopus 로고
    • The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormalities
    • Rhoads G, Jackson L, Schlesselman S et al. The safety and efficacy of chorionic villus sampling for early prenatal diagnosis of cytogenetic abnormalities. N Engl J Med 1989; 320: 609-17.
    • (1989) N Engl J Med , vol.320 , pp. 609-617
    • Rhoads, G.1    Jackson, L.2    Schlesselman, S.3
  • 92
    • 0011826222 scopus 로고
    • Hemolytic disease (erythroblastosis fetalis)
    • Creasy RK, Philadelphia: WB Saunders
    • Bowman J. Hemolytic disease (erythroblastosis fetalis). In: Creasy RK, Resnik R, editors. Maternal- fetal medicine principles and practice, 3rd edn. Philadelphia: WB Saunders; 1994. pp. 730-3.
    • (1994) Maternal- fetal medicine principles and practice, 3rd edn , pp. 730-733
    • Bowman, J.1
  • 93
    • 0029092530 scopus 로고
    • Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease
    • Mackinnon S, Papadopoulos EB, Carabasi MH et al. Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood 1995; 86: 1261-8.
    • (1995) Blood , vol.86 , pp. 1261-1268
    • Mackinnon, S.1    Papadopoulos, E.B.2    Carabasi, M.H.3
  • 94
    • 0027423204 scopus 로고
    • In utero acute graft-versus-host disease in a neonate with severe combined immuIn nodeficiency
    • Alain G, Carrier C, Beaumier L, Bernard J, Lemay M, Lavoie A. In utero acute graft-versus-host disease in a neonate with severe combined immuIn nodeficiency. J Am Acad Dermatol 1993; 29: 862-5.
    • (1993) J Am Acad Dermatol , vol.29 , pp. 862-865
    • Alain, G.1    Carrier, C.2    Beaumier, L.3    Bernard, J.4    Lemay, M.5    Lavoie, A.6
  • 95
    • 0028906667 scopus 로고
    • Engrafted maternal T cells in a severe combined immunodeficiency patient express T-cell receptor variable beta segments characterized by a restricted V-D-J junctional diversity
    • Sottini A, Quiros-Roldan E, Notarangelo LD, Malagoli A, Primi D, Imberti L. Engrafted maternal T cells in a severe combined immunodeficiency patient express T-cell receptor variable beta segments characterized by a restricted V-D-J junctional diversity. Blood 1995; 85: 2105-13.
    • (1995) Blood , vol.85 , pp. 2105-2113
    • Sottini, A.1    Quiros-Roldan, E.2    Notarangelo, L.D.3    Malagoli, A.4    Primi, D.5    Imberti, L.6
  • 96
    • 0029848406 scopus 로고    scopus 로고
    • Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow
    • Flake A, Roncarolo M-G, Puck J et al. Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. N Engl J Med 1996; 335: 1806-10.
    • (1996) N Engl J Med , vol.335 , pp. 1806-1810
    • Flake, A.1    Roncarolo, M.-G.2    Puck, J.3
  • 97
    • 16144362330 scopus 로고    scopus 로고
    • In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDX1)
    • Wengler G, Lanfranchi A, Frusca T et al. In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDX1). Lancet 1996; 348: 1484-7.
    • (1996) Lancet , vol.348 , pp. 1484-1487
    • Wengler, G.1    Lanfranchi, A.2    Frusca, T.3
  • 98
    • 2942699851 scopus 로고    scopus 로고
    • Reconstitution of T-cell compartment after in utero stem cell transplantation: analysis of T-cell repertoire and thymic output
    • Pirovano S, Notarangelo LD, Malacarne F et al. Reconstitution of T-cell compartment after in utero stem cell transplantation: analysis of T-cell repertoire and thymic output. Haematologica 2004; 89: 450-61.
    • (2004) Haematologica , vol.89 , pp. 450-461
    • Pirovano, S.1    Notarangelo, L.D.2    Malacarne, F.3
  • 99
    • 0027320217 scopus 로고
    • The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1
    • Puck JM, Deschenes SM, Porter JC et al. The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1. Hum Mol Genet 1993; 2: 1099-104.
    • (1993) Hum Mol Genet , vol.2 , pp. 1099-1104
    • Puck, J.M.1    Deschenes, S.M.2    Porter, J.C.3
  • 100
    • 0033580206 scopus 로고    scopus 로고
    • Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency
    • Buckley RH, Schiff SE, Schiff RI et al. Hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Engl J Med 1999; 340: 508-16.
    • (1999) N Engl J Med , vol.340 , pp. 508-516
    • Buckley, R.H.1    Schiff, S.E.2    Schiff, R.I.3
  • 101
    • 0034724857 scopus 로고    scopus 로고
    • Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
    • Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000; 288: 669-72.
    • (2000) Science , vol.288 , pp. 669-672
    • Cavazzana-Calvo, M.1    Hacein-Bey, S.2    de Saint Basile, G.3
  • 102
    • 34249890562 scopus 로고    scopus 로고
    • Gene therapy for severe combined immunodeficiency: are we there yet
    • Cavazzana-Calvo M, Fischer A. Gene therapy for severe combined immunodeficiency: are we there yet? J Clin Invest 2007; 117: 1456-65.
    • (2007) J Clin Invest , vol.117 , pp. 1456-1465
    • Cavazzana-Calvo, M.1    Fischer, A.2
  • 103
    • 0030816363 scopus 로고    scopus 로고
    • Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation
    • Gallego MD, Santamaría M, Peña J, Molina IJ. Defective actin reorganization and polymerization of Wiskott-Aldrich T cells in response to CD3-mediated stimulation. Blood 1997; 90: 3089-97.
    • (1997) Blood , vol.90 , pp. 3089-3097
    • Gallego, M.D.1    Santamaría, M.2    Peña, J.3    Molina, I.J.4
  • 104
    • 0019212580 scopus 로고
    • Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection
    • Prchal JT, Carroll AJ, Prchal JF et al. Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection. Blood 1980; 56: 1048-54.
    • (1980) Blood , vol.56 , pp. 1048-1054
    • Prchal, J.T.1    Carroll, A.J.2    Prchal, J.F.3
  • 105
    • 0025253465 scopus 로고
    • Prenatal test for X-linked severe combined immunodeficiency by analysis of maternal X-chromosome inactivation and linkage analysis
    • Puck J, Krauss C, Puck S, Buckley R, Conley M. Prenatal test for X-linked severe combined immunodeficiency by analysis of maternal X-chromosome inactivation and linkage analysis. N Engl J Med 1990; 322: 1063-6.
    • (1990) N Engl J Med , vol.322 , pp. 1063-1066
    • Puck, J.1    Krauss, C.2    Puck, S.3    Buckley, R.4    Conley, M.5
  • 106
    • 0028932527 scopus 로고
    • Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome
    • Wengler G, Gorlin JB, Williamson JM, Rosen FS, Bing DH. Nonrandom inactivation of the X chromosome in early lineage hematopoietic cells in carriers of Wiskott-Aldrich syndrome. Blood 1995; 85: 2471-7.
    • (1995) Blood , vol.85 , pp. 2471-2477
    • Wengler, G.1    Gorlin, J.B.2    Williamson, J.M.3    Rosen, F.S.4    Bing, D.H.5
  • 107
    • 0027437515 scopus 로고
    • Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases
    • Mullen CA, Anderson KD, Blaese RM. Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term follow-up of 62 cases. Blood 1993; 82: 2961-6.
    • (1993) Blood , vol.82 , pp. 2961-2966
    • Mullen, C.A.1    Anderson, K.D.2    Blaese, R.M.3
  • 108
    • 0026740611 scopus 로고
    • Unrelated donor bone marrow transplantation for correction of lethal congenital immunodeficiencies
    • Filipovich AH, Shapiro RS, Ramsay NK et al. Unrelated donor bone marrow transplantation for correction of lethal congenital immunodeficiencies. Blood 1992; 80: 270-6.
    • (1992) Blood , vol.80 , pp. 270-276
    • Filipovich, A.H.1    Shapiro, R.S.2    Ramsay, N.K.3
  • 109
    • 0027316082 scopus 로고
    • Hereditary tyrosinemia type I Selfinduced correction of the fumarylacetoacetase defect
    • Kvittingen EA, Rootwelt H, Brandtzaeg P, Bergan A, Berger R. Hereditary tyrosinemia type I. Selfinduced correction of the fumarylacetoacetase defect. J Clin Invest 1993; 91: 1816-21.
    • (1993) J Clin Invest , vol.91 , pp. 1816-1821
    • Kvittingen, E.A.1    Rootwelt, H.2    Brandtzaeg, P.3    Bergan, A.4    Berger, R.5
  • 110
    • 0029902033 scopus 로고    scopus 로고
    • Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency
    • Hirschhorn R, Yang DR, Puck JM, Huie ML, Jiang CK, Kurlandsky LE. Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency. Nat Genet 1996; 13: 290-6.
    • (1996) Nat Genet , vol.13 , pp. 290-296
    • Hirschhorn, R.1    Yang, D.R.2    Puck, J.M.3    Huie, M.L.4    Jiang, C.K.5    Kurlandsky, L.E.6
  • 111
    • 0030884238 scopus 로고    scopus 로고
    • Molecular biology of Fanconi anemia: implications for diagnosis and therapy
    • D'Andrea AD, Grompe M. Molecular biology of Fanconi anemia: implications for diagnosis and therapy. Blood 1997; 90: 1725-36.
    • (1997) Blood , vol.90 , pp. 1725-1736
    • D'Andrea, A.D.1    Grompe, M.2
  • 112
    • 0028859379 scopus 로고
    • Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells
    • Ellis NA, Lennon DJ, Proytcheva M, Aldadeff B, Henderson EE, German J. Somatic intragenic recombination within the mutated locus BLM can correct the high sister-chromatid exchange phenotype of Bloom syndrome cells. Am J Hum Genet 1995; 57: 1019-27.
    • (1995) Am J Hum Genet , vol.57 , pp. 1019-1027
    • Ellis, N.A.1    Lennon, D.J.2    Proytcheva, M.3    Aldadeff, B.4    Henderson, E.E.5    German, J.6
  • 113
    • 26844488044 scopus 로고    scopus 로고
    • Rescue of ATPa3-deficient murine malignant osteopetrosis by hematopoietic stem cell transplantation in utero
    • Frattini A, Blair HC, Sacco MG et al. Rescue of ATPa3-deficient murine malignant osteopetrosis by hematopoietic stem cell transplantation in utero. Proc Natl Acad Sci U S A 2005; 102: 14629-34.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 14629-34
    • Frattini, A.1    Blair, H.C.2    Sacco, M.G.3
  • 114
    • 0033678140 scopus 로고    scopus 로고
    • Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep
    • Liechty KW, MacKenzie TC, Shaaban AF et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6: 1282-6.
    • (2000) Nat Med , vol.6 , pp. 1282-1286
    • Liechty, K.W.1    MacKenzie, T.C.2    Shaaban, A.F.3
  • 116
    • 0030728405 scopus 로고    scopus 로고
    • In utero hematopoietic stem cell transplantation
    • Flake AW, Zanjani ED. In utero hematopoietic stem cell transplantation. A status report. JAMA 1997; 278: 932-7.
    • (1997) A status report. JAMA , vol.278 , pp. 932-937
    • Flake, A.W.1    Zanjani, E.D.2
  • 117
    • 0029854621 scopus 로고    scopus 로고
    • In utero haematopoietic stem cell transplantation: current perspectives and future potential
    • Jones DR, Bui TH, Anderson EM et al. In utero haematopoietic stem cell transplantation: current perspectives and future potential. Bone Marrow Transplant 1996; 18: 831-37.
    • (1996) Bone Marrow Transplant , vol.18 , pp. 831-837
    • Jones, D.R.1    Bui, T.H.2    Anderson, E.M.3
  • 118
    • 33845299531 scopus 로고    scopus 로고
    • In utero stem cell transplantation
    • Westgren M. In utero stem cell transplantation. Semin Reprod Med 2006; 24: 348-57.
    • (2006) Semin Reprod Med , vol.24 , pp. 348-357
    • Westgren, M.1
  • 119
    • 7144259078 scopus 로고    scopus 로고
    • Microchimerism and tolerance following intrauterine transplantation and transfusion for a-thalassemia-1
    • Hayward A, Ambruso D, Battaglia F et al. Microchimerism and tolerance following intrauterine transplantation and transfusion for a-thalassemia-1. Fetal Diagn Ther 1998; 13: 8-14.
    • (1998) Fetal Diagn Ther , vol.13 , pp. 8-14
    • Hayward, A.1    Ambruso, D.2    Battaglia, F.3
  • 120
    • 0036677704 scopus 로고    scopus 로고
    • Prenatal T-cell reconstitution after in utero transplantation with fetal liver cells in a patient with X-linked severe combined immunodefi- ciency
    • Westgren M, Ringden O, Bartmann P et al. Prenatal T-cell reconstitution after in utero transplantation with fetal liver cells in a patient with X-linked severe combined immunodefi- ciency. Am J Obstet Gynecol 2002; 187: 475-82.
    • (2002) Am J Obstet Gynecol , vol.187 , pp. 475-482
    • Westgren, M.1    Ringden, O.2    Bartmann, P.3
  • 121
    • 0029983013 scopus 로고    scopus 로고
    • Lack of evidence of permanent engraftment after in utero fetal stem cell transplantation in congenital hemoglobinopathies
    • Westgren M, Ringden O, Sturla E-N et al. Lack of evidence of permanent engraftment after in utero fetal stem cell transplantation in congenital hemoglobinopathies. Transplantation 1996; 61: 1176-9.
    • (1996) Transplantation , vol.61 , pp. 1176-1179
    • Westgren, M.1    Ringden, O.2    Sturla, E.-N.3
  • 122
    • 0033595133 scopus 로고    scopus 로고
    • Treatment of severe combined immunodeficiency [Letter to the Editor]
    • Flake AW, Zanjani ED. Treatment of severe combined immunodeficiency [Letter to the Editor]. N Engl J Med 1999; 341: 291.
    • (1999) N Engl J Med , vol.341 , pp. 291
    • Flake, A.W.1    Zanjani, E.D.2
  • 123
    • 85047698986 scopus 로고    scopus 로고
    • B cell function after haploidentical in utero bone marrow transplantation in a patient with severe combined immunodeficiency
    • Bartolome J, Porta F, Lafranchi A et al. B cell function after haploidentical in utero bone marrow transplantation in a patient with severe combined immunodeficiency. Bone Marrow Transplant 2002; 29: 625-8.
    • (2002) Bone Marrow Transplant , vol.29 , pp. 625-628
    • Bartolome, J.1    Porta, F.2    Lafranchi, A.3
  • 124
    • 20544455396 scopus 로고    scopus 로고
    • Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta
    • Le Blanc K, Gotherstrom C, Ringden O et al. Fetal mesenchymal stem-cell engraftment in bone after in utero transplantation in a patient with severe osteogenesis imperfecta. Transplantation 2005; 79: 1607-14.
    • (2005) Transplantation , vol.79 , pp. 1607-1614
    • Le Blanc, K.1    Gotherstrom, C.2    Ringden, O.3


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