The use of CD34+ mobilized peripheral blood as a donor cell source does not improve chimerism after in utero hematopoietic stem cell transplantation in non-human primates

Journal of Medical Primatology

Volumn 34, Issue 4, 2005, Pages 201-208

  Shields, Laurence E ^a,b   Gaur, Lakshmi ^b   Delio, Patrick ^b   Gough, Mike ^b   Potter, Jennifer ^c   Sieverkropp, Aimee ^a   Andrews, Robert G ^a,b,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Fetal therapy; Fetus; Macaque

Indexed keywords

CD34 ANTIGEN; GENOMIC DNA;

ANIMAL EXPERIMENT; APHERESIS; ARTICLE; BONE MARROW BIOPSY; CD34 SELECTION; CELL CULTURE; CELL ISOLATION; CHIMERA; CONTROLLED STUDY; DNA ISOLATION; DONOR; FEMALE; FETUS; FETUS HYDROPS; GRAFT VERSUS HOST REACTION; IN UTERO STEM CELL TRANSPLANTATION; NONHUMAN; PERIPHERAL BLOOD STEM CELL; PREGNANCY; PRIMATE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; ANIMAL DISEASE; BONE MARROW CELL; FETAL THERAPY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HISTOCOMPATIBILITY; IMMUNOLOGY; MACACA; METHODOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRENATAL DEVELOPMENT;

ANIMALIA; PRIMATES;

ANIMALS; ANTIGENS, CD34; BLOOD COMPONENT REMOVAL; BONE MARROW CELLS; CHIMERISM; FEMALE; FETAL THERAPIES; GRAFT VS HOST DISEASE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MACACA NEMESTRINA; POLYMERASE CHAIN REACTION; PREGNANCY; TRANSPLANTATION CHIMERA;

EID: 21644470170     PISSN: 00472565     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0684.2005.00110.x     Document Type: Article

References (49)

1. Ahmed T, Wuest D, Ciavarella D: Peripheral blood stem cell mobilization by cytokines. J Clin Apheresis 7:129-131, 1992.
2. Almeida-Porada G, Flake AW, Glimp HA, Zanjani ED: Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero. Exp Hematol 27:1569-1575, 1999.
3. Almeida-Porada G, Porada CD, Tran N, Zanjani ED: Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation. Blood 95:3620-3627, 2000.
4. Andreux JP, Renard M, Daffos F, Forestier F: Erythropoietic progenitor cells in human fetal blood. Nouv Rev Fr Hematol 33:223-226, 1991.
5. Andrews R, Torok-Storb B, Bernstein I: Myeloid-associated differentiation antigens on stem cells and their progeny identified by monoclonal antibodies. Blood 62:124-132, 1983.
6. Andrews RG, Briddell RA, Kniter GH, Opie T, Bronsden M, Myerson D, Apelbaum FR, McNiece IK: In vivo synergy between recombinant human stem cell factor and recombinant human granulocyte colony-stimulating factor in baboons enhanced circulation of progenitor cells. Blood 84:800-810, 1994.
7. Andrews RG, Bridell RA, Hill R, Gough M, McNiece IK: Engraftment of primates with G-CSF mobilized peripheral blood CD34+ progenitor cells expanded in G-CSF, SCF and MGDF decreases the duration and severity of neutropenia. Stem Cells 17:210-218, 1999.
8. Andrews RG, Peterson LJ, Morris J, Potter J, Heyward S, Gough M, Bryant E, Kiem H: Differential engraftment of genetically modified CD34(+) and CD34(-) hematopoietic cell subsets in lethally irradiated baboons. Exp Hematol 28:508-518, 2000.
9. Asosingh K, Renmans W, Van der Gucht K, Foulon W, Schots R, Van Riet I, De Waele M: Circulating CD34+ cells in cord blood and mobilized blood have a different profile of adhesion molecules than bone marrow CD34+ cells. Eur J Haematol 60:153-160, 1998.
10. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, Hardy W, Devine S, Ucker D, Deans R, Mosely A, Hoffman R: Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42-48, 2002.
11. Bhattacharyya S, Chawla A, Smith K, Zhou Y, Talib S, Wardwell B, Cowan MJ: Multilineage engraftment with minimal graft-versus-host disease following in utero transplantation of S-59 psoralen/ultraviolet a light-treated, sensitized T cells and adult T cell-depleted bone marrow in fetal mice. J Immunol 169:6133-6140, 2002.
12. Boyer PJ, Jones MZ, Nachreiner RF, Refsal KR, Common RS, Kelley J, Lovell KL: Caprine beta-mannosidosis. Abnormal thyroid structure and function in a lysosomal storage disease. Lab Invest 63:100-106, 1990.
13. Brent L, Linch DC, Rodeck CH, Nicolaides K, DeGiorgi L, Sherwood RA, al-Imara L, Mew J, Socha W: On the feasibility of inducing tolerance in man: a study in the cynomolgus monkey. Immunol Lett 21:55-61, 1989.
14. Carrier E, Lee TH, Busch MP, Cowan MJ: Induction of tolerance in nondefective mice after in utero transplantation of major histocompatibility complex-mismatched fetal hematopoietic stem cells. Blood 86:4681-4690, 1995.
15. Clapp W, Baley J, Gerson S: Gestational age-dependent changes in circulating hematopoietic stem cells in newborn infants. J Lab Clin Med 113:422-427, 1989.
16. Conrad S, Ha J, Lohr C, Sackett G: Ultrasound measurement of fetal growth in Macaca nemestrina. Am J Primatol 36:15-36, 1995.
17. Cowan MJ, Golbus M: In utero hematopoietic stem cell transplants for inherited diseases. Am J Pediatr Hematol Oncol 16:35-42, 1994.
18. Demirer T, Buckner CD, Appelbaum FR, Petersen FB, Rowley S, Weaver CH, Lilleby K, Sanders J, Chauncey T, Storb R, Schiffman K, Benyunes MC, Fefer A, Montgomery P, Bensinger WI: Rapid engraftment after autologous transplantation utilizing marrow and recombinant granulocyte colony-stimulating factor-mobilized peripheral blood stem cells in patients with acute myelogenous leukemia. Bone Marrow Transplant 15:915-922, 1995.
19. DeVito J, Graham J, Sackett G: Volumetric growth of the major brain divisions in fetal Macaca nemestrina. J Hirnforsch 30:479-487, 1989.
20. Donahue J, Gilpin E, Young D, Carrier E: Postnatal cytokines and boosts improve chimerism and hematological parameters in beta-thalassemic mice transplanted in utero. Transplantation 71:1491-1494, 2001.
21. Flake AW, Roncarolo MG, Puck JM, Almeida Porada G, Evans MI, Johnson MP, Abella EM, Harrison DD, Zanjani ED: Treatment of X-linked severe combined immunodeficiency by in utero transplantation of paternal bone marrow. N Engl J Med 335:1806-1810, 1996.
22. Fleischman RA, Mintz B: Prevention of genetic anemias in mice by microinjection of normal hematopoietic stem cells into the fetal placenta. Proc Natl Acad Sci U S A 76:5736-5740, 1979.
23. Fleischman RA, Custer RP, Mintz B: Totipotent hematopoietic stem cells: normal self-renewal and differentiation after transplantation between mouse fetuses. Cell 30:351-359, 1982.
24. Gotherstrom C, Ringden O, Westgren M, Tammik C, Le Blanc K: Immunomodulatory effects of human foetal liver-derived mesenchymal stem cells. Bone Marrow Transplant 32:265-272, 2003.
25. Harrison M: In-utero transplantation of fetal liver haematopoietic stem cells in monkeys. Lancet 2:1425-1427, 1989.
26. Hayashi S, Hsieh M, Peranteau WH, Ashizuka S, Flake AW: Complete allogeneic hematopoietic chimerism achieved by in utero hematopoietic cell transplantation and cotransplantation of LLME-treated, MHC-sensitized donor lymphocytes. Exp Hematol 32:290-299, 2004.
27. Horn PA, Topp MS, Morris JC, Riddell SR, Kiem HP: Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells. Blood 100:3960-3967, 2002.
28. Lillie FR: The theory of the free-martin. Science 43:611-613, 1916.
29. McNiece IK, Briddell RA, Hartley CA, Smith KA, Andrews RG: Stem cell factor enhances in vivo effects of granulocyte colony stimulating factor for stimulating mobilization of peripheral blood progenitor cells. Stem Cells Dayt 2:36-41, 1993.
30. McNiece IK, Briddell RA, Hartley CA, Andrews RG: The role of stem cell factor in mobilization of peripheral blood progenitor cells: synergy with G-CSF. Stem Cells Dayt 3:83-88, 1993.
31. Milner R, Shaaban A, Kim HB, Fichter C, Flake AW: Postnatal booster injections increase engraftment after in utero stem cell transplantation. J Surg Res 83:44-47, 1999.
32. Opie TM, Shields LE, Andrews RG: Cell surface antigen expression in early and term gestation fetal hematopoietic progenitor cells. Stem Cells 16:343-348, 1998.
33. Picus J, Aldrich WR, Letvin NL: A naturally occurring bone-marrow-chimeric primate. I. Integrity of its immune system. Transplantation 39:297-303, 1985.
34. Reitsma M, Harrison M, Pallavicini M: Detection of a male-specific sequence in nonhuman primates through use of the polymerase chain reaction. Cytogenet Cell Genet 64:213-216, 1993.
35. Roodman GD, Kuehl TJ, Vandeberg JL, Muirhead DY: In utero bone marrow transplantation of fetal baboons with mismatched adult baboon marrow. Blood Cells 17:367-375, 1991.
36. Ruggeri L, Capanni M, Martelli MF, Velardi A: Cellular therapy: exploiting NK cell alloreactivity in transplantation. Curr Opin Hematol 8:355-359, 2001.
37. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogala D, Frassoni F, Aversa F, Martelli MF, Velardi A: Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295:2097-2100, 2002.
38. Shields LE, Bryant EM, Easterling TR, Andrews RG: Fetal liver cell transplantation for the creation of lymphohematopoietic chimerism in fetal baboons. Am J Obstet Gynecol 173:1157-1160, 1995.
39. Shields LE, Gaur LK, Gough M, Potter J, Sieverkropp A, Andrews RG: In utero stem cell transplantation in non-human primates: the role of T-cell number. Stem Cells 21:304-314, 2003.
40. Shields LE, Gaur L, Potter J, Sieverkropp A, Andrews RG: Fetal immune suppression as adjunctive therapy for in utero stem cell transplantation in non-human primates. Stem Cells 22:759-769, 2004.
41. Sugiura K, Hisha H, Ishikawa J, Adachi Y, Taketani S, Lee S, Nagahama T, Ikehara S: Major histocompatibility complex restriction between hematopoietic stem cells and stromal cells in vitro. Stem Cells 19:46-58, 2001.
42. Waller EK, Ship AM, Mittelstaedt S, Murray TW, Carter R, Kakniashvili I, Lonial S, Holden JT, Boyer MW: Irradiated donor leukocytes promote engraftment of allogeneic bone marrow in major histocompatibility complex mismatched recipients without causing graft-versus-host disease. Blood 94:3222-3233, 1999.
43. Watanabe T, Dave B, Heimann DG, Lethaby E, Kessinger A, Talmadge JE: GM-CSF-mobilized peripheral blood CD34+ cells differ from steady-state bone marrow CD34+ cells in adhesion molecule expression. Bone Marrow Transplant 19:1175-1181, 1997.
44. Wengler GS, Lanfranchi A, Frusca T, Verardi R, Neva A, Brugnoni D, Giliani S, Fiorini M, Mella P, Guandalini F, Mazzolari E, Pecorelli S, Notarangelo LD, Porta F, Ugazio AG: In-utero transplantation of parental CD34 haematopoietic progenitor cells in a patient with X-linked severe combined immunodeficiency (SCIDXI). Lancet 348:1484-1487, 1996.
45. Westgren M, Ringden O, Bartmann P, Bui T, Lindton B, Mattson J, Uzunel M, Zetterquist H: Prenatal T cell reconstruction after in utero transplantation with fetal liver cells in a patient with x-linked SCID. Am J Obstet Gynecol 187:475-482, 2002.
46. Zanjani ED, Ascensao JL, Harrison MR, Tavassoli M: Ex vivo incubation with growth factors enhances the engraftment of fetal hematopoietic cells transplanted in sheep fetuses. Blood 79:3045-3049, 1992.
47. Zanjani ED, Pallavicini MG, Ascensao JL, Flake AW, Langlois RG, Reitsma M, MacKintosh FR, Stutes D, Harrison MR, Tavassoli M: Engraftment and long-term expression of human fetal hematopoietic stem cells in sheep following transplantation in utero. J Clin Invest 89:1178-1188, 1992.
48. Zanjani ED, Ruthven A, Ruthven J, Shaft D, Smith D, Flake AW: In utero hematopoietic stem cell transplantation results in donor specific tolerance and facilitates postnatal 'boosting' of donor cell levels. Blood 84:100a, 1994.
49. Zanjani ED, Almeida-Porada G, Ascensao JL, MacKintosh FR, Flake AW: Transplantation of hematopoietic stem cells in utero. Stem Cells 15:79-93, 1997.