Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling

Food and Chemical Toxicology

Volumn 64, Issue , 2014, Pages 217-224

  Seo, Cho Rong ^a   Yang, Dong Kwon ^b   Song, No Joon ^a   Yun, Ui Jeong ^a   Gwon, A Ryeong ^a   Jo, Dong Gyu ^a   Cho, Jae Youl ^a   Yoon, Keejung ^a   Ahn, Jee Yin ^c   Nho, Chu Won ^d   Park, Woo Jin ^b   Yang, Seung Yul ^e   Park, Kye Won ^a  

^a Sungkyunkwan University   (South Korea)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Sunchon National University   (South Korea)

Author keywords

Adipocyte differentiation; Cucurbitacin B; Cucurbitacin I; PPAR ; STAT3

Indexed keywords

CUCURBITACIN; CUCURBITACIN 1; CUCURBITACIN B; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMALL INTERFERING RNA; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL VIABILITY; GENE TARGETING; LIPID STORAGE; MESENCHYME CELL; NONHUMAN; PROADIPOCYTE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CUCURBITACEAE;

ADIPOCYTE DIFFERENTIATION; CUCURBITACIN B; CUCURBITACIN I; PPARΓ; STAT3;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; MICE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRITERPENES;

EID: 84890647788     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.11.040     Document Type: Article

References (26)

1. Alghasham A.A. Cucurbitacins - a promising target for cancer therapy. Int. J. Health Sci. (Qassim). 2013, 7:77-89.
2. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., Pistell P.J., Poosala S., Becker K.G., Boss O., Gwinn D., Wang M., Ramaswamy S., Fishbein K.W., Spencer R.G., Lakatta E.G., Le Couteur D., Shaw R.J., Navas P., Puigserver P., Ingram D.K., de Cabo R., Sinclair D.A. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444:337-342.
3. Chambliss O.L., Jones C.M. Cucurbitacins: specific insect attractants in Cucurbitaceae. Science 1966, 153:1392-1393.
4. Chan K.T., Li K., Liu S.L., Chu K.H., Toh M., Xie W.D. Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562. Cancer Lett. 2010, 289:46-52.
5. Chen J.C., Chiu M.H., Nie R.L., Cordell G.A., Qiu S.X. Cucurbitacins and cucurbitane glycosides: structures and biological activities. Nat. Prod. Rep. 2005, 22:386-399.
6. Choi H., Eo H., Park K., Jin M., Park E.J., Kim S.H., Park J.E., Kim S. A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model. Biochem. Biophys. Res. Commun. 2007, 359:419-425.
7. Clarkson R.W., Boland M.P., Kritikou E.A., Lee J.M., Freeman T.C., Tiffen P.G., Watson C.J. The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol. Endocrinol. 2006, 20:675-685.
8. Debnath B., Xu S., Neamati N. Small molecule inhibitors of signal transducer and activator of transcription 3 (Stat3) protein. J. Med. Chem. 2012, 55:6645-6668.
9. Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., Auwerx J. Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab. 2008, 8:347-358.
10. Grivennikov S.I., Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 2010, 21:11-19.
11. Hasani-Ranjbar S., Nayebi N., Larijani B., Abdollahi M. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J. Gastroenterol. 2009, 15:3073-3085.
12. Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003, 425:191-196.
13. Kahn B.B., Flier J.S. Obesity and insulin resistance. J. Clin. Invest. 2000, 106:473-481.
14. Kopelman P.G. Obesity as a medical problem. Nature 2000, 404:635-643.
15. Lee D.H., Iwanski G.B., Thoennissen N.H. Cucurbitacin: ancient compound shedding new light on cancer treatment. ScientificWorldJournal. 2010, 10:413-418.
16. Park S.J., Ahmad F., Philp A., Baar K., Williams T., Luo H., Ke H., Rehmann H., Taussig R., Brown A.L., Kim M.K., Beaven M.A., Burgin A.B., Manganiello V., Chung J.H. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 2012, 148:421-433.
17. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
18. Rios J.L. Effects of triterpenes on the immune system. J. Ethnopharmacol. 2010, 128:1-14.
19. Song N.J., Yoon H.J., Kim K.H., Jung S.R., Jang W.S., Seo C.R., Lee Y.M., Kweon D.H., Hong J.W., Lee J.S., Park K.M., Lee K.R., Park K.W. Butein is a novel anti-adipogenic compound. J. Lipid Res. 2013, 54:1385-1396.
20. Spiegelman B.M., Flier J.S. Obesity and the regulation of energy balance. Cell 2001, 104:531-543.
21. Starsichova A., Lincova E., Pernicova Z., Kozubik A., Soucek K. TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells. Cell. Signal. 2010, 22:1734-1744.
22. Sun C., Zhang M., Shan X., Zhou X., Yang J., Wang Y., Li-Ling J., Deng Y. Inhibitory effect of cucurbitacin E on pancreatic cancer cells growth via STAT3 signaling. J. Cancer Res. Clin. Oncol. 2010, 136:603-610.
23. Tannin-Spitz T., Bergman M., Grossman S. Cucurbitacin glucosides: antioxidant and free-radical scavenging activities. Biochem. Biophys. Res. Commun. 2007, 364:181-186.
24. Thoennissen N.H., Iwanski G.B., Doan N.B., Okamoto R., Lin P., Abbassi S., Song J.H., Yin D., Toh M., Xie W.D., Said J.W., Koeffler H.P. Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells. Cancer Res. 2009, 69:5876-5884.
25. van Kester M.S., Out-Luiting J.J., von dem Borne P.A., Willemze R., Tensen C.P., Vermeer M.H. Cucurbitacin I inhibits Stat3 and induces apoptosis in Sezary cells. J. Invest. Dermatol. 2008, 128:1691-1695.
26. Zhang K., Guo W., Yang Y., Wu J. JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPbeta transcription. J. Cell. Biochem. 2011, 112:488-497.