In vivo to in vitro effects of six bioactive lignans of wuzhi tablet (schisandra sphenanthera extract) on the CYP3A/pglycoprotein-mediated absorption and metabolism of tacrolimus

Drug Metabolism and Disposition

Volumn 42, Issue 1, 2014, Pages 193-199

  Qin, Xiao Ling ^a,b   Chen, Xiao ^a   Wang, Ying ^c   Xue, Xin Ping ^a   Wang, Y ^a   Li, Jia Li ^a   Wang, Xue Ding ^a   Zhong, Guo Ping ^a   Wang, Chang Xi ^a   Yang, Hui ^b   Huang, Min ^a   Bi, Hui Chang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Panyu District Central Hospital   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A; GOMISIN A; LIGNAN; MULTIDRUG RESISTANCE PROTEIN; PLANT EXTRACT; SCHISANDRA SPHENANTHERA EXTRACT; SCHISANDRIN A; SCHISANDROL A; SCHISANTHERIN A; SCHIZANDRIN B; SCHIZANDRIN C; TACROLIMUS; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG INHIBITION; DRUG METABOLISM; DRUG TRANSPORT; FIRST PASS EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; RAT; SCHISANDRA; SCHISANDRA SPHENANTHERA; SINGLE DRUG DOSE; TABLET FORMULATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ABSORPTION; ANIMALS; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; CELL LINE, TUMOR; CYCLOOCTANES; CYTOCHROME P-450 CYP3A; DIOXOLES; DRUGS, CHINESE HERBAL; HUMANS; LIGNANS; MALE; MICROSOMES, LIVER; P-GLYCOPROTEINS; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; TABLETS; TACROLIMUS;

EID: 84890639765     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.053892     Document Type: Article

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