Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of cyclosporin A in rats

Phytotherapy Research

Volumn 27, Issue 8, 2013, Pages 1255-1259

  Xue, Xin Ping ^a   Qin, Xiao Ling ^a   Xu, Chenshu ^a   Zhong, Guo Ping ^a   Wang, Ying ^a   Huang, Min ^a   Bi, Hui Chang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

cyclosporin A; herb drug interaction; pharmacokinetics; Schisandra sphenanthera extract; Wuzhi tablet

Indexed keywords

CYCLOSPORIN A; PLANT EXTRACT; SCHISANDRA SPHENANTHERA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MEGADOSE; HERB DRUG INTERACTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; SCHISANDRA; SCHISANDRA SPHENANTHERA; SINGLE DRUG DOSE; TABLET; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

RATTUS; SCHISANDRA SPHENANTHERA;

CYCLOSPORIN A; HERB-DRUG INTERACTION; PHARMACOKINETICS; SCHISANDRA SPHENANTHERA EXTRACT; WUZHI TABLET;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CYCLOSPORINE; DRUGS, CHINESE HERBAL; HERB-DRUG INTERACTIONS; IMMUNOSUPPRESSIVE AGENTS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SCHISANDRA; TABLETS;

EID: 84880759160     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4849     Document Type: Article

References (18)

1. Amundsen R, Åsberg A, Ohm IK, Christensen H,. 2012. Cyclosporine A- and tacrolimus-mediated inhibition of CYP3A4 and CYP3A5 in vitro. Drug Metab Dispos 40: 655-661.
2. Bauer S, Störmer E, Johne A, Krüger H,. 2003. Alterations in cyclosporine A pharmacokinetics and metabolism during treatment with St John's wort in renal transplant patients. Br J Clin Pharmacol 55: 203-211.
3. Dunn CJ, Wagstaff AJ, Perry CM, Plosker GL, Goa KL,. 2001. Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation. Drugs 61: 1957-2016.
4. Faulds D, Goa KL, Benfield P,. 1993. Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in immunoregulatory disorders. Drugs 45: 953-1040.
5. Fukatsu S, Fukudo M, Masuda S, et al,. 2006. Delayed effect of grapefruit juice on pharmacokinetics and pharmacodynamics of tacrolimus in a living-donor liver transplant recipient. Drug Metab Pharmacokinet 21: 122-125.
6. Hermann M, Asberg A, Reubsaet JL, Sather S, Berg KJ, Christensen H,. 2002. Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients. Int J Clin Pharmacol Ther 40: 451-456.
7. Huyke C., Engel K., Simon-Haarhaus B., Quirin K.W., Schempp C.M.,. 2007. Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. Planta Med 73: 1116-1126.
8. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, Watabe T,. 2004. Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 32: 1351-1358.
9. Jin J, Bi H, Hu J, Huang ZY, Huang M,. 2010. Enhancement of oral bioavailability of paclitaxel after oral administration of Schisandrol B in rats. Biopharm Drug Dispos 31: 264-268.
10. Jin J, Bi H, Hu J, et al,. 2011. Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats. Phytother Res 25: 1250-1253.
11. Lemahieu W, Maes B,. 2007. In Vivo Assessment of Cytochrome P450 3A4 and P-Glycoprotein Activity: Impact on Clinical Practice. Current Enzyme Inhibition 3: 217-241.
12. Loo WT, Cheung MN, Chow LW,. 2007. Fructus schisandrae (Wuweizi)-containing compound inhibits secretion of HBsAg and HBeAg in hepatocellular carcinoma cell line. Biomed Pharmacother 61: 606-610.
13. Noble S, Markham A,. 1995. Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral). Drugs 50: 924-41.
14. Qiangrong P, Wang T, Lu Q, Hu X,. 2005. Schisandrin B-a novel inhibitor of P-glycoprotein. Biochem Biophys Res Commun 335: 406-411.
15. Qin XL, Bi HC, Wang CX, et al,. 2010a. Study of the effect ofWuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr 24: 399-405.
16. Qin XL, Bi HC, Wang XD, et al,. 2010b. Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm 389: 114-121.
17. Sun M, Xu X, Lu Q, Pan Q, Hu X,. 2007. Schisandrin B: a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1. Cancer Lett 246: 300-307.
18. Yoo HH, Lee M, Lee MW, Lim SY, Shin J, Kim DH,. 2007. Effects of Schisandra lignans on P-glycoprotein-mediated drug efflux in human intestinal Caco-2. Planta Med 73: 444-450.