Effects of traditional chinese medicine wuzhi capsule on pharmacokinetics of tacrolimus in rats

Drug Metabolism and Disposition

Volumn 41, Issue 7, 2013, Pages 1398-1403

  Wei, Hua ^a   Tao, Xia ^a   Di, Peng ^a   Yang, Yingbo ^a   Li, Jingxian ^a   Qian, Xiaofeng ^a   Feng, Jin ^a   Chen, Wansheng ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHINESE DRUG; DEOXYSCHIZANDRIN; GOMISIN A; HERBACEOUS AGENT; SCHISANHENOL; SCHISANTHERIN A; SCHIZANDRIN; TACROLIMUS; UNCLASSIFIED DRUG; WUZHI;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CHINESE MEDICINE; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG DETERMINATION; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXPOSURE; DRUG HALF LIFE; DRUG POTENTIATION; HERB DRUG INTERACTION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CAPSULES; CYTOCHROME P-450 CYP3A; DRUGS, CHINESE HERBAL; HERB-DRUG INTERACTIONS; IMMUNOSUPPRESSIVE AGENTS; MALE; MEDICINE, CHINESE TRADITIONAL; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

RATTUS; SCHISANDRA SPHENANTHERA;

EID: 84879081686     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.050302     Document Type: Article

References (37)

1. Andersen V, Pedersen N, Larsen NE, Sonne J, and Larsen S (2002) Intestinal first pass metabolism of midazolam in liver cirrhosis-effect of grapefruit juice. Br J Clin Pharmacol 54: 120-124.
2. Bowman LJ and Brennan DC (2008) The role of tacrolimus in renal transplantation. Expert Opin Pharmacother 9:635-643.
3. Chen HD, He H, and Zhang YL (2002) Baiying decoction in the treatment of 43 cases of chronic hepatitis. J Anhui TCM Col 21:17-19.
4. Chinese Pharmacopoeia Commission (2005) Pharmacopoeia of the People's. Republic of China, Vol. 1, p 109, People's Medical Publishing House, Beijing.
5. Christine ES and Susan ET (2004) Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation. Clin Pharmacokinet 43:623-653.
6. Hao H, Wang G, Cui N, Li J, Xie L, and Ding Z (2007) Identification of a novel intestinal first pass metabolic pathway: NQO1 mediated quinone reduction and subsequent glucuronidation. Curr Drug Metab 8:137-149.
7. Huang Q, Pei Q, and Zhou WL (2007) Pharmacokinetic effect of Wuzhi capsules Oil lamivudine tablets in healthy Chinese subjects. Cent South Pharm 5:461-463.
8. Iwasaki K (2007) Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug Metab Pharmacokinet 22:328-335.
9. Iwata H, Tezuka Y, Kadota S, Hiratsuka A, and Watabe T (2004) Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug Metab Dispos 32: 1351-1358.
10. Jeong H and Chiou WL (2006) Role of P-glycoprotein in the hepatic metabolism of tacrolimus. Xenobiotica 36:1-13.
11. Jin J, Bi HC, Hu JQ, Zeng H, Zhong GP, Zhao LZ, Huang ZY, and Huang M (2011) Effect of Wuzhi tablet (Schisandra sphenanthera extract) on the pharmacokinetics of paclitaxel in rats. Phytother Res 25:1250-1253.
12. Kato M (2008) Intestinal first-pass metabolism of CYP3A4 substrates. Drug Metab Pharmacokinet 23:87-94.
13. Loo WT, Cheung MN, and Chow LW (2007) Fructus schisandrae (Wuweizi)-containing compound inhibits secretion of HBsAg and HBeAg in hepatocellular carcinoma cell line. Biomed Pharmacother 61:606-610.
14. Lai L, Hao HP, Wang Q, Zheng CN, Zhou F, Liu YT, Wang YX, Yu G, Kang A, and Peng Y, et al. (2009) Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats. Drug Metab Dispos 37:2399-2407.
15. Lampen A, Christians U, Guengerich FP, Watkins PB, Kolars JC, Bader A, Gonschior AK, Dralle H, Hackbarth I, and Sewing KF (1995) Metabolism of the immunosuppressant tacrolimus in the small intestine: Cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos 23:1315-1324.
16. Lu Y and Chen DF (2009) Analysis of Schisandra chinensis and Schisandra sphenanthera. J Chromatogr A 1216:1980-1990.
17. Mentzer J, Jahania MS, Lasley RD (1998) Tacrolimus as a rescue immunosuppressant after heart and lung transplantation. The U.S. Multicenter FK506 Study Group. Transplantation 65:109-113.
18. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, and Christians U (2001) The pharmacokinetics and metabolic disposition of tacrolimus: A comparison across ethnic groups. Clin Pharmacol Ther 69:24-31.
19. Mu Y, Zhang JN, Zhang SM, Zhou HH, Toma D, Ren SR (2006) Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. J Pharmacol Exp Ther 316:1369-1377.
20. Paine MF, Criss AB, and Watkins PB (2005) Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition. J Pharmacol Exp Ther 312:1151-1160.
21. Qin XL, Bi HC, Wang CX, Li JL, Wang XD, Liu LS, Chen X, and Huang M (2010a) Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method. Biomed Chromatogr 24:399-405.
22. Qin XL, Bi HC, Wang XD, Li JL, Wang Y, Xue XP, Chen X, Wang CX, Xu J, and Wang YT, et al. (2010b) Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506). Int J Pharm 389:114-121.
23. Rengelshausen J, Banfield M, Riedel KD, Burhenne J, Weiss J, Thomsen T, Walter-Sack I, Haefeli WE, and Mikus G (2005) Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics. Clin Pharmacol Ther 78:25-33.
24. Staatz CE and Tett SE (2004) Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation. Clin Pharmacokinet 43:623-653.
25. US Food and Drug Administration (2001) Guidance for Industry- Bioanalytical Method Validation, U.S. Department of Health and Human Services, Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine, CVM Rockville, MD.
26. van Gelder T (2002) Drug interactions with tacrolimus. Drug Saf 25:707-712.
27. Vincent SH, Karanam BV, Painter SK, and Chiu SH (1992) In vitro metabolism of FK-506 in rat, rabbit, and human liver microsomes: Identification of a major metabolite and of cytochrome P450 3A as the major enzymes responsible for its metabolism. Arch Biochem Biophys 294:454-460.
28. Venkataramanan R, Jain A, Cadoff E, Warty V, Iwasaki K, Nagase K, Krajack A, Imventarza O, Todo S, and Fung JJ, et al. (1990) Pharmacokinetics of FK 506: Preclinical and clinical studies. Transplant Proc 22:52-56.
29. Wallemacq P, Armstrong VW, Brunet M, Haufroid V, Holt DW, Johnston A, Kuypers D, Le Meur Y, Marquet P, and Oellerich M, et al. (2009) Opportunities to optimize tacrolimus therapy in solid organ transplantation: Report of the European consensus conference. Ther Drug Monit 31:139-152.
30. Wei H, Xu W, Cai F, Zhao G, Feng J, Sun LN, and Chen WS (2010a) Simultaneous determination of five lignan constituents of Wuzhi capsule in rat plasma by LC-MS/MS: Application to pharmacokinetic study. J Pharm Biomed Anal 52:741-746.
31. Wei H, Sun LN, Tai ZG, Gao S, Xu W, and Chen W (2010b) A simple and sensitive HPLC method for the simultaneous determination of eight bioactive components and fingerprint analysis of Schisandra sphenanthera. Anal Chim Acta 662:97-104.
32. Xiao WL, Huang SX, Wang RR, Zhong JL, Gao XM, He F, Pu JX, Lu Y, Zheng YT, and Zheng QT, et al. (2008) Nortriterpenoids and lignans from Schisandra sphenanthera. Phytochemistry 69:2862-2866.
33. Xin HW, Wu XC, Li Q, Yu AR, Zhu M, Shen Y, Su D, and Xiong L (2007) Effects of Schisandra sphenanthera extract on the pharmacokinetics of tacrolimus in healthy volunteers. Br J Clin Pharmacol 64:469-475.
34. Xin HW, Li Q, Wu XC, He Y, Yu AR, Xiong L, and Xiong Y (2011) Effects of Schisandra sphenanthera extract on the blood concentration of tacrolimus in renal transplant recipients. Eur J Clin Pharmacol 67:1309-1311.
35. Xie HG and Kim RB (2005) St John's wort-associated drug interactions: Short-term inhibition and long-term induction? Clin Pharmacol Ther 78:19-24.
36. Yu SL, Qu YW, and Han YH (2006) The Evaluation of Effectiveness of Drug Induced Hepatic Toxicity by Wuzhi capsules and Silymarin. West Chin Med J 21:466-467.
37. Zhu M, Yeung RY, Lin KF, and Li RC (2000) Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model. Planta Med 66:521-525.