Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases

Xenobiotica

Volumn 38, Issue 2, 2008, Pages 185-222

  Bi, H C ^a   Zuo, Z ^b   Chen, X ^a   Xu, C S ^a   Wen, Y Y ^a   Sun, H Y ^a   Zhao, L Z ^a   Pan, Y ^a   Deng, Y ^a   Liu, P Q ^a   Gu, L Q ^a   Huang, Z Y ^a   Zhou, S F ^c   Huang, M ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Chinese University of Hong Kong   (Hong Kong)

^c RMIT UNIVERSITY   (Australia)

Author keywords

Absorption; Enterohepatic circulation; Excretion; First pass effect; Glucuronide; LC MS MS; Pharmacokinetics; Tanshionone IIA

Indexed keywords

AGLYCONE; CORN OIL; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 3A; GLUCURONIDE; KETOCONAZOLE; QUINIDINE; SALVIA MILTIORRHIZA EXTRACT; TANSHINONE; TANSHINONE 2A; TICLOPIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BILE DUCT; BILIARY EXCRETION; CANNULATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG ANTAGONISM; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG INHIBITION; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG TRANSPORT; FECES; HYDROLYSIS; ISCHEMIC HEART DISEASE; LIVER MICROSOME; MALE; NONHUMAN; RAT; SALVIA MILTIORRHIZA; SINGLE DRUG DOSE; URINARY EXCRETION;

ANIMALS; CACO-2 CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, ANIMAL; MYOCARDIAL ISCHEMIA; PHENANTHRENES; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; SALVIA MILTIORRHIZA; TIME FACTORS;

RATTUS; SALVIA MILTIORRHIZA;

EID: 38149068306     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250701767675     Document Type: Article

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