-
1
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009;27:3584-90.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
-
2
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized phase III trial
-
Sternberg CN, Davis ID, Mardiak J, Szczylik C, Lee E, Wagstaff J, et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trial. J Clin Oncol 2010;28:1061-8.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
Szczylik, C.4
Lee, E.5
Wagstaff, J.6
-
4
-
-
84866948962
-
Biomarkers: The next therapeutic hurdle in metastatic renal cell carcinoma
-
Sonpavde G, Choueiri TK. Biomarkers: the next therapeutic hurdle in metastatic renal cell carcinoma. Br J Cancer 2012;107:1009-16.
-
(2012)
Br J Cancer
, vol.107
, pp. 1009-1016
-
-
Sonpavde, G.1
Choueiri, T.K.2
-
5
-
-
77958072683
-
Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling
-
Bhatt RS, Wang X, Zhang L, Collins MP, Signoretti S, Alsop DC, et al. Renal cancer resistance to antiangiogenic therapy is delayed by restoration of angiostatic signaling. Mol Cancer Ther 2010;9: 2793-802.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 2793-2802
-
-
Bhatt, R.S.1
Wang, X.2
Zhang, L.3
Collins, M.P.4
Signoretti, S.5
Alsop, D.C.6
-
6
-
-
26644471951
-
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
-
DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
-
Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005;8:299-309. (Pubitemid 41443415)
-
(2005)
Cancer Cell
, vol.8
, Issue.4
, pp. 299-309
-
-
Casanovas, O.1
Hicklin, D.J.2
Bergers, G.3
Hanahan, D.4
-
7
-
-
84863798210
-
Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells
-
Makhov PB, Golovine K, Kutikov A, Teper E, Canter DJ, Simhan J, et al. Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells. Mol Cancer Ther 2012;11:1510-7.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 1510-1517
-
-
Makhov, P.B.1
Golovine, K.2
Kutikov, A.3
Teper, E.4
Canter, D.J.5
Simhan, J.6
-
8
-
-
78650339354
-
HGF/c-Met acts as an alternative angiogenic pathway in suni-tinib-resistant tumors
-
Shojaei F, Lee JH, Simmons BH, Wong A, Esparza CO, Plumlee PA, et al. HGF/c-Met acts as an alternative angiogenic pathway in suni-tinib-resistant tumors. Cancer Res 2010;70:10090-100.
-
(2010)
Cancer Res
, vol.70
, pp. 10090-10100
-
-
Shojaei, F.1
Lee, J.H.2
Simmons, B.H.3
Wong, A.4
Esparza, C.O.5
Plumlee, P.A.6
-
9
-
-
79952538238
-
Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib
-
Welti JC, Gourlaouen M, Powles T, Kudahetti SC, Wilson P, Berney DM, et al. Fibroblast growth factor 2 regulates endothelial cell sensitivity to sunitinib. Oncogene 2011;30:1183-93.
-
(2011)
Oncogene
, vol.30
, pp. 1183-1193
-
-
Welti, J.C.1
Gourlaouen, M.2
Powles, T.3
Kudahetti, S.C.4
Wilson, P.5
Berney, D.M.6
-
10
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDer-mott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-54.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
Gettinger, S.N.4
Smith, D.C.5
McDer-Mott, D.F.6
-
11
-
-
84872548337
-
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma
-
Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, et al. Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol 2012;31:181-6.
-
(2012)
J Clin Oncol
, vol.31
, pp. 181-186
-
-
Choueiri, T.K.1
Vaishampayan, U.2
Rosenberg, J.E.3
Logan, T.F.4
Harzstark, A.L.5
Bukowski, R.M.6
-
12
-
-
84863897711
-
Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients
-
Griffioen AW, Mans LA, de Graaf AM, Nowak-Sliwinska P, de Hoog CL, de Jong TA, et al. Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patients. Clin Cancer Res 2012;18:3961-71.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3961-3971
-
-
Griffioen, A.W.1
Mans, L.A.2
De Graaf, A.M.3
Nowak-Sliwinska, P.4
De Hoog, C.L.5
De Jong, T.A.6
-
13
-
-
79952101899
-
Immunomodulatory effects of sorafenib on peripheral immune effector cells in metastatic renal cell carcinoma
-
Busse A, Asemissen AM, Nonnenmacher A, Braun F, Ochsenreither S, Stather D, et al. Immunomodulatory effects of sorafenib on peripheral immune effector cells in metastatic renal cell carcinoma. Eur J Cancer 2011;47:690-6.
-
(2011)
Eur J Cancer
, vol.47
, pp. 690-696
-
-
Busse, A.1
Asemissen, A.M.2
Nonnenmacher, A.3
Braun, F.4
Ochsenreither, S.5
Stather, D.6
-
14
-
-
63549105681
-
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
-
Ko JS, Zea AH, Rini BI, Ireland JL, Elson P, Cohen P, et al. Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin Cancer Res 2009;15:2148-57.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2148-2157
-
-
Ko, J.S.1
Zea, A.H.2
Rini, B.I.3
Ireland, J.L.4
Elson, P.5
Cohen, P.6
-
15
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Ozao-Choy J, Ma G, Kao J, Wang GX, Meseck M, Sung M, et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res 2009;69:2514-22.
-
(2009)
Cancer Res
, vol.69
, pp. 2514-2522
-
-
Ozao-Choy, J.1
Ma, G.2
Kao, J.3
Wang, G.X.4
Meseck, M.5
Sung, M.6
-
16
-
-
84881243221
-
The safety and efficacy of pazopanib prior to planned nephrectomy in metastatic clear cell renal cancer
-
(Suppl 5; abstr 427)
-
Boleti E, Sarwar N, Jones R, Chowdhury S, Crabb S, Shamash J, et al. The safety and efficacy of pazopanib prior to planned nephrectomy in metastatic clear cell renal cancer. J Clin Oncol 30, 2012, (Suppl 5; abstr 427).
-
(2012)
J Clin Oncol
, vol.30
-
-
Boleti, E.1
Sarwar, N.2
Jones, R.3
Chowdhury, S.4
Crabb, S.5
Shamash, J.6
-
17
-
-
79960977418
-
The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer
-
Powles T, Blank C, Chowdhury S, Horenblas S, Peters J, Shamash J, et al. The outcome of patients treated with sunitinib prior to planned nephrectomy in metastatic clear cell renal cancer. Eur Urol 2011;60: 448-54.
-
(2011)
Eur Urol
, vol.60
, pp. 448-454
-
-
Powles, T.1
Blank, C.2
Chowdhury, S.3
Horenblas, S.4
Peters, J.5
Shamash, J.6
-
18
-
-
80053907517
-
A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ
-
Bex A, Blank C, Meinhardt W, van Tinteren H, Horenblas S, Haanen J. A phase II study of presurgical sunitinib in patients with metastatic clear-cell renal carcinoma and the primary tumor in situ. Urology 2011; 78:832-7.
-
(2011)
Urology
, vol.78
, pp. 832-837
-
-
Bex, A.1
Blank, C.2
Meinhardt, W.3
Van Tinteren, H.4
Horenblas, S.5
Haanen, J.6
-
19
-
-
77958022477
-
Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type
-
Lacroix-Triki M, Suarez PH, MacKay A, Lambros MB, Natrajan R, Savage K, et al. Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. J Pathol 2010;222:282-98.
-
(2010)
J Pathol
, vol.222
, pp. 282-298
-
-
Lacroix-Triki, M.1
Suarez, P.H.2
MacKay, A.3
Lambros, M.B.4
Natrajan, R.5
Savage, K.6
-
20
-
-
77953123909
-
An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers
-
Natrajan R, Weigelt B, Mackay A, Geyer FC, Grigoriadis A, Tan DS, et al. An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers. Breast Cancer Res Treat 2010;121:575-89.
-
(2010)
Breast Cancer Res Treat
, vol.121
, pp. 575-589
-
-
Natrajan, R.1
Weigelt, B.2
MacKay, A.3
Geyer, F.C.4
Grigoriadis, A.5
Tan, D.S.6
-
21
-
-
77957951913
-
Whole-genome DNA methylation profiling using Methyl Cap-seq
-
Brinkman AB, Simmer F, Ma K, Kaan A, Zhu J, Stunnenberg HG. Whole-genome DNA methylation profiling using Methyl Cap-seq. Methods 2010;52:232-6.
-
(2010)
Methods
, vol.52
, pp. 232-236
-
-
Brinkman, A.B.1
Simmer, F.2
Ma, K.3
Kaan, A.4
Zhu, J.5
Stunnenberg, H.G.6
-
22
-
-
80052840491
-
Sequential FDG-PET/CT as a biomarker of response to Sunitinib in metastatic clear cell renal cancer
-
Kayani I, Avril N, Bomanji J, Chowdhury S, Rockall A, Sahdev A, et al. Sequential FDG-PET/CT as a biomarker of response to Sunitinib in metastatic clear cell renal cancer. Clin Cancer Res 2011;17:6021-8.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6021-6028
-
-
Kayani, I.1
Avril, N.2
Bomanji, J.3
Chowdhury, S.4
Rockall, A.5
Sahdev, A.6
-
23
-
-
63849092341
-
Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: Clinical outcomes and plasma angiogenesis markers
-
Kontovinis LF, Papazisis KT, Touplikioti P, Andreadis C, Mouratidou D, Kortsaris AH. Sunitinib treatment for patients with clear-cell metastatic renal cell carcinoma: clinical outcomes and plasma angiogenesis markers. BMC Cancer 2009;9:82.
-
(2009)
BMC Cancer
, vol.9
, pp. 82
-
-
Kontovinis, L.F.1
Papazisis, K.T.2
Touplikioti, P.3
Andreadis, C.4
Mouratidou, D.5
Kortsaris, A.H.6
-
24
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Cohen DP, Lu DR, Chen I, Hariharan S, Gore ME, et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2011;103: 763-73.
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
Chen, I.4
Hariharan, S.5
Gore, M.E.6
-
25
-
-
60649087564
-
Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
-
Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009;15:232-9.
-
(2009)
Cancer Cell
, vol.15
, pp. 232-239
-
-
Ebos, J.M.1
Lee, C.R.2
Cruz-Munoz, W.3
Bjarnason, G.A.4
Christensen, J.G.5
Kerbel, R.S.6
-
26
-
-
60649106195
-
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
-
Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009;15: 220-31.
-
(2009)
Cancer Cell
, vol.15
, pp. 220-231
-
-
Paez-Ribes, M.1
Allen, E.2
Hudock, J.3
Takeda, T.4
Okuyama, H.5
Vinals, F.6
-
28
-
-
0028068233
-
Clinical and pathobiological effects of neoadjuvant total androgen ablation therapy on clinically localized prostatic adenocarcinoma
-
Armas OA, Aprikian AG, Melamed J, Cordon-Cardo C, Cohen DW, Erlandson R, et al. Clinical and pathobiological effects of neoadjuvant total androgen ablation therapy on clinically localized prostatic ade-nocarcinoma. Am J Surg Pathol 1994;18:979-91. (Pubitemid 24301720)
-
(1994)
American Journal of Surgical Pathology
, vol.18
, Issue.10
, pp. 979-991
-
-
Armas, O.A.1
Aprikian, A.G.2
Melamed, J.3
Cordon-Cardo, C.4
Cohen, D.W.5
Erlandson, R.6
Fair, W.R.7
Reuter, V.E.8
-
29
-
-
84868712956
-
Changes in circulating pro-angiogenic cytokines, other than VEGF, before progression to sunitinib therapy in advanced renal cell carcinoma patients
-
Porta C, Paglino C, Imarisio I, Ganini C, Sacchi L, Quaglini S, et al. Changes in circulating pro-angiogenic cytokines, other than VEGF, before progression to sunitinib therapy in advanced renal cell carcinoma patients. Oncology 2013;84:115-22.
-
(2013)
Oncology
, vol.84
, pp. 115-122
-
-
Porta, C.1
Paglino, C.2
Imarisio, I.3
Ganini, C.4
Sacchi, L.5
Quaglini, S.6
-
30
-
-
18144364350
-
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis
-
DOI 10.1016/j.cytogfr.2005.01.004
-
Presta M, Dell'Era P, Mitola S, Moroni E, Ronca R, Rusnati M. Fibro-blast growth factor/fibroblast growth factor receptor system in angio-genesis. Cytokine Growth Factor Rev 2005;16:159-78. (Pubitemid 40616114)
-
(2005)
Cytokine and Growth Factor Reviews
, vol.16
, Issue.2 SPEC. ISSUE.
, pp. 159-178
-
-
Presta, M.1
Dell'Era, P.2
Mitola, S.3
Moroni, E.4
Ronca, R.5
Rusnati, M.6
-
31
-
-
84863704553
-
Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors
-
Sennino B, Ishiguro-Oonuma T, Wei Y, Naylor RM, Williamson CW, Bhagwandin V, et al. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov 2012;2:270-87.
-
(2012)
Cancer Discov
, vol.2
, pp. 270-287
-
-
Sennino, B.1
Ishiguro-Oonuma, T.2
Wei, Y.3
Naylor, R.M.4
Williamson, C.W.5
Bhagwandin, V.6
-
32
-
-
84855912001
-
Pericyte depletion results in hypoxia-associated epithelial-to-mesen- chymal transition and metastasis mediated by met signaling pathway
-
Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, et al. Pericyte depletion results in hypoxia-associated epithelial-to-mesen-chymal transition and metastasis mediated by met signaling pathway. Cancer Cell 2012;21:66-81.
-
(2012)
Cancer Cell
, vol.21
, pp. 66-81
-
-
Cooke, V.G.1
Lebleu, V.S.2
Keskin, D.3
Khan, Z.4
O'Connell, J.T.5
Teng, Y.6
-
33
-
-
84872088791
-
Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma
-
Cao Y, Zhang ZL, Zhou M, Elson P, Rini B, Aydin H, et al. Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma. Cancer 2012;119:313-24.
-
(2012)
Cancer
, vol.119
, pp. 313-324
-
-
Cao, Y.1
Zhang, Z.L.2
Zhou, M.3
Elson, P.4
Rini, B.5
Aydin, H.6
-
34
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
DOI 10.1172/JCI200317929
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vascu-lature with kinase inhibitors. J Clin Invest 2003;111:1287-95. (Pubitemid 36554699)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.9
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
35
-
-
33644643376
-
Pericytes limit tumor cell metastasis
-
DOI 10.1172/JCI25705
-
Xian X, Hakansson J, Stahlberg A, Lindblom P, Betsholtz C, Gerhardt H, et al. Pericytes limit tumor cell metastasis. J Clin Invest 2006;116: 642-51. (Pubitemid 43326873)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.3
, pp. 642-651
-
-
Xian, X.1
Hakansson, J.2
Stahlberg, A.3
Lindblom, P.4
Betsholtz, C.5
Gerhardt, H.6
Semb, H.7
-
36
-
-
0026556958
-
A randomized phase II trial of continuous infusion inter-leukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma
-
Weiss GR, Margolin KA, Aronson FR, Sznol M, Atkins MB, Dutcher JP, et al. A randomized phase II trial of continuous infusion inter-leukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma. J Clin Oncol 1992; 10:275-81.
-
(1992)
J Clin Oncol
, vol.10
, pp. 275-281
-
-
Weiss, G.R.1
Margolin, K.A.2
Aronson, F.R.3
Sznol, M.4
Atkins, M.B.5
Dutcher, J.P.6
-
37
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012;366:883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
|