Fumonisin B1 induces global DNA hypomethylation in HepG2 cells - An alternative mechanism of action

Toxicology

Volumn 315, Issue 1, 2014, Pages 65-69

  Chuturgoon, Anil ^a   Phulukdaree, Alisa ^a   Moodley, Devapregasan ^a,b  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Demethylase; DNA hypomethylation; Fumonisin B1; Histones; Liver cancer; Methyltransferase

Indexed keywords

DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; FUMONISIN B1; GENOMIC DNA; HISTONE DEMETHYLASE; KDM5B PROTEIN; KDM5C PROTEIN; METHYL CPG BINDING PROTEIN 2; UNCLASSIFIED DRUG; CARCINOGEN; DEMETHYLASE; DNA (CYTOSINE 5 ) METHYLTRANSFERASE 1; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; FUMONISIN; HISTONE; METHYLTRANSFERASE;

ARTICLE; CELL MIGRATION; CELL STRAIN HEPG2; CHROMATIN; COMET ASSAY; CONTROLLED STUDY; DNA METHYLATION; DNA STRUCTURE; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HISTONE DEMETHYLATION; HISTONE MODIFICATION; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; DRUG EFFECT; FUMONISIN B(1); GENE EXPRESSION REGULATION; LIVER CANCER; METABOLISM;

DEMETHYLASE; DNA HYPOMETHYLATION; FUMONISIN B(1); HISTONES; LIVER CANCER; METHYLTRANSFERASE;

BLOTTING, WESTERN; CARCINOGENS, ENVIRONMENTAL; CHROMATIN; COMET ASSAY; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FUMONISINS; GENE EXPRESSION REGULATION; HEP G2 CELLS; HISTONE DEMETHYLASES; HISTONES; HUMANS; UP-REGULATION;

EID: 84890572933     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.11.004     Document Type: Article

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