Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice

Journal of Hepatology

Volumn 60, Issue 1, 2014, Pages 160-166

  Weerachayaphorn, Jittima ^a,b   Luo, Yuhuan ^a   Mennone, Albert ^a   Soroka, Carol J ^a   Harry, Kathy ^a   Boyer, James L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Mahidol University   (Thailand)

Author keywords

Bile secretion; Hepatic stellate cells; Nrf2; Obstructive cholestasis; Oltipraz

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; BILE ACID; COLLAGENASE 3; GELATINASE B; GLUTATHIONE; OLTIPRAZ; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 4; STAT3 PROTEIN;

ADVERSE OUTCOME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILE FLOW; CONTROLLED STUDY; DISEASE EXACERBATION; EXTRAHEPATIC BILE DUCT OBSTRUCTION; GENE EXPRESSION; LIVER FUNCTION; LIVER HISTOLOGY; LIVER INJURY; LIVER NECROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STELLATE CELL; BILE DUCT; BILE DUCT PRESSURE; CELL ACTIVATION; CHOLESTASIS; LIVER PROTECTION; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION;

AHR; ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ALPHA-NAPHTHYLISOTHIOCYANATE; ALT; ANIT; ARYL HYDROCARBON RECEPTOR; BADF; BAIF; BDL; BILE ACID-DEPENDENT BILE FLOW; BILE ACID-INDEPENDENT BILE FLOW; BILE DUCT LIGATION; BILE SALT EFFLUX PUMP; BILE SECRETION; BSEP; CAR; CARBOXYMETHYLCELLULOSE; CK19; CMC; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOKERATIN 19; ECM; EDTA; ETHYLENEDIAMINETETRAACETIC ACID; EXTRACELLULAR MATRIX; FARNESOID X RECEPTOR; FXR; GLUTATHIONE; GSH; HEPATIC STELLATE CELLS; HSC; IL-1Β; IL-6; INTERLEUKIN-1 BETA; INTERLEUKIN-6; KEAP1; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; LD50; LETHAL DOSAGE; MATRIX METALLOPROTEINASES; MMP; MRP; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN; NAD(P)H QUINONE OXIDOREDUCTASE; NQOI; NRF2; OBSTRUCTIVE CHOLESTASIS; OLTIPRAZ; OPZ; PBC; PDGFΒ; PF; PLATELET-DERIVED GROWTH FACTOR-BETA; PORTAL FIBROBLASTS; PRIMARY BILIARY CIRRHOSIS; TGF-Β1; TIMP; TISSUE INHIBITORS OF METALLOPROTEINASE; TNF-Α; TRANSFORMING GROWTH FACTOR-BETA 1; TUMOR NECROSIS FACTOR-ALPHA; UDCA; URSODEOXYCHOLIC ACID; Α-SMA;

ANGIOGENIC PROTEINS; ANIMALS; BILE; BILE ACIDS AND SALTS; BILE DUCTS; CHOLESTASIS, EXTRAHEPATIC; GLUTATHIONE; LIGATION; MALE; MICE; MICE, INBRED C57BL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NF-E2-RELATED FACTOR 2; PYRAZINES; TRANSFORMING GROWTH FACTOR BETA;

EID: 84890562936     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.08.015     Document Type: Article

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