Increase of bile flow and biliary excretion of glutathione-derived sulfhydryls in rats by drug-metabolizing enzyme inducers is mediated by multidrug resistance protein 2

Toxicological Sciences

Volumn 66, Issue 1, 2002, Pages 16-26

  Johnson, David R ^a,b   Habeebu, Sultan S M ^a   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Drug metabolizing enzyme inducers; EHBR; Glutathione; Mrp2; Organic anion transport

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 3 METHYLCHOLANTHRENE; BENZO[A]PYRENE; DRUG METABOLIZING ENZYME; DRUG VEHICLE; ENZYME INDUCING AGENT; GLUTATHIONE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; PHENOBARBITAL; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; BILIARY EXCRETION; CONTROLLED STUDY; HOMEOSTASIS; HYPERBILIRUBINEMIA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZOPYRENES; BILE; BILIARY TRACT; CARRIER PROTEINS; DRUG INTERACTIONS; GENE EXPRESSION REGULATION; GLUTATHIONE; HYPERBILIRUBINEMIA; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; METHYLCHOLANTHRENE; PHENOBARBITAL; PREGNENOLONE CARBONITRILE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SULFHYDRYL COMPOUNDS;

ANIMALIA;

EID: 0036186927     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/66.1.16     Document Type: Article

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