Effect of ingested lipids on drug dissolution and release with concurrent digestion: A modeling approach

Pharmaceutical Research

Volumn 30, Issue 12, 2013, Pages 3131-3144

  Buyukozturk, Fulden ^a,c   Di Maio, Selena ^a   Budil, David E ^b   Carrier, Rebecca L ^a  

^a Northeastern University   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

^c MATHWORKS INC   (United States)

Author keywords

biorelevant media; colloidal particles; computational modeling; EPR; food effect; mass transport; mechanistic modeling; self emulsifying drug delivery systems

Indexed keywords

FAT DROPLET; LIPID; OIL; POLYSORBATE 80; SOYBEAN OIL;

ARTICLE; CHEMICAL ANALYSIS; CONCENTRATION RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TRANSPORT; EMULSION; FOOD; INTESTINE; INTESTINE FLUID; LIPID ANALYSIS; LIPID DEGRADATION; MICELLE; MOLECULAR MECHANICS; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROCESS MODEL; SELF EMULSIFYING DRUG DELIVERY SYSTEM;

COMPUTER SIMULATION; DIGESTION; DRUG CARRIERS; EATING; EMULSIONS; HUMANS; LIPOLYSIS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SOLUBILITY; SOYBEAN OIL;

EID: 84890550061     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1238-6     Document Type: Article

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