Mineralocorticoid receptor throughout the vessel: A key to vascular dysfunction in obesity

European Heart Journal

Volumn 34, Issue 45, 2013, Pages 3475-3477

  Pojoga, Luminita H ^a   Baudrand, Rene ^a,b   Adler, Gail K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; EPLERENONE; MINERALOCORTICOID RECEPTOR; SPIRONOLACTONE;

ADIPOSE TISSUE; ENDOTHELIAL DYSFUNCTION; HYPERALDOSTERONISM; HYPERTENSION; INSULIN RESISTANCE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW; VASCULAR DISEASE;

ANIMALS; DIET, HIGH-FAT; ENDOTHELIUM, VASCULAR; MALE; MINERALOCORTICOID RECEPTOR ANTAGONISTS; OBESITY; RECEPTORS, MINERALOCORTICOID; SPIRONOLACTONE;

EID: 84890453201     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/eht158     Document Type: Review

References (16)

1. Campia U, Tesauro M, Cardillo C. Human obesity and endothelium-dependent responsiveness. Br J Pharmacol 2012;165:561-573.
2. Ivanes F, Susen S, Mouquet F, Pigny P, Cuilleret F, Sautiere K, Collet JP, Beygui F, Hennache B, Ennezat PV, Juthier F, Richard F, Dallongeville J, Hillaert MA, Doevendans PA, Jude B, Bertrand M, Montalescot G, Van Belle E. Aldosterone, mortality, and acute ischaemic events in coronary artery disease patients outside the setting of acute myocardial infarction or heart failure. Eur Heart J 2012;33:191-202.
3. Tirosh A, Garg R, Adler GK. Mineralocorticoid receptor antagonists and the metabolic syndrome. Curr Hypertens Rep 2010;12:252-257.
4. Calhoun DA, Sharma K. The role of aldosteronism in causing obesity-related cardiovascular risk. Cardiol Clin 2010;28:517-527.
5. Guo C, Martinez-Vasquez D, Mendez GP, Toniolo MF, Yao TM, Oestreicher EM, Kikuchi T, Lapointe N, Pojoga L, Williams GH, Ricchiuti V, Adler GK. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology 2006;147:5363-5373.
6. Briet M, Schiffrin EL. Vascular actions of aldosterone. J Vasc Res 2013;50:89-99.
7. Krug AW, Pojoga LH, Williams GH, Adler GK. Cell membrane-Associated mineralocorticoid receptors? New evidence. Hypertension 2011;57:1019-1025.
8. Briones AM, Nguyen Dinh Cat A, Callera GE, Yogi A, Burger D, He Y, Correa JW, Gagnon AM, Gomez-Sanchez CE, Gomez-Sanchez EP, Sorisky A, Ooi TC, Ruzicka M, Burns KD, Touyz RM. Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-Associated obesity and vascular dysfunction. Hypertension 2012;59:1069-1078.
9. Rickard AJ, Morgan J, Tesch G, FunderJW, Fuller PJ, Young MJ. Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/saltinduced cardiac fibrosis and increased blood pressure. Hypertension 2009;54: 537-543.
10. McCurley A, Pires PW,Bender SB,AronovitzM,ZhaoMJ,MetzgerD,Chambon P, HillMA, Dorrance AM, Mendelsohn ME, Jaffe IZ. Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors. Nat Med 2012;18: 1429-1433.
11. Caprio M, Newfell BG, la Sala A, Baur W, Fabbri A, Rosano G, Mendelsohn ME, Jaffe IZ. Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion. Circ Res 2008;102:1359-1367.
12. Schäfer N, Lohmann C, Winnik S, van Tits LJ, Miranda MX, Vergopoulos A, Ruschitzka F, Nussberger J, Berger S, Lüscher TF, Verrey F, Matter CM. Endothelial mineralocorticoid receptor activation mediates endothelial dysfunction in diet-induced obesity. Eur Heart J 2013;34:3515-3524.
13. Pojoga LH, Adamova Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol 2010;298:H1776-H1788.
14. Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown NJ, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: An epigenetic regulator of saltsensitive hypertension. Am J Hypertens 2012;25:812-817.
15. Sun M, Huang X, Yan Y, Chen J,Wang Z, Xie M, Li J. Rac1 is a possible link between obesity and oxidative stress in Chinese overweight adolescents. Obesity 2012;20: 2233-2240.
16. Baudrand R, Carvajal CA, Riquelme A, Morales M, Solis N, Pizarro M, Escalona A, Boza C, Perez G, Dominguez A, Arrese M, Fardella CE. Overexpression of 11betahydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. Obes Surg 2010;20: 77-83.