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Volumn 12, Issue 4, 2010, Pages 252-257

Mineralocorticoid receptor antagonists and the metabolic syndrome

Author keywords

Aldosterone; Eplerenone; Insulin resistance; Mineralocorticoid receptor; Obesity; Spironolactone

Indexed keywords

ALDOSTERONE; ALISKIREN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EPLERENONE; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERCELLULAR ADHESION MOLECULE 1; LIPID; MINERALOCORTICOID; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLACEBO; SPIRONOLACTONE;

EID: 77956265232     PISSN: 15226417     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11906-010-0126-2     Document Type: Review
Times cited : (62)

References (50)
  • 1
    • 12844262139 scopus 로고    scopus 로고
    • The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities study
    • 10.2337/diacare.28.2.385 15677797
    • AM McNeill WD Rosamond CJ Girman, et al. 2005 The metabolic syndrome and 11-year risk of incident cardiovascular disease in the Atherosclerosis Risk in Communities study Diabetes Care 28 385 390 10.2337/diacare.28.2.385 15677797
    • (2005) Diabetes Care , vol.28 , pp. 385-390
    • McNeill, A.M.1    Rosamond, W.D.2    Girman, C.J.3
  • 2
    • 0742266631 scopus 로고    scopus 로고
    • The metabolic syndrome and chronic kidney disease in U.S. adults
    • 14757614
    • J Chen P Muntner LL Hamm, et al. 2004 The metabolic syndrome and chronic kidney disease in U.S. adults Ann Intern Med 140 167 174 14757614
    • (2004) Ann Intern Med , vol.140 , pp. 167-174
    • Chen, J.1    Muntner, P.2    Hamm, L.L.3
  • 3
    • 30944451953 scopus 로고    scopus 로고
    • Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus
    • 10.1161/CIRCULATIONAHA.105.539528 1:CAS:528:DC%2BD2MXhtF2rtbfL 16275870
    • PW Wilson RB D'Agostino H Parise, et al. 2005 Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus Circulation 112 3066 3072 10.1161/CIRCULATIONAHA.105.539528 1:CAS:528:DC%2BD2MXhtF2rtbfL 16275870
    • (2005) Circulation , vol.112 , pp. 3066-3072
    • Wilson, P.W.1    D'Agostino, R.B.2    Parise, H.3
  • 4
    • 77952420536 scopus 로고    scopus 로고
    • The metabolic syndrome predicts incident congestive heart failure: A 20-year follow-up study of elderly Finns
    • 10.1016/j.atherosclerosis.2009.10.042 1:CAS:528:DC%2BC3cXlsFOgur4%3D 19945701
    • J Wang K Sarnola S Ruotsalainen, et al. 2010 The metabolic syndrome predicts incident congestive heart failure: a 20-year follow-up study of elderly Finns Atherosclerosis 210 237 242 10.1016/j.atherosclerosis.2009.10.042 1:CAS:528:DC%2BC3cXlsFOgur4%3D 19945701
    • (2010) Atherosclerosis , vol.210 , pp. 237-242
    • Wang, J.1    Sarnola, K.2    Ruotsalainen, S.3
  • 5
    • 34548329794 scopus 로고    scopus 로고
    • The metabolic syndrome predicts cardiovascular mortality: A 13-year follow-up study in elderly non-diabetic Finns
    • 10.1093/eurheartj/ehl524 17303589
    • J Wang S Ruotsalainen L Moilanen, et al. 2007 The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns Eur Heart J 28 857 864 10.1093/eurheartj/ehl524 17303589
    • (2007) Eur Heart J , vol.28 , pp. 857-864
    • Wang, J.1    Ruotsalainen, S.2    Moilanen, L.3
  • 6
    • 28944434431 scopus 로고    scopus 로고
    • Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus
    • 10.1001/archinte.165.22.2644 16344423
    • SG Wannamethee AG Shaper L Lennon RW Morris 2005 Metabolic syndrome vs Framingham Risk Score for prediction of coronary heart disease, stroke, and type 2 diabetes mellitus Arch Intern Med 165 2644 2650 10.1001/archinte.165.22.2644 16344423
    • (2005) Arch Intern Med , vol.165 , pp. 2644-2650
    • Wannamethee, S.G.1    Shaper, A.G.2    Lennon, L.3    Morris, R.W.4
  • 7
    • 58549091475 scopus 로고    scopus 로고
    • Mineralocorticoid receptors: Emerging complexity and functional diversity
    • 10.1016/j.steroids.2008.10.010 1:CAS:528:DC%2BD1MXhtFentrs%3D 19022273
    • A Odermatt AG Atanasov 2009 Mineralocorticoid receptors: emerging complexity and functional diversity Steroids 74 163 171 10.1016/j.steroids.2008. 10.010 1:CAS:528:DC%2BD1MXhtFentrs%3D 19022273
    • (2009) Steroids , vol.74 , pp. 163-171
    • Odermatt, A.1    Atanasov, A.G.2
  • 8
    • 67349208215 scopus 로고    scopus 로고
    • New aspects of rapid aldosterone signaling
    • 10.1016/j.mce.2009.02.005 1:CAS:528:DC%2BD1MXnsFantL8%3D 19549592
    • C Grossmann M Gekle 2009 New aspects of rapid aldosterone signaling Mol Cell Endocrinol 308 53 62 10.1016/j.mce.2009.02.005 1:CAS:528: DC%2BD1MXnsFantL8%3D 19549592
    • (2009) Mol Cell Endocrinol , vol.308 , pp. 53-62
    • Grossmann, C.1    Gekle, M.2
  • 9
    • 58149165339 scopus 로고    scopus 로고
    • Aldosterone and cardiovascular disease
    • 10.1016/j.cpcardiol.2008.10.002 19135616
    • KK Gaddam E Pimenta S Husain DA Calhoun 2009 Aldosterone and cardiovascular disease Curr Probl Cardiol 34 51 84 10.1016/j.cpcardiol.2008.10. 002 19135616
    • (2009) Curr Probl Cardiol , vol.34 , pp. 51-84
    • Gaddam, K.K.1    Pimenta, E.2    Husain, S.3    Calhoun, D.A.4
  • 10
    • 38549092093 scopus 로고    scopus 로고
    • Aldosterone and vascular inflammation
    • 10.1161/HYPERTENSIONAHA.107.095489 1:CAS:528:DC%2BD1cXmt1OhsQ%3D%3D 18172061
    • NJ Brown 2008 Aldosterone and vascular inflammation Hypertension 51 161 167 10.1161/HYPERTENSIONAHA.107.095489 1:CAS:528:DC%2BD1cXmt1OhsQ%3D%3D 18172061
    • (2008) Hypertension , vol.51 , pp. 161-167
    • Brown, N.J.1
  • 11
    • 59849118673 scopus 로고    scopus 로고
    • Reconsidering the roles of the mineralocorticoid receptor
    • 10.1161/HYPERTENSIONAHA.108.119966 1:CAS:528:DC%2BD1MXlvFSrsQ%3D%3D 19139379
    • JW Funder 2009 Reconsidering the roles of the mineralocorticoid receptor Hypertension 53 286 290 10.1161/HYPERTENSIONAHA.108.119966 1:CAS:528: DC%2BD1MXlvFSrsQ%3D%3D 19139379
    • (2009) Hypertension , vol.53 , pp. 286-290
    • Funder, J.W.1
  • 12
    • 33846963787 scopus 로고    scopus 로고
    • Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity
    • 10.1038/nm1545 1:CAS:528:DC%2BD2sXhsVykur0%3D 17273168
    • JA Leopold A Dam BA Maron, et al. 2007 Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity Nat Med 13 189 197 10.1038/nm1545 1:CAS:528:DC%2BD2sXhsVykur0%3D 17273168
    • (2007) Nat Med , vol.13 , pp. 189-197
    • Leopold, J.A.1    Dam, A.2    Maron, B.A.3
  • 13
    • 57349168398 scopus 로고    scopus 로고
    • Modification of mineralocorticoid receptor function by Rac1 GTPase: Implication in proteinuric kidney disease
    • 10.1038/nm.1879 1:CAS:528:DC%2BD1cXhsVWgsr7L 19029984
    • S Shibata M Nagase S Yoshida, et al. 2008 Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease Nat Med 14 1370 1376 10.1038/nm.1879 1:CAS:528:DC%2BD1cXhsVWgsr7L 19029984
    • (2008) Nat Med , vol.14 , pp. 1370-1376
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3
  • 14
    • 70350743265 scopus 로고    scopus 로고
    • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors
    • 10.1161/CIRCRESAHA.109.196576 1:CAS:528:DC%2BD1MXhsVCiurrP 19762686
    • CA Lemarie SM Simeone A Nikonova, et al. 2009 Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors Circ Res 105 852 859 10.1161/CIRCRESAHA.109.196576 1:CAS:528:DC%2BD1MXhsVCiurrP 19762686
    • (2009) Circ Res , vol.105 , pp. 852-859
    • Lemarie, C.A.1    Simeone, S.M.2    Nikonova, A.3
  • 15
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • 10.1056/NEJM199909023411001 1:CAS:528:DyaK1MXmtVyrurk%3D 10471456
    • B Pitt F Zannad WJ Remme, et al. 1999 The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators N Engl J Med 341 709 717 10.1056/NEJM199909023411001 1:CAS:528:DyaK1MXmtVyrurk%3D 10471456
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 16
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • 10.1056/NEJMoa030207 1:CAS:528:DC%2BD3sXis1ehurY%3D 12668699
    • B Pitt W Remme F Zannad, et al. 2003 Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction N Engl J Med 348 1309 1321 10.1056/NEJMoa030207 1:CAS:528: DC%2BD3sXis1ehurY%3D 12668699
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 17
    • 67651048925 scopus 로고    scopus 로고
    • Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: A randomized controlled trial
    • 10.1016/j.jacc.2009.03.066 1:CAS:528:DC%2BD1MXhtFaisLfP 19643310
    • NC Edwards RP Steeds PM Stewart, et al. 2009 Effect of spironolactone on left ventricular mass and aortic stiffness in early-stage chronic kidney disease: a randomized controlled trial J Am Coll Cardiol 54 505 512 10.1016/j.jacc.2009.03.066 1:CAS:528:DC%2BD1MXhtFaisLfP 19643310
    • (2009) J Am Coll Cardiol , vol.54 , pp. 505-512
    • Edwards, N.C.1    Steeds, R.P.2    Stewart, P.M.3
  • 18
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • 10.1161/01.CIR.0000091405.00772.6E 1:CAS:528:DC%2BD3sXnvVajur8%3D 14517164
    • B Pitt N Reichek R Willenbrock, et al. 2003 Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study Circulation 108 1831 1838 10.1161/01.CIR.0000091405.00772.6E 1:CAS:528:DC%2BD3sXnvVajur8%3D 14517164
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 19
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • 10.1681/ASN.2009070737 1:CAS:528:DC%2BD1MXhs1Witb3P 19926893
    • UF Mehdi B Adams-Huet P Raskin, et al. 2009 Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy J Am Soc Nephrol 20 2641 2650 10.1681/ASN.2009070737 1:CAS:528:DC%2BD1MXhs1Witb3P 19926893
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3
  • 20
    • 35948958973 scopus 로고    scopus 로고
    • Body Mass Index Predicts Aldosterone Production in Normotensive Adults on a High-Salt Diet
    • 10.1210/jc.2007-1088 1:CAS:528:DC%2BD2sXhtlartbjK 17726083
    • R Bentley-Lewis G Adler T Perlstein, et al. 2007 Body Mass Index Predicts Aldosterone Production in Normotensive Adults on a High-Salt Diet J Clin Endocrinol Metab 92 4472 4475 10.1210/jc.2007-1088 1:CAS:528:DC%2BD2sXhtlartbjK 17726083
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4472-4475
    • Bentley-Lewis, R.1    Adler, G.2    Perlstein, T.3
  • 21
    • 34347406538 scopus 로고    scopus 로고
    • Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis
    • 10.1096/fj.06-7970com 1:CAS:528:DC%2BD2sXnvVagtr8%3D 17384139
    • M Caprio B Feve A Claes, et al. 2007 Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis FASEB J 21 2185 2194 10.1096/fj.06-7970com 1:CAS:528:DC%2BD2sXnvVagtr8%3D 17384139
    • (2007) FASEB J , vol.21 , pp. 2185-2194
    • Caprio, M.1    Feve, B.2    Claes, A.3
  • 22
    • 29244449321 scopus 로고    scopus 로고
    • Mineralocorticoid-stimulating activity of adipose tissue
    • 10.1016/j.beem.2005.07.002 1:CAS:528:DC%2BD2MXht1GhsLnO 16311217
    • V Lamounier-Zepter M Ehrhart-Bornstein SR Bornstein 2005 Mineralocorticoid-stimulating activity of adipose tissue Best Pract Res Clin Endocrinol Metab 19 567 575 10.1016/j.beem.2005.07.002 1:CAS:528: DC%2BD2MXht1GhsLnO 16311217
    • (2005) Best Pract Res Clin Endocrinol Metab , vol.19 , pp. 567-575
    • Lamounier-Zepter, V.1    Ehrhart-Bornstein, M.2    Bornstein, S.R.3
  • 23
    • 10744220710 scopus 로고    scopus 로고
    • Human adipocytes secrete mineralocorticoid-releasing factors
    • 10.1073/pnas.2336140100 1:CAS:528:DC%2BD3sXpsFGiur4%3D 14614137
    • M Ehrhart-Bornstein V Lamounier-Zepter A Schraven, et al. 2003 Human adipocytes secrete mineralocorticoid-releasing factors Proc Natl Acad Sci U S A 100 14211 14216 10.1073/pnas.2336140100 1:CAS:528:DC%2BD3sXpsFGiur4%3D 14614137
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14211-14216
    • Ehrhart-Bornstein, M.1    Lamounier-Zepter, V.2    Schraven, A.3
  • 24
    • 0032798782 scopus 로고    scopus 로고
    • Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans
    • 10.1016/S0952-3278(99)80020-9 1:CAS:528:DyaK1MXltleltrc%3D 10471129
    • TL Goodfriend BM Egan DE Kelley 1999 Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans Prostaglandins Leukot Essent Fatty Acids 60 401 405 10.1016/S0952-3278(99)80020-9 1:CAS:528: DyaK1MXltleltrc%3D 10471129
    • (1999) Prostaglandins Leukot Essent Fatty Acids , vol.60 , pp. 401-405
    • Goodfriend, T.L.1    Egan, B.M.2    Kelley, D.E.3
  • 25
    • 14644395574 scopus 로고    scopus 로고
    • Weight loss and the renin-angiotensin-aldosterone system
    • 10.1161/01.HYP.0000154361.47683.d3 1:CAS:528:DC%2BD2MXhtlOis7k%3D 15630041
    • S Engeli J Bohnke K Gorzelniak, et al. 2005 Weight loss and the renin-angiotensin-aldosterone system Hypertension 45 356 362 10.1161/01.HYP.0000154361.47683.d3 1:CAS:528:DC%2BD2MXhtlOis7k%3D 15630041
    • (2005) Hypertension , vol.45 , pp. 356-362
    • Engeli, S.1    Bohnke, J.2    Gorzelniak, K.3
  • 26
    • 0028081792 scopus 로고
    • Insulin and the renin-angiotensin-aldosterone system: Influence of ACE inhibition
    • 1:CAS:528:DyaK2MXitlCisbc%3D 7700069
    • E Ferrannini G Seghieri E Muscelli 1994 Insulin and the renin-angiotensin-aldosterone system: influence of ACE inhibition J Cardiovasc Pharmacol 24 Suppl 3 S61 S69 1:CAS:528:DyaK2MXitlCisbc%3D 7700069
    • (1994) J Cardiovasc Pharmacol , vol.24 , Issue.SUPPL. 3
    • Ferrannini, E.1    Seghieri, G.2    Muscelli, E.3
  • 27
    • 0022608081 scopus 로고
    • Effect of adrenal steroids on insulin release from cultured rat islets of Langerhans
    • 10.1007/BF00456122 1:CAS:528:DyaL28XhvVSgtb0%3D 3516767
    • J Pierluissi FO Navas SJ Ashcroft 1986 Effect of adrenal steroids on insulin release from cultured rat islets of Langerhans Diabetologia 29 119 121 10.1007/BF00456122 1:CAS:528:DyaL28XhvVSgtb0%3D 3516767
    • (1986) Diabetologia , vol.29 , pp. 119-121
    • Pierluissi, J.1    Navas, F.O.2    Ashcroft, S.J.3
  • 28
    • 64849092310 scopus 로고    scopus 로고
    • Fasting plasma glucose and serum lipids in patients with primary aldosteronism: A controlled cross-sectional study
    • 10.1161/HYPERTENSIONAHA.108.122002 1:CAS:528:DC%2BD1MXivVemtrw%3D 19221213
    • J Matrozova O Steichen L Amar, et al. 2009 Fasting plasma glucose and serum lipids in patients with primary aldosteronism: a controlled cross-sectional study Hypertension 53 605 610 10.1161/HYPERTENSIONAHA.108.122002 1:CAS:528:DC%2BD1MXivVemtrw%3D 19221213
    • (2009) Hypertension , vol.53 , pp. 605-610
    • Matrozova, J.1    Steichen, O.2    Amar, L.3
  • 29
    • 77952927441 scopus 로고    scopus 로고
    • Mineralocorticoid antagonists treatment versus surgery in primary aldosteronism
    • n 29 (Epub ahead of print)
    • Catena C, Colussi G, Di Fabio A, et al.: Mineralocorticoid antagonists treatment versus surgery in primary aldosteronism. Horm Metab Res 2010 Jan 29 (Epub ahead of print).
    • (2010) Horm Metab Res
    • Catena, C.1    Colussi, G.2    Di Fabio, A.3
  • 30
    • 15944366224 scopus 로고    scopus 로고
    • The renin-angiotensin-aldosterone system, glucose metabolism and diabetes
    • 10.1016/j.tem.2005.02.003 1:CAS:528:DC%2BD2MXivV2gs7o%3D 15808810
    • G Giacchetti LA Sechi S Rilli RM Carey 2005 The renin-angiotensin- aldosterone system, glucose metabolism and diabetes Trends Endocrinol Metab 16 120 126 10.1016/j.tem.2005.02.003 1:CAS:528:DC%2BD2MXivV2gs7o%3D 15808810
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 120-126
    • Giacchetti, G.1    Sechi, L.A.2    Rilli, S.3    Carey, R.M.4
  • 31
    • 33748752420 scopus 로고    scopus 로고
    • Insulin sensitivity in patients with primary aldosteronism: A follow-up study
    • 10.1210/jc.2006-0736 1:CAS:528:DC%2BD28XpslajtLg%3D 16822818
    • C Catena R Lapenna S Baroselli, et al. 2006 Insulin sensitivity in patients with primary aldosteronism: a follow-up study J Clin Endocrinol Metab 91 3457 3463 10.1210/jc.2006-0736 1:CAS:528:DC%2BD28XpslajtLg%3D 16822818
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3457-3463
    • Catena, C.1    Lapenna, R.2    Baroselli, S.3
  • 32
    • 34547443383 scopus 로고    scopus 로고
    • Adiponectin and insulin sensitivity in primary aldosteronism
    • 10.1016/j.amjhyper.2007.03.012 1:CAS:528:DC%2BD2sXosF2hur4%3D 17679033 Patients with primary aldosteronism had more insulin resistance (higher HOMA index) and lower levels of adiponectin than patients with low-renin essential hypertension in the absence of MetS
    • F Fallo P Della Mea N Sonino, et al. 2007 Adiponectin and insulin sensitivity in primary aldosteronism Am J Hypertens 20 855 861 10.1016/j.amjhyper.2007.03.012 1:CAS:528:DC%2BD2sXosF2hur4%3D 17679033 Patients with primary aldosteronism had more insulin resistance (higher HOMA index) and lower levels of adiponectin than patients with low-renin essential hypertension in the absence of MetS
    • (2007) Am J Hypertens , vol.20 , pp. 855-861
    • Fallo, F.1    Della Mea, P.2    Sonino, N.3
  • 33
    • 0034101846 scopus 로고    scopus 로고
    • Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment
    • 1:CAS:528:DC%2BD3cXitFejt70%3D 10768828
    • G Sindelka J Widimsky T Haas, et al. 2000 Insulin action in primary hyperaldosteronism before and after surgical or pharmacological treatment Exp Clin Endocrinol Diabetes 108 21 25 1:CAS:528:DC%2BD3cXitFejt70%3D 10768828
    • (2000) Exp Clin Endocrinol Diabetes , vol.108 , pp. 21-25
    • Sindelka, G.1    Widimsky, J.2    Haas, T.3
  • 34
    • 77951649148 scopus 로고    scopus 로고
    • Aldosterone production and insulin resistance in healthy adults
    • 10.1210/jc.2009-2521 1:CAS:528:DC%2BC3cXltFSntr4%3D 20130077 In normotensive healthy adults, high angiotensin II-stimulated aldosterone level was an independent predictor of insulin resistance even after adjusting for age, body mass index, and diastolic blood pressure
    • R Garg S Hurwitz GH Williams, et al. 2010 Aldosterone production and insulin resistance in healthy adults J Clin Endocrinol Metab 95 1986 1990 10.1210/jc.2009-2521 1:CAS:528:DC%2BC3cXltFSntr4%3D 20130077 In normotensive healthy adults, high angiotensin II-stimulated aldosterone level was an independent predictor of insulin resistance even after adjusting for age, body mass index, and diastolic blood pressure
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 1986-1990
    • Garg, R.1    Hurwitz, S.2    Williams, G.H.3
  • 35
    • 72049094255 scopus 로고    scopus 로고
    • Aldosterone status associated with insulin resistance in patients with heart failure-data from the ALOFT study
    • 10.1136/hrt.2009.173344 1:CAS:528:DC%2BC3cXivVCgur0%3D 19713201
    • EM Freel IK Tsorlalis JD Lewsey, et al. 2009 Aldosterone status associated with insulin resistance in patients with heart failure-data from the ALOFT study Heart 95 1920 1924 10.1136/hrt.2009.173344 1:CAS:528: DC%2BC3cXivVCgur0%3D 19713201
    • (2009) Heart , vol.95 , pp. 1920-1924
    • Freel, E.M.1    Tsorlalis, I.K.2    Lewsey, J.D.3
  • 36
    • 67651091717 scopus 로고    scopus 로고
    • Impact of excess aldosterone on glucose homeostasis in adult male rat
    • 10.1016/j.cca.2009.06.030 1:CAS:528:DC%2BD1MXpt1KisLc%3D 19567248
    • J Selvaraj T Muthusamy C Srinivasan K Balasubramanian 2009 Impact of excess aldosterone on glucose homeostasis in adult male rat Clin Chim Acta 407 51 57 10.1016/j.cca.2009.06.030 1:CAS:528:DC%2BD1MXpt1KisLc%3D 19567248
    • (2009) Clin Chim Acta , vol.407 , pp. 51-57
    • Selvaraj, J.1    Muthusamy, T.2    Srinivasan, C.3    Balasubramanian, K.4
  • 37
    • 66449100734 scopus 로고    scopus 로고
    • The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways
    • 10.1210/en.2008-0239 1:CAS:528:DC%2BD1MXlsFCjtLw%3D 19106228
    • JF Ndisang N Lane A Jadhav 2009 The heme oxygenase system abates hyperglycemia in Zucker diabetic fatty rats by potentiating insulin-sensitizing pathways Endocrinology 150 2098 2108 10.1210/en.2008-0239 1:CAS:528: DC%2BD1MXlsFCjtLw%3D 19106228
    • (2009) Endocrinology , vol.150 , pp. 2098-2108
    • Ndisang, J.F.1    Lane, N.2    Jadhav, A.3
  • 38
    • 44049097881 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
    • 10.1161/CIRCULATIONAHA.107.748640 1:CAS:528:DC%2BD1cXkvFSjtL4%3D 18427128 In obese, db/db mice, MR blockade reduced circulating triglyceride levels, decreased adipose tissue expression of inflammatory cytokines, and increased expression of adiponectin and PPARγ. In 3 T3-L1 preadipocytes, aldosterone increased expression of inflammatory cytokines and decreased expression of adiponectin and PPARγ, supporting a direct effect of aldosterone on gene expression
    • C Guo V Ricchiuti BQ Lian, et al. 2008 Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines Circulation 117 2253 2261 10.1161/CIRCULATIONAHA.107.748640 1:CAS:528:DC%2BD1cXkvFSjtL4%3D 18427128 In obese, db/db mice, MR blockade reduced circulating triglyceride levels, decreased adipose tissue expression of inflammatory cytokines, and increased expression of adiponectin and PPARγ. In 3 T3-L1 preadipocytes, aldosterone increased expression of inflammatory cytokines and decreased expression of adiponectin and PPARγ, supporting a direct effect of aldosterone on gene expression
    • (2008) Circulation , vol.117 , pp. 2253-2261
    • Guo, C.1    Ricchiuti, V.2    Lian, B.Q.3
  • 39
    • 70449718904 scopus 로고    scopus 로고
    • Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice
    • 10.1093/cvr/cvp191 1:CAS:528:DC%2BD1MXhtFarsbnP 19505930 In obese, db/db and ob/ob mice, MR blockade reduced insulin resistance and improved adipose tissue inflammation (decreased reactive oxygen species and macrophage infiltration). In 3 T3-L1 adipocytes, aldosterone increased intracellular reactive oxygen species
    • A Hirata N Maeda A Hiuge, et al. 2009 Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice Cardiovasc Res 84 164 172 10.1093/cvr/cvp191 1:CAS:528:DC%2BD1MXhtFarsbnP 19505930 In obese, db/db and ob/ob mice, MR blockade reduced insulin resistance and improved adipose tissue inflammation (decreased reactive oxygen species and macrophage infiltration). In 3 T3-L1 adipocytes, aldosterone increased intracellular reactive oxygen species
    • (2009) Cardiovasc Res , vol.84 , pp. 164-172
    • Hirata, A.1    Maeda, N.2    Hiuge, A.3
  • 40
    • 0038401018 scopus 로고    scopus 로고
    • Transcriptional inhibition of the human insulin receptor gene by aldosterone
    • 10.1016/S0960-0760(03)00072-4 1:CAS:528:DC%2BD3sXktFCqt7g%3D 12767279
    • C Calle J Campion M Garcia-Arencibia, et al. 2003 Transcriptional inhibition of the human insulin receptor gene by aldosterone J Steroid Biochem Mol Biol 84 543 553 10.1016/S0960-0760(03)00072-4 1:CAS:528:DC%2BD3sXktFCqt7g%3D 12767279
    • (2003) J Steroid Biochem Mol Biol , vol.84 , pp. 543-553
    • Calle, C.1    Campion, J.2    Garcia-Arencibia, M.3
  • 41
    • 63849107748 scopus 로고    scopus 로고
    • Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3 T3-L1 adipocytes
    • 10.1210/en.2008-1018 1:CAS:528:DC%2BD1MXktVWmu7Y%3D 19095745 Aldosterone treatment in the adipocyte cell line resulted in IRS-1 serine phosphorylation and degradation, leading to decreased insulin stimulation of both Akt activation and glucose uptake. This mechanism was suggested to involve aldosterone-mediated intracellular oxidative stress
    • T Wada S Ohshima E Fujisawa, et al. 2009 Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3 T3-L1 adipocytes Endocrinology 150 1662 1669 10.1210/en.2008-1018 1:CAS:528: DC%2BD1MXktVWmu7Y%3D 19095745 Aldosterone treatment in the adipocyte cell line resulted in IRS-1 serine phosphorylation and degradation, leading to decreased insulin stimulation of both Akt activation and glucose uptake. This mechanism was suggested to involve aldosterone-mediated intracellular oxidative stress
    • (2009) Endocrinology , vol.150 , pp. 1662-1669
    • Wada, T.1    Ohshima, S.2    Fujisawa, E.3
  • 42
    • 77956267023 scopus 로고    scopus 로고
    • Clinical effects of eplerenone, a selective aldosterone blocker, in Japanese patients with essential hypertension
    • Oct 29 (Epub ahead of print)
    • Sato A, Fukuda S: Clinical effects of eplerenone, a selective aldosterone blocker, in Japanese patients with essential hypertension. J Hum Hypertens 2009 Oct 29 (Epub ahead of print).
    • (2009) J Hum Hypertens
    • Sato, A.1    Fukuda, S.2
  • 43
    • 77953165944 scopus 로고    scopus 로고
    • Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet
    • 10.1210/en.2009-0869 1:CAS:528:DC%2BC3cXlsFKgsr8%3D 20211973 MR blockade improved glucose metabolism (assessed by the glucose tolerance test and insulin tolerance test), reduced triglyceride and cholesterol levels, reduced hepatic inflammation (decreased hepatic expression of TNFα, interleukin-6, and MCP-1), and reduced hepatic steatosis in mice fed a high-fat and high-fructose diet
    • T Wada H Kenmochi Y Miyashita, et al. 2010 Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet Endocrinology 151 2040 2049 10.1210/en.2009-0869 1:CAS:528: DC%2BC3cXlsFKgsr8%3D 20211973 MR blockade improved glucose metabolism (assessed by the glucose tolerance test and insulin tolerance test), reduced triglyceride and cholesterol levels, reduced hepatic inflammation (decreased hepatic expression of TNFα, interleukin-6, and MCP-1), and reduced hepatic steatosis in mice fed a high-fat and high-fructose diet
    • (2010) Endocrinology , vol.151 , pp. 2040-2049
    • Wada, T.1    Kenmochi, H.2    Miyashita, Y.3
  • 44
    • 75949124215 scopus 로고    scopus 로고
    • High inflammatory activity related to the number of metabolic syndrome components
    • 10.1111/j.1751-7176.2009.00229.x 1:CAS:528:DC%2BC3cXivFWntLg%3D
    • B Kirilmaz F Asgun E Alioglu, et al. 2010 High inflammatory activity related to the number of metabolic syndrome components J Clin Hypertens (Greenwich) 12 136 144 10.1111/j.1751-7176.2009.00229.x 1:CAS:528: DC%2BC3cXivFWntLg%3D
    • (2010) J Clin Hypertens (Greenwich) , vol.12 , pp. 136-144
    • Kirilmaz, B.1    Asgun, F.2    Alioglu, E.3
  • 45
    • 44949169677 scopus 로고    scopus 로고
    • Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion
    • 10.1161/CIRCRESAHA.108.174235 1:CAS:528:DC%2BD1cXmt1yhtrs%3D 18467630
    • M Caprio BG Newfell A la Sala, et al. 2008 Functional mineralocorticoid receptors in human vascular endothelial cells regulate intercellular adhesion molecule-1 expression and promote leukocyte adhesion Circ Res 102 1359 1367 10.1161/CIRCRESAHA.108.174235 1:CAS:528:DC%2BD1cXmt1yhtrs%3D 18467630
    • (2008) Circ Res , vol.102 , pp. 1359-1367
    • Caprio, M.1    Newfell, B.G.2    La Sala, A.3
  • 46
    • 72449191387 scopus 로고    scopus 로고
    • Aldosterone up-regulates 12- and 15-lipoxygenase expression and LDL oxidation in human vascular smooth muscle cells
    • 10.1002/jcb.22352 1:CAS:528:DC%2BD1MXhsV2gsLrK 19795383 Treating vascular smooth muscle cells with aldosterone resulted in increased expression of 12- and 15-lipoxygenase expression and increased LDL oxidation. These effects were blocked by MR antagonists or an EGF-receptor antagonist, demonstrating potential interactions between these two receptors
    • R Limor M Kaplan O Sharon, et al. 2009 Aldosterone up-regulates 12- and 15-lipoxygenase expression and LDL oxidation in human vascular smooth muscle cells J Cell Biochem 108 1203 1210 10.1002/jcb.22352 1:CAS:528: DC%2BD1MXhsV2gsLrK 19795383 Treating vascular smooth muscle cells with aldosterone resulted in increased expression of 12- and 15-lipoxygenase expression and increased LDL oxidation. These effects were blocked by MR antagonists or an EGF-receptor antagonist, demonstrating potential interactions between these two receptors
    • (2009) J Cell Biochem , vol.108 , pp. 1203-1210
    • Limor, R.1    Kaplan, M.2    Sharon, O.3
  • 47
    • 34447136169 scopus 로고    scopus 로고
    • Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus
    • 10.1210/jc.2007-0393 1:CAS:528:DC%2BD2sXotVylsL4%3D 17488800
    • HV Joffe RY Kwong MD Gerhard-Herman, et al. 2007 Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus J Clin Endocrinol Metab 92 2552 2558 10.1210/jc.2007-0393 1:CAS:528:DC%2BD2sXotVylsL4%3D 17488800
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 2552-2558
    • Joffe, H.V.1    Kwong, R.Y.2    Gerhard-Herman, M.D.3
  • 48
    • 27744459326 scopus 로고    scopus 로고
    • Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: A pilot study
    • 1:CAS:528:DC%2BD2MXhtFKqtrvI 16275882
    • H Izawa T Murohara K Nagata, et al. 2005 Mineralocorticoid receptor antagonism ameliorates left ventricular diastolic dysfunction and myocardial fibrosis in mildly symptomatic patients with idiopathic dilated cardiomyopathy: a pilot study Circulation 112 2940 2945 1:CAS:528:DC%2BD2MXhtFKqtrvI 16275882
    • (2005) Circulation , vol.112 , pp. 2940-2945
    • Izawa, H.1    Murohara, T.2    Nagata, K.3
  • 49
    • 0036841840 scopus 로고    scopus 로고
    • Aldosterone antagonist improves diastolic function in essential hypertension
    • 10.1161/01.HYP.0000036399.80194.D8 1:CAS:528:DC%2BD38XotFWltLc%3D 12411457
    • AM Grandi D Imperiale R Santillo, et al. 2002 Aldosterone antagonist improves diastolic function in essential hypertension Hypertension 40 647 652 10.1161/01.HYP.0000036399.80194.D8 1:CAS:528:DC%2BD38XotFWltLc%3D 12411457
    • (2002) Hypertension , vol.40 , pp. 647-652
    • Grandi, A.M.1    Imperiale, D.2    Santillo, R.3
  • 50
    • 77951453096 scopus 로고    scopus 로고
    • Effect of valsartan on the incidence of diabetes and cardiovascular events
    • The NAVIGATOR Study Group. 10.1056/NEJMoa1001121 In this large, placebo-controlled, randomized trial among patients with impaired glucose tolerance (many of whom met the MetS diagnostic criteria), the use of valsartan for 5 years led to a relative reduction of 14% in the incidence of diabetes. This study supports a role for blockade of the RAAS in preventing progression to diabetes
    • The NAVIGATOR Study Group 2010 Effect of valsartan on the incidence of diabetes and cardiovascular events N Engl J Med 363 1477 1490 10.1056/NEJMoa1001121 In this large, placebo-controlled, randomized trial among patients with impaired glucose tolerance (many of whom met the MetS diagnostic criteria), the use of valsartan for 5 years led to a relative reduction of 14% in the incidence of diabetes. This study supports a role for blockade of the RAAS in preventing progression to diabetes
    • (2010) N Engl J Med , vol.363 , pp. 1477-1490


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