Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds

Journal of Medicinal Chemistry

Volumn 56, Issue 23, 2013, Pages 9789-9801

  Hilpert, Hans ^a   Mauser, Harald ^a   Humm, Roland ^a   Anselm, Lilli ^a   Kuehne, Holger ^a   Hartmann, Guido ^a   Gruener, Sabine ^a   Banner, David W ^a   Benz, Joerg ^a   Gsell, Bernard ^a   Kuglstatter, Andreas ^a   Stihle, Martine ^a   Thoma, Ralf ^a   Sanchez, Rubén Alvarez ^a   Iding, Hans ^a   Wirz, Beat ^a   Haap, Wolfgang ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 ACETYL 4 (2 CHLORO BENZENESULFONYL)PYRROLIDINE 2 CARBOXYLIC ACID (1 CYANO CYCLOPROPYL)AMIDE; 4 BENZENESULFONYL 2 (MORPHOLINE 4 CARBONYL) CYCLOPENTANECARBOXYLIC ACID CYANOMETHYL AMIDE; CATHEPSIN B; CATHEPSIN K; CATHEPSIN K INHIBITOR; CATHEPSIN L; CATHEPSIN S; CATHEPSIN S INHIBITOR; CYCLOPENTANE; INTERLEUKIN 2; LIGAND; PROLINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG BINDING SITE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; IN VITRO STUDY; IN VIVO STUDY; LIGAND BINDING; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRANSGENIC MOUSE;

ANIMALS; CATHEPSINS; CYCLOPENTANES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; MICE; PROLINE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84890443550     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401528k     Document Type: Article

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