Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7189-7193

  Moss, Neil ^a   Xiong, Zhaoming ^a   Burke, Mike ^a   Cogan, Derek ^a   Gao, Donghong A ^a   Haverty, Kathleen ^a   Heim Riether, Alexander ^a   Hickey, Eugene R ^a   Nagaraja, Raj ^a   Netherton, Matthew ^a   O'Shea, Kathy ^a   Ramsden, Philip ^a   Schwartz, Racheline ^a   Shih, Daw Tsun ^a   Ward, Yancey ^a   Young, Erick ^a   Zhang, Qing ^a  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Cathepsin S; Metabolic stability; Reversible covalent inhibitors; SAR; Triazole

Indexed keywords

CATHEPSIN S INHIBITOR; TRIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

AMIDES; CATHEPSINS; HALF-LIFE; HUMANS; MICROSOMES, LIVER; PROTEASE INHIBITORS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; TRIAZOLES;

EID: 84869092523     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.054     Document Type: Article

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