Novel synthetic protective compound, KR-22335, against cisplatin-induced auditory cell death

Journal of Applied Toxicology

Volumn 34, Issue 2, 2014, Pages 191-204

  Shin, Yoo Seob ^a   Song, Suk Jin ^b   Kang, Sungun ^a   Hwang, Hye Sook ^a   Jung, Young Sik ^b   Kim, Chul Ho ^a  

^a Ajou University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Apoptosis; Cisplatin; Hearing preservation; Ototoxicity; Zebrafish

Indexed keywords

CASPASE 3; CISPLATIN; KR 22335; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUDITORY SYSTEM; CELL CYCLE ARREST; CELL DAMAGE; CELL DEATH; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME ACTIVATION; FEMALE; HAIR CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STEREOCILIUM; TRANSMISSION ELECTRON MICROSCOPY; ZEBRA FISH;

DANIO RERIO;

APOPTOSIS; CISPLATIN; HEARING PRESERVATION; OTOTOXICITY; ZEBRAFISH;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CISPLATIN; HAIR CELLS, AUDITORY; HUMANS; IN SITU NICK-END LABELING; MITOCHONDRIA; OXIDATIVE STRESS; PROTECTIVE AGENTS; QUINOLONES; REACTIVE OXYGEN SPECIES; ZEBRAFISH;

EID: 84890426625     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2852     Document Type: Article

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