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Volumn 22, Issue 1, 2007, Pages 95-100

Modulatory effects of N-acetylcysteine on cerebral cortex and cerebellum regions of ageing rat brain

Author keywords

Antioxidative defense; Brain ageing; Lipid peroxidation; N acetylcysteine; Reduced glutathione

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CATALASE; GLUTATHIONE; LIPID PEROXIDE;

EID: 33847389304     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (33)
  • 1
    • 2442571752 scopus 로고
    • Birren JE, Bengston VL, Eds, Springer, Berlin
    • Cristofalo VJ: Emergent Theories of Ageing. In: Birren JE, Bengston VL, (Eds.), Springer, Berlin, 1988, pp. 118-127.
    • (1988) Emergent Theories of Ageing , pp. 118-127
    • Cristofalo, V.J.1
  • 2
    • 31044450597 scopus 로고    scopus 로고
    • Free radical mechanisms of aging processes under physiological conditions
    • Afanas'ev IB: Free radical mechanisms of aging processes under physiological conditions. Biogerontol 2005; 6:283-290.
    • (2005) Biogerontol , vol.6 , pp. 283-290
    • Afanas'ev, I.B.1
  • 3
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11:298-300.
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 4
  • 5
    • 0029789043 scopus 로고    scopus 로고
    • NO-induced oxidative stress and glutathione metabolism in rodent and human cells
    • Luperchio S, Tamir S, Tannenbaum SR: NO-induced oxidative stress and glutathione metabolism in rodent and human cells. Free Radical Biol. Med 1996; 21:513-519.
    • (1996) Free Radical Biol. Med , vol.21 , pp. 513-519
    • Luperchio, S.1    Tamir, S.2    Tannenbaum, S.R.3
  • 7
    • 0043132416 scopus 로고    scopus 로고
    • Role of oxidative stress in age-related reduction of NO-cGMP-mediated vasicular relaxation in SHR
    • Payne JA, Reckelhoff JF, Khalil RA: Role of oxidative stress in age-related reduction of NO-cGMP-mediated vasicular relaxation in SHR. Am J Physiol Regul Integr Comp Physiol 2003; 285:R542-R551.
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Payne, J.A.1    Reckelhoff, J.F.2    Khalil, R.A.3
  • 8
    • 0027171266 scopus 로고
    • Oxidant, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM: Oxidant, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90:7915-7922.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 9
    • 10044225524 scopus 로고    scopus 로고
    • N-acetylcysteine exposure on lead-induced lipid peroxidative damage and oxidative defense system in brain regions of rats
    • Nehru B, Kanwar SS: N-acetylcysteine exposure on lead-induced lipid peroxidative damage and oxidative defense system in brain regions of rats. Biol Trace Elem Res 2004; 101:257-264.
    • (2004) Biol Trace Elem Res , vol.101 , pp. 257-264
    • Nehru, B.1    Kanwar, S.S.2
  • 10
    • 0024205742 scopus 로고
    • Acetylcysteine: A drug that is much more than a mucokinetic
    • Ziment I: Acetylcysteine: a drug that is much more than a mucokinetic. Biomed Pharmacother 1988; 42:513-520.
    • (1988) Biomed Pharmacother , vol.42 , pp. 513-520
    • Ziment, I.1
  • 11
    • 0032039959 scopus 로고    scopus 로고
    • Clinical applications of N-acetylcysteine
    • Kelly GS: Clinical applications of N-acetylcysteine. Alt Med Rev 1998; 3:114-127.
    • (1998) Alt Med Rev , vol.3 , pp. 114-127
    • Kelly, G.S.1
  • 12
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6:593-597.
    • (1989) Free Radic Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 13
    • 0013914976 scopus 로고
    • Mechanism of lipid peroxide formation in animal tissues
    • Wills ED: Mechanism of lipid peroxide formation in animal tissues. Biochem J 1966; 99:667-676.
    • (1966) Biochem J , vol.99 , pp. 667-676
    • Wills, E.D.1
  • 14
    • 3042934967 scopus 로고
    • Tissue sulfhydryl groups
    • Ellman GL: Tissue sulfhydryl groups. Arch Biochim Biophys 1959; 82:70-77.
    • (1959) Arch Biochim Biophys , vol.82 , pp. 70-77
    • Ellman, G.L.1
  • 15
    • 0017804313 scopus 로고
    • Generation of superoxide radical during auto oxidation of hydroxylamine and an assay for superoxide dismutase
    • Kono Y: Generation of superoxide radical during auto oxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochim Biophys 1978; 186:189-195.
    • (1978) Arch Biochim Biophys , vol.186 , pp. 189-195
    • Kono, Y.1
  • 18
    • 0031974128 scopus 로고    scopus 로고
    • Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age
    • Rodríguez-Martínez MA, Alonso MJ, Redondo J, Salaices M, Marín J: Role of lipid peroxidation and the glutathione-dependent antioxidant system in the impairment of endothelium-dependent relaxations with age. British J Pharmacol 1998; 123:113-121.
    • (1998) British J Pharmacol , vol.123 , pp. 113-121
    • Rodríguez-Martínez, M.A.1    Alonso, M.J.2    Redondo, J.3    Salaices, M.4    Marín, J.5
  • 19
    • 0034875773 scopus 로고    scopus 로고
    • ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain
    • Leutner S, Eckert A, Muller WE: ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain. J Neural Transm 2001; 108:955-967.
    • (2001) J Neural Transm , vol.108 , pp. 955-967
    • Leutner, S.1    Eckert, A.2    Muller, W.E.3
  • 22
  • 23
    • 0034672943 scopus 로고    scopus 로고
    • Metabolism and functions of glutathione in brain
    • Dringen R: Metabolism and functions of glutathione in brain. Prog Neurobiol 2000; 62:649-671.
    • (2000) Prog Neurobiol , vol.62 , pp. 649-671
    • Dringen, R.1
  • 25
    • 0018854538 scopus 로고
    • Glutathione contents of tissues in aging mouse
    • Hazelton A, Lang A: Glutathione contents of tissues in aging mouse. Biochem J 1980; 188:25-30.
    • (1980) Biochem J , vol.188 , pp. 25-30
    • Hazelton, A.1    Lang, A.2
  • 27
    • 0022338582 scopus 로고
    • In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds
    • De Flora S, Bennicelli C, Camoirano A, Serra D, Romano M, Rossi GA, Morelli A, De Flora A: In vivo effects of N-acetylcysteine on glutathione metabolism and on the biotransformation of carcinogenic and/or mutagenic compounds. Carcinogenesis 1985; 6:1735-1745.
    • (1985) Carcinogenesis , vol.6 , pp. 1735-1745
    • De Flora, S.1    Bennicelli, C.2    Camoirano, A.3    Serra, D.4    Romano, M.5    Rossi, G.A.6    Morelli, A.7    De Flora, A.8
  • 28
    • 0030071905 scopus 로고    scopus 로고
    • N-acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity
    • Hoffer E, Baum Y, Tabak A, Taitelman U: N-acetylcysteine increases the glutathione content and protects rat alveolar type II cells against paraquat-induced cytotoxicity. Toxicol Lett 1996; 84:7-12.
    • (1996) Toxicol Lett , vol.84 , pp. 7-12
    • Hoffer, E.1    Baum, Y.2    Tabak, A.3    Taitelman, U.4
  • 29
    • 0023860819 scopus 로고
    • Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine
    • Issels RD, Nagele A, Eckert KG, Wilmanna W: Promotion of cystine uptake and its utilization for glutathione biosynthesis induced by cysteamine and N-acetylcysteine. Biochem Pharnacol 1988; 37:881-888.
    • (1988) Biochem Pharnacol , vol.37 , pp. 881-888
    • Issels, R.D.1    Nagele, A.2    Eckert, K.G.3    Wilmanna, W.4
  • 30
    • 0025685192 scopus 로고
    • Lung antioxidant enzymes, peroxidation, glutathione system and oxygen consumption in catalase inactivated young and old Rana Perezi frogs
    • Perez-Campo R, López-Tarres M, Patin D, Eequeros E, Barja deQG: Lung antioxidant enzymes, peroxidation, glutathione system and oxygen consumption in catalase inactivated young and old Rana Perezi frogs. Mech Aging Dev 1990; 36:281-292.
    • (1990) Mech Aging Dev , vol.36 , pp. 281-292
    • Perez-Campo, R.1    López-Tarres, M.2    Patin, D.3    Eequeros, E.4    deQG, B.5
  • 31
    • 0033772773 scopus 로고    scopus 로고
    • Age-associated changes of superoxide dismutase and catalase activities in the rat brain
    • Tsay H, Wang P, Wang S, Ku H: Age-associated changes of superoxide dismutase and catalase activities in the rat brain. J Biomed Sci 2000; 7:466-474.
    • (2000) J Biomed Sci , vol.7 , pp. 466-474
    • Tsay, H.1    Wang, P.2    Wang, S.3    Ku, H.4
  • 32
    • 0026036405 scopus 로고
    • Expression of superoxide dismutase and catalase in rat brain as a function of age
    • Semsci I, Rao G, Richardson A: Expression of superoxide dismutase and catalase in rat brain as a function of age. Mech Aging Dev 1991; 58:13-19.
    • (1991) Mech Aging Dev , vol.58 , pp. 13-19
    • Semsci, I.1    Rao, G.2    Richardson, A.3
  • 33
    • 0033651092 scopus 로고    scopus 로고
    • Current issues concerning the role of oxidative stress in aging: A perspective
    • Sohal RS, Mockett RJ, Orr WC: Current issues concerning the role of oxidative stress in aging: a perspective. Results Probl Cell Differ 2000; 29:45-66.
    • (2000) Results Probl Cell Differ , vol.29 , pp. 45-66
    • Sohal, R.S.1    Mockett, R.J.2    Orr, W.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.