Cyanidin-3-glucoside extracted from mulberry fruit can reduce N-methyl-N-nitrosourea-induced retinal degeneration in rats

Current Eye Research

Volumn 39, Issue 1, 2014, Pages 79-87

  Lee, Seung Hee ^a   Jeong, Eojin ^a   Paik, Sun Sook ^a   Jeon, Ji Hyun ^a   Jung, Sung Won ^a   Kim, Hyun Bok ^b   Kim, Muyan ^c   Chun, Myung Hoon ^a   Kim, In Beom ^a,d  

^a The Catholic University of Korea   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c GS Eye Center   (South Korea)

^d The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Cyanidin 3 O glucoside; Electroretinogram; Mulberry; Photoreceptor; Retinal degeneration

Indexed keywords

CYANIDIN 3 GLUCOSIDE; EOSIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HEMATOXYLIN; METHYLNITROSOUREA; RHODOPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DARK ADAPTATION; DRUG EFFECT; ELECTRORETINOGRAM; ELECTRORETINOGRAPHY; FUNCTIONAL ASSESSMENT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MORUS ALBA; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; RETINA DEGENERATION; RETINA INJURY; WESTERN BLOTTING;

ALKYLATING AGENTS; ANIMALS; ANTHOCYANINS; APOPTOSIS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; GLUCOSIDES; MALE; METHYLNITROSOUREA; MORUS; NIGHT VISION; PHOTORECEPTOR CELLS, VERTEBRATE; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; RETINAL DEGENERATION;

EID: 84890403472     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2013.825275     Document Type: Article

References (37)

1. Lamb TD, Pugh Jr EN. Dark adaptation and the retinoid cycle of vision. Prog Retin Eye Res 2004;23:307-380
2. Lamb TD, Pugh Jr EN. Phototransduction, dark adaptation, and rhodopsin regeneration the proctor lecture. Invest Ophthalmol Vis Sci 2006;47:5137-5152
3. Brennan LA, Kantorow M. Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations. Exp Eye Res 2009;88:195-203
4. Woodford BJ, Blanks JC. Uptake of tritiated thymidine in mitochondria of the retina. Invest Ophthalmol Vis Sci 1989; 30:2528-2532
5. Rattner A, Nathans J. Macular degeneration: Recent advances and therapeutic opportunities. Nat Rev Neurosci 2006;7:860-872
6. Coleman HR, Chan CC, Ferris 3rd FL, Chew EY. Agerelated macular degeneration. Lancet 2008;372:1835-1845
7. Fletcher AE. Free radicals, antioxidants and eye diseases: Evidence from epidemiological studies on cataract and agerelated macular degeneration. Ophthalmic Res 2010;44: 191-198
8. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, Pokharel GP, et al. Global data on visual impairment in the year 2002. Bull World Health Organ 2004;82:844-851
9. Chiu CJ, Taylor A. Nutritional antioxidants and age-related cataract and maculopathy. Exp Eye Res 2007;84:229-245
10. Markakis P. Anthocyanins as Food Color. New York: Academic Press; 1982
11. Stevenson DE, Hurst RD. Polyphenolic phytochemicals-just antioxidants or much more? Cell Mol Life Sci 2007;64: 2900-2916
12. Canter PH, Ernst E. Herbal supplement use by persons aged over 50 years in Britain: Frequently used herbs, concomitant use of herbs, nutritional supplements and prescription drugs, rate of informing doctors and potential for negative interactions. Drugs Aging 2004;21:597-605
13. Kalt W, Hanneken A, Milbury P, Tremblay F. Recent research on polyphenolics in vision and eye health. J Agric Food Chem 2010;58:4001-4007
14. Rhone M, Basu A. Phytochemicals and age-related eye diseases. Nutr Rev 2008;66:465-472
15. Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J Agric Food Chem 2003; 51:3560-3563
16. Tirupula KC, Balem F, Yanamala N, Klein-Seetharaman J. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects. Photochem Photobiol 2009;85:463-470
17. Yanamala N, Tirupula KC, Balem F, Klein-Seetharaman J. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 1. Structural aspects. Photochem Photobiol 2009; 85:454-462
18. Paik SS, Jeong E, Jung SW, Ha TJ, Kang S, Sim S, et al. Anthocyanins from the seed coat of black soybean reduce retinal degeneration induced by N-methyl-N-nitrosourea. Exp Eye Res 2012;97:55-62
19. Lee JH, Kang NS, Shin SO, Shin SH, Lim SG, Suh DY, et al. Characterisation of anthocyanins in the black soybean (Glycine max L.) by HPLC-DAD-ESI/MS analysis. Food Chem 2009;112:226-231
20. Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 2001;49:4208-4213
21. Jeong E, Paik SS, Jung SW, Chun MH, Kim IB. Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea. Anat Cell Biol 2011;44:314-23
22. Kim HB, Kim SL, Koh SH, Seok YS, Kim YS, Sung GB, et al. The development of natural pigment with mulberry fruit as a food additive. Korean J Crop Sci 2011;56:18-22
23. Kim HB, Kim SL. Identification of C3G (cyanidin-3-glucoside) from mulberry fruits and quantification with different varieties. Korean J Seric Sci 2003;45:90-95
24. Kim IB, Kim KY, Joo CK, Lee MY, Oh SJ, Chung JW, et al. Reaction of Muller cells after increased intraocular pressure in the rat retina. Exp Brain Res 1998;121:419-424
25. O'Callaghan JP. Assessment of neurotoxicity: Use of glial fibrillary acidic protein as a biomarker. Biomed Environ Sci 1991;4:197-206
26. Pawlowska AM, Oleszek W, Braca A. Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. J Agric Food Chem 2008;56: 3377-3380
27. Militante J, Lombardini JB. Age-related retinal degeneration in animal models of aging: Possible involvement of taurine deficiency and oxidative stress. Neurochem Res 2004;29:151-160
28. Kähkönen MP, Heinonen M. Antioxidant activity of anthocyanins and their aglycons. J Agric Food Chem 2003;51:628-633
29. Wang H, Cao G, Prior RL. Oxygen radical absorbing capacity of anthocyanins. J Agric Food Chem 1997;45: 304-309
30. Bhuiyan MI, Kim HB, Kim SY, Cho KO. The Neuroprotective Potential of Cyanidin-3-glucoside Fraction Extracted from Mulberry Following Oxygenglucose Deprivation. Korean J Physiol Pharmacol 2011;15: 353-361
31. Kang TH, Hur JY, Kim HB, Ryu JH, Kim SY. Neuroprotective effects of the cyanidin-3-O-beta-d-glucopyranoside isolated from mulberry fruit against cerebral ischemia. Neurosci Lett 2006;391:122-126
32. Cuevas-Rodríguez EO, Dia VP, Yousef GG, García-Saucedo PA, López-Medina J, Paredes-López O, et al. Inhibition of pro-inflammatory responses and antioxidant capacity of Mexican blackberry (Rubus spp.) extracts. J Agric Food Chem 2010;58:9542-9548
33. Seeram NP, Momin RA, Nair MG, Bourquin LD. Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine 2001;8: 362-369
34. Wang Q, Xia M, Liu C, Guo H, Ye Q, Hu Y, et al. Cyanidin-3-O-beta- glucoside inhibits iNOS and COX-2 expression by inducing liver X receptor alpha activation in THP-1 macrophages. Life Sci 2008;83:176-184
35. Rozovsky I, Finch CE, Morgan TE. Age-related activation of microglia and astrocytes: In vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation. Neurobiol Aging 1998;19: 97-103
36. Sharma V, Mishra M, Ghosh S, Tewari R, Basu A, Seth P, et al. Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: Implications in neuroprotection. Brain Res Bull 2007;73:55-63
37. Wu BY, Yu AC. Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes. J Neurosci Res 2000;62:730-736