Quercetin inhibits c-fos, heat shock protein, and glial fibrillary acidic protein expression in injured astrocytes

Journal of Neuroscience Research

Volumn 62, Issue 5, 2000, Pages 730-736

  Wu, Bing Yi ^a,b   Yu, Albert Cheung Hoi ^a,c  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Astrocytes; Culture; GFAP; Injury; Quercetin

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN; QUERCETIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL DAMAGE; CELL GROWTH; GROWTH INHIBITION; MACROMOLECULE; MOUSE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; SCRATCHING; STIMULUS RESPONSE; STRESS;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOTTING, WESTERN; BRAIN; BRAIN INJURIES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; HEAT-SHOCK PROTEINS; HEAT-SHOCK RESPONSE; MICE; MICE, INBRED ICR; PROTO-ONCOGENE PROTEINS C-FOS; QUERCETIN;

EID: 0033665893     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20001201)62:5<730::AID-JNR13>3.0.CO;2-K     Document Type: Article

References (41)

1. Relationship between flavonoid structure and inhibition of phosphatidylinositol 3-kinase: A comparison with tyrosine kinase and protein kinase C inhibition
2. Synthesis and turnover of cytoskekletal proteins in cultured astrocytes
3. Dimethyl sulfoxide, but not acidosis induced mettallothionein mRNA expression in neonatal rat primary astrocyte cultures is inhibited by the bioflavonoid, quercetin
4. The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimdines) and growth in human cells
5. GFAP and astrogliosis
6. A RT-PCR study of gene expression in a mechanical injury model
7. The glial scar and central nervous system repair
8. Astrocytes and Parkinson's disease
9. Astrogliosis in culture: III. Effect of recombinant retrovirus expressing antisense glial fibrillary acidic protein RNA
10. Pharmacokinetics and bioavailability of the flavonol quercetin in humans
11. Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells
12. Activation of c-fos in the brain
13. Astrogliosis in culture. IV. Effects of basic fibroblast growth factors
14. Inhibition of estrone sulfatase in human liver microsomes by quercetin and other flavonoids
15. Querceun inhibited DNA synthesis and induced apoptosis associated with increase in c-fos mRNA level and the upregulation of p21 WAF1CIP1 mRNA and protein expression during liver regeneration after partial hepatectomy
16. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line
17. Effect of quercetin and sunphenon on response of cancer cells to heat shock damage
18. Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: Role of heat-shock protein-70
19. Astrocytes produced and released interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma under traumatic and metabolic injuries
20. Neuritic outgrowth associated with astroglial phenotypic changes induced by antisense glial fibrillary acidic protein (GFAP) mRNA in injured neuron-astrocyte cocultures
21. The stress protein response and its potential relationship to prolonged seizure activity
22. Specific regulation of HSPs in human tumor cell lines by flavonoids
23. Quercetin suppresses heat shock response by down regulation of HSF1
24. Inhibition of ischemic tolerance in the gerbil hippocampus by quercetin and anti-heat shock protein antibody
25. Modulation of mammalian sperm motility by quercetin
26. Quantification of reactive gliosis as an approach to neurotoxicity assessment
27. Heat-shock protein protection
28. Antitumor agents, 154. Cytotoxic and antimitotic flaonols from polanisia dodecandra
29. In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds
30. Heat shock protects cultured rat astrocytes in a model of reperfusion injury
31. Electrophoretic transfer of protein from polyacrylamide gel to nitrocellulose sheets: Procedure and some application
32. Glail reaction in aging and Alzheimer's disease
33. Inhibition of lactate export by quercetin acidifies rat glial cells in vitro
34. Cell culture models for reactive gliosis: New perspectives
35. Quercetin induced apoptosis in human leukemia HL-60 cells
36. HSP70 protects murine astrocytes from glucose deprivation injury
37. Expression of interleukin-1 alpha, tumor necrosis factor alpha and interleukin-6 genes in astrocytes under ischemic injury
38. Hypoxia-induced dysfunctions and injury of astrocytes in primary cell cultures
39. Inhibition of GFAP synthesis by antisense RNA in astrocytes
40. Astrogliosis in culture: I. The model and the effect of antisense oligonucleotides on glial fibfillary acidic protein synthesis
41. Gene expression in neural cells during and after ischemia