Modulation of AT-1R/CHOP-JNK-Caspase12 pathway by olmesartan treatment attenuates ER stress-induced renal apoptosis in streptozotocin-induced diabetic mice

European Journal of Pharmaceutical Sciences

Volumn 44, Issue 5, 2011, Pages 627-634

  Lakshmanan, Arun Prasath ^a   Thandavarayan, Rajarajan A ^a   Palaniyandi, Suresh S ^b   Sari, Flori R ^a   Meilei, Harima ^a   Giridharan, Vijayasree V ^a   Soetikno, Vivian ^a   Suzuki, Kenji ^c   Kodama, Makoto ^c   Watanabe, Kenichi ^a  

^a NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCES   (Japan)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Apoptosis; Diabetic nephropathy; Endoplasmic reticulum stress; Olmesartan

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN II; CASPASE 12; GLUCOSE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INOSITOL REQUIRING ELEMENT 1ALPHA; MALONALDEHYDE; MEMBRANE PROTEIN; OLMESARTAN; PROCASPASE 12; PROTEIN PRECURSOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KIDNEY MASS; LIPID PEROXIDATION; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; CASPASE 12; DIABETES MELLITUS, EXPERIMENTAL; ENDOPLASMIC RETICULUM; HEAT-SHOCK PROTEINS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KIDNEY; LIPID PEROXIDATION; MALONDIALDEHYDE; MEMBRANE PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, ANGIOTENSIN, TYPE 1; SUPEROXIDES; TETRAZOLES; TNF RECEPTOR-ASSOCIATED FACTOR 2; TRANSCRIPTION FACTOR CHOP;

EID: 82155162347     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.10.009     Document Type: Article

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