Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

Neurobiology of Disease

Volumn 34, Issue 2, 2009, Pages 189-198

  Lee, Hyung ^a   Park, Jong Wook ^a   Kim, Sang Pyo ^a   Lo, Eng H ^b   Lee, Seong Ryong ^a  

^a Keimyung University   (South Korea)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Doxycycline; Global ischemia; Matrix metalloproteinase; Neuroprotection

Indexed keywords

DOXYCYCLINE; GELATIN; GELATINASE; GELATINASE B; LAMININ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; C57BL 6 MOUSE; CELL LOSS; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; GEL; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL; NERVE CELL LESION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TREATMENT OUTCOME; UPREGULATION; ZYMOGRAPHY;

ANIMALS; ANTI-BACTERIAL AGENTS; BRAIN ISCHEMIA; CELL DEATH; CEREBRAL INFARCTION; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DOXYCYCLINE; DRUG ADMINISTRATION SCHEDULE; IN SITU NICK-END LABELING; LAMININ; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; TREATMENT OUTCOME;

EID: 64649102029     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.12.012     Document Type: Article

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