메뉴 건너뛰기




Volumn 5, Issue 24, 2013, Pages 3033-3050

The bioanalytical challenge of determining unbound concentration and protein binding for drugs

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; BIPERIDEN; BUPIVACAINE; DEXAMETHASONE; DRUG; HUMAN ALBUMIN; IBUPROFEN; LIDOCAINE; MEPIVACAINE; NAPROXEN; OROSOMUCOID; PHENYTOIN; PRILOCAINE; QUININE DERIVATIVE; ROBALZOTAN; ROPIVACAINE; SODIUM FLUORIDE; VERAPAMIL; WARFARIN;

EID: 84890335615     PISSN: 17576180     EISSN: 17576199     Source Type: Journal    
DOI: 10.4155/bio.13.274     Document Type: Review
Times cited : (54)

References (84)
  • 1
    • 70349255612 scopus 로고    scopus 로고
    • Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of b blockers using a new mechanism-based PK-PD modelling approach
    • van Steeg TJ, Boralli VB, Krekels EHJ et al. Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of b blockers using a new mechanism-based PK-PD modelling approach. J. Pharm. Sci. 98(10) 3816-3828 (2009
    • (2009) J. Pharm. Sci , vol.98 , Issue.10 , pp. 3816-3828
    • Van Steeg, T.J.1    Boralli, V.B.2    Krekels, E.H.J.3
  • 2
    • 58149180223 scopus 로고    scopus 로고
    • Some features of the kinetics and equilibrium of drug binding to plasma proteins
    • Berezhkovskiy LM. Some features of the kinetics and equilibrium of drug binding to plasma proteins. Expert Opin. Drug Metab. Toxicol. 4(12), 1479-1498 (2008
    • (2008) Expert Opin. Drug Metab. Toxicol , vol.4 , Issue.12 , pp. 1479-1498
    • Berezhkovskiy, L.M.1
  • 5
    • 0031472928 scopus 로고    scopus 로고
    • Species differences of serum albumins: I drug binding sites
    • Kosa T, Maruyama T, Otagiri M. Species differences of serum albumins: I. Drug binding sites. Pharm. Res. 14(11), 1607-1612 (1997
    • (1997) Pharm. Res , vol.14 , Issue.11 , pp. 1607-1612
    • Kosa, T.1    Maruyama, T.2    Otagiri, M.3
  • 6
    • 0034894719 scopus 로고    scopus 로고
    • Human alpha-1-glycoprotein and its interactions with drugs
    • Israili ZH, Dayton PG. Human alpha-1-glycoprotein and its interactions with drugs. Drug Metab. Rev. 33(2), 161-235 (2001
    • (2001) Drug Metab. Rev , vol.33 , Issue.2 , pp. 161-235
    • Israili, Z.H.1    Dayton, P.G.2
  • 7
    • 0036155217 scopus 로고    scopus 로고
    • Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine
    • Li J-H, Xu J-Q, Cao X-M et al. Influence of the ORM1 phenotypes on serum unbound concentration and protein binding of quinidine. Clin. Chim. Acta 317(1-2), 85-92 (2002
    • (2002) Clin. Chim. Acta , vol.317 , Issue.1-2 , pp. 85-92
    • Li, J.-H.1    Xu, J.-Q.2    Cao, X.-M.3
  • 8
    • 0027234379 scopus 로고
    • Evidence for differences in binding of drugs to the two main genetic variants of a1-acid glycoprotein
    • Herve F, Gomas E, Duche JC, Tillement JP. Evidence for differences in binding of drugs to the two main genetic variants of a1-acid glycoprotein. Br. J. Clin. Pharm. 36(3), 241-249 (1993
    • (1993) Br. J. Clin. Pharm , vol.36 , Issue.3 , pp. 241-249
    • Herve, F.1    Gomas, E.2    Duche, J.C.3    Tillement, J.P.4
  • 10
    • 13844250391 scopus 로고    scopus 로고
    • Enantioselective Pharmacokinetics of ibuprofen and involved mechanisms
    • Hao H, Wang G, Sun J. Enantioselective Pharmacokinetics of ibuprofen and involved mechanisms. Drug Metab. Rev. 37(1), 215-234 (2005
    • (2005) Drug Metab. Rev , vol.37 , Issue.1 , pp. 215-234
    • Hao, H.1    Wang, G.2    Sun, J.3
  • 11
    • 0035717211 scopus 로고    scopus 로고
    • Chiral separation by chromatographic and electromigration techniques: A review
    • Gübitz G, Schmid MG. Chiral separation by chromatographic and electromigration techniques: A review. Biopharm. Drug Dispos. 22(7-8), 291-336 (2001
    • (2001) Biopharm. Drug Dispos , vol.22 , Issue.7-8 , pp. 291-336
    • Gübitz, G.1    Schmid, M.G.2
  • 12
    • 33845514543 scopus 로고    scopus 로고
    • Usefulness of monitoring free (unbound) concentrations of therapeutic drugs in patient management
    • Dasgupta A. Usefulness of monitoring free (unbound) concentrations of therapeutic drugs in patient management. Clin. Chim. Acta 377(1-2), 1-13 (2007
    • (2007) Clin. Chim. Acta , vol.377 , Issue.1-2 , pp. 1-13
    • Dasgupta, A.1
  • 13
    • 0345698742 scopus 로고    scopus 로고
    • The significance of lipoproteins in serum binding variations of propofol
    • Zamacona MK, Suarez E, Garcia E, Aguirre C, Calvo R. The significance of lipoproteins in serum binding variations of propofol. Anesth. Analg. 87(5), 1147-1151 (1998
    • (1998) Anesth. Analg , vol.87 , Issue.5 , pp. 1147-1151
    • Zamacona, M.K.1    Suarez, E.2    Garcia, E.3    Aguirre, C.4    Calvo, R.5
  • 14
    • 0031901271 scopus 로고    scopus 로고
    • Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs
    • Wasan KM, Cassidy SM. Role of plasma lipoproteins in modifying the biological activity of hydrophobic drugs. J. Pharm. Sci. 87(4), 411-424 (1998
    • (1998) J. Pharm. Sci , vol.87 , Issue.4 , pp. 411-424
    • Wasan, K.M.1    Cassidy, S.M.2
  • 15
    • 33745944468 scopus 로고    scopus 로고
    • Characterization of drug-binding levels to serum albumin using a wavelength modulation surface plasmon resonance sensor
    • Liu X, Song D, Zhang Q, Tian Y, Liu Z, Zhang H. Characterization of drug-binding levels to serum albumin using a wavelength modulation surface plasmon resonance sensor. Sens. Actuators B Chem. 117(1), 188-195 (2006
    • (2006) Sens. Actuators B Chem , vol.117 , Issue.1 , pp. 188-195
    • Liu, X.1    Song, D.2    Zhang, Q.3    Tian, Y.4    Liu, Z.5    Zhang, H.6
  • 16
    • 79953665313 scopus 로고    scopus 로고
    • Characterization of drug interactions with serum proteins by using high performance affinity chromatography
    • Hage DS, Anguizola J, Barnaby O et al. Characterization of drug interactions with serum proteins by using high performance affinity chromatography. Curr. Drug Metab. 12(4), 313-328 (2011
    • (2011) Curr. Drug Metab , vol.12 , Issue.4 , pp. 313-328
    • Hage, D.S.1    Anguizola, J.2    Barnaby, O.3
  • 17
    • 84871773262 scopus 로고    scopus 로고
    • High performance affinity chromatography (HPAC) as a high-throughput screening tool in drug discovery to study drug-plasma protein interactions
    • Vuignier K, Guillarme D, Veuthey JL, Carrupt PA, Schappler J. High performance affinity chromatography (HPAC) as a high-throughput screening tool in drug discovery to study drug-plasma protein interactions. J. Pharm. Biomed. Anal. 74, 205-212 (2013
    • (2013) J. Pharm. Biomed. Anal , vol.74 , pp. 205-212
    • Vuignier, K.1    Guillarme, D.2    Veuthey, J.L.3    Carrupt, P.A.4    Schappler, J.5
  • 18
    • 33645971661 scopus 로고    scopus 로고
    • The role of unbound drug in pharmacokinetics/pharmacodynamics and in therapy
    • Calvo R, Lukas JC, Rodriguez M, Leal N, Suarez E. The role of unbound drug in pharmacokinetics/pharmacodynamics and in therapy. Curr. Pharm. Des. 12(8), 977-987 (2006
    • (2006) Curr. Pharm. Des , vol.12 , Issue.8 , pp. 977-987
    • Calvo, R.1    Lukas, J.C.2    Rodriguez, M.3    Leal, N.4    Suarez, E.5
  • 19
    • 78649706279 scopus 로고    scopus 로고
    • The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery
    • Smith DA, Di L, Kerns EH. The effect of plasma protein binding on in vivo efficacy: Misconceptions in drug discovery. Nature Rev. Drug Discov. 9(12), 929-939 (2010
    • (2010) Nature Rev. Drug Discov , vol.9 , Issue.12 , pp. 929-939
    • Smith, D.A.1    Di L Kerns, E.H.2
  • 20
    • 0036908023 scopus 로고    scopus 로고
    • Free drug fraction vs free drug concentration: A matter of frequent confusion
    • Toutain PL, Bousquet-Melou A. Free drug fraction vs free drug concentration: A matter of frequent confusion. J. Vet. Pharmacol. Ther. 25(6), 460-463 (2002
    • (2002) J. Vet. Pharmacol. Ther , vol.25 , Issue.6 , pp. 460-463
    • Toutain, P.L.1    Bousquet-Melou, A.2
  • 22
    • 0036218554 scopus 로고    scopus 로고
    • Changes in plasma protein binding has little clinical relevance
    • Benet LZ, Hoener BA. Changes in plasma protein binding has little clinical relevance. Clin. Pharmacol. Ther. 71(3), 115-121 (2002
    • (2002) Clin. Pharmacol. Ther , vol.71 , Issue.3 , pp. 115-121
    • Benet, L.Z.1    Hoener, B.A.2
  • 23
    • 84873050688 scopus 로고    scopus 로고
    • The clinical relevance of plasma protein binding changes
    • Roberts JA, Pea F, Lipman J. The clinical relevance of plasma protein binding changes. Clin. Pharmacokinet. 52(1), 1-8 (2013
    • (2013) Clin. Pharmacokinet , vol.52 , Issue.1 , pp. 1-8
    • Roberts, J.A.1    Pea, F.2    Lipman, J.3
  • 24
    • 76649085489 scopus 로고    scopus 로고
    • Significance of protein binding in pharmacokinetics and pharmacodynamics
    • Schmidt S, Gonzalez D, Derendorf H. Significance of protein binding in pharmacokinetics and pharmacodynamics. J. Pharm. Sci. 99(3), 1107-1122 (2010
    • (2010) J. Pharm. Sci , vol.99 , Issue.3 , pp. 1107-1122
    • Schmidt, S.1    Gonzalez, D.2    Derendorf, H.3
  • 25
    • 79551662332 scopus 로고    scopus 로고
    • Do we need to optimize plasma protein binding and tissue binding in drug discovery?
    • Liu X, Chen C, Hop CE. Do we need to optimize plasma protein binding and tissue binding in drug discovery? Curr. Top. Med. Chem. 11(4), 450-466 (2011
    • (2011) Curr. Top. Med. Chem , vol.11 , Issue.4 , pp. 450-466
    • Liu, X.1    Chen, C.2    Hop, C.E.3
  • 26
    • 0029922030 scopus 로고    scopus 로고
    • Drug protein binding studies New trends in analytical and experimental methodology
    • Oravcová J, Böhs B, Lindner W. Drug protein binding studies. New trends in analytical and experimental methodology. J. Chromatogr. B 677(1), 1-28 (1996
    • (1996) J. Chromatogr , vol.B 677 , Issue.1 , pp. 1-28
    • Oravcová, J.1    Böhs, B.2    Lindner, W.3
  • 27
    • 7444236750 scopus 로고    scopus 로고
    • Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME
    • Heringa MB, Hermens JLM. Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME). Trends Anal. Chem. 22(10), 575-587 (2003
    • (2003) Trends Anal. Chem , vol.22 , Issue.10 , pp. 575-587
    • Heringa, M.B.1    Hermens, J.L.M.2
  • 28
    • 0032897673 scopus 로고    scopus 로고
    • High-performance frontal analysis for drug-protein binding study
    • Shibukawa A, Kuroda Y, Nagakawa T. High-performance frontal analysis for drug-protein binding study. J. Pharm. Biomed. Anal. 18(6), 1047-1055 (1999
    • (1999) J. Pharm. Biomed. Anal , vol.18 , Issue.6 , pp. 1047-1055
    • Shibukawa, A.1    Kuroda, Y.2    Nagakawa, T.3
  • 30
    • 80051694070 scopus 로고    scopus 로고
    • Monitoring free drug concentrations: Challenges
    • Musteata FM. Monitoring free drug concentrations: Challenges. Bioanalysis 3(15), 1753-1768 (2011
    • (2011) Bioanalysis , vol.3 , Issue.15 , pp. 1753-1768
    • Musteata, F.M.1
  • 31
    • 84862828843 scopus 로고    scopus 로고
    • Compilation of 222 drugs plasma protein binding data and guidance for study design
    • Zhang F, Xue J, Shao J, Jia L. Compilation of 222 drugs plasma protein binding data and guidance for study design. Drug Discov. Today 17(9-10), 475-485 (2012
    • (2012) Drug Discov. Today , vol.17 , Issue.9-10 , pp. 475-485
    • Zhang, F.1    Xue, J.2    Shao, J.3    Jia, L.4
  • 32
    • 84879193775 scopus 로고    scopus 로고
    • QSAR models for the prediction of plasma protein binding
    • Ghafourian T, Amin Z. QSAR models for the prediction of plasma protein binding. Bioimpacts 3(1), 21-27 (2013
    • (2013) Bioimpacts , vol.3 , Issue.1 , pp. 21-27
    • Ghafourian, T.1    Amin, Z.2
  • 33
    • 60749101939 scopus 로고    scopus 로고
    • Plasma/serum protein binding determinations
    • Banker MJ, Clark TH. Plasma/serum protein binding determinations. Curr. Drug Metab. 9(9), 854-859 (2008
    • (2008) Curr. Drug Metab , vol.9 , Issue.9 , pp. 854-859
    • Banker, M.J.1    Clark, T.H.2
  • 34
    • 33749434494 scopus 로고    scopus 로고
    • Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization
    • Zhang J, Musson DG. Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization. J. Chromatogr. B 843(1), 47-56 (2006
    • (2006) J. Chromatogr , vol.B 843 , Issue.1 , pp. 47-56
    • Zhang, J.1    Musson, D.G.2
  • 36
    • 0019944388 scopus 로고
    • Free drug concentrations are constant in serial fractions of plasma ultrafiltrate
    • Judd RL, Pesce AJ. Free drug concentrations are constant in serial fractions of plasma ultrafiltrate. Clin. Chem. 28(7), 1726-1727 (1982
    • (1982) Clin. Chem , vol.28 , Issue.7 , pp. 1726-1727
    • Judd, R.L.1    Pesce, A.J.2
  • 37
    • 26444541994 scopus 로고    scopus 로고
    • Effect of ultrafiltrate volume on determination of free phenytoin concentrations
    • McMillin GA, Juenke J, Dasgupta A. Effect of ultrafiltrate volume on determination of free phenytoin concentrations. Ther. Drug Monit. 27(5), 630-633 (2005
    • (2005) Ther. Drug Monit , vol.27 , Issue.5 , pp. 630-633
    • McMillin, G.A.1    Juenke, J.2    Dasgupta, A.3
  • 38
    • 84871419978 scopus 로고    scopus 로고
    • Effect of volume ratio of ultrafiltrate to sample solution on the analysis of free drug and measurement of free carbamazepine in clinical drug monitoring
    • Dong W, Zhang Z, Liang X, Sun Y, Jiang Y. Effect of volume ratio of ultrafiltrate to sample solution on the analysis of free drug and measurement of free carbamazepine in clinical drug monitoring. Eur. J. Pharm. Sci. 48(1-2), 332-338 (2013
    • (2013) Eur. J. Pharm. Sci , vol.48 , Issue.1-2 , pp. 332-338
    • Dong, W.1    Zhang, Z.2    Liang, X.3    Sun, Y.4    Jiang, Y.5
  • 39
    • 84871735543 scopus 로고    scopus 로고
    • A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds
    • Wang C, Williams NS. A mass balance approach for calculation of recovery and binding enables the use of ultrafiltration as a rapid method for measurement of plasma protein binding for even highly lipophilic compounds. J. Pharm. Biomed. Anal. 75, 112-117 (2013
    • (2013) J. Pharm. Biomed. Anal , vol.75 , pp. 112-117
    • Wang, C.1    Williams, N.S.2
  • 40
    • 0038198608 scopus 로고    scopus 로고
    • Modulation of non-specific binding in ultrafiltration protein binding studies
    • Lee K-J, Mower R, Hollenbeck T et al. Modulation of non-specific binding in ultrafiltration protein binding studies. Pharm. Res. 20(7), 1015-1021 (2003
    • (2003) Pharm. Res , vol.20 , Issue.7 , pp. 1015-1021
    • Lee, K.-J.1    Mower, R.2    Hollenbeck, T.3
  • 41
    • 33645045860 scopus 로고    scopus 로고
    • Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticostereoids
    • Taylor S, Harker A. Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticostereoids. J. Pharm. Biomed. Anal. 41(1), 299-303 (2006
    • (2006) J. Pharm. Biomed. Anal , vol.41 , Issue.1 , pp. 299-303
    • Taylor, S.1    Harker, A.2
  • 42
    • 81855173594 scopus 로고    scopus 로고
    • Correction for nonspecific binding to various components of ultrafiltration apparatus and impact on estimating in vivo rat clearance for a congeneric series of 5-ethyl, 5-n-alkyl barbituric acids
    • Ballard P, Rowland M. Correction for nonspecific binding to various components of ultrafiltration apparatus and impact on estimating in vivo rat clearance for a congeneric series of 5-ethyl, 5-n-alkyl barbituric acids. Drug Metab. Dispos. 39(12), 2165-2168 (2011
    • (2011) Drug Metab. Dispos , vol.39 , Issue.12 , pp. 2165-2168
    • Ballard, P.1    Rowland, M.2
  • 43
    • 79954501848 scopus 로고    scopus 로고
    • Validation of 96-well equilibrium dialysis with non-radiolabeled drug for definitive measurement of protein binding and application to clinical development of highly-bound drugs
    • Zamek-Gliszczynski MJ, Ruterbories KJ, Ajamie RT et al. Validation of 96-well equilibrium dialysis with non-radiolabeled drug for definitive measurement of protein binding and application to clinical development of highly-bound drugs. J. Pharm. Sci. 100(6), 2498-2507 (2011
    • (2011) J. Pharm. Sci , vol.100 , Issue.6 , pp. 2498-2507
    • Zamek-Gliszczynski, M.J.1    Ruterbories, K.J.2    Ajamie, R.T.3
  • 44
    • 0035091313 scopus 로고    scopus 로고
    • Simultaneous determination of total and free drug plasma concentrations combined with batch-wise pH-adjustment for the free concentration determinations
    • Nilsson LB, Schmidt S. Simultaneous determination of total and free drug plasma concentrations combined with batch-wise pH-adjustment for the free concentration determinations. J. Pharm. Biomed. Anal. 24(5-6), 921-927 (2001
    • (2001) J. Pharm. Biomed. Anal , vol.24 , Issue.5-6 , pp. 921-927
    • Nilsson, L.B.1    Schmidt, S.2
  • 45
    • 0142217486 scopus 로고    scopus 로고
    • Shift of pH of biological fluids during storage and processing: Effect on bioanalysis
    • Fura A, Harper TW, Zhang H, Fung L, Shyu WC. Shift of pH of biological fluids during storage and processing: Effect on bioanalysis. J. Pharm. Biomed. Anal. 32(3), 513-522 (2003
    • (2003) J. Pharm. Biomed. Anal , vol.32 , Issue.3 , pp. 513-522
    • Fura, A.1    Harper, T.W.2    Zhang, H.3    Fung, L.4    Shyu, W.C.5
  • 46
    • 13244250954 scopus 로고    scopus 로고
    • The pH dependency of the binding of drugs to plasma proteins in man
    • Hinderling PH, Hartmann D. The pH dependency of the binding of drugs to plasma proteins in man. Ther. Drug Monit. 27(1), 71-85 (2005
    • (2005) Ther. Drug Monit , vol.27 , Issue.1 , pp. 71-85
    • Hinderling, P.H.1    Hartmann, D.2
  • 47
    • 46449118907 scopus 로고    scopus 로고
    • Impact of pH on plasma protein binding in equilibrium dialysis
    • Kochansky CJ, McMasters DR, Lu P et al. Impact of pH on plasma protein binding in equilibrium dialysis. Mol. Pharm. 5(3), 438-448 (2008
    • (2008) Mol. Pharm , vol.5 , Issue.3 , pp. 438-448
    • Kochansky, C.J.1    McMasters, D.R.2    Lu, P.3
  • 48
    • 0018803472 scopus 로고
    • Conformational changes in human serum albumin around the neutral pH from circular dichroic measurements
    • Wilting J, Weideman MM, Roomer ACJ, Perrin JH. Conformational changes in human serum albumin around the neutral pH from circular dichroic measurements. Biochim. Biophys. Acta 579(2), 469-473 (1979
    • (1979) Biochim. Biophys. Acta , vol.579 , Issue.2 , pp. 469-473
    • Wilting, J.1    Weideman, M.M.2    Roomer, A.C.J.3    Perrin, J.H.4
  • 49
    • 0033045696 scopus 로고    scopus 로고
    • Interactive binding to the two principal ligand binding sites of human serum albumin: Effect of the neutral-to-base transition
    • Yamasaki K, Maruyama T, Yoshimoto K et al. Interactive binding to the two principal ligand binding sites of human serum albumin: Effect of the neutral-to-base transition. Biochim. Biophys. Acta 1432(2), 313-323 (1999
    • (1999) Biochim. Biophys. Acta , vol.1432 , Issue.2 , pp. 313-323
    • Yamasaki, K.1    Maruyama, T.2    Yoshimoto, K.3
  • 50
    • 0024593566 scopus 로고
    • Drug binding to a1-acid glycoprotein studied by circular dichroism
    • Otagiri M, Yamanichi R, Maruyama T et al. Drug binding to a1-acid glycoprotein studied by circular dichroism. Pharm. Res. 6(2), 156-159 (1989
    • (1989) Pharm. Res , vol.6 , Issue.2 , pp. 156-159
    • Otagiri, M.1    Yamanichi, R.2    Maruyama, T.3
  • 51
    • 0025942640 scopus 로고
    • PH-dependency of basic ligand binding to a1-acid glycoprotein (orosomucoid
    • Urien S, Bree F, Testa B, Tillement J-P. pH-dependency of basic ligand binding to a1-acid glycoprotein (orosomucoid). Biochem. J. 280(Pt 1), 277-280 (1991
    • (1991) Biochem. J , vol.280 , Issue.PART 1 , pp. 277-280
    • Urien, S.1    Bree, F.2    Testa, B.3    Tillement, J.-P.4
  • 52
    • 0034308903 scopus 로고    scopus 로고
    • Evaluation of solid-phase microextraction for the study of protein binding in human plasma samples
    • Abdel-Rehim M, Carlsson C, Bielenstein M, Arvidsson T, Blomberg LG. Evaluation of solid-phase microextraction for the study of protein binding in human plasma samples. J. Chromatogr. Sci. 38(10), 458-464 (2000
    • (2000) J. Chromatogr. Sci , vol.38 , Issue.10 , pp. 458-464
    • Abdel-Rehim, M.1    Carlsson, C.2    Bielenstein, M.3    Arvidsson, T.4    Blomberg, L.G.5
  • 53
    • 0034953125 scopus 로고    scopus 로고
    • Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy
    • Kodama H, Kodama Y, Itokazu N, Shinozawa S, Kanemaru R, Sugimoto T. Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy. J. Clin. Pharm. Ther. 26(3), 175-179 (2001
    • (2001) J. Clin. Pharm. Ther , vol.26 , Issue.3 , pp. 175-179
    • Kodama, H.1    Kodama, Y.2    Itokazu, N.3    Shinozawa, S.4    Kanemaru, R.5    Sugimoto, T.6
  • 54
    • 0034511743 scopus 로고    scopus 로고
    • Factors influencing the protein binding of IQO4, a new isoquinolinedione derivative
    • Moon YJ, Kim SH, Ryu CK, Lee MG. Factors influencing the protein binding of IQO4, a new isoquinolinedione derivative. Res. Commun. Mol. Pathol. Pharmacol. 108(2-3), 167-177 (2000
    • (2000) Res. Commun. Mol. Pathol. Pharmacol , vol.108 , Issue.2-3 , pp. 167-177
    • Moon, Y.J.1    Kim, S.H.2    Ryu, C.K.3    Lee, M.G.4
  • 55
    • 29044432751 scopus 로고    scopus 로고
    • High-throughput screening of protein binding by equilibrium dialysis combined with liquid chromatography and mass spectrometry
    • Wan H, Rehngren M. High-throughput screening of protein binding by equilibrium dialysis combined with liquid chromatography and mass spectrometry. J. Chromatogr. A 1102(1-2), 125-134 (2006
    • (2006) J. Chromatogr , vol.A 1102 , Issue.1-2 , pp. 125-134
    • Wan, H.1    Rehngren, M.2
  • 56
    • 65449136735 scopus 로고    scopus 로고
    • Characterization of drug-protein interactions in blood using high-performance affinity chromatography
    • Hage DS, Jackson A, Sobansky MR, Schiel JE, Yoo MJ, Joseph KS. Characterization of drug-protein interactions in blood using high-performance affinity chromatography. J. Sep. Sci. 32(5-6), 835-853 (2009
    • (2009) J. Sep. Sci , vol.32 , Issue.5-6 , pp. 835-853
    • Hage, D.S.1    Jackson, A.2    Sobansky, M.R.3    Schiel, J.E.4    Yoo, M.J.5    Joseph, K.S.6
  • 59
    • 33847678183 scopus 로고    scopus 로고
    • On the calculation of the concentration dependence of drug binding to plasma proteins with multiple binding sites of different affinities: Determination of the possible variation of the unbound drug fraction and calculation of the number of binding sites of the protein
    • Berezhkovskiy LM. On the calculation of the concentration dependence of drug binding to plasma proteins with multiple binding sites of different affinities: Determination of the possible variation of the unbound drug fraction and calculation of the number of binding sites of the protein. J. Pharm. Sci. 96(2), 249-257 (2007
    • (2007) J. Pharm. Sci , vol.96 , Issue.2 , pp. 249-257
    • Berezhkovskiy, L.M.1
  • 60
    • 59849123581 scopus 로고    scopus 로고
    • Consideration of the linear concentration increase of the unbound drug fraction in plasma
    • Berezhkovskiy LM. Consideration of the linear concentration increase of the unbound drug fraction in plasma. J. Pharm. Sci. 98(2), 383-393 (2009
    • (2009) J. Pharm. Sci , vol.98 , Issue.2 , pp. 383-393
    • Berezhkovskiy, L.M.1
  • 61
    • 0029889951 scopus 로고    scopus 로고
    • Measurement and analysis of unbound drug concentrations
    • Wright JD, Boudinot FD, Ujhelyi MR. Measurement and analysis of unbound drug concentrations. Clin. Pharmacokinet. 30(6), 445-462 (1996
    • (1996) Clin. Pharmacokinet , vol.30 , Issue.6 , pp. 445-462
    • Wright, J.D.1    Boudinot, F.D.2    Ujhelyi, M.R.3
  • 63
    • 0344267753 scopus 로고    scopus 로고
    • Serum protein binding of tolteridine and its major mertabolites in humans and several animal species
    • Påhlman I, Gozzi P. Serum protein binding of tolteridine and its major mertabolites in humans and several animal species. Biopharm. Drug Dispos. 20(2), 91-99 (1999
    • (1999) Biopharm. Drug Dispos , vol.20 , Issue.2 , pp. 91-99
    • Påhlman, I.1    Gozzi, P.2
  • 64
    • 26444483440 scopus 로고    scopus 로고
    • Stabilizing drug molecules in biological samples
    • Chen J, Hsieh Y. Stabilizing drug molecules in biological samples. Ther. Drug Monit. 27(5), 617-624 (2005
    • (2005) Ther. Drug Monit , vol.27 , Issue.5 , pp. 617-624
    • Chen, J.1    Hsieh, Y.2
  • 65
    • 77952258130 scopus 로고    scopus 로고
    • Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor
    • Eng H, McDonald TS, Wolford A et al. Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor. Xenobiotica 40(6), 369-380 (2010
    • (2010) Xenobiotica , vol.40 , Issue.6 , pp. 369-380
    • Eng, H.1    McDonald, T.S.2    Wolford, A.3
  • 66
    • 78650643244 scopus 로고    scopus 로고
    • Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/M.S
    • Fung EN, Zheng N, Arnold ME, Zeng J. Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS. Bioanalysis 2(4), 733-743 (2010
    • (2010) Bioanalysis , vol.2 , Issue.4 , pp. 733-743
    • Fung, E.N.1    Zheng, N.2    Arnold, M.E.3    Zeng, J.4
  • 67
    • 70449526714 scopus 로고    scopus 로고
    • Improving ex vivo stability of drug ester compounds in rat and dog serum: Inhibition of the specific esterase and implications on their identity
    • Koitka M, Höchel J, Gieschen H, Borchert H-H. Improving ex vivo stability of drug ester compounds in rat and dog serum: Inhibition of the specific esterase and implications on their identity. J. Pharm. Biomed. Anal. 51, 664-678 (2010
    • (2010) J. Pharm. Biomed. Anal , vol.51 , pp. 664-678
    • Koitka, M.1    Höchel, J.2    Gieschen, H.3    Borchert, H.-H.4
  • 68
    • 79953176303 scopus 로고    scopus 로고
    • A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril
    • Wenlock MC, Barton P, Austin RP. A kinetic method for the determination of plasma protein binding of compounds unstable in plasma: Specific application to enalapril. J. Pharm. Biomed. Anal. 55(3), 385-390 (2011
    • (2011) J. Pharm. Biomed. Anal , vol.55 , Issue.3 , pp. 385-390
    • Wenlock, M.C.1    Barton, P.2    Austin, R.P.3
  • 69
    • 82455180410 scopus 로고    scopus 로고
    • Turbulent flow liquid chromatography tandem mass spectrometry for the analysis of bioavailable testosterone in serum
    • Wright M, Couchman L, Halsall D. Turbulent flow liquid chromatography tandem mass spectrometry for the analysis of bioavailable testosterone in serum. Endocrine Abstracts 25, P29 (2011
    • (2011) Endocrine Abstracts , vol.25 , pp. 29
    • Wright, M.1    Couchman, L.2    Halsall, D.3
  • 70
    • 33750699643 scopus 로고    scopus 로고
    • Analysis of free drug fractions using near infrared fluorescent labels and an ultrafast immunoextraction/displacement assay
    • Ohnmacht CN, Schiel JE, Hage DS. Analysis of free drug fractions using near infrared fluorescent labels and an ultrafast immunoextraction/displacement assay. Anal. Chem. 78(21), 7547-7556 (2006
    • (2006) Anal. Chem , vol.78 , Issue.21 , pp. 7547-7556
    • Ohnmacht, C.N.1    Schiel, J.E.2    Hage, D.S.3
  • 71
    • 83655190961 scopus 로고    scopus 로고
    • Development of a flow based ultrafast immunoextraction and reverse displacement immunoassay: Analysis of free drug fractions
    • Schiel JE, Tong Z, Sakulthaew C, Hage DS. Development of a flow based ultrafast immunoextraction and reverse displacement immunoassay: Analysis of free drug fractions. Anal. Chem. 83(24), 9384-9390 (2011
    • (2011) Anal. Chem , vol.83 , Issue.24 , pp. 9384-9390
    • Schiel, J.E.1    Tong, Z.2    Sakulthaew, C.3    Hage, D.S.4
  • 72
    • 0036007254 scopus 로고    scopus 로고
    • Stability of 11-nor-D9-carboxytetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry
    • Skopp G, Pötsch L. Stability of 11-nor-D9- carboxytetrahydrocannabinol glucuronide in plasma and urine assessed by liquid chromatography-tandem mass spectrometry. Clin. Chem. 48(2), 301-306 (2002
    • (2002) Clin. Chem , vol.48 , Issue.2 , pp. 301-306
    • Skopp, G.1    Pötsch, L.2
  • 73
    • 0027154750 scopus 로고
    • Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry
    • Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proc. Natl Acad. Sci. USA 90(9), 3979-3801 (1993
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , Issue.9 , pp. 3979-3801
    • Ding, A.1    Ojingwa, J.C.2    McDonagh, A.F.3    Burlingame, A.L.4    Benet, L.Z.5
  • 74
    • 79959861661 scopus 로고    scopus 로고
    • Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry
    • Deng Y, Wong H, Graham RA et al. Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry. J. Chromatogr. B 879(22), 2119-2126 (2011
    • (2011) J. Chromatogr , vol.B 879 , Issue.22 , pp. 2119-2126
    • Deng, Y.1    Wong, H.2    Graham, R.A.3
  • 75
    • 1842482952 scopus 로고    scopus 로고
    • High-throughput determination of the free fraction of drugs strongly bound to plasma proteins
    • Schumacher J, Kohlsdorfer C, Bühner K, Brandenburger T, Kruk R. High-throughput determination of the free fraction of drugs strongly bound to plasma proteins. J. Pharm. Sci. 93(4), 816-830 (2004
    • (2004) J. Pharm. Sci , vol.93 , Issue.4 , pp. 816-830
    • Schumacher, J.1    Kohlsdorfer, C.2    Bühner, K.3    Brandenburger, T.4    Kruk, R.5
  • 76
    • 0036708022 scopus 로고    scopus 로고
    • Evaluation of highly bound drugs; interspecies, intersubject and related comparisons
    • Collins JM, Klecker RW. Evaluation of highly bound drugs; interspecies, intersubject and related comparisons. J. Clin. Pharmacol. 42(9), 971-975 (2002
    • (2002) J. Clin. Pharmacol , vol.42 , Issue.9 , pp. 971-975
    • Collins, J.M.1    Klecker, R.W.2
  • 77
    • 19544368019 scopus 로고    scopus 로고
    • Studies of drug binding to plasma proteins using a variant of equilibrium dialysis
    • Eriksson MAL, Gabrielsson J, Nilsson LB. Studies of drug binding to plasma proteins using a variant of equilibrium dialysis. J. Pharm. Biomed. Anal. 38(3), 381-389 (2005
    • (2005) J. Pharm. Biomed. Anal , vol.38 , Issue.3 , pp. 381-389
    • Eriksson, M.A.L.1    Gabrielsson, J.2    Nilsson, L.B.3
  • 78
    • 0031404916 scopus 로고    scopus 로고
    • Heat treatment to inactivate HIV does not alter protein binding of selected drugs
    • Mosley AK, Brouwer KLR. Heat treatment to inactivate HIV does not alter protein binding of selected drugs. Ther. Drug Monit. 19(4), 477-479 (1997
    • (1997) Ther. Drug Monit , vol.19 , Issue.4 , pp. 477-479
    • Mosley, A.K.1    Brouwer, K.L.R.2
  • 79
    • 0023845364 scopus 로고
    • Comparative study of inactivation of herpes simplex virus types 1 and 2 by commonly used antiseptic agents
    • Croughan WS, Behbehani AM. Comparative study of inactivation of herpes simplex virus types 1 and 2 by commonly used antiseptic agents. J. Clin. Microbiol. 26(2), 213-215 (1988
    • (1988) J. Clin. Microbiol , vol.26 , Issue.2 , pp. 213-215
    • Croughan, W.S.1    Behbehani, A.M.2
  • 80
    • 3843135290 scopus 로고    scopus 로고
    • In vitro blood distribution and plasma protein binding of the tyrosine kinase inhibitor imatinib and its active metabolite, CGP74588, in rat mouse, dog, monkey, healthy humans and patients with acute lymphatic leukaemia
    • Kretz O, Weiss HM, Schumacher MM, Gross G. In vitro blood distribution and plasma protein binding of the tyrosine kinase inhibitor imatinib and its active metabolite, CGP74588, in rat mouse, dog, monkey, healthy humans and patients with acute lymphatic leukaemia. Br. J. Clin. Pharmacol. 58(2), 212-216 (2004
    • (2004) Br. J. Clin. Pharmacol , vol.58 , Issue.2 , pp. 212-216
    • Kretz, O.1    Weiss, H.M.2    Schumacher, M.M.3    Gross, G.4
  • 81
    • 0035724321 scopus 로고    scopus 로고
    • Validation of methods to study the distribution and protein binding of tacrolimus in human blood
    • Zahir H, Nand RA, Brown KF, Tattam BN, McLachlan AJ. Validation of methods to study the distribution and protein binding of tacrolimus in human blood. J. Pharmacol. Toxicol. Methods 46(1), 27-35 (2001
    • (2001) J. Pharmacol. Toxicol. Methods , vol.46 , Issue.1 , pp. 27-35
    • Zahir, H.1    Nand, R.A.2    Brown, K.F.3    Tattam, B.N.4    McLachlan, A.J.5
  • 82
    • 78649392445 scopus 로고    scopus 로고
    • Ion suppression and enhancement effects of co-eluting analytes in multi-analyte approaches: Systematic investigation using ultra-high-performance liquid chromatography-mass spectrometry with atmospheric-pressure chemical ionization or electrospray ionization
    • Remane D, Meyer MR, Wissenbach DK, Maurer HH. Ion suppression and enhancement effects of co-eluting analytes in multi-analyte approaches: Systematic investigation using ultra-high-performance liquid chromatography-mass spectrometry with atmospheric-pressure chemical ionization or electrospray ionization. Rapid Commun. Mass Spectrom. 24(21), 3103-3108 (2010
    • (2010) Rapid Commun. Mass Spectrom , vol.24 , Issue.21 , pp. 3103-3108
    • Remane, D.1    Meyer, M.R.2    Wissenbach, D.K.3    Maurer, H.H.4
  • 83
    • 33749434494 scopus 로고    scopus 로고
    • Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization
    • Zhang J, Musson DG. Investigation of high-throughput ultrafiltration for the determination of an unbound compound in human plasma using liquid chromatography and tandem mass spectrometry with electrospray ionization. J. Chromatogr. B 843(1), 47-56 (2006
    • (2006) J. Chromatogr , vol.B 843 , Issue.1 , pp. 47-56
    • Zhang, J.1    Musson, D.G.2
  • 84
    • 79960562681 scopus 로고    scopus 로고
    • Determination of unbound ticagrelor and its active metabolite (AR-C124910XX) in human plasma by equilibrium dialysis and LC-MS/M.S
    • Sillén H, Cook M, Davis P. Determination of unbound ticagrelor and its active metabolite (AR-C124910XX) in human plasma by equilibrium dialysis and LC-MS/MS. J. Chromatogr. B 879(23), 2315-2322 (2011
    • (2011) J. Chromatogr , vol.B 879 , Issue.23 , pp. 2315-2322
    • Sillén, H.1    Cook, M.2    Davis, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.