Consideration of the linear concentration increase of the unbound drug fraction in plasma

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 383-393

  Berezhkovskiy, Leonid M ^a  

^a GENENTECH INC   (United States)

Author keywords

Affinity; Concentration dependence of the unbound drug fraction; Multiple binding sites; Naproxen; Pharmacokinetics; Protein binding

Indexed keywords

NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ACCURACY; BINDING AFFINITY; DRUG BINDING SITE; DRUG BLOOD LEVEL; DRUG PROTEIN BINDING; MATHEMATICAL MODEL; NOTE; ARTICLE; BIOLOGICAL MODEL; BLOOD; DOSE RESPONSE; DRUG INTERACTION; HUMAN; PROTEIN BINDING; STATISTICAL MODEL;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; LINEAR MODELS; MODELS, BIOLOGICAL; NAPROXEN; PROTEIN BINDING;

EID: 59849123581     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21470     Document Type: Article

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