Effect of temperature on serum protein binding characteristics of phenytoin in monotherapy paediatric patients with epilepsy

Journal of Clinical Pharmacy and Therapeutics

Volumn 26, Issue 3, 2001, Pages 175-179

  Kodama, H ^a   Kodama, Y ^a   Itokazu, N ^b   Shinozawa, S ^a   Kanemaru, R ^c   Sugimoto, T ^b  

^a UNIVERSITY OF MIYAZAKI   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c Kanemaru Neurosurgery Hospital   (Japan)

Author keywords

Epilepsy; Monotherapy; Paediatrics; Phenytoin

Indexed keywords

PHENYTOIN;

ADOLESCENT; ARTICLE; BENIGN CHILDHOOD EPILEPSY; BINDING SITE; CHILD; CLINICAL ARTICLE; DRUG PROTEIN BINDING; FEMALE; HUMAN; MALE; PLASMA PROTEIN BINDING; TEMPERATURE; ULTRAFILTRATION;

ADOLESCENT; ANTICONVULSANTS; BLOOD PROTEINS; CHILD; CHILD, PRESCHOOL; EPILEPSY; FEMALE; HUMANS; INFANT; MALE; MODELS, BIOLOGICAL; PHENYTOIN; PROTEIN BINDING; TEMPERATURE; ULTRAFILTRATION;

EID: 0034953125     PISSN: 02694727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2710.2001.00340.x     Document Type: Article

References (23)

1. Treatment of epilepsy and febrile convulsions in children
2. Clinical pharmacokinetics of phenytoin
3. Anticonvulsants
4. Plasma protein binding of diphenylhydantoin in patients with epilepsy
5. The clinical value of free phenytoin levels
6. Audit of a monitoring service for free phenytoin
7. Protein binding and CSF penetration of phenytoin following acute oral dosing in man
8. Serum concentrations of free diphenylhydantoin and their relationship to clinical intoxication
9. Plasma protein binding of diphenylhydantoin in man: Interaction with other drugs and the effect of temperature and plasma dilution
10. Phenytoin binding to partially purified albumin in renal disease
11. Plasma protein binding interaction between phenytoin and valproic acid in vitro
12. Binding parameters of valproic acid to serum protein in healthy adults at steady state
13. Effect of unbound clearance on binding parameters of valproic acid to serum proteins
14. Comparative evaluation of microultrafiltration devices for determination of protein binding
15. pH lability in serum during equilibrium dialysis
16. Decreased plasma protein binding of valproate in patients with acute head trauma
17. In vivo determination of valproate binding constants during sole and multi-drug therapy
18. Problems in therapeutic drug monitoring: Free drug level monitoring
19. SI units in drug therapeutics
20. Temperature dependence of phenytoin-protein binding in serum: Effects of uremia and hypoalbuminemia
21. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography