Free drug fraction vs. free drug concentration: A matter of frequent confusion

Journal of Veterinary Pharmacology and Therapeutics

Volumn 25, Issue 6, 2002, Pages 460-463

  Toutain, P L ^a   Bousquet Melou, A ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PHENYLBUTAZONE; WARFARIN;

ARTICLE; DRUG BINDING; DRUG ELIMINATION; DRUG ISOLATION; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL;

PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PROTEIN BINDING; VETERINARY MEDICINE;

EID: 0036908023     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.2002.00442.x     Document Type: Article

References (7)

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2. Lewis, R.J., Trager, W.F., Chan, K.K., Breckenridge, A.K., Orme, M., Rowland, M. & Schary, W. (1974) Warfarin: Stereochemical aspects of its metabolism and the interaction with phenylbutazone. Journal of Clinical Investigation, 53, 1607-1617.
3. McEInay, J.C. (1996) Drug interactions at plasma and tissue binding sites. In Mechanisms of Drug Interactions. Ed. D'Arcy, P.F., McElnay, J.C & Welling, P.G. pp. 125-149. Springer, Berlin.
4. Rolan, P.E. (1994) Plasma protein binding displacement interactions - Why are they still regarded as clinically important? British Journal of Clinical Pharmacology, 37, 125-128.
5. Rowland, M. & Tozer, T.N. (1995) Clinical Pharmacokinetics: Concepts and Applications, 3rd Edn. Williams & Wilkins, Baltimore.
6. Toutain, P.L., Lefebvre, H.P. & Bousquet-Mélou, A. (2000a) Relevance of kinetic concepts to interpret a plasma concentration in clinical biochemistry. Revue de Médecine Vétérinaire, 151, 643-648.
7. Toutain, P.L., Lefebvre, H.P. & King, J.N. (2000b) Benazeprilat disposition and effect in dogs revisited with a pharmacokinetic/pharmacodynamic modeling approach. Journal of Pharmacology and Experimental Therapeutics, 292, 1087-1093.