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Volumn 4, Issue NOV, 2013, Pages

A discovery study of daunorubicin induced cardiotoxicity in a sample of acute myeloid leukemia patients prioritizes P450 oxidoreductase polymorphisms as a potential risk factor

Author keywords

Acute myeloid leukemia; Adverse drug reactions; Anthracycline induced cardiotoxicity; Complex trait; Daunorubicin; Global test; P450 oxidoreductase variants

Indexed keywords


EID: 84890306213     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2013.00231     Document Type: Article
Times cited : (56)

References (52)
  • 1
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • doi: 10.1038/nature09534
    • Abecasis, G. R., Altshuler, D., Auton, A., Brooks, L. D., Durbin, R. M., Gibbs, R. A., et al. (2010). A map of human genome variation from population-scale sequencing. Nature 467, 1061-1073. doi: 10.1038/nature09534.
    • (2010) Nature , vol.467 , pp. 1061-1073
    • Abecasis, G.R.1    Altshuler, D.2    Auton, A.3    Brooks, L.D.4    Durbin, R.M.5    Gibbs, R.A.6
  • 2
    • 70350183757 scopus 로고    scopus 로고
    • Genetic scoring analysis: a way forward in genome wide association studies?
    • doi: 10.1007/s10654-009-9387-y
    • Amin, N., Van Duijn, C. M., and Janssens, A. C. (2009). Genetic scoring analysis: a way forward in genome wide association studies? Eur. J. Epidemiol. 24, 585-587. doi: 10.1007/s10654-009-9387-y.
    • (2009) Eur. J. Epidemiol. , vol.24 , pp. 585-587
    • Amin, N.1    Van Duijn, C.M.2    Janssens, A.C.3
  • 3
    • 0018741206 scopus 로고
    • NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals
    • doi: 10.1073/pnas.76.2.954
    • Bachur, N. R., Gordon, S. L., Gee, M. V., and Kon, H. (1979). NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicals. Proc. Natl. Acad. Sci. U.S.A. 76, 954-957. doi: 10.1073/pnas.76.2.954.
    • (1979) Proc. Natl. Acad. Sci. U.S.A. , vol.76 , pp. 954-957
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3    Kon, H.4
  • 4
    • 70949106022 scopus 로고    scopus 로고
    • Haploview: visualization and analysis of SNP genotype data
    • pdb ip71, doi: 10.1101/pdb.ip71
    • Barrett, J. C. (2009). Haploview: visualization and analysis of SNP genotype data. Cold Spring Harb. Protoc. 2009, pdb ip71. doi: 10.1101/pdb.ip71.
    • (2009) Cold Spring Harb. Protoc. , vol.2009
    • Barrett, J.C.1
  • 5
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B (Methodol.) 57, 289-300.
    • (1995) J. R. Stat. Soc. Series B (Methodol.) , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 6
    • 46049104446 scopus 로고    scopus 로고
    • Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer
    • doi: 10.1002/cncr.23534
    • Blanco, J. G., Leisenring, W. M., Gonzalez-Covarrubias, V. M., Kawashima, T. I., Davies, S. M., Relling, M. V., et al. (2008). Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer. Cancer 112, 2789-2795. doi: 10.1002/cncr.23534.
    • (2008) Cancer , vol.112 , pp. 2789-2795
    • Blanco, J.G.1    Leisenring, W.M.2    Gonzalez-Covarrubias, V.M.3    Kawashima, T.I.4    Davies, S.M.5    Relling, M.V.6
  • 7
    • 81855225220 scopus 로고    scopus 로고
    • Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes-a report from the Children's Oncology Group
    • doi: 10.1200/JCO.2011.34.8987
    • Blanco, J. G., Sun, C. L., Landier, W., Chen, L., Esparza-Duran, D., Leisenring, W., et al. (2012). Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes-a report from the Children's Oncology Group. J. Clin. Oncol. 30, 1415-1421. doi: 10.1200/JCO.2011.34.8987.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1415-1421
    • Blanco, J.G.1    Sun, C.L.2    Landier, W.3    Chen, L.4    Esparza-Duran, D.5    Leisenring, W.6
  • 8
    • 62649155943 scopus 로고    scopus 로고
    • A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals
    • doi: 10.1016/j.ajhg.2009.01.005
    • Browning, B. L., and Browning, S. R. (2009). A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet. 84, 210-223. doi: 10.1016/j.ajhg.2009.01.005.
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 210-223
    • Browning, B.L.1    Browning, S.R.2
  • 9
    • 84868198825 scopus 로고    scopus 로고
    • Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression
    • doi: 10.1038/ng.2416
    • Cowper-Sal Lari, R., Zhang, X., Wright, J. B., Bailey, S. D., Cole, M. D., Eeckhoute, J., et al. (2012). Breast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expression. Nat. Genet. 44, 1191-1198. doi: 10.1038/ng.2416.
    • (2012) Nat. Genet. , vol.44 , pp. 1191-1198
    • Cowper-Sal Lari, R.1    Zhang, X.2    Wright, J.B.3    Bailey, S.D.4    Cole, M.D.5    Eeckhoute, J.6
  • 10
    • 74949138296 scopus 로고    scopus 로고
    • Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function
    • doi: 10.1161/CIRCULATIONAHA.109.895771
    • De Angelis, A., Piegari, E., Cappetta, D., Marino, L., Filippelli, A., Berrino, L., et al. (2010). Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121, 276-292. doi: 10.1161/CIRCULATIONAHA.109.895771.
    • (2010) Circulation , vol.121 , pp. 276-292
    • De Angelis, A.1    Piegari, E.2    Cappetta, D.3    Marino, L.4    Filippelli, A.5    Berrino, L.6
  • 12
    • 78649317608 scopus 로고    scopus 로고
    • Predicting genetic predisposition in humans: the promise of whole-genome markers
    • doi: 10.1038/nrg2898
    • De Los Campos, G., Gianola, D., and Allison, D. B. (2010). Predicting genetic predisposition in humans: the promise of whole-genome markers. Nat. Rev. Genet. 11, 880-886. doi: 10.1038/nrg2898.
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 880-886
    • De Los Campos, G.1    Gianola, D.2    Allison, D.B.3
  • 13
    • 34347208347 scopus 로고    scopus 로고
    • Mapping genes that contribute to daunorubicin-induced cytotoxicity
    • doi: 10.1158/0008-5472.CAN-06-4431
    • Duan, S., Bleibel, W. K., Huang, R. S., Shukla, S. J., Wu, X., Badner, J. A., et al. (2007). Mapping genes that contribute to daunorubicin-induced cytotoxicity. Cancer Res. 67, 5425-5433. doi: 10.1158/0008-5472.CAN-06-4431.
    • (2007) Cancer Res. , vol.67 , pp. 5425-5433
    • Duan, S.1    Bleibel, W.K.2    Huang, R.S.3    Shukla, S.J.4    Wu, X.5    Badner, J.A.6
  • 14
    • 84055218304 scopus 로고    scopus 로고
    • Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management
    • doi: 10.1002/ajh.22246
    • Estey, E. H. (2012). Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management. Am. J. Hematol. 87, 89-99. doi: 10.1002/ajh.22246.
    • (2012) Am. J. Hematol. , vol.87 , pp. 89-99
    • Estey, E.H.1
  • 15
    • 64549141601 scopus 로고    scopus 로고
    • Anthracycline cardiotoxicity: why are we still interested?
    • Ewer, S. M., and Ewer, M. S. (2009). Anthracycline cardiotoxicity: why are we still interested? Oncology (Williston Park) 23, 234-235, 239.
    • (2009) Oncology (Williston Park) , vol.23
    • Ewer, S.M.1    Ewer, M.S.2
  • 16
    • 0030804864 scopus 로고    scopus 로고
    • Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity
    • doi: 10.1016/S0891-5849(97)00025-7
    • Gille, L., and Nohl, H. (1997). Analyses of the molecular mechanism of adriamycin-induced cardiotoxicity. Free Radic. Biol. Med. 23, 775-782. doi: 10.1016/S0891-5849(97)00025-7.
    • (1997) Free Radic. Biol. Med. , vol.23 , pp. 775-782
    • Gille, L.1    Nohl, H.2
  • 17
    • 84857733494 scopus 로고    scopus 로고
    • The inheritance procedure: multiple testing of tree-structured hypotheses
    • doi: 10.1515/1544-6115.1554
    • Goeman, J. J., and Finos, L. (2012). The inheritance procedure: multiple testing of tree-structured hypotheses. Stat. Appl. Genet. Mol. Biol. 11:11. doi: 10.1515/1544-6115.1554.
    • (2012) Stat. Appl. Genet. Mol. Biol. , vol.11 , pp. 11
    • Goeman, J.J.1    Finos, L.2
  • 19
    • 66849098131 scopus 로고    scopus 로고
    • Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation
    • doi: 10.2217/pgs.09.7
    • Gomes, A. M., Winter, S., Klein, K., Turpeinen, M., Schaeffeler, E., Schwab, M., et al. (2009). Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation. Pharmacogenomics 10, 579-599. doi: 10.2217/pgs.09.7.
    • (2009) Pharmacogenomics , vol.10 , pp. 579-599
    • Gomes, A.M.1    Winter, S.2    Klein, K.3    Turpeinen, M.4    Schaeffeler, E.5    Schwab, M.6
  • 20
    • 78650552869 scopus 로고    scopus 로고
    • Identification of predictive pathways for non-hodgkin lymphoma prognosis
    • doi: 10.4137/CIN.S6315
    • Han, X., Li, Y., Huang, J., Zhang, Y., Holford, T., Lan, Q., et al. (2012). Identification of predictive pathways for non-hodgkin lymphoma prognosis. Cancer Inform. 9, 281-292. doi: 10.4137/CIN.S6315.
    • (2012) Cancer Inform. , vol.9 , pp. 281-292
    • Han, X.1    Li, Y.2    Huang, J.3    Zhang, Y.4    Holford, T.5    Lan, Q.6
  • 21
    • 26244444318 scopus 로고    scopus 로고
    • What makes a good genetic association study?
    • doi: 10.1016/S0140-6736(05)67531-9
    • Hattersley, A. T., and McCarthy, M. I. (2005). What makes a good genetic association study? Lancet 366, 1315-1323. doi: 10.1016/S0140-6736(05)67531-9.
    • (2005) Lancet , vol.366 , pp. 1315-1323
    • Hattersley, A.T.1    McCarthy, M.I.2
  • 22
    • 50549104256 scopus 로고    scopus 로고
    • Why most discovered true associations are inflated
    • doi: 10.1097/EDE.0b013e31818131e7
    • Ioannidis, J. P. (2008). Why most discovered true associations are inflated. Epidemiology 19, 640-648. doi: 10.1097/EDE.0b013e31818131e7.
    • (2008) Epidemiology , vol.19 , pp. 640-648
    • Ioannidis, J.P.1
  • 23
    • 70450184788 scopus 로고    scopus 로고
    • Splicing, cis genetic variation and disease
    • doi: 10.1042/BST0371311
    • Jensen, C. J., Oldfield, B. J., and Rubio, J. P. (2009). Splicing, cis genetic variation and disease. Biochem. Soc. Trans. 37, 1311-1315. doi: 10.1042/BST0371311.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 1311-1315
    • Jensen, C.J.1    Oldfield, B.J.2    Rubio, J.P.3
  • 24
    • 85027930455 scopus 로고    scopus 로고
    • Flow cytometry-based assessment of mitoxantrone efflux from leukemic blasts varies with response to induction chemotherapy in acute myeloid leukemia
    • doi: 10.1002/cyto.b.21028
    • Kim, H. P., Bernard, L., Berkowitz, J., Nitta, J., and Hogge, D. E. (2012). Flow cytometry-based assessment of mitoxantrone efflux from leukemic blasts varies with response to induction chemotherapy in acute myeloid leukemia. Cytometry B. Clin. Cytom. 82, 283-294. doi: 10.1002/cyto.b.21028.
    • (2012) Cytometry B. Clin. Cytom. , vol.82 , pp. 283-294
    • Kim, H.P.1    Bernard, L.2    Berkowitz, J.3    Nitta, J.4    Hogge, D.E.5
  • 25
    • 23044517485 scopus 로고    scopus 로고
    • The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines
    • doi: 10.1038/sj.bjc.6602639
    • Kostrzewa-Nowak, D., Paine, M. J., Wolf, C. R., and Tarasiuk, J. (2005). The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br. J. Cancer 93, 89-97. doi: 10.1038/sj.bjc.6602639.
    • (2005) Br. J. Cancer , vol.93 , pp. 89-97
    • Kostrzewa-Nowak, D.1    Paine, M.J.2    Wolf, C.R.3    Tarasiuk, J.4
  • 26
    • 65949099120 scopus 로고    scopus 로고
    • Genetic risk prediction-are we there yet?
    • doi: 10.1056/NEJMp0810107
    • Kraft, P., and Hunter, D. J. (2009). Genetic risk prediction-are we there yet? N. Engl. J. Med. 360, 1701-1703. doi: 10.1056/NEJMp0810107.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1701-1703
    • Kraft, P.1    Hunter, D.J.2
  • 27
    • 79961178050 scopus 로고    scopus 로고
    • Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia
    • doi: 10.1002/pbc.23074
    • Lopez-Lopez, E., Martin-Guerrero, I., Ballesteros, J., Pinan, M. A., Garcia-Miguel, P., Navajas, A., et al. (2011). Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia. Pediatr. Blood Cancer 57, 612-619. doi: 10.1002/pbc.23074.
    • (2011) Pediatr. Blood Cancer , vol.57 , pp. 612-619
    • Lopez-Lopez, E.1    Martin-Guerrero, I.2    Ballesteros, J.3    Pinan, M.A.4    Garcia-Miguel, P.5    Navajas, A.6
  • 28
    • 84875485693 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: early promise, but concerted effort needed
    • doi: 10.1126/science.1234139
    • McLeod, H. L. (2013). Cancer pharmacogenomics: early promise, but concerted effort needed. Science 339, 1563-1566. doi: 10.1126/science.1234139.
    • (2013) Science , vol.339 , pp. 1563-1566
    • McLeod, H.L.1
  • 30
    • 84876180106 scopus 로고    scopus 로고
    • Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery
    • doi: 10.1371/journal.pone.0060164
    • Miaskowski, C., Dodd, M., Paul, S. M., West, C., Hamolsky, D., Abrams, G., et al. (2013). Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. PLoS ONE 8:e60164. doi: 10.1371/journal.pone.0060164.
    • (2013) PLoS ONE , vol.8
    • Miaskowski, C.1    Dodd, M.2    Paul, S.M.3    West, C.4    Hamolsky, D.5    Abrams, G.6
  • 31
    • 79952068290 scopus 로고    scopus 로고
    • Consequences of POR mutations and polymorphisms
    • doi: 10.1016/j.mce.2010.10.022
    • Miller, W. L., Agrawal, V., Sandee, D., Tee, M. K., Huang, N., Choi, J. H., et al. (2011). Consequences of POR mutations and polymorphisms. Mol. Cell. Endocrinol. 336, 174-179. doi: 10.1016/j.mce.2010.10.022.
    • (2011) Mol. Cell. Endocrinol. , vol.336 , pp. 174-179
    • Miller, W.L.1    Agrawal, V.2    Sandee, D.3    Tee, M.K.4    Huang, N.5    Choi, J.H.6
  • 32
    • 79952103287 scopus 로고    scopus 로고
    • Gene-environment interactions in human disease: nuisance or opportunity?
    • doi: 10.1016/j.tig.2010.12.004
    • Ober, C., and Vercelli, D. (2011). Gene-environment interactions in human disease: nuisance or opportunity? Trends Genet. 27, 107-115. doi: 10.1016/j.tig.2010.12.004.
    • (2011) Trends Genet. , vol.27 , pp. 107-115
    • Ober, C.1    Vercelli, D.2
  • 33
    • 70349304990 scopus 로고    scopus 로고
    • Novel regulatory mechanisms for the CFTR gene
    • doi: 10.1042/BST0370843
    • Ott, C. J., Blackledge, N. P., Leir, S. H., and Harris, A. (2009). Novel regulatory mechanisms for the CFTR gene. Biochem. Soc. Trans. 37, 843-848. doi: 10.1042/BST0370843.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 843-848
    • Ott, C.J.1    Blackledge, N.P.2    Leir, S.H.3    Harris, A.4
  • 34
    • 69949121284 scopus 로고    scopus 로고
    • Asymptotic tests of association with multiple SNPs in linkage disequilibrium
    • doi: 10.1002/gepi.20402
    • Pan, W. (2009). Asymptotic tests of association with multiple SNPs in linkage disequilibrium. Genet. Epidemiol. 33, 497-507. doi: 10.1002/gepi.20402.
    • (2009) Genet. Epidemiol. , vol.33 , pp. 497-507
    • Pan, W.1
  • 36
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • doi: 10.1038/ng1847
    • Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909. doi: 10.1038/ng1847.
    • (2006) Nat. Genet. , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 37
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: a tool set for whole-genome association and population-based linkage analyses
    • doi: 10.1086/519795
    • Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A., Bender, D., et al. (2007). PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575. doi: 10.1086/519795.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1    Neale, B.2    Todd-Brown, K.3    Thomas, L.4    Ferreira, M.A.5    Bender, D.6
  • 38
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • doi: 10.1038/nature08185
    • Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O'Donovan, M. C., Sullivan, P. F., et al. (2009). Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748-752. doi: 10.1038/nature08185.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5    Sullivan, P.F.6
  • 39
    • 70350767248 scopus 로고    scopus 로고
    • Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood
    • doi: 10.1080/10428190903177212
    • Rajic, V., Aplenc, R., Debeljak, M., Prestor, V. V., Karas-Kuzelicki, N., Mlinaric-Rascan, I., et al. (2009). Influence of the polymorphism in candidate genes on late cardiac damage in patients treated due to acute leukemia in childhood. Leuk. Lymphoma 50, 1693-1698. doi: 10.1080/10428190903177212.
    • (2009) Leuk. Lymphoma , vol.50 , pp. 1693-1698
    • Rajic, V.1    Aplenc, R.2    Debeljak, M.3    Prestor, V.V.4    Karas-Kuzelicki, N.5    Mlinaric-Rascan, I.6
  • 40
    • 84907095419 scopus 로고    scopus 로고
    • R: A Language and Environment for Statistical Computing
    • R-Development-Core-Team.
    • R-Development-Core-Team. (2011). R: A Language and Environment for Statistical Computing. Vienna: F.F.S. Computing.
    • (2011) Vienna: F.F.S. Computing
  • 41
    • 77955906955 scopus 로고    scopus 로고
    • Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection?
    • doi: 10.1016/j.pcad.2010.06.007
    • Sawyer, D. B., Peng, X., Chen, B., Pentassuglia, L., and Lim, C. C. (2010). Mechanisms of anthracycline cardiac injury: can we identify strategies for cardioprotection? Prog. Cardiovasc. Dis. 53, 105-113. doi: 10.1016/j.pcad.2010.06.007.
    • (2010) Prog. Cardiovasc. Dis. , vol.53 , pp. 105-113
    • Sawyer, D.B.1    Peng, X.2    Chen, B.3    Pentassuglia, L.4    Lim, C.C.5
  • 42
    • 82155164179 scopus 로고    scopus 로고
    • Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes
    • doi: 10.1371/journal.pone.0027964
    • Stringer, S., Wray, N. R., Kahn, R. S., and Derks, E. M. (2011). Underestimated effect sizes in GWAS: fundamental limitations of single SNP analysis for dichotomous phenotypes. PLoS ONE 6:e27964. doi: 10.1371/journal.pone.0027964.
    • (2011) PLoS ONE , vol.6
    • Stringer, S.1    Wray, N.R.2    Kahn, R.S.3    Derks, E.M.4
  • 43
    • 73349098768 scopus 로고    scopus 로고
    • Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
    • doi: 10.1200/JCO.2008.20.4156
    • Trevino, L. R., Shimasaki, N., Yang, W., Panetta, J. C., Cheng, C., Pei, D., et al. (2009). Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J. Clin. Oncol. 27, 5972-5978. doi: 10.1200/JCO.2008.20.4156.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 5972-5978
    • Trevino, L.R.1    Shimasaki, N.2    Yang, W.3    Panetta, J.C.4    Cheng, C.5    Pei, D.6
  • 44
    • 84867693534 scopus 로고    scopus 로고
    • Cancer heterogeneity: origins and implications for genetic association studies
    • doi: 10.1016/j.tig.2012.07.001
    • Urbach, D., Lupien, M., Karagas, M. R., and Moore, J. H. (2012). Cancer heterogeneity: origins and implications for genetic association studies. Trends Genet. 28, 538-543. doi: 10.1016/j.tig.2012.07.001.
    • (2012) Trends Genet. , vol.28 , pp. 538-543
    • Urbach, D.1    Lupien, M.2    Karagas, M.R.3    Moore, J.H.4
  • 46
    • 84863001655 scopus 로고    scopus 로고
    • Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children
    • doi: 10.1200/JCO.2010.34.3467
    • Visscher, H., Ross, C. J., Rassekh, S. R., Barhdadi, A., Dube, M. P., Al-Saloos, H., et al. (2012). Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children. J. Clin. Oncol. 30, 1422-1428. doi: 10.1200/JCO.2010.34.3467.
    • (2012) J. Clin. Oncol. , vol.30 , pp. 1422-1428
    • Visscher, H.1    Ross, C.J.2    Rassekh, S.R.3    Barhdadi, A.4    Dube, M.P.5    Al-Saloos, H.6
  • 47
    • 84871302357 scopus 로고    scopus 로고
    • Cancer pharmacogenomics: strategies and challenges
    • doi: 10.1038/nrg3352
    • Wheeler, H. E., Maitland, M. L., Dolan, M. E., Cox, N. J., and Ratain, M. J. (2012). Cancer pharmacogenomics: strategies and challenges. Nat. Rev. Genet. 14, 23-34. doi: 10.1038/nrg3352.
    • (2012) Nat. Rev. Genet. , vol.14 , pp. 23-34
    • Wheeler, H.E.1    Maitland, M.L.2    Dolan, M.E.3    Cox, N.J.4    Ratain, M.J.5
  • 48
    • 33644876141 scopus 로고    scopus 로고
    • NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity
    • doi: 10.1161/CIRCULATIONAHA.105.576850
    • Wojnowski, L., Kulle, B., Schirmer, M., Schluter, G., Schmidt, A., Rosenberger, A., et al. (2005). NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity. Circulation 112, 3754-3762. doi: 10.1161/CIRCULATIONAHA.105.576850.
    • (2005) Circulation , vol.112 , pp. 3754-3762
    • Wojnowski, L.1    Kulle, B.2    Schirmer, M.3    Schluter, G.4    Schmidt, A.5    Rosenberger, A.6
  • 49
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • doi: 10.1038/ng.608
    • Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., et al. (2010). Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 42, 565-569. doi: 10.1038/ng.608.
    • (2010) Nat. Genet. , vol.42 , pp. 565-569
    • Yang, J.1    Benyamin, B.2    McEvoy, B.P.3    Gordon, S.4    Henders, A.K.5    Nyholt, D.R.6
  • 50
    • 67649958842 scopus 로고    scopus 로고
    • Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management
    • doi: 10.1016/j.jacc.2009.02.050
    • Yeh, E. T., and Bickford, C. L. (2009). Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J. Am. Coll. Cardiol. 53, 2231-2247. doi: 10.1016/j.jacc.2009.02.050.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 2231-2247
    • Yeh, E.T.1    Bickford, C.L.2
  • 51
    • 79960616137 scopus 로고    scopus 로고
    • Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose
    • doi: 10.1124/dmd.111.038836
    • Zhang, X., Li, L., Ding, X., and Kaminsky, L. S. (2011). Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose. Drug Metab. Dispos. 39, 1433-1439. doi: 10.1124/dmd.111.038836.
    • (2011) Drug Metab. Dispos. , vol.39 , pp. 1433-1439
    • Zhang, X.1    Li, L.2    Ding, X.3    Kaminsky, L.S.4
  • 52
    • 70449529313 scopus 로고    scopus 로고
    • Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats
    • doi: 10.1016/j.taap.2009.09.012
    • Zordoky, B. N., Anwar-Mohamed, A., Aboutabl, M. E., and El-Kadi, A. O. (2010). Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicol. Appl. Pharmacol. 242, 38-46. doi: 10.1016/j.taap.2009.09.012.
    • (2010) Toxicol. Appl. Pharmacol. , vol.242 , pp. 38-46
    • Zordoky, B.N.1    Anwar-Mohamed, A.2    Aboutabl, M.E.3    El-Kadi, A.O.4


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