Underestimated effect sizes in GWAS: Fundamental limitations of single SNP analysis for dichotomous phenotypes

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Stringer, Sven ^a   Wray, Naomi R ^b,c   Kahn, René S ^a   Derks, Eske M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CALCULATION; EFFECT SIZE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HERITABILITY; HUMAN; PHENOTYPE; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM;

GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MODELS, GENETIC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 82155164179     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027964     Document Type: Article

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