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Volumn 95, Issue PART 1, 2014, Pages 26-37

Human metapneumovirus inhibits the IL-6-induced JAK/STAT3 signalling cascade in airway epithelium

Author keywords

[No Author keywords available]

Indexed keywords

IFNAR1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 2; LUCIFERASE; PROTEIN; PROTEIN KINASE P60; SMAD2 PROTEIN; SMAD4 PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR YY1; UNCLASSIFIED DRUG;

EID: 84890288920     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.055632-0     Document Type: Article
Times cited : (17)

References (62)
  • 1
    • 0035890906 scopus 로고    scopus 로고
    • Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells
    • Abu-Ghazaleh, R., Kabir, J., Jia, H., Lobo, M. & Zachary, I. (2001). Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells. Biochem J 360, 255-264.
    • (2001) Biochem J , vol.360 , pp. 255-264
    • Abu-Ghazaleh, R.1    Kabir, J.2    Jia, H.3    Lobo, M.4    Zachary, I.5
  • 2
    • 0030067103 scopus 로고    scopus 로고
    • Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression
    • Akbar, A. N., Borthwick, N. J., Wickremasinghe, R. G., Panayoitidis, P., Pilling, D., Bofill, M., Krajewski, S., Reed, J. C. & Salmon, M. (1996). Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) gene expression. Eur J Immunol 26, 294-299.
    • (1996) Eur J Immunol , vol.26 , pp. 294-299
    • Akbar, A.N.1    Borthwick, N.J.2    Wickremasinghe, R.G.3    Panayoitidis, P.4    Pilling, D.5    Bofill, M.6    Krajewski, S.7    Reed, J.C.8    Salmon, M.9
  • 3
    • 33846332013 scopus 로고    scopus 로고
    • Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors
    • Allen, D. L. & Unterman, T. G. (2007). Regulation of myostatin expression and myoblast differentiation by FoxO and SMAD transcription factors. Am J Physiol Cell Physiol 292, C188-C199.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Allen, D.L.1    Unterman, T.G.2
  • 4
    • 10044230781 scopus 로고    scopus 로고
    • Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies
    • Alvarez, R., Harrod, K. S., Shieh, W. J., Zaki, S. & Tripp, R. A. (2004). Human metapneumovirus persists in BALB/c mice despite the presence of neutralizing antibodies. J Virol 78, 14003-14011.
    • (2004) J Virol , vol.78 , pp. 14003-14011
    • Alvarez, R.1    Harrod, K.S.2    Shieh, W.J.3    Zaki, S.4    Tripp, R.A.5
  • 5
    • 67349275024 scopus 로고    scopus 로고
    • IL-22: A critical mediator in mucosal host defense
    • Aujla, S. J. & Kolls, J. K. (2009). IL-22: a critical mediator in mucosal host defense. J Mol Med (Berl) 87, 451-454.
    • (2009) J Mol Med (Berl) , vol.87 , pp. 451-454
    • Aujla, S.J.1    Kolls, J.K.2
  • 6
    • 26444489068 scopus 로고    scopus 로고
    • Inhibition of interferon-stimulated JAK-STAT signaling by a tickborne flavivirus and identification of NS5 as an interferon antagonist
    • Best, S. M., Morris, K. L., Shannon, J. G., Robertson, S. J., Mitzel, D. N., Park, G. S., Boer, E., Wolfinbarger, J. B. & Bloom, M. E. (2005). Inhibition of interferon-stimulated JAK-STAT signaling by a tickborne flavivirus and identification of NS5 as an interferon antagonist. J Virol 79, 12828-12839.
    • (2005) J Virol , vol.79 , pp. 12828-12839
    • Best, S.M.1    Morris, K.L.2    Shannon, J.G.3    Robertson, S.J.4    Mitzel, D.N.5    Park, G.S.6    Boer, E.7    Wolfinbarger, J.B.8    Bloom, M.E.9
  • 7
    • 33846815515 scopus 로고    scopus 로고
    • Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kB-dependent, interferon-independent mechanism and facilitate virus growth
    • Bitko, V., Shulyayeva, O., Mazumder, B., Musiyenko, A., Ramaswamy, M., Look, D. C. & Barik, S. (2007). Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kB-dependent, interferon-independent mechanism and facilitate virus growth. J Virol 81, 1786-1795.
    • (2007) J Virol , vol.81 , pp. 1786-1795
    • Bitko, V.1    Shulyayeva, O.2    Mazumder, B.3    Musiyenko, A.4    Ramaswamy, M.5    Look, D.C.6    Barik, S.7
  • 8
    • 0035006109 scopus 로고    scopus 로고
    • Tyrosinephosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
    • Cacalano, N. A., Sanden, D. & Johnston, J. A. (2001). Tyrosinephosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nat Cell Biol 3, 460-465.
    • (2001) Nat Cell Biol , vol.3 , pp. 460-465
    • Cacalano, N.A.1    Sanden, D.2    Johnston, J.A.3
  • 9
    • 0028173026 scopus 로고
    • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity
    • DiCosmo, B. F., Geba, G. P., Picarella, D., Elias, J. A., Rankin, J. A., Stripp, B. R., Whitsett, J. A. & Flavell, R. A. (1994). Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. J Clin Invest 94, 2028-2035.
    • (1994) J Clin Invest , vol.94 , pp. 2028-2035
    • DiCosmo, B.F.1    Geba, G.P.2    Picarella, D.3    Elias, J.A.4    Rankin, J.A.5    Stripp, B.R.6    Whitsett, J.A.7    Flavell, R.A.8
  • 10
    • 45249091224 scopus 로고    scopus 로고
    • Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation
    • Dinwiddie, D. L. & Harrod, K. S. (2008). Human metapneumovirus inhibits IFN-α signaling through inhibition of STAT1 phosphorylation. Am J Respir Cell Mol Biol 38, 661-670.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 661-670
    • Dinwiddie, D.L.1    Harrod, K.S.2
  • 14
    • 0035200941 scopus 로고    scopus 로고
    • Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms
    • Ghoshal, K., Majumder, S., Zhu, Q., Hunzeker, J., Datta, J., Shah, M., Sheridan, J. F. & Jacob, S. T. (2001). Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms. Mol Cell Biol 21, 8301-8317.
    • (2001) Mol Cell Biol , vol.21 , pp. 8301-8317
    • Ghoshal, K.1    Majumder, S.2    Zhu, Q.3    Hunzeker, J.4    Datta, J.5    Shah, M.6    Sheridan, J.F.7    Jacob, S.T.8
  • 17
    • 27744449447 scopus 로고    scopus 로고
    • Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus
    • Guerrero-Plata, A., Casola, A. & Garofalo, R. P. (2005). Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. J Virol 79, 14992-14997.
    • (2005) J Virol , vol.79 , pp. 14992-14997
    • Guerrero-Plata, A.1    Casola, A.2    Garofalo, R.P.3
  • 18
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich, P. C., Behrmann, I., Müller-Newen, G., Schaper, F. & Graeve, L. (1998). Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J 334, 297-314.
    • (1998) Biochem J , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Müller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 19
    • 1942509360 scopus 로고    scopus 로고
    • Silencing STATs: Lessons from paramyxovirus interferon evasion
    • Horvath, C. M. (2004). Silencing STATs: lessons from paramyxovirus interferon evasion. Cytokine Growth Factor Rev 15, 117-127.
    • (2004) Cytokine Growth Factor Rev , vol.15 , pp. 117-127
    • Horvath, C.M.1
  • 20
    • 78649622426 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: A biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells
    • Huang, W. L., Yeh, H. H., Lin, C. C., Lai, W. W., Chang, J. Y., Chang, W. T. & Su, W. C. (2010). Signal transducer and activator of transcription 3 activation up-regulates interleukin-6 autocrine production: a biochemical and genetic study of established cancer cell lines and clinical isolated human cancer cells. Mol Cancer 9, 309.
    • (2010) Mol Cancer , vol.9 , pp. 309
    • Huang, W.L.1    Yeh, H.H.2    Lin, C.C.3    Lai, W.W.4    Chang, J.Y.5    Chang, W.T.6    Su, W.C.7
  • 21
    • 40549120730 scopus 로고    scopus 로고
    • Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus
    • Huck, B., Neumann-Haefelin, D., Schmitt-Graeff, A., Weckmann, M., Mattes, J., Ehl, S. & Falcone, V. (2007). Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus. Respir Res 8, 6.
    • (2007) Respir Res , vol.8 , pp. 6
    • Huck, B.1    Neumann-Haefelin, D.2    Schmitt-Graeff, A.3    Weckmann, M.4    Mattes, J.5    Ehl, S.6    Falcone, V.7
  • 22
    • 0031925588 scopus 로고    scopus 로고
    • Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity
    • Itoh, M., Hotta, H. & Homma, M. (1998). Increased induction of apoptosis by a Sendai virus mutant is associated with attenuation of mouse pathogenicity. J Virol 72, 2927-2934.
    • (1998) J Virol , vol.72 , pp. 2927-2934
    • Itoh, M.1    Hotta, H.2    Homma, M.3
  • 23
    • 31044451533 scopus 로고    scopus 로고
    • Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia
    • Jones, M. R., Quinton, L. J., Simms, B. T., Lupa, M. M., Kogan, M. S. & Mizgerd, J. P. (2006). Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis 193, 360-369.
    • (2006) J Infect Dis , vol.193 , pp. 360-369
    • Jones, M.R.1    Quinton, L.J.2    Simms, B.T.3    Lupa, M.M.4    Kogan, M.S.5    Mizgerd, J.P.6
  • 24
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: The signal orchestration model
    • Kamimura, D., Ishihara, K. & Hirano, T. (2003). IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol 149, 1-38.
    • (2003) Rev Physiol Biochem Pharmacol , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 25
    • 0033584297 scopus 로고    scopus 로고
    • Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
    • Karni, R., Jove, R. & Levitzki, A. (1999). Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors. Oncogene 18, 4654-4662.
    • (1999) Oncogene , vol.18 , pp. 4654-4662
    • Karni, R.1    Jove, R.2    Levitzki, A.3
  • 26
    • 50649124445 scopus 로고    scopus 로고
    • Deleted in pancreatic carcinoma locus 4/Smad4 participates in the regulation of apoptosis by affecting the Bcl-2/Bax balance in non-small cell lung cancer
    • Ke, Z., Zhang, X., Ma, L. & Wang, L. (2008). Deleted in pancreatic carcinoma locus 4/Smad4 participates in the regulation of apoptosis by affecting the Bcl-2/Bax balance in non-small cell lung cancer. Hum Pathol 39, 1438-1445.
    • (2008) Hum Pathol , vol.39 , pp. 1438-1445
    • Ke, Z.1    Zhang, X.2    Ma, L.3    Wang, L.4
  • 29
    • 0042890511 scopus 로고    scopus 로고
    • Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosisinducing ligand
    • Kotelkin, A., Prikhod'ko, E. A., Cohen, J. I., Collins, P. L. & Bukreyev, A. (2003). Respiratory syncytial virus infection sensitizes cells to apoptosis mediated by tumor necrosis factor-related apoptosisinducing ligand. J Virol 77, 9156-9172.
    • (2003) J Virol , vol.77 , pp. 9156-9172
    • Kotelkin, A.1    Prikhod'ko, E.A.2    Cohen, J.I.3    Collins, P.L.4    Bukreyev, A.5
  • 30
    • 2442660474 scopus 로고    scopus 로고
    • Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract
    • Kuiken, T., van den Hoogen, B. G., van Riel, D. A., Laman, J. D., van Amerongen, G., Sprong, L., Fouchier, R. A. & Osterhaus, A. D. (2004). Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract. Am J Pathol 164, 1893-1900.
    • (2004) Am J Pathol , vol.164 , pp. 1893-1900
    • Kuiken, T.1    van den Hoogen, B.G.2    van Riel, D.A.3    Laman, J.D.4    van Amerongen, G.5    Sprong, L.6    Fouchier, R.A.7    Osterhaus, A.D.8
  • 32
    • 2542496701 scopus 로고    scopus 로고
    • Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy
    • other authors
    • Laham, F. R., Israele, V., Casellas, J. M., Garcia, A. M., Lac Prugent, C. M., Hoffman, S. J., Hauer, D., Thumar, B., Name, M. I. & other authors (2004). Differential production of inflammatory cytokines in primary infection with human metapneumovirus and with other common respiratory viruses of infancy. J Infect Dis 189, 2047-2056.
    • (2004) J Infect Dis , vol.189 , pp. 2047-2056
    • Laham, F.R.1    Israele, V.2    Casellas, J.M.3    Garcia, A.M.4    Lac Prugent, C.M.5    Hoffman, S.J.6    Hauer, D.7    Thumar, B.8    Name, M.I.9
  • 33
    • 14944382549 scopus 로고    scopus 로고
    • Seroepidemiology of human metapneumovirus (hMPV) on the basis of a novel enzymelinked immunosorbent assay utilizing hMPV fusion protein expressed in recombinant vesicular stomatitis virus
    • Leung, J., Esper, F., Weibel, C. & Kahn, J. S. (2005). Seroepidemiology of human metapneumovirus (hMPV) on the basis of a novel enzymelinked immunosorbent assay utilizing hMPV fusion protein expressed in recombinant vesicular stomatitis virus. J Clin Microbiol 43, 1213-1219.
    • (2005) J Clin Microbiol , vol.43 , pp. 1213-1219
    • Leung, J.1    Esper, F.2    Weibel, C.3    Kahn, J.S.4
  • 34
    • 22944453695 scopus 로고    scopus 로고
    • Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-α-positive breast cancer cells
    • Li, Q., Wu, L., Oelschlager, D. K., Wan, M., Stockard, C. R., Grizzle, W. E., Wang, N., Chen, H., Sun, Y. & Cao, X. (2005). Smad4 inhibits tumor growth by inducing apoptosis in estrogen receptor-α-positive breast cancer cells. J Biol Chem 280, 27022-27028.
    • (2005) J Biol Chem , vol.280 , pp. 27022-27028
    • Li, Q.1    Wu, L.2    Oelschlager, D.K.3    Wan, M.4    Stockard, C.R.5    Grizzle, W.E.6    Wang, N.7    Chen, H.8    Sun, Y.9    Cao, X.10
  • 35
    • 1642494720 scopus 로고    scopus 로고
    • Reactive oxygen species mediate virus-induced STAT activation: Role of tyrosine phosphatases
    • Liu, T., Castro, S., Brasier, A. R., Jamaluddin, M., Garofalo, R. P. & Casola, A. (2004). Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. J Biol Chem 279, 2461-2469.
    • (2004) J Biol Chem , vol.279 , pp. 2461-2469
    • Liu, T.1    Castro, S.2    Brasier, A.R.3    Jamaluddin, M.4    Garofalo, R.P.5    Casola, A.6
  • 36
    • 67449083079 scopus 로고    scopus 로고
    • Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment
    • Liu, Y., Haas, D. L., Poore, S., Isakovic, S., Gahan, M., Mahalingam, S., Fu, Z. F. & Tripp, R. A. (2009). Human metapneumovirus establishes persistent infection in the lungs of mice and is reactivated by glucocorticoid treatment. J Virol 83, 6837-6848.
    • (2009) J Virol , vol.83 , pp. 6837-6848
    • Liu, Y.1    Haas, D.L.2    Poore, S.3    Isakovic, S.4    Gahan, M.5    Mahalingam, S.6    Fu, Z.F.7    Tripp, R.A.8
  • 38
    • 84863462044 scopus 로고    scopus 로고
    • Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis
    • Madonna, S., Scarponi, C., Pallotta, S., Cavani, A. & Albanesi, C. (2012). Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis. Cell Death Dis 3, e334.
    • (2012) Cell Death Dis , vol.3
    • Madonna, S.1    Scarponi, C.2    Pallotta, S.3    Cavani, A.4    Albanesi, C.5
  • 39
    • 33746327008 scopus 로고    scopus 로고
    • Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease
    • Martinello, R. A., Esper, F., Weibel, C., Ferguson, D., Landry, M. L. & Kahn, J. S. (2006). Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J Infect 53, 248-254.
    • (2006) J Infect , vol.53 , pp. 248-254
    • Martinello, R.A.1    Esper, F.2    Weibel, C.3    Ferguson, D.4    Landry, M.L.5    Kahn, J.S.6
  • 40
    • 33745308594 scopus 로고    scopus 로고
    • Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection
    • Matsuzaki, Y., Xu, Y., Ikegami, M., Besnard, V., Park, K. S., Hull, W. M., Wert, S. E. & Whitsett, J. A. (2006). Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection. J Immunol 177, 527-537.
    • (2006) J Immunol , vol.177 , pp. 527-537
    • Matsuzaki, Y.1    Xu, Y.2    Ikegami, M.3    Besnard, V.4    Park, K.S.5    Hull, W.M.6    Wert, S.E.7    Whitsett, J.A.8
  • 42
    • 54249165892 scopus 로고    scopus 로고
    • Effect of IL-6 deficiency on susceptibility to HSV-1 respiratory infection and intrinsic macrophage antiviral resistance
    • Murphy, E. A., Davis, J. M., Brown, A. S., Carmichael, M. D., Ghaffar, A. & Mayer, E. P. (2008). Effect of IL-6 deficiency on susceptibility to HSV-1 respiratory infection and intrinsic macrophage antiviral resistance. J Interferon Cytokine Res 28, 589-595.
    • (2008) J Interferon Cytokine Res , vol.28 , pp. 589-595
    • Murphy, E.A.1    Davis, J.M.2    Brown, A.S.3    Carmichael, M.D.4    Ghaffar, A.5    Mayer, E.P.6
  • 43
    • 0037790930 scopus 로고    scopus 로고
    • STAT protein interference and suppression of cytokine signal transduction by measles virus V protein
    • Palosaari, H., Parisien, J. P., Rodriguez, J. J., Ulane, C. M. & Horvath, C. M. (2003). STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. J Virol 77, 7635-7644.
    • (2003) J Virol , vol.77 , pp. 7635-7644
    • Palosaari, H.1    Parisien, J.P.2    Rodriguez, J.J.3    Ulane, C.M.4    Horvath, C.M.5
  • 45
    • 0028964911 scopus 로고
    • Interleukin-9 is a major anti-apoptotic factor for thymic lymphomas
    • Renauld, J. C., Vink, A., Louahed, J. & Van Snick, J. (1995). Interleukin-9 is a major anti-apoptotic factor for thymic lymphomas. Blood 85, 1300-1305.
    • (1995) Blood , vol.85 , pp. 1300-1305
    • Renauld, J.C.1    Vink, A.2    Louahed, J.3    Van Snick, J.4
  • 46
    • 84866517656 scopus 로고    scopus 로고
    • Loss of expression and function of SOCS3 is an early event in HNSCC: Altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion
    • Rossa, C., Jr, Sommer, G., Spolidorio, L. C., Rosenzweig, S. A., Watson, D. K. & Kirkwood, K. L. (2012). Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. PLoS ONE 7, e45197.
    • (2012) PLoS ONE , vol.7
    • Rossa Jr., C.1    Sommer, G.2    Spolidorio, L.C.3    Rosenzweig, S.A.4    Watson, D.K.5    Kirkwood, K.L.6
  • 47
    • 4344700576 scopus 로고    scopus 로고
    • Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance
    • Schmidt, S., Rainer, J., Ploner, C., Presul, E., Riml, S. & Kofler, R. (2004). Glucocorticoid-induced apoptosis and glucocorticoid resistance: molecular mechanisms and clinical relevance. Cell Death Differ 11 (Suppl 1), S45-S55.
    • (2004) Cell Death Differ , vol.11 , Issue.SUPPL. 1
    • Schmidt, S.1    Rainer, J.2    Ploner, C.3    Presul, E.4    Riml, S.5    Kofler, R.6
  • 48
    • 0031041172 scopus 로고    scopus 로고
    • Regulation of apoptosis by viral gene products
    • Teodoro, J. G. & Branton, P. E. (1997). Regulation of apoptosis by viral gene products. J Virol 71, 1739-1746.
    • (1997) J Virol , vol.71 , pp. 1739-1746
    • Teodoro, J.G.1    Branton, P.E.2
  • 50
    • 0038664389 scopus 로고    scopus 로고
    • STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling
    • Ulane, C. M., Rodriguez, J. J., Parisien, J. P. & Horvath, C. M. (2003). STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. J Virol 77, 6385-6393.
    • (2003) J Virol , vol.77 , pp. 6385-6393
    • Ulane, C.M.1    Rodriguez, J.J.2    Parisien, J.P.3    Horvath, C.M.4
  • 51
    • 79957580066 scopus 로고    scopus 로고
    • Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: Control by Rac1
    • Ungefroren, H., Groth, S., Sebens, S., Lehnert, H., Gieseler, F. & Fändrich, F. (2011). Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer 10, 67.
    • (2011) Mol Cancer , vol.10 , pp. 67
    • Ungefroren, H.1    Groth, S.2    Sebens, S.3    Lehnert, H.4    Gieseler, F.5    Fändrich, F.6
  • 53
    • 0030856428 scopus 로고    scopus 로고
    • Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia
    • van der Poll, T., Keogh, C. V., Guirao, X., Buurman, W. A., Kopf, M. & Lowry, S. F. (1997). Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis 176, 439-444.
    • (1997) J Infect Dis , vol.176 , pp. 439-444
    • van der Poll, T.1    Keogh, C.V.2    Guirao, X.3    Buurman, W.A.4    Kopf, M.5    Lowry, S.F.6
  • 56
    • 48649102936 scopus 로고    scopus 로고
    • The immune response to respiratory syncytial virus infection: Friend or foe?
    • Welliver, R. C., Sr (2008). The immune response to respiratory syncytial virus infection: friend or foe? Clin Rev Allergy Immunol 34, 163-173.
    • (2008) Clin Rev Allergy Immunol , vol.34 , pp. 163-173
    • Welliver, R.C.1    Sr2
  • 59
    • 0036667371 scopus 로고    scopus 로고
    • The role of interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants
    • Yu, M., Zheng, X., Witschi, H. & Pinkerton, K. E. (2002). The role of interleukin-6 in pulmonary inflammation and injury induced by exposure to environmental air pollutants. Toxicol Sci 68, 488-497.
    • (2002) Toxicol Sci , vol.68 , pp. 488-497
    • Yu, M.1    Zheng, X.2    Witschi, H.3    Pinkerton, K.E.4
  • 60
    • 33847009160 scopus 로고    scopus 로고
    • SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines
    • other authors
    • Zhang, J., Kalyankrishna, S., Wislez, M., Thilaganathan, N., Saigal, B., Wei, B., Ma, L., Wistuba, II, Johnson, F. M. & other authors (2007). SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines. Am J Pathol 170, 366-376.
    • (2007) Am J Pathol , vol.170 , pp. 366-376
    • Zhang, J.1    Kalyankrishna, S.2    Wislez, M.3    Thilaganathan, N.4    Saigal, B.5    Wei, B.6    Ma, L.7    Wistuba, I.I.8    Johnson, F.M.9
  • 61
    • 75149192643 scopus 로고    scopus 로고
    • IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line
    • Zhang, X., Yin, P., Di, D., Luo, G., Zheng, L., Wei, J., Zhang, J., Shi, Y., Zhang, J. & Xu, N. (2009). IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line. Anticancer Res 29, 4497-4501.
    • (2009) Anticancer Res , vol.29 , pp. 4497-4501
    • Zhang, X.1    Yin, P.2    Di, D.3    Luo, G.4    Zheng, L.5    Wei, J.6    Zhang, J.7    Shi, Y.8    Zhang, J.9    Xu, N.10
  • 62
    • 79955020418 scopus 로고    scopus 로고
    • Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/-mice
    • Zhang, X., Goel, T., Goodfield, L. L., Muse, S. J. & Harvill, E. T. (2011). Decreased leukocyte accumulation and delayed Bordetella pertussis clearance in IL-6-/-mice. J Immunol 186, 4895-4904.
    • (2011) J Immunol , vol.186 , pp. 4895-4904
    • Zhang, X.1    Goel, T.2    Goodfield, L.L.3    Muse, S.J.4    Harvill, E.T.5


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