Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms

Molecular and Cellular Biology

Volumn 21, Issue 24, 2001, Pages 8301-8317

  Ghoshal, K ^a   Majumder, S ^a   Zhu, Q ^a   Hunzeker, J ^a   Datta, J ^a   Shah, M ^a   Sheridan, J F ^a   Jacob, S T ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 10; INTERLEUKIN 6; METALLOTHIONEIN; MIFEPRISTONE; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION REGULATION; INFLUENZA VIRUS; LIVER; LUNG; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; UPPER RESPIRATORY TRACT INFECTION; VIRUS INFECTION;

ANIMALS; ANTIOXIDANTS; BASE SEQUENCE; BINDING SITES; BLOTTING, NORTHERN; CELL NUCLEUS; CYTOKINES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-6; LIVER; LUNG; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIFEPRISTONE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; ORTHOMYXOVIRIDAE; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

ANIMALIA; DNA VIRUSES; INFLUENZA VIRUS;

EID: 0035200941     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.24.8301-8317.2001     Document Type: Article

References (68)

1. Roles of STAT3 defined by tissue-specific gene targeting
2. Impaired Stat3 activation following localized inflammatory stimulus in IL-6-deficient mice
3. Interleukin-6 and CAAT/enhancer binding protein beta-deficient mice act as tools to dissect the IL-6 signalling pathway and IL-6 regulation
4. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene activation in the liver
5. Regulation of metallothionein gene expression by oxidative stress and metal ions
6. Purification and characterization of a rat liver protein that recognizes CCAAT-homologous sequences of the metallothionein promoter and trans-activates this promoter
7. Distinct rat proteins can recognize CCAAT-homologous sequences of the metallothionein promoter and transactivate this promoter
8. The role of oxidative stress in viral infections
9. Hormone-induced nucleosome positioning in the MMTV promoter is reversible
10. The role of IL-6 in the inflammatory and humoral response to adenoviral vectors
11. Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1
12. Oxidative stress in lungs of mice infected with influenza A virus
13. Prevention and control of influenza: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
14. Oxidant stress responses in influenza virus pneumonia: Gene expression and transcription factor activation
15. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
16. Oxidative stress activates metal-responsive transcription factor-1 binding activity: Occupancy in vivo of metal response elements in the metallothionein-I gene promoter
17. Type I interferons
18. Neuroendocrine regulation of cytokine production during experimental influenza viral infection: Effects of restraint stress-induced elevation in endogenous corticosterone
19. Determination of metallothionein in tissues by cadmium-hemogiobin affinity assay
20. Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events
21. Regulation of metallothionein gene expression
22. Overexpression of the large subunit of the protein Ku suppresses metallothionein-I induction by heavy metals
23. Analysis of promoter methylation and its role in silencing metallothionein-I gene expression in some tumor cells
24. Transcriptional induction of metallothionein-I and -II genes in the livers of Cu,Zn-superoxide dismutase knockout mice
25. Suppression of metallothionein gene expression in a rat hepatoma because of promoter-specific DNA methylation
26. Thionein induction in response to restraint stress: Transcriptional control, adaptation to stress, and role of glucocorticoid
27. Tissue specific in vitro transcription from the mouse albumin promoter
28. Embryonic lethality and liver degeneration in mice lacking the metal- responsive transcriptional activator MTF-1
29. Metallothionein
30. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
31. Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus
32. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus
33. Kinetics of giucocorticoid response to restraint stress and/or experimental influenza viral infection in two inbred strains of mice. Modulates mononuclear cell trafficking during an experimental influenza viral infection
34. Metallothionein induction by restraint stress: Role of glucocorticoids and IL-6
35. The transcription factor MTF-1 is essential for basal and heavy metal-induced metallothionein gene expression
36. STATs: Signal transducers and activators of transcription
37. Control of zinc transfer between thionein, metallothionein, and zinc proteins
38. Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression
39. The antioxidant function of metallothioneln in the heart
40. Suppression by metallothionein of doxorubicin-induced cardiomyocyte apoptosis through inhibition of p38 mitogen-activated protein kinases
41. Requirement for cooperative interaction of interleukin-6 responsive element type 2 and giucocorticoid responsive element in the synergistic activation of mouse metallothionein-I gene by interleukin-6 and glucocorticoid
42. A murine model of Menkes disease reveals a physiological function of
43. Metallothionein I and II protect against zinc deficiency and zinc
44. A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes
45. Enhanced apoptosis in metallothionein null cells
46. Enhanced sensitivity to oxidative stress in cultured embryonic cells from transgenic mice deficient in metallothionein I and II genes
47. Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression
48. Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I
49. Silencing of metallothionein-I gene in mouse lymphosarcoma cells by methylation
50. Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein
51. The function of zinc metallothionein: A link between cellular zinc and redox state
52. Inhibitory sites in enzymes: Zinc removal and reactivation by thionein
53. Metallothionein in physiological and pathphysiological processes
54. Role of IL-6 in the induction of hepatic metallothionein in mice after partial hepatectomy
55. Constitutive and metalinducible protein: DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting
56. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deflcient mice
57. Oxidants and antioxidants in viral diseases: Disease mechanisms and metabolic regulation
58. Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia
59. Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter
60. Oxygen free radicals and metallothionein
61. Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures
62. Crosstalk between the interleukin-6 (IL-6)-JAK-STAT and the giucocorticoid-nuclear receptor pathway: Synergistic activation of IL-6 response element by IL-6 and glucocorticoid
63. Yeast and mammalian metallothloneins functionally substitute for yeast copper-zinc superoxide dismutase
64. Possible role for metallothionein in protection against radiation-induced oxidative stress: Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals
65. Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation
66. Interferon gamma response region in the promoter of the human DPA gene
67. Zinc metallothionein imported into liver mitochondria modulates respiration
68. STAT3 acts as a coactivator of glucocorticoid receptor signaling