Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells

Journal of Immunology

Volumn 179, Issue 5, 2007, Pages 2741-2747

  Groskreutz, Dayna J ^a   Monick, Martha M ^a   Yarovinsky, Timur O ^a   Powers, Linda S ^a   Quelle, Dawn E ^a   Varga, Steven M ^a   Look, Dwight C ^a   Hunninghake, Gary W ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; NUTLIN 3; PROTEIN P53; IMIDAZOLE DERIVATIVE; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; PIPERAZINE DERIVATIVE; PROTEASOME; PROTEIN KINASE B; PROTEIN MDM2;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; RESPIRATORY EPITHELIUM; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION; CYTOLOGY; DRUG ANTAGONISM; METABOLISM; PHYSIOLOGY; RESPIRATORY SYSTEM; VIROLOGY; VIRUS REPLICATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CELL SURVIVAL; EPITHELIAL CELLS; HUMANS; IMIDAZOLES; INTERLEUKIN-6; PIPERAZINES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MDM2; RESPIRATORY SYNCYTIAL VIRUSES; RESPIRATORY SYSTEM; TUMOR SUPPRESSOR PROTEIN P53; VIRUS REPLICATION;

EID: 38449101569     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.179.5.2741     Document Type: Article

References (47)

1. Eigen, H. 1999. The RSV-asthma link: the emerging story. Introduction. J. Pediatr. 135: 1.
2. Eriksson, M., R. Bennet, and A. Nilsson. 2000. Wheezing following lower respiratory tract infections with respiratory syncytial virus and influenza A in infancy. Pediatr. Allergy Immunol. 11: 193-197.
3. Johnston, S. L., P. K. Pattemore, G. Sanderson, S. Smith, F. Lampe, L. Josephs, P. Symington, S. O'Toole, S. H. Myint, D. A. Tyrrell, et al. 1995. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. Br. Med. J. 310: 1225-1229.
4. Sigurs, N., R. Bjarnason, F. Sigurbergsson, B. Kjellman, and B. Bjorksten. 1995. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: a prospective cohort study with matched controls. Pediatrics 95: 500-505.
5. Smyth, R. L., J. N. Fletcher, H. M. Thomas, C. A. Hart, and P. J. Openshaw. 1999. Respiratory syncytial virus and wheeze. Lancet 354: 1997-1998.
6. Stein, R. T., D. Sherrill, W. J. Morgan, C. J. Holberg, M. Halonen, L. M. Taussig, A. L. Wright, and F. D. Martinez. 1999. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet 354: 541-545.
7. Lemen, R. J. 1995. Respiratory syncytial virus and bronchiolitis. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 36: 78-85.
8. Azevedo, A. M., E. L. Durigon, V. Okasima, D. A. Queiroz, D. de Moraes-Vasconcelos, A. J. Duarte, and A. S. Grumach. 2003. Detection of influenza, parainfluenza, adenovirus and respiratory syncytial virus during asthma attacks in children older than 2 years old. Allergol. Immunopathol. 31: 311-317.
9. Collins, P. L., R. L. Chanock, and B. R. Murphy. 2001. Respiratory syncytial virus. In Fields Virology, 4 ed. D. M. Knipe, and P. M. Howley, eds. Lippincott Williams & Wilkins, Philadelphia, PA. p. 1443.
10. Garofalo, R., M. Sabry, M. Jamaluddin, R. K. Yu, A. Casola, P. L. Ogra, and A. R. Brasier. 1996. Transcriptional activation of the interleukin-8 gene by respiratory syncytial virus infection in alveolar epithelial cells: nuclear translocation of the RelA transcription factor as a mechanism producing airway mucosal inflammation. J. Virol. 70: 8773-8781.
11. Harris, J., and D. Werling. 2003. Binding and entry of respiratory syncytial virus into host cells and initiation of the innate immune response. Cell Microbiol. 5: 671-680.
12. Garofalo, R., F. Mei, R. Espejo, G. Ye, H. Haeberle, S. Baron, P. L. Ogra, and V. E. Reyes. 1996. Respiratory syncytial virus infection of human respiratory epithelial cells up-regulates class I MHC expression through the induction of IFN-β and IL-1α. J. Immunol. 157: 2506-2513.
13. Mastronarde, J. G., B. He, M. M. Monick, N. Mukaida, K. Matsushima, and G. W. Hunninghake. 1996. Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-κB and NF-IL-6. J. Infect. Dis. 174: 262-267.
14. Bitko, V., A. Velazquez, L. Yang, Y. C. Yang, and S. Barik. 1997. Transcriptional induction of multiple cytokines by human respiratory syncytial virus requires activation of NF-κB and is inhibited by sodium salicylate and aspirin. Virology 232: 369-378.
15. Haeberle, H. A., R. Takizawa, A. Casola, A. R. Brasier, H. J. Dieterich, N. Van Rooijen, Z. Gatalica, and R. P. Garofalo. 2002. Respiratory syncytial virus-induced activation of nuclear factor-κB in the lung involves alveolar macrophages and Toll-like receptor 4-dependent pathways. J. Infect. Dis. 186: 1199-1206.
16. Eliyahu, D., D. Michalovitz, S. Eliyahu, O. Pinhasi-Kimhi, and M. Oren. 1989. Wild-type p53 can inhibit oncogene-mediated focus formation. Proc. Natl. Acad. Sci. USA 86: 8763-8767.
17. Finlay, C. A., P. W. Hinds, and A. J. Levine. 1989. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57: 1083-1093.
18. Hainaut, P., T. Soussi, B. Shomer, M. Hollstein, M. Greenblatt, E. Hovig, C. C. Harris, and R. Montesano. 1997. Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res. 25: 151-157.
19. Harris, S. L., and A. J. Levine. 2005. The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
20. Yonish-Rouach, E., D. Resnitzky, J. Lotem, L. Sachs, A. Kimchi, and M. Oren. 1991. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347.
21. Shaw, P., R. Bovey, S. Tardy, R. Sahli, B. Sordat, and J. Costa. 1992. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89: 4495-4499.
22. Mayo, L. D., J. E. Dixon, D. L. Durden, N. K. Tonks, and D. B. Donner. 2002. PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J. Biol. Chem. 277: 5484-5489.
23. Momand, J., G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine. 1992. The Mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69: 1237-1245.
24. Momand, J., H. H. Wu, and G. Dasgupta. 2000. MDM2-master regulator of the p53 tumor suppressor protein. Gene 242: 15-29.
25. Kohn, K. W., and Y. Pommier. 2005. Molecular interaction map of the p53 and Mdm2 logic elements, which control the Off-On switch of p53 in response to DNA damage. Biochem. Biophys. Res. Commun. 331: 816-827.
26. Haupt, Y., R. Maya, A. Kazaz, and M. Oren. 1997. Mdm2 promotes the rapid degradation of p53. Nature 387: 296-299.
27. Zhou, B. P., Y. Liao, W. Xia, Y. Zou, B. Spohn, and M. C. Hung. 2001. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat. Cell Biol. 3: 973-982.
28. Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. Mdm2 expression is induced by wild type p53 activity. EMBO J. 12: 461-468.
29. Wu, X., J. H. Bayle, D. Olson, and A. J. Levine. 1993. The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7: 1126-1132.
30. Mayo, L. D., and D. B. Donner. 2001. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proc. Natl. Acad. Sci. USA 98: 11598-11603.
31. Feng, J., R. Tamaskovic, Z. Yang, D. P. Brazil, A. Merlo, D. Hess, and B. A. Hemmings. 2004. Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation. J. Biol. Chem. 279: 35510-35517.
32. Technau-Ihling, K., C. Ihling, J. Kromeier, and G. Brandner. 2001. Influenza A virus infection of mice induces nuclear accumulation of the tumor suppressor protein p53 in the lung. Arch. Virol. 146: 1655-1666.
33. Turpin, E., K. Luke, J. Jones, T. Tumpey, K. Konan, and S. Schultz-Cherry. 2005. Influenza virus infection increases p53 activity: role of p53 in cell death and viral replication. J. Virol. 79: 8802-8811.
34. Marques, J. T., D. Rebouillat, C. V. Ramana, J. Murakami, J. E. Hill, A. Gudkov, R. H. Silverman, G. R. Stark, and B. R. Williams. 2005. Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J. Virol. 79: 11105-11114.
35. Casavant, N. C., M. H. Luo, K. Rosenke, T. Winegardner, A. Zurawska, and E. A. Fortunato. 2006. Potential role for p53 in the permissive life cycle of human cytomegalovirus. J. Virol. 80: 8390-8401.
36. Pampin, M., Y. Simonin, B. Blondel, Y. Percherancier, and M. K. Chelbi-Alix. 2006. Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense. J. Virol. 80: 8582-8592.
37. Royds, J. A., M. Hibma, B. R. Dix, L. Hananeia, I. A. Russell, A. Wiles, D. Wynford-Thomas, and A. W. Braithwaite. 2006. p53 promotes adenoviral replication and increases late viral gene expression. Oncogene 25: 1509-1520.
38. Boldrini, L., S. Gisfredi, S. Ursino, M. Lucchi, A. Mussi, F. Basolo, R. Pingitore, and G. Fontanini. 2005. Interleukin-8 in non-small cell lung carcinoma: relation with angiogenic pattern and p53 alterations. Lung Cancer 50: 309-317.
39. Johansen, C., E. Flindt, K. Kragballe, J. Henningsen, M. Westergaard, K. Kristiansen, and L. Iversen. 2005. Inverse regulation of the nuclear factor-κB binding to the p53 and interleukin-8 κB response elements in lesional psoriatic skin. J. Invest. Dermatol. 124: 1284-1292.
40. Wang, J., W. Ouyang, J. Li, L. Wei, Q. Ma, Z. Zhang, Q. Tong, J. He, and C. Huang. 2005. Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor B induced by UV radiation. Cancer Res. 65: 6601-6611.
41. Thomas, K. W., M. M. Monick, J. M. Staber, T. Yarovinsky, A. B. Carter, and G. W. Hunninghake. 2002. Respiratory syncytial virus inhibits apoptosis and induces NF-κB activity through a phosphatidylinositol 3-kinase-dependent pathway. J. Biol. Chem. 277: 492-501.
42. Monick, M. M., K. Cameron, J. Staber, L. S. Powers, T. O. Yarovinsky, J. G. Koland, and G. W. Hunninghake. 2005. Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis. J. Biol. Chem. 280: 2147-2158.
43. Aldallal, N., E. E. McNaughton, L. J. Manzel, A. M. Richards, J. Zabner, T. W. Ferkol, and D. C. Look. 2002. Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 166: 1248-1256.
44. Groskreutz, D. J., M. M. Monick, L. S. Powers, T. O. Yarovinsky, D. C. Look, and G. W. Hunninghake. 2006. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J. Immunol. 176: 1733-1740.
45. Rozen, S., and H. Skaletsky. 2000. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 132: 365-386.
46. Vassilev, L. T., B. T. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, N. Kong, U. Kammlott, C. Lukacs, C. Klein, et al. 2004. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303: 844-848.
47. Mastronarde, J. G., M. M. Monick, N. Mukaida, K. Matsushima, and G. W. Hunninghake. 1998. Activator protein-1 is the preferred transcription factor for cooperative interaction with nuclear factor-κB in respiratory syncytial virus-induced interleukin-8 gene expression in airway epithelium. J. Infect. Dis. 177: 1275-1281.