A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 10143-10148

  Choi, Soo Kyung ^a   Yoon, Song Ro ^a   Calabrese, Peter ^a   Arnheim, Norman ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Apert syndrome; Paternal age; Positive selection; Spermatogonia; Testis

Indexed keywords

NUCLEOTIDE;

ACROCEPHALOSYNDACTYLY; ADULT; ARTICLE; DONOR; GENE MUTATION; GENETIC ANALYSIS; GERM CELL; HUMAN; HUMAN TISSUE; MALE; MEIOSIS; MUTATION RATE; PATERNAL AGE; PRIORITY JOURNAL; SPERMATOGONIUM; TESTIS;

ACROCEPHALOSYNDACTYLIA; ADULT; AGE FACTORS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; GERM-LINE MUTATION; HUMANS; MALE; MIDDLE AGED; MODELS, GENETIC; PATERNAL AGE; POINT MUTATION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; SELECTION (GENETICS); SPERMATOGONIA; TESTIS;

LURIA;

EID: 48249134332     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801267105     Document Type: Article

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