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Volumn 7, Issue 8, 2012, Pages

Selfish spermatogonial selection: Evidence from an immunohistochemical screen in testes of elderly men

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 3; PROTEIN KINASE B;

EID: 84864644667     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0042382     Document Type: Article
Times cited : (29)

References (66)
  • 2
    • 0032231407 scopus 로고    scopus 로고
    • Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome
    • Wilkin DJ, Szabo JK, Cameron R, Henderson S, Bellus GA, et al. ((1998)) Mutations in fibroblast growth-factor receptor 3 in sporadic cases of achondroplasia occur exclusively on the paternally derived chromosome. Am J Hum Genet 63:711-716.
    • (1998) Am J Hum Genet , vol.63 , pp. 711-716
    • Wilkin, D.J.1    Szabo, J.K.2    Cameron, R.3    Henderson, S.4    Bellus, G.A.5
  • 4
    • 4143100212 scopus 로고    scopus 로고
    • Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome
    • Tartaglia M, Cordeddu V, Chang H, Shaw A, Kalidas K, et al. ((2004)) Paternal germline origin and sex-ratio distortion in transmission of PTPN11 mutations in Noonan syndrome. Am J Hum Genet 75:492-497.
    • (2004) Am J Hum Genet , vol.75 , pp. 492-497
    • Tartaglia, M.1    Cordeddu, V.2    Chang, H.3    Shaw, A.4    Kalidas, K.5
  • 6
    • 84856922362 scopus 로고    scopus 로고
    • Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease
    • Goriely A, Wilkie AOM, ((2012)) Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease. Am J Hum Genet 90:175-200.
    • (2012) Am J Hum Genet , vol.90 , pp. 175-200
    • Goriely, A.1    Wilkie, A.O.M.2
  • 7
    • 0042490798 scopus 로고    scopus 로고
    • Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line
    • Goriely A, McVean GA, Rojmyr M, Ingemarsson B, Wilkie AOM, ((2003)) Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line. Science 301:643-646.
    • (2003) Science , vol.301 , pp. 643-646
    • Goriely, A.1    McVean, G.A.2    Rojmyr, M.3    Ingemarsson, B.4    Wilkie, A.O.M.5
  • 8
    • 17844393110 scopus 로고    scopus 로고
    • Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
    • Goriely A, McVean GA, van Pelt AM, O'Rourke AW, Wall SA, et al. ((2005)) Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia. Proc Natl Acad Sci U S A 102:6051-6056.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 6051-6056
    • Goriely, A.1    McVean, G.A.2    van Pelt, A.M.3    O'Rourke, A.W.4    Wall, S.A.5
  • 9
    • 68249084502 scopus 로고    scopus 로고
    • The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect
    • Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, et al. ((2009)) The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect. PLoS Genet 5:e1000558.
    • (2009) PLoS Genet , vol.5
    • Yoon, S.R.1    Qin, J.2    Glaser, R.L.3    Jabs, E.W.4    Wexler, N.S.5
  • 10
    • 0037069429 scopus 로고    scopus 로고
    • The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect
    • Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, et al. ((2002)) The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A 99:14952-14957.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14952-14957
    • Tiemann-Boege, I.1    Navidi, W.2    Grewal, R.3    Cohn, D.4    Eskenazi, B.5
  • 11
    • 70350646899 scopus 로고    scopus 로고
    • Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
    • Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, et al. ((2009)) Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 41:1247-1252.
    • (2009) Nat Genet , vol.41 , pp. 1247-1252
    • Goriely, A.1    Hansen, R.M.2    Taylor, I.B.3    Olesen, I.A.4    Jacobsen, G.K.5
  • 12
    • 84872830140 scopus 로고    scopus 로고
    • The effects of advanced paternal age on genetic risks are mediated through dysregulation of HRAS signalling in the testis
    • Montreal, Canada, Abstract 114
    • Goriely A, McGowan SJ, Pfeifer SP, Itani A, McVean GAT, et al. ((2011)) The effects of advanced paternal age on genetic risks are mediated through dysregulation of HRAS signalling in the testis. 12th International Congress of Human Genetics (ICHG2011). Montreal, Canada. 44, abstract 114.
    • (2011) 12th International Congress of Human Genetics (ICHG2011) , pp. 44
    • Goriely, A.1    McGowan, S.J.2    Pfeifer, S.P.3    Itani, A.4    McVean, G.A.T.5
  • 13
    • 14644396631 scopus 로고    scopus 로고
    • Testicular germ-cell tumours in a broader perspective
    • Oosterhuis JW, Looijenga LH, ((2005)) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5:210-222.
    • (2005) Nat Rev Cancer , vol.5 , pp. 210-222
    • Oosterhuis, J.W.1    Looijenga, L.H.2
  • 14
    • 0028029941 scopus 로고
    • Spermatocytic seminoma
    • Eble JN, ((1994)) Spermatocytic seminoma. Hum Pathol 25:1035-1042.
    • (1994) Hum Pathol , vol.25 , pp. 1035-1042
    • Eble, J.N.1
  • 15
    • 79959942259 scopus 로고    scopus 로고
    • OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia
    • Lim J, Goriely A, Turner GD, Ewen KA, Jacobsen GK, et al. ((2011)) OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol 224:473-483.
    • (2011) J Pathol , vol.224 , pp. 473-483
    • Lim, J.1    Goriely, A.2    Turner, G.D.3    Ewen, K.A.4    Jacobsen, G.K.5
  • 16
    • 34547912860 scopus 로고    scopus 로고
    • Recent advances and future directions in research on testicular germ cell cancer
    • Rajpert-De Meyts E, ((2007)) Recent advances and future directions in research on testicular germ cell cancer. Int J Androl 30:192-197.
    • (2007) Int J Androl , vol.30 , pp. 192-197
    • Rajpert-De Meyts, E.1
  • 17
    • 79960869231 scopus 로고    scopus 로고
    • Human spermatogonial stem cells: a possible origin for spermatocytic seminoma
    • Waheeb R, Hofmann MC, ((2011)) Human spermatogonial stem cells: a possible origin for spermatocytic seminoma. Int J Androl 34:e296-305.
    • (2011) Int J Androl , vol.34
    • Waheeb, R.1    Hofmann, M.C.2
  • 18
    • 9344246885 scopus 로고    scopus 로고
    • Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells
    • Kubota H, Avarbock MR, Brinster RL, ((2004)) Growth factors essential for self-renewal and expansion of mouse spermatogonial stem cells. Proc Natl Acad Sci U S A 101:16489-16494.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16489-16494
    • Kubota, H.1    Avarbock, M.R.2    Brinster, R.L.3
  • 19
    • 67649217254 scopus 로고    scopus 로고
    • Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation
    • Lee J, Kanatsu-Shinohara M, Morimoto H, Kazuki Y, Takashima S, et al. ((2009)) Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation. Cell Stem Cell 5:76-86.
    • (2009) Cell Stem Cell , vol.5 , pp. 76-86
    • Lee, J.1    Kanatsu-Shinohara, M.2    Morimoto, H.3    Kazuki, Y.4    Takashima, S.5
  • 21
    • 48249134332 scopus 로고    scopus 로고
    • A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations
    • Choi SK, Yoon SR, Calabrese P, Arnheim N, ((2008)) A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proc Natl Acad Sci U S A 105:10143-10148.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10143-10148
    • Choi, S.K.1    Yoon, S.R.2    Calabrese, P.3    Arnheim, N.4
  • 22
    • 84858441293 scopus 로고    scopus 로고
    • Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B
    • Choi S-K, Yoon S-R, Calabrease P, Arnheim N, ((2012)) Positive Selection for New Disease Mutations in the Human Germline: Evidence from the Heritable Cancer Syndrome Multiple Endocrine Neoplasia Type 2B. PLoS Genetics 8:e1002420.
    • (2012) PLoS Genetics , vol.8
    • Choi, S.-K.1    Yoon, S.-R.2    Calabrease, P.3    Arnheim, N.4
  • 23
    • 33749577195 scopus 로고    scopus 로고
    • Age and sex effects on human mutation rates: an old problem with new complexities
    • Crow JF, ((2006)) Age and sex effects on human mutation rates: an old problem with new complexities. J Radiat Res (Tokyo) 47 Suppl B. pp. B75-82.
    • (2006) J Radiat Res (Tokyo) , vol.47 , Issue.SUPPL. B
    • Crow, J.F.1
  • 24
    • 44349168757 scopus 로고    scopus 로고
    • Increased achondroplasia mutation frequency with advanced age and evidence for G1138A mosaicism in human testis biopsies
    • Dakouane Giudicelli M, Serazin V, Le Sciellour CR, Albert M, Selva J, et al. ((2008)) Increased achondroplasia mutation frequency with advanced age and evidence for G1138A mosaicism in human testis biopsies. Fertil Steril 89:1651-1656.
    • (2008) Fertil Steril , vol.89 , pp. 1651-1656
    • Dakouane Giudicelli, M.1    Serazin, V.2    Le Sciellour, C.R.3    Albert, M.4    Selva, J.5
  • 25
    • 84899055960 scopus 로고    scopus 로고
    • Testes and epididymes
    • Glass J, ((2005)) Testes and epididymes. In: Standring S, editor. Gray's Anatomy: The anatomical basis of clinical practice (39th ed.). Edinburgh: Elsevier Churchill Livingston. pp. 1304-1310.
    • (2005) , pp. 1304-1310
    • Glass, J.1    Standring, S.2
  • 26
    • 75449141332 scopus 로고
    • The cycle of the seminiferous epithelium in man
    • Clermont Y, ((1963)) The cycle of the seminiferous epithelium in man. Am J Anat 112:35-51.
    • (1963) Am J Anat , vol.112 , pp. 35-51
    • Clermont, Y.1
  • 27
    • 52949135494 scopus 로고    scopus 로고
    • The cycle of the seminiferous epithelium in humans: a need to revisit?
    • Amann RP, ((2008)) The cycle of the seminiferous epithelium in humans: a need to revisit? J Androl 29:469-487.
    • (2008) J Androl , vol.29 , pp. 469-487
    • Amann, R.P.1
  • 28
    • 0021344892 scopus 로고
    • Dislocated type-A spermatogonia in human seminiferous tubules
    • Holstein AF, Bustos-Obregon E, Hartmann M, ((1984)) Dislocated type-A spermatogonia in human seminiferous tubules. Cell Tissue Res 236:35-40.
    • (1984) Cell Tissue Res , vol.236 , pp. 35-40
    • Holstein, A.F.1    Bustos-Obregon, E.2    Hartmann, M.3
  • 29
    • 0024596666 scopus 로고
    • Pattern of compartmentation in human seminiferous tubules showing dislocation of spermatogonia
    • Bergmann M, Nashan D, Nieschlag E, ((1989)) Pattern of compartmentation in human seminiferous tubules showing dislocation of spermatogonia. Cell Tissue Res 256:183-190.
    • (1989) Cell Tissue Res , vol.256 , pp. 183-190
    • Bergmann, M.1    Nashan, D.2    Nieschlag, E.3
  • 30
    • 0020288345 scopus 로고
    • On the morphology of the transitional zone of the seminiferous tubule and the rete testis in man
    • Lindner SG, ((1982)) On the morphology of the transitional zone of the seminiferous tubule and the rete testis in man. Andrologia 14:352-362.
    • (1982) Andrologia , vol.14 , pp. 352-362
    • Lindner, S.G.1
  • 31
    • 79953150209 scopus 로고    scopus 로고
    • Histological and ultrastructural analysis of the seminiferous tubule wall in ageing testis
    • Pop OT, Cotoi CG, Plesea IE, Gherghiceanu M, Enache SD, et al. ((2011)) Histological and ultrastructural analysis of the seminiferous tubule wall in ageing testis. Rom J Morphol Embryol 52:241-248.
    • (2011) Rom J Morphol Embryol , vol.52 , pp. 241-248
    • Pop, O.T.1    Cotoi, C.G.2    Plesea, I.E.3    Gherghiceanu, M.4    Enache, S.D.5
  • 32
    • 52949140829 scopus 로고    scopus 로고
    • Study of spermatogenesis and thickening of lamina propria in the human seminiferous tubules
    • Sato Y, Nozawa S, Iwamoto T, ((2008)) Study of spermatogenesis and thickening of lamina propria in the human seminiferous tubules. Fertil Steril 90:1310-1312.
    • (2008) Fertil Steril , vol.90 , pp. 1310-1312
    • Sato, Y.1    Nozawa, S.2    Iwamoto, T.3
  • 33
    • 0023216997 scopus 로고
    • The spermatocytic seminoma: views on pathogenesis
    • Muller J, Skakkebaek NE, Parkinson MC, ((1987)) The spermatocytic seminoma: views on pathogenesis. Int J Androl 10:147-156.
    • (1987) Int J Androl , vol.10 , pp. 147-156
    • Muller, J.1    Skakkebaek, N.E.2    Parkinson, M.C.3
  • 34
    • 0022849935 scopus 로고
    • Spermatogenesis and aging in the human
    • Johnson L, ((1986)) Spermatogenesis and aging in the human. J Androl 7:331-354.
    • (1986) J Androl , vol.7 , pp. 331-354
    • Johnson, L.1
  • 35
    • 0023124372 scopus 로고
    • Decrease in the number of human Ap and Ad spermatogonia and in the Ap/Ad ratio with advancing age. New data on the spermatogonial stem cell
    • Nistal M, Codesal J, Paniagua R, Santamaria L, ((1987)) Decrease in the number of human Ap and Ad spermatogonia and in the Ap/Ad ratio with advancing age. New data on the spermatogonial stem cell. J Androl 8:64-68.
    • (1987) J Androl , vol.8 , pp. 64-68
    • Nistal, M.1    Codesal, J.2    Paniagua, R.3    Santamaria, L.4
  • 37
  • 38
    • 0014893015 scopus 로고
    • Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males
    • Johnsen SG, ((1970)) Testicular biopsy score count-a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. Hormones 1:2-25.
    • (1970) Hormones , vol.1 , pp. 2-25
    • Johnsen, S.G.1
  • 39
    • 0024847727 scopus 로고
    • Objective measurement of testicular volume by ultrasonography: evaluation of the technique and comparison with orchidometer estimates
    • Behre HM, Nashan D, Nieschlag E, ((1989)) Objective measurement of testicular volume by ultrasonography: evaluation of the technique and comparison with orchidometer estimates. Int J Androl 12:395-403.
    • (1989) Int J Androl , vol.12 , pp. 395-403
    • Behre, H.M.1    Nashan, D.2    Nieschlag, E.3
  • 40
    • 0026110478 scopus 로고
    • Testicular biopsy and scrotal exploration in the management of male infertility
    • Tan KH, Lim PH, ((1991)) Testicular biopsy and scrotal exploration in the management of male infertility. Singapore Med J 32:41-46.
    • (1991) Singapore Med J , vol.32 , pp. 41-46
    • Tan, K.H.1    Lim, P.H.2
  • 41
    • 33845665444 scopus 로고    scopus 로고
    • Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: Mini Review
    • McLachlan RI, Rajpert-De Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE, ((2007)) Histological evaluation of the human testis-approaches to optimizing the clinical value of the assessment: Mini Review. Hum Reprod 22:2-16.
    • (2007) Hum Reprod , vol.22 , pp. 2-16
    • McLachlan, R.I.1    Rajpert-De Meyts, E.2    Hoei-Hansen, C.E.3    de Kretser, D.M.4    Skakkebaek, N.E.5
  • 42
    • 38949169584 scopus 로고    scopus 로고
    • European Consensus Conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I
    • Krege S, Beyer J, Souchon R, Albers P, Albrecht W, et al. ((2008)) European Consensus Conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus group (EGCCCG): Part I. Eur Urol. 53:478-496.
    • (2008) Eur Urol , vol.53 , pp. 478-496
    • Krege, S.1    Beyer, J.2    Souchon, R.3    Albers, P.4    Albrecht, W.5
  • 43
    • 34250658833 scopus 로고    scopus 로고
    • Akt mediates self-renewal division of mouse spermatogonial stem cells
    • Lee J, Kanatsu-Shinohara M, Inoue K, Ogonuki N, Miki H, et al. ((2007)) Akt mediates self-renewal division of mouse spermatogonial stem cells. Development 134:1853-1859.
    • (2007) Development , vol.134 , pp. 1853-1859
    • Lee, J.1    Kanatsu-Shinohara, M.2    Inoue, K.3    Ogonuki, N.4    Miki, H.5
  • 45
    • 84860508756 scopus 로고    scopus 로고
    • Identification and Regulation of a Stage-Specific Stem Cell Niche Enriched by Nanog Positive Spermatogonial Stem Cells in the Mouse Testis
    • Ventela ST, Makela JA, Kulmala J, Westermarck J, Toppari J, ((2012)) Identification and Regulation of a Stage-Specific Stem Cell Niche Enriched by Nanog Positive Spermatogonial Stem Cells in the Mouse Testis. Stem Cells.
    • (2012) Stem Cells
    • Ventela, S.T.1    Makela, J.A.2    Kulmala, J.3    Westermarck, J.4    Toppari, J.5
  • 46
    • 0030031515 scopus 로고    scopus 로고
    • Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes
    • Ren ZP, Hedrum A, Ponten F, Nister M, Ahmadian A, et al. ((1996)) Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes. Oncogene 12:765-773.
    • (1996) Oncogene , vol.12 , pp. 765-773
    • Ren, Z.P.1    Hedrum, A.2    Ponten, F.3    Nister, M.4    Ahmadian, A.5
  • 47
    • 0031000631 scopus 로고    scopus 로고
    • Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin
    • Ren ZP, Ahmadian A, Ponten F, Nister M, Berg C, et al. ((1997)) Benign clonal keratinocyte patches with p53 mutations show no genetic link to synchronous squamous cell precancer or cancer in human skin. Am J Pathol 150:1791-1803.
    • (1997) Am J Pathol , vol.150 , pp. 1791-1803
    • Ren, Z.P.1    Ahmadian, A.2    Ponten, F.3    Nister, M.4    Berg, C.5
  • 48
    • 76649128993 scopus 로고    scopus 로고
    • Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
    • Park SY, Gonen M, Kim HJ, Michor F, Polyak K, ((2010)) Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest 120:636-644.
    • (2010) J Clin Invest , vol.120 , pp. 636-644
    • Park, S.Y.1    Gonen, M.2    Kim, H.J.3    Michor, F.4    Polyak, K.5
  • 49
    • 22044440001 scopus 로고    scopus 로고
    • Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma
    • Chang H, Stewart AK, Qi XY, Li ZH, Yi QL, et al. ((2005)) Immunohistochemistry accurately predicts FGFR3 aberrant expression and t(4;14) in multiple myeloma. Blood 106:353-355.
    • (2005) Blood , vol.106 , pp. 353-355
    • Chang, H.1    Stewart, A.K.2    Qi, X.Y.3    Li, Z.H.4    Yi, Q.L.5
  • 50
    • 34548407864 scopus 로고    scopus 로고
    • FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer
    • Tomlinson DC, Baldo O, Harnden P, Knowles MA, ((2007)) FGFR3 protein expression and its relationship to mutation status and prognostic variables in bladder cancer. J Pathol 213:91-98.
    • (2007) J Pathol , vol.213 , pp. 91-98
    • Tomlinson, D.C.1    Baldo, O.2    Harnden, P.3    Knowles, M.A.4
  • 51
    • 55849140517 scopus 로고    scopus 로고
    • Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening
    • Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, et al. ((2008)) Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiol Biomarkers Prev 17:3208-3215.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 3208-3215
    • Poynter, J.N.1    Siegmund, K.D.2    Weisenberger, D.J.3    Long, T.I.4    Thibodeau, S.N.5
  • 52
    • 78650390294 scopus 로고    scopus 로고
    • Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin
    • Marcar L, Maclaine NJ, Hupp TR, Meek DW, ((2010)) Mage-A cancer/testis antigens inhibit p53 function by blocking its interaction with chromatin. Cancer Res 70:10362-10370.
    • (2010) Cancer Res , vol.70 , pp. 10362-10370
    • Marcar, L.1    Maclaine, N.J.2    Hupp, T.R.3    Meek, D.W.4
  • 53
    • 77952066111 scopus 로고    scopus 로고
    • Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer
    • Zhu X, Asa SL, Ezzat S, ((2010)) Genetic and epigenetic mechanisms down-regulate FGF receptor 2 to induce melanoma-associated antigen A in breast cancer. Am J Pathol 176:2333-2343.
    • (2010) Am J Pathol , vol.176 , pp. 2333-2343
    • Zhu, X.1    Asa, S.L.2    Ezzat, S.3
  • 54
    • 0034062277 scopus 로고    scopus 로고
    • Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family
    • Rimoldi D, Salvi S, Schultz-Thater E, Spagnoli GC, Cerottini JC, ((2000)) Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family. Int J Cancer 86:749-751.
    • (2000) Int J Cancer , vol.86 , pp. 749-751
    • Rimoldi, D.1    Salvi, S.2    Schultz-Thater, E.3    Spagnoli, G.C.4    Cerottini, J.C.5
  • 55
    • 42249103255 scopus 로고    scopus 로고
    • Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis
    • Martinez-Torrecuadrada JL, Cheung LH, Lopez-Serra P, Barderas R, Canamero M, et al. ((2008)) Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Mol Cancer Ther 7:862-873.
    • (2008) Mol Cancer Ther , vol.7 , pp. 862-873
    • Martinez-Torrecuadrada, J.L.1    Cheung, L.H.2    Lopez-Serra, P.3    Barderas, R.4    Canamero, M.5
  • 56
    • 32244441965 scopus 로고    scopus 로고
    • The expression of fibroblast growth factors and their receptors in Hodgkin's lymphoma
    • Khnykin D, Troen G, Berner JM, Delabie J, ((2006)) The expression of fibroblast growth factors and their receptors in Hodgkin's lymphoma. J Pathol 208:431-438.
    • (2006) J Pathol , vol.208 , pp. 431-438
    • Khnykin, D.1    Troen, G.2    Berner, J.M.3    Delabie, J.4
  • 57
    • 0029559922 scopus 로고
    • Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus
    • Johnston CL, Cox HC, Gomm JJ, Coombes RC, ((1995)) Fibroblast growth factor receptors (FGFRs) localize in different cellular compartments. A splice variant of FGFR-3 localizes to the nucleus. J Biol Chem 270:30643-30650.
    • (1995) J Biol Chem , vol.270 , pp. 30643-30650
    • Johnston, C.L.1    Cox, H.C.2    Gomm, J.J.3    Coombes, R.C.4
  • 58
    • 15444379488 scopus 로고    scopus 로고
    • Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death
    • Tan PH, Bay BH, Yip G, Selvarajan S, Tan P, et al. ((2005)) Immunohistochemical detection of Ki67 in breast cancer correlates with transcriptional regulation of genes related to apoptosis and cell death. Mod Pathol 18:374-381.
    • (2005) Mod Pathol , vol.18 , pp. 374-381
    • Tan, P.H.1    Bay, B.H.2    Yip, G.3    Selvarajan, S.4    Tan, P.5
  • 59
    • 0021212003 scopus 로고
    • Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67
    • Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, et al. ((1984)) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715.
    • (1984) J Immunol , vol.133 , pp. 1710-1715
    • Gerdes, J.1    Lemke, H.2    Baisch, H.3    Wacker, H.H.4    Schwab, U.5
  • 60
    • 0034659682 scopus 로고    scopus 로고
    • Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4
    • Landry C, Brasseur F, Spagnoli GC, Marbaix E, Boon T, et al. ((2000)) Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4. Int J Cancer 86:835-841.
    • (2000) Int J Cancer , vol.86 , pp. 835-841
    • Landry, C.1    Brasseur, F.2    Spagnoli, G.C.3    Marbaix, E.4    Boon, T.5
  • 61
    • 0035576197 scopus 로고    scopus 로고
    • MAGE-A4, a germ cell specific marker, is expressed differentially in testicular tumors
    • Aubry F, Satie AP, Rioux-Leclercq N, Rajpert-De Meyts E, Spagnoli GC, et al. ((2001)) MAGE-A4, a germ cell specific marker, is expressed differentially in testicular tumors. Cancer 92:2778-2785.
    • (2001) Cancer , vol.92 , pp. 2778-2785
    • Aubry, F.1    Satie, A.P.2    Rioux-Leclercq, N.3    Rajpert-De Meyts, E.4    Spagnoli, G.C.5
  • 62
    • 71949101970 scopus 로고    scopus 로고
    • Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer
    • Al-Saad S, Donnem T, Al-Shibli K, Persson M, Bremnes RM, et al. ((2009)) Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Anticancer Res 29:4175-4183.
    • (2009) Anticancer Res , vol.29 , pp. 4175-4183
    • Al-Saad, S.1    Donnem, T.2    Al-Shibli, K.3    Persson, M.4    Bremnes, R.M.5
  • 63
    • 42149176654 scopus 로고    scopus 로고
    • AKT signaling promotes derivation of embryonic germ cells from primordial germ cells
    • Kimura T, Tomooka M, Yamano N, Murayama K, Matoba S, et al. ((2008)) AKT signaling promotes derivation of embryonic germ cells from primordial germ cells. Development 135:869-879.
    • (2008) Development , vol.135 , pp. 869-879
    • Kimura, T.1    Tomooka, M.2    Yamano, N.3    Murayama, K.4    Matoba, S.5
  • 64
    • 63549133332 scopus 로고    scopus 로고
    • EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab
    • Gori S, Sidoni A, Colozza M, Ferri I, Mameli MG, et al. ((2009)) EGFR, pMAPK, pAkt and PTEN status by immunohistochemistry: correlation with clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. Ann Oncol 20:648-654.
    • (2009) Ann Oncol , vol.20 , pp. 648-654
    • Gori, S.1    Sidoni, A.2    Colozza, M.3    Ferri, I.4    Mameli, M.G.5
  • 65
    • 17044445366 scopus 로고    scopus 로고
    • Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines
    • dos Santos NR, Torensma R, de Vries TJ, Schreurs MW, de Bruijn DR, et al. ((2000)) Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. Cancer Res 60:1654-1662.
    • (2000) Cancer Res , vol.60 , pp. 1654-1662
    • dos Santos, N.R.1    Torensma, R.2    de Vries, T.J.3    Schreurs, M.W.4    de Bruijn, D.R.5
  • 66
    • 0034932719 scopus 로고    scopus 로고
    • Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications
    • Stoop H, van Gurp R, de Krijger R, Geurts van Kessel A, Koberle B, et al. ((2001)) Reactivity of germ cell maturation stage-specific markers in spermatocytic seminoma: diagnostic and etiological implications. Lab Invest 81:919-928.
    • (2001) Lab Invest , vol.81 , pp. 919-928
    • Stoop, H.1    van Gurp, R.2    de Krijger, R.3    Geurts van Kessel, A.4    Koberle, B.5


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