The preparation and evaluation of water-soluble SKLB610 nanosuspensions with improved bioavailability

AAPS PharmSciTech

Volumn 14, Issue 3, 2013, Pages 1236-1243

  Huang, Yunchuang ^a   Luo, Xun ^a   You, Xinyu ^b   Xia, Yong ^a   Song, Xuejiao ^a   Yu, Luoting ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

bioavailability; dissolution; media milling; nanosuspension; SKLB610

Indexed keywords

ANTINEOPLASTIC AGENT; N METHYL 4 [4 [3 (TRIFLUOROMETHYL)BENZAMIDO]PHENOXY]PICOLINAMIDE; PICOLINAMIDE; POLYMER; SKLB 610; STABILIZING AGENT; SURFACTANT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; ATOMIC FORCE MICROSCOPY; CONTROLLED STUDY; DISPERSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG HALF LIFE; DRUG MANUFACTURE; DRUG SOLUBILITY; FREEZE DRYING; MALE; MAXIMUM PLASMA CONCENTRATION; NANOPHARMACEUTICS; NANOSUSPENSION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SCREENING; SUSPENSION; THERMOGRAVIMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY; WET MEDIUM MILLING; X RAY POWDER DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; BIOLOGICAL AVAILABILITY; MALE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; PICOLINIC ACIDS; POWDER DIFFRACTION; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 84890238821     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0005-7     Document Type: Article

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