Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin g form of the glycan-recognizing antibody 2G12

Cell Reports

Volumn 5, Issue 5, 2013, Pages 1443-1455

  Wu, Yunji ^a   West, AnthonyP ^a   Kim, HelenJ ^b   Thornton, MatthewE ^a,d   Ward, AndrewB ^b   Bjorkman, PamelaJ ^a,c  

^a California Institute of Technology   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY 2G12; MONOMER;

ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; ELECTRON MICROSCOPY; EMBRYO; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; VIRUS NEUTRALIZATION; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MOLECULAR SEQUENCE DATA;

EID: 84890222476     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.11.015     Document Type: Article

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