Human giant congenital melanocytic nevus exhibits potential proteomic alterations leading to melanotumorigenesis

Proteome Science

Volumn 10, Issue 1, 2012, Pages

  Kim, Hyoung Kyu ^a   Kim, Yong Kyu ^b   Song, In Sung ^a   Lee, Sung Ryul ^a   Jeong, Seung Hun ^a   Kim, Min Hee ^a   Seo, Dae Yun ^a   Kim, Nari ^a   Rhee, Byoung Doo ^a   Ko, Kyoung Soo ^a   Tark, Kwan Chul ^c   Park, Chul Gyoo ^d   Cho, Je Yoel ^e   Han, Jin ^a  

^a Inje University College of Medicine   (South Korea)

^b Apgujung YK Plastic Surgery Center   (South Korea)

^c Yonsei University   (South Korea)

^d National Medical Center   (South Korea)

^e Seoul National University   (South Korea)

Author keywords

14 3 3 epsilon; 14 3 3 tau; Giant congenital melanocytic nevi; Melanotumorigenesis; Proteomics; Systemic analysis

Indexed keywords

NEUROTROPHIN; PROHIBITIN; PROTEIN 14 3 3;

ADOLESCENT; ADULT; ARTICLE; BIOINFORMATICS; BREAST CANCER; CELL FUNCTION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ESTROGEN RECEPTOR NEGATIVE BREAST CANCER; FEMALE; GIANT CONGENITAL MELANOCYTIC NEVUS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MALE; MELANOCYTIC NEVUS; MELANOSOME; MELANOTUMORIGENESIS; PRESCHOOL CHILD; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MODIFICATION; PROTEOMICS; SCHOOL CHILD; SKIN CARCINOGENESIS; TANDEM MASS SPECTROMETRY; UPREGULATION; WESTERN BLOTTING;

EID: 84865052493     PISSN: None     EISSN: 14775956     Source Type: Journal    
DOI: 10.1186/1477-5956-10-50     Document Type: Article

References (47)

1. Rhodes AR, Albert LS, Weinstock MA. Congenital nevomelanocytic nevi: proportionate area expansion during infancy and early childhood. J Am Acad Dermatol 1996, 34:51-62. 10.1016/S0190-9622(96)90834-8, 8543695.
2. Cramer SF. The melanocytic differentiation pathway in congenital melanocytic nevi: theoretical considerations. Pediatr Pathol 1988, 8:253-265. 10.3109/15513818809042969, 3174507.
3. Brooks C, Scope A, Braun RP, Marghoob AA. Dermoscopy of nevi and melanoma in childhood. Expet Rev Dermatol 2011, 6:19-34.
4. Marghoob AA, Schoenbach SP, Kopf AW, Orlow SJ, Nossa R, Bart RS. Large congenital melanocytic nevi and the risk for the development of malignant melanoma. A prospective study. Arch Dermatol 1996, 132:170-175. 10.1001/archderm.1996.03890260072011, 8629825.
5. Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol 2006, 155:1-8.
6. Pollock PM, Harper UL, Hansen KS, Yudt LM, Stark M, Robbins CM, Moses TY, Hostetter G, Wagner U, Kakareka J, et al. High frequency of BRAF mutations in nevi. Nat Genet 2003, 33:19-20. 10.1038/ng1054, 12447372.
7. Bauer J, Curtin JA, Pinkel D, Bastian BC. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J Invest Dermatol 2007, 127:179-182. 10.1038/sj.jid.5700490, 16888631.
8. Stefanaki C, Antoniou C, Stefanaki K, Petrikos G, Argyrakos T, Constantinidou CV, Karentzou O, Stratigos A, Katsambas A. Bcl-2 and Bax in congenital naevi. Br J Dermatol 2006, 154:1175-1179. 10.1111/j.1365-2133.2006.07177.x, 16704651.
9. Bartenjev I, Rudolf Z, Stabuc B, Vrhovec I, Perkovic T, Kansky A. Cathepsin D expression in early cutaneous malignant melanoma. Int J Dermatol 2000, 39:599-602. 10.1046/j.1365-4362.2000.00025.x, 10971728.
10. Podhajcer OL, Bover L, Bravo AI, Ledda MF, Kairiyama C, Calb I, Guerra L, Capony F, Mordoh J. Expression of cathepsin D in primary and metastatic human melanoma and dysplastic nevi. J Invest Dermatol 1995, 104:340-344. 10.1111/1523-1747.ep12665371, 7860998.
11. Ni-Komatsu L, Orlow SJ. Identification of Novel Pigmentation Modulators by Chemical Genetic Screening. J Invest Dermatol 2007, 127:1585-1592. 10.1038/sj.jid.5700852, 17568802.
12. Huang SK, Darfler MM, Nicholl MB, You J, Bemis KG, Tegeler TJ, Wang M, Wery J-P, Chong KK, Nguyen L, et al. LC/MS-Based quantitative proteomic analysis of paraffin-embedded archival melanomas reveals potential proteomic biomarkers associated with metastasis. PLoS One 2009, 4:e4430. 10.1371/journal.pone.0004430, 2637971, 19221597.
13. Wang X, Wang Y, Yu L, Sakakura K, Visus C, Schwab JH, Ferrone CR, Favoino E, Koya Y, Campoli MR, et al. CSPG4 in cancer: multiple roles. Curr Mol Med 2010, 10:419-429. 10.2174/156652410791316977, 20455858.
14. Schuierer MM, Bataille F, Hagan S, Kolch W, Bosserhoff AK. Reduction in Raf kinase inhibitor protein expression is associated with increased Ras-extracellular signal-regulated kinase signaling in melanoma cell lines. Cancer Res 2004, 64:5186-5192. 10.1158/0008-5472.CAN-03-3861, 15289323.
15. Givant-Horwitz V, Davidson B, Reich R. Laminin-induced signaling in tumor cells: the role of the M(r) 67,000 laminin receptor. Cancer Res 2004, 64:3572-3579. 10.1158/0008-5472.CAN-03-3424, 15150114.
16. Han MJ, Wang H, Beer LA, Tang HY, Herlyn M, Speicher DW. A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling. Proteomics 2010, 10:4450-4462. 10.1002/pmic.200900549, 3070844, 21136598.
17. Marchetti D, McQuillan DJ, Spohn WC, Carson DD, Nicolson GL. Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res 1996, 56:2856-2863.
18. Marchetti D, Nicolson GL. Human melanoma cell invasion: selected neurotrophin enhancement of invasion and heparanase activity. J Investig Dermatol Symp Proc 1997, 2:99-105.
19. Bruning A, Juckstock J, Blankenstein T, Makovitzky J, Kunze S, Mylonas I. The metastasis-associated gene MTA3 is downregulated in advanced endometrioid adenocarcinomas. Histol Histopathol 2010, 25:1447-1456.
20. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000, 100:57-70. 10.1016/S0092-8674(00)81683-9, 10647931.
21. Garber K. Energy boost: The Warburg effect returns in a new theory of cancer. J Natl Cancer Inst 2004, 96:1805-1806. 10.1093/jnci/96.24.1805, 15601632.
22. Kanehisa M, Limviphuvadh V, Tanabe M. Knowledge-Based Analysis of Protein Interaction Networks in Neurodegenerative Diseases 2010,
23. Wang KJ, Wang RT, Zhang JZ. Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma. World J Gastroenterol 2004, 10:2179-2183.
24. Srisomsap C, Subhasitanont P, Otto A, Mueller EC, Punyarit P, Wittmann-Liebold B, Svasti J. Detection of cathepsin B up-regulation in neoplastic thyroid tissues by proteomic analysis. Proteomics 2002, 2:706-712. 10.1002/1615-9861(200206)2:6<706::AID-PROT706>3.0.CO;2-E, 12112852.
25. Seow TK, Ong SE, Liang RC, Ren EC, Chan L, Ou K, Chung MC. Two-dimensional electrophoresis map of the human hepatocellular carcinoma cell line, HCC-M, and identification of the separated proteins by mass spectrometry. Electrophoresis 2000, 21:1787-1813. 10.1002/(SICI)1522-2683(20000501)21:9<1787::AID-ELPS1787>3.0.CO;2-A, 10870966.
26. Takahashi Y. The 14-3-3 proteins: gene, gene expression, and function. Neurochem Res 2003, 28:1265-1273. 10.1023/A:1024296932670, 12834267.
27. Vakifahmetoglu H, Olsson M, Tamm C, Heidari N, Orrenius S, Zhivotovsky B. DNA damage induces two distinct modes of cell death in ovarian carcinomas. Cell Death Differ 2008, 15:555-566. 10.1038/sj.cdd.4402286, 18064041.
28. Guweidhi A, Kleeff J, Giese N, El Fitori J, Ketterer K, Giese T, Buchler M, Korc M, Friess H. Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis. Carcinogenesis 2004, 25:1575-1585. 10.1093/carcin/bgh159, 15073049.
29. Ito Y, Miyoshi E, Uda E, Yoshida H, Uruno T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Matsuura N, et al. 14-3-3 sigma possibly plays a constitutive role in papillary carcinoma, but not in follicular tumor of the thyroid. Cancer Lett 2003, 200:161-166. 10.1016/S0304-3835(03)00282-9, 14568170.
30. Ferguson A, Evron E, Umbricht C, Pandita T, Chan T, Hermeking H, Marks J, Lambers A, Futreal P, Stampfer M, Sukumar S. High frequency of hypermethylation at the 14-3-3sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci USA 2000, 97:6049-6054. 10.1073/pnas.100566997, 18556, 10811911.
31. Wang B, Liu K, Lin F-T, Lin W-C. A Role for 14-3-3τ in E2F1 Stabilization and DNA Damage-induced Apoptosis. J Biol Chem 2004, 279:54140-54152. 10.1074/jbc.M410493200, 15494392.
32. Lau JMC, Jin X, Ren J, Avery J, DeBosch BJ, Treskov I, Lupu TS, Kovacs A, Weinheimer C, Muslin AJ. The 14-3-3τ Phosphoserine-binding protein is required for cardiomyocyte survival. Mol Cell Biol 2007, 27:1455-1466. 10.1128/MCB.01369-06, 1800730, 17145769.
33. Wang B, Liu K, Lin H-Y, Bellam N, Ling S, Lin W-C. 14-3-3τ Regulates Ubiquitin-Independent Proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol 2010, 30:1508-1527. 10.1128/MCB.01335-09, 2832502, 20086099.
34. Su TT, Parry DH, Donahoe B, Chien CT, O'Farrell PH, Purdy A. Cell cycle roles for two 14-3-3 proteins during Drosophila development. J Cell Sci 2001, 114:3445-3454. 2754241, 11682604.
35. Toyo-oka K, Shionoya A, Gambello MJ, Cardoso C, Leventer R, Ward HL, Ayala R, Tsai LH, Dobyns W, Ledbetter D, et al. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet 2003, 34:274-285. 10.1038/ng1169, 12796778.
36. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol 2002, 156:817-828. 10.1083/jcb.200112059, 2173313, 11864996.
37. Zuo S, Xue Y, Tang S, Yao J, Du R, Yang P, Chen X. 14-3-3 Epsilon Dynamically Interacts with Key Components of Mitogen-Activated Protein Kinase Signal Module for Selective Modulation of the TNF-α-Induced Time Course-Dependent NF-κB Activity. J Proteome Res 2010, 9:3465-3478. 10.1021/pr9011377, 20462248.
38. Liang S, Xu Y, Shen G, Liu Q, Zhao X, Xu Z, Xie X, Gong F, Li R, Wei Y. Quantitative protein expression profiling of 14-3-3 isoforms in human renal carcinoma shows 14-3-3 epsilon is involved in limitedly increasing renal cell proliferation. Electrophoresis 2009, 30:4152-4162. 10.1002/elps.200900249, 19960480.
39. Liu Y, Tian RF, Li YM, Liu WP, Cao L, Yang XL, Cao WD, Zhang X. The expression of seven 14-3-3 isoforms in human meningioma. Brain Res 2010, 1336:98-102.
40. Che XH, Chen H, Xu ZM, Shang C, Sun KL, Fu WN. 14-3-3epsilon contributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion. BMC Cancer 2010, 10:306. 10.1186/1471-2407-10-306, 2904731, 20565895.
41. Choi K-C, Lee S, Kwak SY, Kim M-S, Choi HK, Kim KH, Chung JH, Park SH. Increased expression of 14-3-3 [var epsilon] protein in intrinsically aged and photoaged human skin in vivo. Mech Ageing Dev 2005, 126:629-636. 10.1016/j.mad.2004.11.013, 15888315.
42. Park HJ, Kim BG, Lee SJ, Heo SH, Kim JY, Kwon TH, Lee EB, Ryoo HM, Cho JY. Proteomic profiling of endothelial cells in human lung cancer. J Proteome Res 2008, 7:1138-1150. 10.1021/pr7007237, 18220333.
43. Narayanasamy A, Ahn JM, Sung HJ, Kong DH, Ha KS, Lee SY, Cho JY. Fucosylated glycoproteomic approach to identify a complement component 9 associated with squamous cell lung cancer (SQLC). J Proteomics 2011, 74:2948-2958. 10.1016/j.jprot.2011.07.019, 21840429.
44. Jensen LJ, Kuhn M, Stark M, Chaffron S, Creevey C, Muller J, Doerks T, Julien P, Roth A, Simonovic M, et al. STRING 8--a global view on proteins and their functional interactions in 630 organisms. Nucleic Acids Res 2009, 37:D412-D416. 10.1093/nar/gkn760, 2686466, 18940858.
45. Mi H, Dong Q, Muruganujan A, Gaudet P, Lewis S, Thomas PD. PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium. Nucl Acids Res 2010, 38:D204-D210. 10.1093/nar/gkp1019, 2808919, 20015972.
46. Tatusov RL, Fedorova ND, Jackson JD, Jacobs AR, Kiryutin B, Koonin EV, Krylov DM, Mazumder R, Mekhedov SL, Nikolskaya AN, et al. The COG database: an updated version includes eukaryotes. BMC Bioinformatics 2003, 4:41. 10.1186/1471-2105-4-41, 222959, 12969510.
47. Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman W-H, Pages F, Trajanoski Z, Galon J. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics 2009, 25:1091-1093. 10.1093/bioinformatics/btp101, 2666812, 19237447.