5′-Triphosphate-siRNA activates RIG-I-dependent type i interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells

European Journal of Pharmacology

Volumn 721, Issue 1-3, 2013, Pages 86-95

  Chen, Xiaojuan ^a   Qian, Yuanyu ^b   Yan, Fei ^a   Tu, Jian ^c   Yang, Xingxing ^a   Xing, Yaling ^a   Chen, Zhongbin ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

^c MACQUARIE UNIVERSITY   (Australia)

Author keywords

5 Triphosphated siRNA; Hepatitis B virus; HepG2.2.15 cells; IFN ; RNAi

Indexed keywords

5' TRIPHOSPHATE; BETA INTERFERON; HEPATITIS B ANTIGEN; HEPATITIS B(E) ANTIGEN; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS DNA; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; HEPATITIS B SURFACE ANTIGEN; INTERFERON; MESSENGER RNA; POLYPHOSPHATE; TOLL LIKE RECEPTOR; TRIPHOSPHORIC ACID;

5' UNTRANSLATED REGION; ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HEPATITIS B; HEPATITIS B VIRUS; INNATE IMMUNITY; INTERFERON PRODUCTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RIG I GENE; RNA SEQUENCE; RNA TRANSCRIPTION; VIRUS INHIBITION; VIRUS REPLICATION; 3-(4,5)-DIMETHYLTHIAHIAZOL-2-Y1)-2,5-DIPHENYTETRAZOLIUM BROMIDE; 3P-SIRNA; 5′-TRIPHOSPHATED SIRNA; BF-SIRNA; BIFUNCTIONAL SIRNA; BIOSYNTHESIS; CALF INTESTINE ALKALINE PHOSPHATASE; CHEMISTRY; CIAP; DNA REPLICATION; DOUBLE STRAND DNA; DOUBLE STRAND RNA; DSDNA; DSRNA; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; GENETICS; HBV E ANTIGEN; HBV S ANTIGEN; HCC; HEPG2 CELL LINE; HEPG2.2.15 CELLS; HUMAN; IFNΑ/Β; LIVER CELL CARCINOMA; METABOLISM; MTT; NC-SIRNA; NEGATIVE CONTROL SIRNA; OD; OPTICAL DENSITY; PATHOGEN-RECOGNITION RECEPTOR; PHYSIOLOGY; PRR; RETINOIC ACID-INDUCIBLE GENE I; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIG-I; RNA INTERFERENCE; RNAI; RT-PCR; SINGLE STRAND RNA; SSRNA; TLR;

3-(4,5)-DIMETHYLTHIAHIAZOL-2-Y1)-2,5-DIPHENYTETRAZOLIUM BROMIDE; 3P-SIRNA; 5′-TRIPHOSPHATED SIRNA; BF-SIRNA; BIFUNCTIONAL SIRNA; CALF INTESTINE ALKALINE PHOSPHATASE; CIAP; DOUBLE STRAND DNA; DOUBLE STRAND RNA; DSDNA; DSRNA; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HBEAG; HBSAG; HBV; HBV E ANTIGEN; HBV S ANTIGEN; HCC; HEPATITIS B VIRUS; HEPATOCELLULAR CARCINOMA; HEPG2.2.15 CELLS; IFN; IFNΑ/Β; INTERFERON; MTT; NC-SIRNA; NEGATIVE CONTROL SIRNA; OD; OPTICAL DENSITY; PATHOGEN-RECOGNITION RECEPTOR; PRR; RETINOIC ACID-INDUCIBLE GENE I; REVERSE TRANSCRIPTION PCR; RIG-I; RNA INTERFERENCE; RNAI; RT-PCR; SINGLE STRAND RNA; SIRNA; SMALL INTERFERING RNA; SSRNA; TLR; TOLL-LIKE RECEPTOR;

BASE SEQUENCE; DEAD-BOX RNA HELICASES; DNA REPLICATION; HEP G2 CELLS; HEPATITIS B ANTIGENS; HEPATITIS B VIRUS; HUMANS; IMMUNITY, INNATE; INTERFERON TYPE I; POLYPHOSPHATES; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; VIRUS REPLICATION;

EID: 84890120130     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.09.050     Document Type: Article

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