Mn SOD activity and protein in a patient with chromosome 6-linked autosomal recessive parkinsonism in comparison with Parkinson's disease and control

Neurology

Volumn 49, Issue 5, 1997, Pages 1257-1262

  Shimoda Matsubayashi, Satoe ^a   Hattori, T ^a   Matsumine, H ^a   Shinohara, A ^a   Yoritaka, A ^a   Mori, H ^a   Kondo, T ^a   Chiba, M ^a   Mizuno, Y ^a  

^a JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; DNA; LEVODOPA; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN; PROTEIN PRECURSOR; SIGNAL PEPTIDE; VALINE;

ADULT; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHROMOSOME 6; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MUTATION; PARKINSON DISEASE; PARKINSONISM; PEDIGREE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

EID: 0030716843     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.49.5.1257     Document Type: Article

References (25)

1. Schapira AHV, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1989;1:1269.
2. Hattori N, Tanaka M, Ozawa T, Mizuno Y. Immunohistochemical studies on complex I, II, III, and IV of mitochondria in Parkinson's disease. Ann Neurol 1991;30:563-571.
3. Mizuno Y, Ikebe S, Hattori N, et al. Role of mitochondria in the etiology and pathogenesis of Parkinson's disease. Biochim Biophys Acta 1995;1271:265-274.
4. Jenner P, Dexter DT, Sian J, Schapira AHV, Marsden CD. Oxidative stress as a cause of nigra cell death in Parkinson's disease and incidental Lewy body disease. Ann Neurol 1992; 32(Suppl):S82-87.
5. Matsumine H, Saito M, Shimoda-Matsubayashi S, et al. Localization of a gene for autosomal recessive form of juvenile parkinsonism (AR-JP) to chromosome 6q25.2-27. Am J Hum Genet 1997;60:588-596.
6. Shimoda-Matsubayashi S, Matsumine H, Kobayashi T, Nakagawa-Hattori Y, Shimizu Y, Mizuno Y. Structural dimorphism in the mitochondrial targeting sequence in the human manganese superoxide dismutase gene. BBRC 1996;226:561-565.
7. Chou PY, Fasman GD. Prediction of protein conformation. Biochemistry 1974;13:222-245.
8. Roise D, Horvath SJ, Tomich JM, Richards JH, Schatz G. A chemically synthesized pre-sequence of an imported mitochondrial protein can form an amphiphilic helix and perturb natural and artificial phospholipid bilayers. EMBO J 1986;5:1327-1334.
9. Lemire BD, Fankhauser C, Baker A, Schatz G. The mitochondrial targeting function of randomly generated peptide sequences correlates with predicted helical amphiphilicity. J Biol Chem 1989;264:20206-20215.
10. Thornton K, Wang Y, Weiner H, Gorenstein DG. Import, processing, and two-dimensional NMR structure of a linker-deleted signal peptide of rat liver mitochondrial aldehyde dehydrogenase. J Biol Chem 1993;268:19906-19914.
11. Ishikawa A, Tsuji S. Clinical analysis of 17 patients in 12 Japanese families with autosomal-recessive type juvenile parkinsonism. Neurology 1996;47:160-166.
12. Ozawa K, Seta K, Takeda H, Ando K, Hanada H, Araki C. On the isolation of mitochondria with high respiratory control from rat brain. J Biochem (Tokyo) 1966;59:501-510.
13. Srere PA. Citrate synthase. In: Lowenstein JM, ed. Methods in enzymology, vol 13. Citric acid cycle. New York: Academic Press, 1969:3-11.
14. Oyanagui Y. Reevaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem 1984;142:290-296.
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-275.
16. Kurobe N, Inagaki T, Kato K. Sensitive enzyme immunoassay for human Mn superoxide dismutase. Clin Chim Acta 1990; 192:171-180.
17. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-685.
18. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-4354.
19. Matsudaira P. Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes. J Biol Chem 1987;262:10035-10038.
20. Yoritaka A, Hattori N, Mori H, Kanefusa K, Mizuno Y. An immunohistochemical study on manganese superoxide dismutase in Parkinson's disease. J Neurol Sci 1997;148:181-186.
21. Marttila RJ, Lorentz H, Rinne UK. Oxygen toxicity protecting enzymes in Parkinson's disease: increase of superoxide dismutase-like activity in the substantia nigra and basal nucleus. J Neurol Sci 1988;86:321-331.
22. Saggu H, Cooksey J, Dexter D, et al. A selective increase in particulate superoxide dismutase activity in parkinsonian substantia nigra. J Neurochem 1989;53:692-697.
23. Poirier J, Dea D, Baccichet A, Thiffault C. Superoxide dismutase expression in Parkinson's disease. Ann NY Acad Sci 1994;738:116-120.
24. Gutteridge JNC. Iron and oxygen radicals in brain. Ann Neurol 1992;32(Suppl):S16-S21.
25. Youdim MBH, Ben-Shachar, Riederer P. Review: the possible role of iron in the etiopathology of Parkinson's disease. Mov Disord 1993;8:1-12.