NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics

Biochemical and Biophysical Research Communications

Volumn 442, Issue 3-4, 2013, Pages 139-146

  Kaneta, Yasuyuki ^a,b   Ullrich, Axel ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Checkpoint system; Cytokinesis; Mitotic arrest; NEK9; Therapeutic target

Indexed keywords

NEK9 PROTEIN; NOCODAZOLE; PROTEIN KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CHROMATIN CONDENSATION; CHROMOSOME; CONTROLLED STUDY; CYTOKINESIS; DAUGHTER CELL; EPITHELIUM CELL; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KIDNEY CARCINOMA; M PHASE CELL CYCLE CHECKPOINT; METAPHASE; MICRONUCLEUS; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN DEPLETION; PROTEIN TARGETING; RNA INTERFERENCE; WESTERN BLOTTING;

CHECKPOINT SYSTEM; CYTOKINESIS; MITOTIC ARREST; NEK9; THERAPEUTIC TARGET;

APOPTOSIS; CELL LINE, TUMOR; CENTRAL NERVOUS SYSTEM NEOPLASMS; CYTOKINESIS; GENE KNOCKDOWN TECHNIQUES; GLIOBLASTOMA; HUMANS; KIDNEY NEOPLASMS; M PHASE CELL CYCLE CHECKPOINTS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MOLECULAR TARGETED THERAPY; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SPINDLE APPARATUS;

EID: 84890036911     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.04.105     Document Type: Article

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