Ultra-high capacity liquid chromatography chip/quadrupole time-of-flight mass spectrometry for pharmaceutical analysis

Journal of Chromatography A

Volumn 1218, Issue 23, 2011, Pages 3669-3674

  Zhao, Chunxia ^a   Wu, Zeming ^a   Xue, Gang ^b   Wang, Jian ^b   Zhao, Yining ^b   Xu, Zhixiu ^c   Lin, Dayin ^c   Herbert, Godel ^c   Chang, Yuwei ^a   Cai, Kaiyang ^a   Xu, Guowang ^a  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b PFIZER INC   (United States)

^c AGILENT TECHNOLOGIES   (Germany)

Author keywords

HPLC Chip; Liquid chromatography; Mass spectrometry; Pharmaceutical analysis; Ultra high capacity chip

Indexed keywords

ANALYTICAL COLUMNS; DEGRADATION PRODUCTS; DRUG ANALYSIS; DRUG TESTING; HIGH SENSITIVITY; HPLC-CHIP; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY; LOW LEVEL; MINIMAL MATRIX; NANO-LC; NANOFLOWS; PEAK AREA; PHARMACEUTICAL ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITIES; RETENTION TIME; SAMPLE CONSUMPTION; SERUM SAMPLES; SMALL MOLECULES; TIME OF FLIGHT; TIME OF FLIGHT MASS SPECTROMETRY; TRAPPING COLUMN; ULTRA-HIGH;

COLUMN CHROMATOGRAPHY; DEGRADATION; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMPURITIES; MASS SPECTROMETRY; TRACE ANALYSIS;

LIQUIDS;

ACECAINIDE; ATENOLOL; CAFFEINE; GALLOPAMIL; IMIPRAMINE; PROPRANOLOL;

ARTICLE; CONTROLLED STUDY; DEGRADATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG MIXTURE; DRUG SCREENING; LIMIT OF DETECTION; MOUSE; NANOCHIP; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SIGNAL DETECTION; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ANIMALS; CAPILLARY ELECTROCHROMATOGRAPHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMIPRAMINE; MASS SPECTROMETRY; MICE; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 79955959561     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.04.020     Document Type: Article

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