Aspects of nonviral gene therapy: Correlation of molecular parameters with lipoplex structure and transfection efficacy in pyridinium-based cationic lipids

International Journal of Pharmaceutics

Volumn 461, Issue 1-2, 2014, Pages 145-156

  Parvizi, Paria ^a   Jubeli, Emile ^b   Raju, Liji ^b   Khalique, Nada Abdul ^b   Almeer, Ahmed ^b   Allam, Hebatalla ^b   Manaa, Maryem Al ^b   Larsen, Helge ^c   Nicholson, David ^d   Pungente, Michael D ^b   Fyles, Thomas M ^a  

^a UNIVERSITY OF VICTORIA   (Canada)

^b WEILL CORNELL MEDICAL COLLEGE   (Qatar)

^c UNIVERSITY OF STAVANGER   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Cationic lipids; DNA transfer; Gene therapy; Lipoplex formulation; Pyridinium based lipids; SAXS; Shape parameter

Indexed keywords

1,2 DIMYRISTOYL SN GLYCERO 3 ETHYLPHOSPHOCHOLINE; 1,2 DIOLEOYL SN GLYCERO 3 PHOSPHATIDYLETHANOLAMINE; BETA GALACTOSIDASE; CATIONIC LIPID; CHOLESTEROL; DEOXYRIBONUCLEASE I; LIPID; LIPOFECTAMINE; LIPOPLEX; PHOSPHATIDYLETHANOLAMINE; PHOSPHORYLCHOLINE; PLASMID DNA; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG; 1,2-DIMYRISTOYL-SN-GLYCERO-3-ETHYLPHOSPHOCHOLINE; 1,2-DIOLEOYL-GLYCERO-3-PHOSPHATIDYL ETHANOLAMINE; CATION; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DNA; GREEN FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME DEGRADATION; GENETIC TRANSFECTION; NONHUMAN; NONVIRAL GENE THERAPY; PARTITION COEFFICIENT; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENE THERAPY; GENETICS; HAMSTER; METABOLISM; PLASMID; PROCEDURES;

ANIMALS; BETA-GALACTOSIDASE; CATIONS; CHO CELLS; CHOLESTEROL; CRICETINAE; CRICETULUS; DEOXYRIBONUCLEASE I; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DNA; GENETIC THERAPY; GREEN FLUORESCENT PROTEINS; LIPIDS; PHOSPHATIDYLETHANOLAMINES; PLASMIDS; PYRIDINIUM COMPOUNDS; TRANSFECTION;

EID: 84890004422     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.11.045     Document Type: Article

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