메뉴 건너뛰기




Volumn 7, Issue 8, 2005, Pages 1023-1034

A QSAR-modeling perspective on cationic transfection lipids. 1. Predicting effeciency and understanding mechanisms

Author keywords

Gene therapy; Lipoplex; Liposome; Non viral vectors

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; LIPID;

EID: 23944489540     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.746     Document Type: Article
Times cited : (35)

References (69)
  • 1
    • 0024988334 scopus 로고
    • Gene transfer into humans. Immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction
    • Rosenberg SA, Aebersold P, Cornetta K, et al. Gene transfer into humans. Immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. New Engl J Med 1990; 323: 570-578.
    • (1990) New Engl. J. Med. , vol.323 , pp. 570-578
    • Rosenberg, S.A.1    Aebersold, P.2    Cornetta, K.3
  • 2
    • 0038482054 scopus 로고    scopus 로고
    • The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy
    • Miller AD. The problem with cationic liposome/micelle-based non-viral vector systems for gene therapy. Current Med Chem 2003; 10: 1195-1211.
    • (2003) Current Med. Chem. , vol.10 , pp. 1195-1211
    • Miller, A.D.1
  • 3
    • 33645426090 scopus 로고    scopus 로고
    • Gene therapy's twisted path to success
    • March
    • Lesney MS. Gene therapy's twisted path to success. Modern Drug Discovery 2004; March: 32-36.
    • (2004) Modern Drug Discovery , pp. 32-36
    • Lesney, M.S.1
  • 4
    • 0037805562 scopus 로고    scopus 로고
    • Cationic transfection lipids
    • Liu D, Ren T, Gao X. Cationic transfection lipids. Curr Med Chem 2003; 10: 1307-1315.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1307-1315
    • Liu, D.1    Ren, T.2    Gao, X.3
  • 5
    • 1642503835 scopus 로고    scopus 로고
    • Cationic lipid-DNA complexes for gene therapy: Understanding the relationship between complex structure and gene delivery pathways at the molecular level
    • Ewert K, Slack NL, Ahmad A, et al. Cationic lipid-DNA complexes for gene therapy: understanding the relationship between complex structure and gene delivery pathways at the molecular level. Curr Med Chem 2004; 11: 133-149.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 133-149
    • Ewert, K.1    Slack, N.L.2    Ahmad, A.3
  • 6
    • 0034640230 scopus 로고    scopus 로고
    • Gene therapy on trial
    • Marshall E. Gene therapy on trial. Science 2000; 288: 951-957.
    • (2000) Science , vol.288 , pp. 951-957
    • Marshall, E.1
  • 7
    • 0037131386 scopus 로고    scopus 로고
    • Gene therapy. What to do when clear success comes with an unclear risk?
    • Marshall E. Gene therapy. What to do when clear success comes with an unclear risk? Science 2002; 298: 510-511.
    • (2002) Science , vol.298 , pp. 510-511
    • Marshall, E.1
  • 8
    • 0038819927 scopus 로고    scopus 로고
    • Cationic liposomes as in vivo delivery vehicles
    • Smyth Templeton N. Cationic liposomes as in vivo delivery vehicles. Curr Med Chem 2003; 10: 1279-1287.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1279-1287
    • Smyth Templeton, N.1
  • 10
    • 0038482013 scopus 로고    scopus 로고
    • Structure-activity relationship in cationic lipid mediated gene transfection
    • Niculescu-Duvaz D, Heyes J, Springer CJ. Structure-activity relationship in cationic lipid mediated gene transfection. Curr Med Chem 2003; 10: 1233-1261.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1233-1261
    • Niculescu-Duvaz, D.1    Heyes, J.2    Springer, C.J.3
  • 12
    • 0038143170 scopus 로고    scopus 로고
    • New strategy in gene transfection by cationic transfection lipids with a cationic cholesterol
    • Nakanishi M. New strategy in gene transfection by cationic transfection lipids with a cationic cholesterol. Curr Med Chem 2003; 10: 1289-1296.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1289-1296
    • Nakanishi, M.1
  • 13
    • 1642544672 scopus 로고    scopus 로고
    • Modeling of cationic lipid-DNA complexes
    • May S, Ben-Shaul A. Modeling of cationic lipid-DNA complexes. Curr Med Chem 2004; 11: 151-167.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 151-167
    • May, S.1    Ben-Shaul, A.2
  • 14
    • 0038143157 scopus 로고    scopus 로고
    • Cationic transfection lipids in gene therapy: Successes, set-backs, challenges and promises
    • Kumar VV, Singh RS, Chaudhuri A. Cationic transfection lipids in gene therapy: successes, set-backs, challenges and promises. Curr Med Chem 2003; 10: 1297-1306.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1297-1306
    • Kumar, V.V.1    Singh, R.S.2    Chaudhuri, A.3
  • 15
    • 0037805642 scopus 로고    scopus 로고
    • Cationic lipid vectors for plasmid DNA delivery
    • Hirko A, Tang F, Hughes JA. Cationic lipid vectors for plasmid DNA delivery. Curr Med Chem 2003; 10: 1185-1193.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1185-1193
    • Hirko, A.1    Tang, F.2    Hughes, J.A.3
  • 16
    • 18744426403 scopus 로고    scopus 로고
    • Cationic liposomes for gene delivery: Novel cationic lipids and enhancement by proteins and peptides
    • Duzgunes N, De Ilarduya CT, Simoes S, et al. Cationic liposomes for gene delivery: novel cationic lipids and enhancement by proteins and peptides. Curr Med Chem 2003; 10: 1213-1220.
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1213-1220
    • Duzgunes, N.1    De Ilarduya, C.T.2    Simoes, S.3
  • 18
    • 0033198888 scopus 로고    scopus 로고
    • Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro
    • Tang F, Hughes JA. Use of dithiodiglycolic acid as a tether for cationic lipids decreases the cytotoxicity and increases transgene expression of plasmid DNA in vitro. Bioconjugate Chem 1999; 10: 791-796.
    • (1999) Bioconjugate Chem. , vol.10 , pp. 791-796
    • Tang, F.1    Hughes, J.A.2
  • 19
    • 0032693447 scopus 로고    scopus 로고
    • Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid
    • Ajmani PS, Tang F, Krishnaswami S, et al. Enhanced transgene expression in rat brain cell cultures with a disulfide-containing cationic lipid. Neurosci Lett 1999; 277: 141-144.
    • (1999) Neurosci. Lett. , vol.277 , pp. 141-144
    • Ajmani, P.S.1    Tang, F.2    Krishnaswami, S.3
  • 20
    • 0032488539 scopus 로고    scopus 로고
    • Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA
    • Tang F, Hughes JA. Introduction of a disulfide bond into a cationic lipid enhances transgene expression of plasmid DNA. Biochem Biophy Res Commun 1998; 242: 141-145.
    • (1998) Biochem. Biophy. Res. Commun. , vol.242 , pp. 141-145
    • Tang, F.1    Hughes, J.A.2
  • 22
    • 0032543524 scopus 로고    scopus 로고
    • Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery
    • Wang J, Guo X, Xu Y, Barron L, Szoka FC. Synthesis and characterization of long chain alkyl acyl carnitine esters. Potentially biodegradable cationic lipids for use in gene delivery. J Med Chem 1998; 41: 2207-2215.
    • (1998) J. Med. Chem. , vol.41 , pp. 2207-2215
    • Wang, J.1    Guo, X.2    Xu, Y.3    Barron, L.4    Szoka, F.C.5
  • 23
    • 0343307124 scopus 로고    scopus 로고
    • Cationic lipids used in gene transfer
    • Zabner J. Cationic lipids used in gene transfer. Adv Drug Del Rev 1997; 27: 17-28.
    • (1997) Adv. Drug Del. Rev. , vol.27 , pp. 17-28
    • Zabner, J.1
  • 24
    • 0031028138 scopus 로고    scopus 로고
    • Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery
    • van der Woude I, Wagenaar A, Meekel AA, et al. Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery. Proc Natl Acad Sci U S A 1997; 94: 1160-1165.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 1160-1165
    • van der Woude, I.1    Wagenaar, A.2    Meekel, A.A.3
  • 27
    • 0035935745 scopus 로고    scopus 로고
    • Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery
    • Banerjee R, Mahidhar Y, Chaudhuri A, Gopal V, Rao NM. Design, synthesis, and transfection biology of novel cationic glycolipids for use in liposomal gene delivery. J Med Chem 2001; 44: 4176-4185.
    • (2001) J. Med. Chem. , vol.44 , pp. 4176-4185
    • Banerjee, R.1    Mahidhar, Y.2    Chaudhuri, A.3    Gopal, V.4    Rao, N.M.5
  • 28
    • 0037622183 scopus 로고    scopus 로고
    • Three-dimensional imaging of lipid gene-carriers: Membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes
    • Lin AJ, Slack NL, Ahmad A, George CX, Samuel CE, Safinya CR. Three-dimensional imaging of lipid gene-carriers: membrane charge density controls universal transfection behavior in lamellar cationic liposome-DNA complexes. Biophys J 2003; 84: 3307-3316.
    • (2003) Biophys. J. , vol.84 , pp. 3307-3316
    • Lin, A.J.1    Slack, N.L.2    Ahmad, A.3    George, C.X.4    Samuel, C.E.5    Safinya, C.R.6
  • 29
    • 0037364747 scopus 로고    scopus 로고
    • Cyclooxygenase (COX) inhibitors: A comparative QSAR study
    • Garg R, Kurup A, Mekapati SB, Hansch C. Cyclooxygenase (COX) inhibitors: a comparative QSAR study. Chem Rev 2003; 103: 703-731.
    • (2003) Chem. Rev. , vol.103 , pp. 703-731
    • Garg, R.1    Kurup, A.2    Mekapati, S.B.3    Hansch, C.4
  • 30
    • 0037365307 scopus 로고    scopus 로고
    • Prediction of aquatic toxicity: Use of optimization of correlation weights of local graph invariants
    • Toropov AA, Schultz TW. Prediction of aquatic toxicity: use of optimization of correlation weights of local graph invariants. J Chem Inform Comp Sci 2003; 43: 560-567.
    • (2003) J. Chem. Inform. Comp. Sci. , vol.43 , pp. 560-567
    • Toropov, A.A.1    Schultz, T.W.2
  • 31
    • 0002942605 scopus 로고
    • Thermodynamic and geometric aspects of amphiphile aggregation into micelles, vesicles and bilayers, and the interactions between them
    • Giorgio D, Corti M (eds). North Holland: Amsterdam
    • Israelachvili JN. Thermodynamic and geometric aspects of amphiphile aggregation into micelles, vesicles and bilayers, and the interactions between them. In Physics of Amphiphiles: Micelles, Vesicles, and Microemulsions. Giorgio D, Corti M (eds). North Holland: Amsterdam, 1985; 24-58.
    • (1985) Physics of Amphiphiles: Micelles, Vesicles, and Microemulsions , pp. 24-58
    • Israelachvili, J.N.1
  • 32
    • 0008700109 scopus 로고    scopus 로고
    • Uptake, distribution, and accumulation of dyes and fluorescent probes within living cells: A structure-activity modelling approach
    • Horobin RW. Uptake, distribution, and accumulation of dyes and fluorescent probes within living cells: a structure-activity modelling approach. Adv Colour Sci Technol 2001; 4: 101-107.
    • (2001) Adv. Colour Sci. Technol. , vol.4 , pp. 101-107
    • Horobin, R.W.1
  • 35
    • 16044364926 scopus 로고    scopus 로고
    • A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung
    • Wheeler CJ, Felgner PL, Tsai YJ, et al. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. Proc Natl Acad Sci U S A 1996; 93: 11 454-11 459.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 11454-11459
    • Wheeler, C.J.1    Felgner, P.L.2    Tsai, Y.J.3
  • 36
    • 0345426296 scopus 로고    scopus 로고
    • Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery
    • Banerjee R, Das PK, Srilalshmi GV, Chaudhuri A, Gopal V, Rao NM. Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery. J Med Chem 1999; 42: 4292-4299.
    • (1999) J. Med. Chem. , vol.42 , pp. 4292-4299
    • Banerjee, R.1    Das, P.K.2    Srilalshmi, G.V.3    Chaudhuri, A.4    Gopal, V.5    Rao, N.M.6
  • 37
    • 0034686602 scopus 로고    scopus 로고
    • Synthesis and biological delivery of new glycosidic cationic lipids for DNA delivery
    • Bessodes M, Dubertret C, Jaslin G, Scherman D. Synthesis and biological delivery of new glycosidic cationic lipids for DNA delivery. Bioorg Med Chem Lett 2000; 10: 1393-1395.
    • (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1393-1395
    • Bessodes, M.1    Dubertret, C.2    Jaslin, G.3    Scherman, D.4
  • 38
    • 0032539538 scopus 로고    scopus 로고
    • Monomolecular collapse of plasmid DNA into stable virus-like particles
    • Blessing T, Remy JS, Behr JP. Monomolecular collapse of plasmid DNA into stable virus-like particles. Proc Natl Acad Sci U S A 1998; 95: 1427-1431.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 1427-1431
    • Blessing, T.1    Remy, J.S.2    Behr, J.P.3
  • 39
    • 0031559941 scopus 로고    scopus 로고
    • The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids
    • El Ouahabi A, Thiry M, Pector V, Fuks R, Ruysschaert JM, Vandenbranden M. The role of endosome destabilizing activity in the gene transfer process mediated by cationic lipids. FEBS Lett 1997; 414: 187-192.
    • (1997) FEBS Lett. , vol.414 , pp. 187-192
    • El Ouahabi, A.1    Thiry, M.2    Pector, V.3    Fuks, R.4    Ruysschaert, J.M.5    Vandenbranden, M.6
  • 40
    • 0035078043 scopus 로고    scopus 로고
    • Sugar-based tertiary amino gemini surfactants with a vesicle-to-micelle transition in the endosomal pH range mediate efficient transfection in vivo
    • Fielden ML, Perrin C, Kremer A, et al. Sugar-based tertiary amino gemini surfactants with a vesicle-to-micelle transition in the endosomal pH range mediate efficient transfection in vivo. Eur J Biochem 2001; 268: 1269-1279.
    • (2001) Eur. J. Biochem. , vol.268 , pp. 1269-1279
    • Fielden, M.L.1    Perrin, C.2    Kremer, A.3
  • 41
    • 0035142187 scopus 로고    scopus 로고
    • Highly fluorinated lipospermines for gene transfer: Synthesis and evaluation of their in vitro transfection efficiency
    • Gaucheron J, Santaella C, Vierling P. Highly fluorinated lipospermines for gene transfer: synthesis and evaluation of their in vitro transfection efficiency. Bioconjugate Chem 2001; 12: 114-128.
    • (2001) Bioconjugate Chem. , vol.12 , pp. 114-128
    • Gaucheron, J.1    Santaella, C.2    Vierling, P.3
  • 42
    • 0033541601 scopus 로고    scopus 로고
    • Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor
    • Kikuchi A, Aoki Y, Sugaya S, et al. Development of novel cationic liposomes for efficient gene transfer into peritoneal disseminated tumor. Hum Gene Ther 1999; 10: 947-955.
    • (1999) Hum. Gene Ther. , vol.10 , pp. 947-955
    • Kikuchi, A.1    Aoki, Y.2    Sugaya, S.3
  • 43
    • 12244273280 scopus 로고    scopus 로고
    • Combinatorial synthesis of new cationic lipids and high-throughput screening of their transfection properties
    • Lenssen K, Jantscheff P, von Kiedrowski G, Massing U. Combinatorial synthesis of new cationic lipids and high-throughput screening of their transfection properties. Chembiochem 2002; 3: 852-858.
    • (2002) Chembiochem. , vol.3 , pp. 852-858
    • Lenssen, K.1    Jantscheff, P.2    von Kiedrowski, G.3    Massing, U.4
  • 44
    • 0032913604 scopus 로고    scopus 로고
    • Properties of cationic liposomes composed of cationic lipid YKS 220 having an ester linkage: Adequate stability, high transfection efficiency, and low cytotoxicity
    • Obika S, Yu W, Shimoyama A, et al. Properties of cationic liposomes composed of cationic lipid YKS 220 having an ester linkage: adequate stability, high transfection efficiency, and low cytotoxicity. Biol Pharmaceut Bull 1999; 22: 187-190.
    • (1999) Biol. Pharmaceut. Bull. , vol.22 , pp. 187-190
    • Obika, S.1    Yu, W.2    Shimoyama, A.3
  • 45
    • 0031660643 scopus 로고    scopus 로고
    • Physico-chemical characterization of a double long-chain cationic amphiphile (Vectamidine) by microelectrophoresis
    • Pector V, Caspers J, Banerjee S, et al. Physico-chemical characterization of a double long-chain cationic amphiphile (Vectamidine) by microelectrophoresis. Biochim Biophys Acta 1998; 1372: 339-346.
    • (1998) Biochim. Biophys. Acta , vol.1372 , pp. 339-346
    • Pector, V.1    Caspers, J.2    Banerjee, S.3
  • 46
    • 0037215860 scopus 로고    scopus 로고
    • Surface charge density determines the efficiency of cationic gemini surfactant based lipofection
    • Ryhanen SJ, Saily MJ, Paukku T, et al. Surface charge density determines the efficiency of cationic gemini surfactant based lipofection. Biophys J 2003; 84: 578-587.
    • (2003) Biophys. J. , vol.84 , pp. 578-587
    • Ryhanen, S.J.1    Saily, M.J.2    Paukku, T.3
  • 47
    • 0030592714 scopus 로고    scopus 로고
    • Effect of zeta potential of cationic liposomes containing cationic cholesterol derivatives on gene transfection
    • Takeuchi K-i, Ishihara M, Kawaaura C, Noji M, Furuno T, Nakanishi M. Effect of zeta potential of cationic liposomes containing cationic cholesterol derivatives on gene transfection. FEBS Lett 1996; 397: 207-209.
    • (1996) FEBS Lett. , vol.397 , pp. 207-209
    • Takeuchi, K.-I.1    Ishihara, M.2    Kawaaura, C.3    Noji, M.4    Furuno, T.5    Nakanishi, M.6
  • 48
    • 0029844310 scopus 로고    scopus 로고
    • Guanidinium-cholesterol cationic-lipids: Efficient vectors for the transfection of eukaryotic cells
    • Vigneron J-P, Oudrhiri N, Fauquet M, et al. Guanidinium-cholesterol cationic-lipids: efficient vectors for the transfection of eukaryotic cells. Proc Natl Acad Sci U S A 1996; 93: 9682-9686.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 9682-9686
    • Vigneron, J.-P.1    Oudrhiri, N.2    Fauquet, M.3
  • 49
    • 84908735741 scopus 로고
    • Biomembrane fusion
    • Lacey JA. Biomembrane fusion. Biol Membranes 1982; 4: 367-415.
    • (1982) Biol. Membranes , vol.4 , pp. 367-415
    • Lacey, J.A.1
  • 53
    • 0001661311 scopus 로고    scopus 로고
    • Octanol/water partitioning of surfactants and its relevance to toxicity and environmental behavior
    • AEPSAT: Barcelona
    • Morrall SW, Herzog RR, Kloepper-Sams P, Rosen MJ. Octanol/water partitioning of surfactants and its relevance to toxicity and environmental behavior. Proc 4th World Surfactants Congress, vol. 3. AEPSAT: Barcelona, 1996; 220-227.
    • (1996) Proc 4th World Surfactants Congress , vol.3 , pp. 220-227
    • Morrall, S.W.1    Herzog, R.R.2    Kloepper-Sams, P.3    Rosen, M.J.4
  • 55
    • 0034157389 scopus 로고    scopus 로고
    • Role of membrane organization and membrane domains in endocytic lipid trafficking
    • Mukherjee S, Maxfield RF. Role of membrane organization and membrane domains in endocytic lipid trafficking. Traffic 2000; 1: 203-211.
    • (2000) Traffic , vol.1 , pp. 203-211
    • Mukherjee, S.1    Maxfield, R.F.2
  • 56
    • 0035997044 scopus 로고    scopus 로고
    • The effects of acyl chain length and saturation of diacylglycerols and phosphatidylcholines on membrane monolayer curvature
    • Szule JA, Fuller NL, Rand RP. The effects of acyl chain length and saturation of diacylglycerols and phosphatidylcholines on membrane monolayer curvature. Biophys J 2002; 83: 977-984.
    • (2002) Biophys. J. , vol.83 , pp. 977-984
    • Szule, J.A.1    Fuller, N.L.2    Rand, R.P.3
  • 57
    • 3042675949 scopus 로고    scopus 로고
    • Fluorescent probes for endoplasmic reticulum - Why are they selective? An experimental and QSAR-modelling study
    • Colston J, Horobin RW, Rashid-Doubell F, Pediani J, Johal KK. Fluorescent probes for endoplasmic reticulum - why are they selective? An experimental and QSAR-modelling study. Biotechnic Histochem 2003; 78: 323-333.
    • (2003) Biotechnic. Histochem. , vol.78 , pp. 323-333
    • Colston, J.1    Horobin, R.W.2    Rashid-Doubell, F.3    Pediani, J.4    Johal, K.K.5
  • 58
    • 0037085646 scopus 로고    scopus 로고
    • 2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells
    • 2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells. Biochem J 2002; 362: 741-747.
    • (2002) Biochem. J. , vol.362 , pp. 741-747
    • Dekkers, D.W.1    Comfurius, P.2    Bevers, E.M.3    Zwaal, R.F.4
  • 59
    • 0034707098 scopus 로고    scopus 로고
    • Short chain phospholipids as detergents
    • Hauser H. Short chain phospholipids as detergents. Biochim Biophys Acta 2000; 1508: 165-181.
    • (2000) Biochim. Biophys. Acta , vol.1508 , pp. 165-181
    • Hauser, H.1
  • 60
    • 0034707095 scopus 로고    scopus 로고
    • Surface active drugs: Self-association and interaction with membranes and surfactants. Physicochemical and biological aspects
    • Schreier S, Malheiros SV, de Paula E. Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects. Biochim Biophys Acta 2000; 1508: 210-234.
    • (2000) Biochim. Biophys. Acta , vol.1508 , pp. 210-234
    • Schreier, S.1    Malheiros, S.V.2    de Paula, E.3
  • 61
    • 0029949266 scopus 로고    scopus 로고
    • Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection
    • Xu Y, Szoka FC. Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection. Biochemistry 1996; 35: 5616-5623.
    • (1996) Biochemistry , vol.35 , pp. 5616-5623
    • Xu, Y.1    Szoka, F.C.2
  • 62
    • 1342277307 scopus 로고    scopus 로고
    • Overcoming barriers to nonviral gene delivery
    • Gregoriadis G, McCormack B (eds). IOS Press: Amsterdam
    • Behr JP. Overcoming barriers to nonviral gene delivery. In: Targetting of drugs, Gregoriadis G, McCormack B (eds). IOS Press: Amsterdam, 2000; 76-80.
    • (2000) Targetting of Drugs , pp. 76-80
    • Behr, J.P.1
  • 63
    • 0032580453 scopus 로고    scopus 로고
    • Polycation-DNA complexes for gene delivery: A comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids
    • Pouton CW, Lucas P, Thomas BJ, Uduehi AN, Milroy DA, Moss SH. Polycation-DNA complexes for gene delivery: a comparison of the biopharmaceutical properties of cationic polypeptides and cationic lipids. J Controlled Rel 1998; 53: 289-299.
    • (1998) J. Controlled Rel. , vol.53 , pp. 289-299
    • Pouton, C.W.1    Lucas, P.2    Thomas, B.J.3    Uduehi, A.N.4    Milroy, D.A.5    Moss, S.H.6
  • 65
    • 0036225362 scopus 로고    scopus 로고
    • Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation
    • Oupicky D, Ogris M, Howard KA, Dash PR, Ulbrich K, Seymour LW. Importance of lateral and steric stabilization of polyelectrolyte gene delivery vectors for extended systemic circulation. Mol Ther 2002; 5: 463-472.
    • (2002) Mol. Ther. , vol.5 , pp. 463-472
    • Oupicky, D.1    Ogris, M.2    Howard, K.A.3    Dash, P.R.4    Ulbrich, K.5    Seymour, L.W.6
  • 66
    • 0033995526 scopus 로고    scopus 로고
    • Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes
    • Kawakami S, Sato A, Nishikawa M, Yamashita F, Hashida M. Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes. Gene Ther 2000; 7: 292-299.
    • (2000) Gene Ther. , vol.7 , pp. 292-299
    • Kawakami, S.1    Sato, A.2    Nishikawa, M.3    Yamashita, F.4    Hashida, M.5
  • 67
    • 0035189482 scopus 로고    scopus 로고
    • Quantitative analysis of synthetic gene delivery vector design properties
    • Varga CM, Hong K, Lauffenburger DA. Quantitative analysis of synthetic gene delivery vector design properties. Mol Ther 2001; 4: 438-446.
    • (2001) Mol. Ther. , vol.4 , pp. 438-446
    • Varga, C.M.1    Hong, K.2    Lauffenburger, D.A.3
  • 68
    • 0034062140 scopus 로고    scopus 로고
    • Structural basis of DOTMA for its high intravenous transfection activity in mouse
    • Ren T, Song YK, Zhang G, Liu D. Structural basis of DOTMA for its high intravenous transfection activity in mouse. Gene Ther 2000; 7: 764-768.
    • (2000) Gene Ther. , vol.7 , pp. 764-768
    • Ren, T.1    Song, Y.K.2    Zhang, G.3    Liu, D.4
  • 69
    • 3242686248 scopus 로고    scopus 로고
    • Reactivity descriptors for the hydrogen bonding ability of pyridine bases
    • Dimitrova M, Ilieva S, Galabov B. Reactivity descriptors for the hydrogen bonding ability of pyridine bases. SAR and QSAR Environ Res 2004; 15: 311-319.
    • (2004) SAR and QSAR Environ. Res. , vol.15 , pp. 311-319
    • Dimitrova, M.1    Ilieva, S.2    Galabov, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.