Efficient cationic lipid-mediated delivery of antisense oligonucleotides into eukaryotic cells: Down-regulation of the corticotropin-releasing factor receptor

Nucleic Acids Research

Volumn 29, Issue 10, 2001, Pages 2079-2087

  Shi, Fuxin ^b   Nomden, Anita ^b   Oberle, Volker ^b   Engberts, Jan B F N ^a   Hoekstra, Dick ^b  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOPHILE; ANTISENSE OLIGONUCLEOTIDE; CATION; CORTICOTROPIN RELEASING FACTOR RECEPTOR; LIPID; MESSENGER RNA; NEUROPEPTIDE; PLASMA PROTEIN; PYRIDINIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CHO CELL; CONTROLLED STUDY; ENDOSOME; EUKARYOTIC CELL; FLUORESCENCE; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; LIPID MEMBRANE; LYSOSOME; MEMBRANE STABILIZATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN TRANSPORT; RECEPTOR DOWN REGULATION;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; EUKARYOTA;

EID: 0035872913     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/29.10.2079     Document Type: Article

References (38)

1. Tao, M., Miyano-Kurosaki, N., Takai, K. and Takaku, H. (1999) Specific inhibition of human telomerase activity by transfection reagent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells. FEBS Lett., 454, 312-316.
2. Owens, M.J., Mulchahey, J.J., Kasckow, J.W., Plotsky, P.M. and Nemeroff, C.B. (1995) Exposure to an antisense oligonucleotide decreases corticotropin-releasing factor receptor binding in rat pituitary cultures. J. Neurochem., 64, 2358-2361.
3. Owens, M.J. and Nemeroff, C.B. (1991) Physiology and pharmacology of corticotropin-releasing factor. Pharmacol. Rev., 43, 425-473.
4. Gonzalez, M.A., Serrano, F., Llorente, M., Abad, J.L., Garcia-Ortiz, M.J. and Bernad, A. (1998) A hammerhead ribozyme targeted to the human chemokine receptor CCR5. Biochem. Biophys. Res. Commun., 251, 592-596.
5. Krieg, A.M. and Stein, C.A. (1995) Phosphorothioate oligodeoxynucleotides: antisense or anti-protein? Antisense Res. Dev., 5, 241.
6. Eckstein, F. and Thomson, J.B. (1995) Phosphate analogs for study of DNA polymerases. Methods Enzymol., 262, 189-202.
7. Stein, C.A. and Cohen, J.S. (1988) Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res., 48, 2659-2668.
8. Uhlmann, E. and Peyman, A. (1990) Antisense oligonucleotides: a new therapeutic principle. Chem. Rev. 90, 544-584.
9. Bergan, R., Hakim, F., Schwartz, G.N., Kyle, E., Cepada, R., Szabo, J.M., Fowler, D., Gress, R. and Neckers, L. (1996) Electroporation of synthetic oligodeoxynucleotides: a novel technique for ex vivo bone marrow purging. Blood, 88, 731-741.
10. Mathiesen, I. (1999) Electropermeabilization of skeletal muscle enhances gene transfer in vivo. Gene Ther., 6, 508-514.
11. Zelphati, O., Zon, G. and Leserman, L. (1993) Inhibition of HIV-1 replication in cultured cells with antisense oligonucleotides encapsulated in immunoliposomes. Antisense Res. Dev., 3, 323-338.
12. Delong, R., Stephenson, K., Loftus, T., Fisher, M., Alahari, S., Nolting, A. and Juliano, R.L. (1997) Characterization of complexes of oligonucleotides with polyamidoamine starburst dendrimers and effects on intracellular delivery. J. Pharm. Sci., 86, 762-764.
13. Van der Woude, I., Wagenaar, A., Meekel, A.A., ter Beest, M.B., Ruiters, M.H., Engberts, J.B.F.N. and Hoekstra, D. (1997) Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery. Proc. Natl Acad. Sci. USA, 94, 1160-1165.
14. Meekel, A.A.P., Wagenaar, A., Smisterova, J., Kroeze, J., Haadsma, P., Bosgraaf, B., Stuart, M.C.A., Brisson, A., Ruiters, M.H.J., Hoekstra, D. et al. (2000) Synthesis of pyrimidinium amphiphiles used for transfection and some characteristics of amphiphile/DNA complex formation. Eur. J. Org. Chem., 2000, 665-673.
15. Carmichael, J., DeGraff, W.G., Gazdar, A.F., Minna, J.D. and Mitchell, J.B. (1987) Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res., 47, 936-942.
16. Kramer, E.M., Koch, T., Niehaus, A. and Trotter, J. (1997) Oligodendrocytes direct glycosyl phosphatidylinositol-anchored proteins to the myelin sheath in glycosphingolipid-rich complexes. J. Biol. Chem., 272, 8937-8945.
17. Oberle, V., Zuhorn, I.S., Audouy, S., Bakowsky, U., Smisterova, J., Engberts, J.B.F.N. and Hoekstra, D. (2000) Cationic amphiphiles as delivery system for genes into eukaryotic cells. NATO ASI Series, 323, 146-155.
18. Audouy, S., Molema, G., de Leij, L.M.F.H. and Hoekstra, D. (2000) Serum as modulator of lipoplex-mediated gene transfection: Dependence of amphiphile, cell type and complex stability. J Gene Med., 2, 465-476.
19. Struck, D.K., Hoekstra, D. and Pagano, R.E. (1981) Use of resonance energy transfer to monitor membrane fusion. Biochemistry, 20, 4093-4099.
20. Tomlinson, E. and Rolland, A.P. (1996) Controllable gene therapy. Pharmaceutics of non-viral gene delivery systems. J. Control Release, 39, 357-372.
21. Litzinger, D.C., Brown, J.M., Wala, I., Kaufman, S.A., Van, G.Y., Farrell, C.L. and Collins, D. (1996) Fate of cationic liposomes and their complex with oligonucleotide in vivo. Biochim. Biophys. Acta, 1281, 139-149.
22. DeLong, R.K., Yoo, H., Alahari, S.K., Fisher, M., Short, S.M., Kang, S.H., Kole, R., Janout, V., Regan, S.L. and Juliano, R.L. (1999) Novel cationic amphiphiles as delivery agents for antisense oligonucleotides. Nucleic Acids Res., 27, 3334-3341.
23. Boshart, M., Weber, F., Jahn, G., Dorsch-Hasler, K., Fleckenstein, B. and Schaffner, W. (1985) A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell, 41, 521-530.
24. Kok, J.W., Eskelinen, S., Hoekstra, K. and Hoekstra, D. (1989) Salvage of glucosylceramide by recycling after internalization along the pathway of receptor-mediated endocytosis. Proc. Natl Acad. Sci. USA, 86, 9896-9900.
25. Kok, J.W., Hoekstra, K., Eskelinen, S. and Hoekstra, D. (1992) Recycling pathways of glucosylceramide in BHK cells: distinct involvement of early and late endosomes. J. Cell Sci., 103, 1139-1152.
26. Van der Woude, I., Visser, H.W., ter Beest, M.B., Wagenaar, A., Ruiters, M.H., Engberts, J.B.F.N. and Hoekstra, D. (1995) Parameters influencing the introduction of plasmid DNA into cells by the use of synthetic amphiphiles as a carrier system. Biochim. Biophys. Acta, 1240, 34-40.
27. Hirsch-Lerner, D. and Barenholz, Y. (1999) Hydration of lipoplexes commonly used in gene delivery: follow-up by laurdan fluorescence changes and quantification by differential scanning calorimetry. Biochim. Biophys. Acta, 1461, 47-57.
28. Oberle, V., Bakowsky, U., Zuhorn, I.S. and Hoekstra, D. (2000) Lipoplex formation under equilibrium conditions reveals a three-step mechanism. Biophys. J., 79, 1447-1454.
29. Sixou, S., Szoka, F.C., Jr, Green, G.A., Giusti, B., Zon, G. and Chin, D.J. (1994) Intracellular oligonucleotide hybridization detected by fluorescence resonance energy transfer (FRET). Nucleic Acids Res., 22, 662-668.
30. Leonetti, J.P., Mechti, N., Degols, G., Gagnor, C. and Lebleu, B. (1991) Intracellular distribution of microinjected antisense oligonucleotides. Proc. Natl Acad. Sci. USA, 88, 2702-2706.
31. Fisher, T.L., Terhorst, T., Cao, X. and Wagner, R.W. (1993) Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells. Nucleic Acids Res., 21, 3857-3865.
32. Wagner, R.W., Matteucci, M.D., Lewis, J.G., Gutierrez, A.J., Moulds, C. and Froehler, B.C. (1993) Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines. Science, 260, 1510-1513.
33. Loke, S.L., Stein, C.A., Zhang, X.H., Mori, K., Nakanishi, M., Subasinghe, C., Cohen, J.S. and Neckers, L.M. (1989) Characterization of oligonucleotide transport into living cells. Proc. Natl Acad. Sci. USA, 86, 3474-3478.
34. Tonkinson, J.L. and Stein, C.A. (1994) Patterns of intracellular compartmentalization, trafficking and acidification of 5'-fluorescein labeled phosphodiester and phosphorothioate oligodeoxynucleotides in HL60 cells. Nucleic Acids Res, 22, 4268-4275.
35. Chin, D.J., Green, G.A., Zon, G., Szoka, F.C., Jr and Straubinger, R.M. (1990) Rapid nuclear accumulation of injected oligodeoxyribonucleotides. New Biol., 2, 1091-1100.
36. Leonetti, J.P., Mechti, N., Degols, G., Gagnor, C. and Lebleu, B. (1991) Intracellular distribution of microinjected antisense oligonucleotides. Proc. Natl Acad. Sci. USA, 88, 2702-2706.
37. Marcusson, E.G., Bhat, B., Manoharan, M., Bennett, C.F. and Dean, N.M. (1998) Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus. Nucleic Acids Res., 26, 2016-2023.
38. Godbey, W.T., Wu, K.K. and Mikos, A.G. (1999) Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery. Proc. Natl Acad. Sci. USA, 96, 5177-5181.