Biological Contributions to PTSD: Differentiating Normative from Pathological Response

The Oxford Handbook of Traumatic Stress Disorders

Volumn , Issue , 2012, Pages

  Yehuda, Rachel ^a   Pratchett, Laura ^a   Pelcovitz, Michelle ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Catecholamines; Cortisol; Glucocorticoid receptors; Hypothalamic pituitary adrenal axis; Negative feedback; Pathophysiology

Indexed keywords

EID: 84889679120     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1093/oxfordhb/9780195399066.013.0012     Document Type: Chapter

References (149)

1. Aardal-Eriksson, E., Eriksson, T. E., & Thorell, L. (2001). Salivary cortisol, posttraumatic stress symptoms and general health in the acute phase and during 9-month follow-up. Biological Psychiatry 50, 986-993.
2. Adams, R. E., & Boscarino, J. A. (2006). Predictors of PTSD and delayed PTSD after disaster: The impact of exposure and psychosocial resources. Journal of Nervous and Mental Disease, 194(7), 485-493.
3. Afifi, T., O., Asmundson, G., J., Taylor, S., & Jang, K., L. (2010). The role of genes and environment on trauma exposure and posttraumatic stress disorder symptoms: A review of twin studies. Clinical Psychology Review, 30(1), 101-112.
4. Altemus, M., Cloitre, M., & Dhabhar, F. R. (2003). Enhanced cellular immune responses in women with PTSD related to childhood abuse. American Journal of Psychiatry, 160(9), 1705-1707.
5. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed., text rev.). Washington, DC: Author.
6. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: Author.
7. Anisman, H., Griffiths, J., Matheson, K., Ravindran, A. V., & Merali, Z. (2001). Posttraumatic stress symptoms and salivary cortisol levels. American Journal of Psychiatry, 158(9), 1509-1511.
8. Baker, D. G., West, S. A., Nicholson, W. E., Ekhator, N. N., Kasckow, J. W., Hill, K. K., et al. (1999). Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder American Journal of Psychiatry, 156, 585-588.
9. Bierer, L., M., Tischler, L., Labinsky, E., Cahill, S., Foa, E., & Yehuda, R. (2006). Clinical correlates of 24-hr. cortisol and norepinephrine excretion among subjects seeking treatment following the world trade center attacks on 9/11. Annals of the New York Academy of Sciences, 1071, 514-520.
10. Bohus, B., & Lissak, K. (1968). Adrenocortical hormones and avoidance behaviour of rats. International Journal of Neuropharmacology, 7(4), 301-306.
11. Bonne, O., Brandes, D., Gilboa, A., Gomori, J. M., Shenton, M. E., Pitman, R. K., et al. (2001). American Journal of Psychiatry, 158(8), 1248-1251.
12. Bremner, J. D. (2007) Functional neuroimaging in post-traumatic stress disorder. Expert Review of Neurotherapeutics, 7, 393-405.
13. Bremner, J. D., Randall, P., Scott, T. M., Bronen, R. A., Seibyl, J. P., Southwick, S. M., et al. (1995). MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. American Journal of Psychiatry, 152(7), 973-981.
14. Bremner, J. D., Randall, P., Vermetten, E., Staib, L., Bronen, R. A., Mazure, C., et al. (1997). Magnetic resonance imaging-based measurement of hipoocampal colume in posttraumatic stress disorder related to childhood physical and sexual abuse-a preliminary report. Biological Psychiatry, 41(1), 23-32.
15. Bremner, J. D., Staib, L. H., Kaloupek, D., Southwick, S. M., Soufer, R., & Charney, D. S. (1999). Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study. Biological Psychiatry, 45(7), 806-816.
16. Breslau, N., Kessler, R. C., Chilcoat, H. D., Schultz L. R., Davis, G. C., & Andreski, P. (1998). Trauma and posttraumatic stress disorder in the community: The 1996 Detroit Area Survey of Trauma. Archives of General Psychiatry, 55(7), 626-632.
17. Brewin, C. R., Andrews, B., & Valentine, J. D. (2000). Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. Journal of Consulting and Clinical Psychology, 68(5), 748-766.
18. Briere, J., Scott, C., & Weathers, F. (2005). Peritraumatic and persistent dissociation in the presumed etiology of PTSD. American Journal of Psychiatry, 162(12), 2295-2301.
19. Britton, J. C., Phan, K. L., Taylor, S. F., Fig, L. M., & Liberzon, I. (2005). Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biological Psychiatry, 57(8), 832-840.
20. Brunet, A., Weiss, D. S., Metzler, T. S., Best, S. R., Neylan, T. C., Rogers, C., et al. (2001). The Peritraumatic Distress Inventory: A proposed measure of PTSD Criterion A2. American Journal of Psychiatry, 158(9), 1480-1485.
21. Bryant, R. A. (2003). Early predictors of posttraumatic stress disorder. Biological Psychiatry, 53, 789-795.
22. Bryant, R. A., & Harvey A. G. (2002). Delayed-onset posttraumatic stress disorder: A prospective evaluation. Australian and New Zealand Journal of Psychiatry, 36(2), 205-209.
23. Bryant, R. A., & Panasetis, P. (2001). Panic symptoms during trauma and acute stress disorder. Behaviour Research Therapy, 39, 961-966.
24. Buckley, T. C., Blanchard, E. B., & Hickling, E. J. (1996). A prospective examination of delayed onset PTSD secondary to motor vehicle accidents. Journal of Abnormal Psychology, 105, 617-625.
25. Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Sciences, 4(6), 215-222.
26. Cahill, L., Prins, B., Weber, M., & McGaugh, J. L. (1994). Beta-adrenergic activation and memory for emotional events. Nature, 371(6499), 702-704.
27. Carty, J., O.'Donnell, M. L., & Creamer, M. (2006). Delayed-onset PTSD: A prospective study of injury survivors. Journal of Affective Disorders, 90, 257-261.
28. Charney, D. S., Deutch, A. Y., Krystal, J. H., Southwick, S. M., & Davis, M. (1993). Psychobiologic mechanisms of posttraumatic stress disorder. Archives of General Psychiatry, 50(4), 295-305.
29. Coupland, N. J., Hegadoren, K. M., & Myrholm, J. (2003). Increased beclomethasone-induced vasoconstriction in women with posttraumatic stress disorder. Journal of Psychiatric Research, 37(3), 221-228.
30. Dancu, C., V., Riggs, D. S., Hearst-Ikeda, D., Shoyer, B. G., & Foa, E. B. (1996). Dissociative experiences and posttraumatic stress disorder among female victims of criminal assault and rape. Journal of Traumatic Stress, 9(2), 253-267.
31. De Bellis, M. D., Baum, A. S., Birmaher, B., Keshavan, M. S., Eccard, C. H., Boring, A. M., et al. (1999). A. E. Bennett Research Award. Developmental traumatology. Part I: Biological stress systems. Biological Psychiatry, 45(10), 1259-1270.
32. de Kloet, E. R., Joels, M., Oitzl, M., & Sutanto, W. (1991). Implication of brain corticosteroid receptor diversity for the adaptation syndrome concept. Methods and Achievements in Experimental Pathology, 14, 104-132.
33. Delahanty, D. L., Raimonde, A. J., & Spoonster, E. (2000). Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims. Biological Psychiatry, 48, 940-947.
34. de Quervain, D. J., & Margraf, J. (2008). Glucocorticoids for the treatment of post-traumatic stress disorder and phobias: A novel therapeutic approach. European Journal of Pharmacology, 583, 365-371.
35. Díaz-Marsá, M., Carrasco, J. L., Basurte, E., Pastrana, J. I., Sáiz-Ruiz, J., & López-Ibor, J. J. (2007). Findings with 0.25 mg dexamethasone suppression test in eating disorders: Association with childhood trauma. CNS Spectrums, 12(9), 675-680.
36. Ehlers, A., Mayou, R. A., & Bryant, B. (1998). Psychological predictors of chronic PTSD after motor vehicle accidents. Journal of Abnormal Psychology, 107(3), 508-519.
37. Etkin, A., & Wager, T., D. (2007). Functional neuroimaging of anxiety: A meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry, 164, 1476-1488.
38. Fikretoglu, D., Brunet, A., Best, S. R., Metzler, T. J., Delucchi, K., Weiss, D. S., et al. (2007). Peritraumatic fear, helplessness and horror and peritraumatic dissociation: Do physical and cognitive symptoms of panic mediate the relationship between the two? Behaviour Research and Therapy, 45(1), 39-47.
39. Galea, S., Ahern, J., Resnick, H., Kilpratric, D., Bucuvalas, M., Gold, J., et al.(2002). Psychological sequelae of the September 11 terrorist attacks. New England Journal of Medicine, 346(13), 982-987.
40. Galea, S., Boscarino, J., Resnik, H., & Vlahov, D. (2003). Trends of probable post-traumatic stress disorder in New York City after the September 11 terrorist attacks. American Journal of Epidemiology, 158(6), 514-524.
41. Gilbertson, M. W., Gurvits, T. V., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2001). Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder. Journal of Traumatic Stress, 14(2), 413-432.
42. Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., et al. (2002). Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nature Neuroscience, 5(11), 1242-1247.
43. Glover, D., & Poland, R. (2002) Urinary cortisol and catecholamines in mothers of child cancer survivors with and without PTSD. Psychoneuroendocrinology, 27(7), 805-819.
44. Gotovac, K., Sabioncello, A., Rabatic, S., Berki, T., & Dekaris, D. (2003). Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: Lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). Clinical and Experimental Immunology, 131(2), 335-339.
45. Gray, M., J., Bolton, E. E., & Litz, B. T. (2004). A. longitudinal analysis of PTSD symptom course: Delayed-onset PTSD in Somalia peacekeepers. Journal of Consulting and Clinical Psychology, 72(5), 909-913.
46. Griffin, M. G., Resick, P. A., & Yehuda, R. (2005) Enhanced cortisol suppression following dexamethasone administration in domestic violence survivors. American Journal of Psychiatry, 162(6), 1192-1199.
47. Grossman, R., Yehuda, R., New, A., Schmeidler, J., Silverman, J., Mitropoulous, V., et al. (2003). Dexamethasone suppression test findings in subjects with personality disorders: Associations with posttraumatic stress disorder and major depression. American Journal of Psychiatry, 160(7), 1291-1298.
48. Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., et al. (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biological Psychiatry, 40(11), 1091-1099.
49. Guthrie, R. M., & Bryant, R. A. (2005). Auditory startle response in firefighters before and after trauma exposure. American Journal of Psychiatry, 162(2), 283-290.
50. Harvey, A. G., & Bryant, R. A. (2002). Acute stress disorder: A synthesis and critique. Psychological Bulletin, 128(6), 886-902.
51. Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J. C. (1995). Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders. Neuroendocrinology, 62(4), 340-347.
52. Kasai, K., Yamasue, H., Gilbertson, M. W., Shenton, M. E., Rauch, S. L., & Pitman, R. K. (2008). Evidence for acquired pregenual anterior cingulated gray matter loss from a twin study of combat-related posttraumatic stress disorder. Biological Psychiatry, 63(6), 550-556.
53. Kellner, M., Baker, D. G., & Yehuda, R. (1997). Salivary cortisol in Operation Desert Storm returnees. Biological Psychiatry, 42(9), 849-850.
54. Kessler, R. C., Sonnega, A., Bromet, E., Hughes, M., & Nelson, C. B. (1995). Posttraumatic stress disorder in the National Comorbidity Survey. Archives of General Psychiatry, 52(12), 1048-1060.
55. Koopman, C., Classen, C., Cardena, E., & Spiegel, D. (1995). When disaster strikes, acute stress disorder may follow. Journal of Traumatic Stress, 8(1), 29-46.
56. Koopman, C., Classen, C., & Spiegel, D. (1994). Predictors of posttraumatic stress symptoms among survivors of the Oakland/Berkeley, Calif., firestorm. American Journal of Psychiatry, 151(6), 888-894.
57. Kosten,T. R., Wahby, V., Giller, E., & Mason, J. (1990). The dexamethasone suppression test and thyrotropinreleasing hormone stimulation test in posttraumatic stress disorder. Biological Psychiatry, 28, 657-664.
58. Landfield, P. W., & Eldridge, J. C. (1994). The glucocorticoid hypothesis of age-related hippocampal neurodegeneration: Role of dysregulated intraneuronal calcium. Annals of the New York Academy of Sciences, 746, 308-312.
59. Lange, W., Wulff, H., Berea, C., Beblo, T., Saavedra, A. S., Mensebach, C., et al. (2005). Dexamethasone suppression test in borderline personality disorder-Effects of posttraumatic stress disorder. Psychoneuroendocrinology, 30(9), 919-923.
60. Lanius, R. A., Williamson, P. C., Hopper, J., Densmore, M., Boksman, K., Gupta, M. A., et al. (2003). Recall of emotional states in posttraumatic stress disorder: An fMRI investigation. Biological Psychiatry, 53(3), 204-210.
61. Lemieux, A. M., & Coe, C. L. (1995) Abuse-related posttraumatic stress disorder: Evidence for chronic neuroendocrine activation in women. Psychosomatic Medicine, 57(2), 105-115.
62. Lemieux, A., Coe, C. L., & Carnes, M. (2008). Symptom severity predicts degree of T cell activation in adult women following childhood maltreatment. Brain, Behavior, and Immunity, 22(6), 994-1003.
63. Liberzon, I., Taylor, S. F., Amdur, R., Jung, T. D., Chamberlain, K. R., Minoshima, S., et al. (1999). Brain activation in PTSD in response to trauma-related stimuli. Biological Psychiatry, 45(7), 817-826.
64. Lowy, M. T. (1989). Quantification of type I. and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues. Brain Research, 503(2), 191-197.
65. Macklin, M. L., Metzger, L. J., Litz, B. T., McNally, R. J., Lasko, N. B., Orr, S. P., et al. (1998). Lower precombat intelligence is a risk factor for posttraumatic stress disorder. Journal of Consulting and Clinical Psychology, 66(2), 323-326.
66. Maes, M., Delmeire, L., Mylle, J., & Altamura, C. (2001). Risk and preventive factors of post-traumatic stress disorder (PTSD): Alcohol consumption and intoxication prior to a traumatic event diminishes the relative risk to develop PTSD in response to that trauma. Journal of Affective Disorders, 63, 113-121.
67. Maes, M., Lin, A., Bonaccorso, S., van Hunsel, F., Van Gastel, A., Delmeire, L., et al. (1998) Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatrica Scandinavica, 98(4), 328-335.
68. Marmar, C., Metzler, T., Chemtob, C., Delucchi, K., Liberman, A., Fagan, J., et al. (2005, July). Impact of the World Trade Center attacks on New York City police officers; A prospective study. Annual Conference on Criminal Justice Research and Evaluation, Washington, DC.
69. Marmar, C. R., Metzler, T. J., & Otte, C. (2004). The Peritraumatic Dissociative Experiences Questionnaire. In J. P. Wilson and T. M. Keane (Eds), Assessing psychological trauma and PTSD (pp.). New York: Guilford.
70. Marmar, C. R., Weiss, D. S., Metzler, T. J., Delucchi, K. L., Best, S. R., & Wentworth, K. A. (1999). Longitudinal course and predictors of continuing distress in emergency services Personnel. Journal of Nervous and Mental Disease, 187, 15-22.
71. Marmar, C., Weiss, D., Schlenger, W., Fairbank, J., Jordan, B., Kulka, R., et al. (1994). Peritraumatic dissociation and post-traumatic stress in male Vietnam theater veterans. American Journal of Psychiatry, 151(6), 902-907.
72. Marshall, G. N., & Schell, T. L. (2002). Reappraising the link between peritraumatic dissociation and PTSD symptom severity: Evidence from a longitudinal study of community violence survivors. Journal of Abnormal Psychology, 111(4), 626-636.
73. Mason, J. W., Giller, E. L., Kosten, T. R., Ostroff, R. B., & Podd, L. (1986). Urinary free-cortisol levels in posttraumatic stress disorder patients. Journal of Nervous and Mental. Disease, 174(3), 145-159.
74. Mayou, R., Bryant, B., & Duthrie, R. (1993). Psychiatric consequences of road traffic accidents. British Medical Journal, 307, 647-651.
75. McEwen, B. S., Gould, E. A., & Sakai, R. R. (1992). The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. British Journal of Psychiatry, 15(Suppl.), 18-23.
76. McEwen, B. S., & Sapolsky, R. M. (1995). Stress and cognitive function. Current Opinion in Neurobiology, 5(2), 205-216.
77. McEwen, B. S., & Seeman, T. (1999). Protective and damaging effects of mediators of stress: Elaborating and testing the concepts of allostasis and allostatic load. Annals of the New York Academy of Sciences, 896, 30-47.
78. McFarlane A. C. (1989). The aetiology of post-traumatic morbidity: Predisposing, precipitating and perpetuating factors. British Journal of Psychiatry, 154, 221-228.
79. McNally R. J. (2003). Psychological mechanisms in acute response to trauma. Biological Psychiatry, 53(9), 779-788.
80. Milad, M. R., Quinn, B. T., Pitman, R. K., Orr, S. P., Fischl, B., & Rauch, S. L. (2005). Thickness of ventromedial prefrontal cortex in humans in correlated with extinction memory. Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10706-10711.
81. Morgan, C. A. 3rd, Southwick, S., Hazlett, G., Rasmusson, A., Hoyt, G., Zimolo, Z., et al. (2004). Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Archives of General Psychiatry, 61(8), 819-825.
82. Murray, J., Ehlers, A., & Mayou, R. A. (2002). Dissociation and post-traumatic stress disorder: Two prospective studies of road traffic accident survivors. British Journal of Psychiatry, 180, 363-368.
83. Newport, D. J., Heim, C., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2004). Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biological Psychiatry, 55(1), 10-20.
84. Neylan, T. C., Schuff, N., Lenoci, M., Yehuda, R., Weiner, M. W., & Marmar, C. R. (2003). Cortisol levels are positively correlated with hippocampal N-acetylaspartate. Biological Psychiatry, 54(10), 1118-1121.
85. Nixon, R. D., & Bryant, R. A. (2003). Peritraumatic and persistent panic attacks in acute stress disorder. Behaviour Research and Therapy, 41(10), 1237-1242.
86. Orr, S. P., Metzger, L. J., Lasko, N. B., Macklin, M. L., Hu, F. B., Shalev, A. Y. et al. (2003). Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: Association with posttraumatic stress disorder. Archives of General Psychiatry, 60(3), 283-288.
87. Orcutt, H. K., Erickson, D. J., & Wolfe, J. (2002). A prospective analysis of trauma exposure: The mediating role of PTSD symptomatology. Journal of Traumatic Stress, 15(3), 259-266.
88. Otte, C., Lenoci, M., Metzler, T., Yehuda, R., Marmar, C. R., & Neylan, T. C. (2005). Hypothalamic-pituitary-adrenal axis activity and sleep in posttraumatic stress disorder. Neuropsychopharmacology, 30(6), 1173-1180.
89. Ozer, E. J., Best, S. R., Lipsey, T. L., & Weiss, D. S. (2003). Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis. Psychological Bulletin, 129, 52-73.
90. Pervanidou, P., Kolaitis, G., Charitaki, S., Margeli, A., Ferentinos, S., Bakoula, C., et al. (2007). Elevated morning serum interleukin (IL)-6 or evening salivary cortisol concentrations predict posttraumatic stress disorder in children and adolescents six months after a motor vehicle accident. Psychoneuroendocrinology, 32, 991-999.
91. Phan, K. L., Britton, J. C., Taylor, S. F., Fig, L. M., & Liberzon, I. (2006). Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry, 63(2), 184-192.
92. Pitman, R. K. (1989). Post-traumatic stress disorder, hormones, and memory. Biological Psychiatry, 26, 221-223.
93. Pitman, R. K., Gilbertson, M. W., Gurvits, T. V., May, F. S., Lasko, N. B., Metzger, L. J., et al. (2006). Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure. Annals of the New York Academy of Sciences, 1071, 242-254.
94. Pitman, R. K., & Orr, S. P. (1990) Twenty-four hour urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder. Biological Psychiatry, 27(2), 245-247.
95. Pitman, R. K., Sanders, K. M., Zusman, R. M., Healy, A. R., Cheema, F., Lasko, N. B., et al. (2002). Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biological Psychiatry, 51(2), 189-192.
96. Pitman, R. K., Shalev, A. Y., & Orr, S. P. (2000). Posttraumatic stress disorder: Emotion, conditioning, and memory. In M. D. Corbetta & M. S. Gazzaniga (Eds.), The new cognitive neurosciences (pp. 687-700). New York: Plenum Press.
97. Rasmusson, A. M., Lipschitz, D. S., Wang, S., Hu, S., Vojvoda, D., Bremner, J. D., et al. (2001). Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biological Psychiatry, 50(12), 965-977.
98. Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006). Neurocircuitry models of posttraumatic stress disorder and extinction: Human neuroimaging research-Past, present, and future. Biological Psychiatry, 60(4), 376-382.
99. Rauch, S. L., Shin, L. M., Segal, E., Pitman, R. K., Carson, M. A., McMullin, K., et al. (2003). Selectively reduced regional cortical volumes in post-traumatic stress disorder. Neuroreport, 14(7), 913-916.
100. Rauch, S. L., van der Kolk, B. A., Fisler, R. E., Alpert, N. M., Orr, S. P., Savage, C. R., et al. (1996). A symptom provocation study of posttraumatic stress disorder using positron emission topography and script-driven imagery, Archives of General Psychiatry, 53(5), 380-387.
101. Resnick, H. S., Yehuda, R., Pitman, R. K., & Foy D. W. (1995). Effect of previous trauma on acute plasma cortisol level following rape. American Journal of Psychiatry, 152(11), 1675-1677.
102. Sapolsky, R. M. (1994). The physiological relevance of glucocorticoid endangerment of the hippocampus. Annals of the New York Academy of Sciences, 746, 294-304.
103. Sapolsky, R. M., (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57(10), 925-935.
104. Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984). Stress down-regulates corticosterone receptors in a sitespecific manner in the brain. Endocrinology, 114, 287-292.
105. Schelling, G., Briegel, J., Roozendaal, B., Stoll, C., Rothenhausler, H. B., & Kapfhammer, H. P. (2001). The effect of stress doses of hydrocortisone during septic shock on posttraumatic stress disorder in survivors. Biological Psychiatry, 50(12), 978-985.
106. Shalev, A. Y. (1992). Posttraumatic stress disorder among injured survivors of a terrorist attack: Predictive value of early intrusions and avoidane symptoms. Journal of Nervous and Mental Disease, 180, 505-509.
107. Shalev, A. Y., Sahar, T., Freedman, S., Peri, T., Glick, N., Brandes, D., et al. (1998). A prospective study of heart rate response following trauma and the subsequent development of posttraumatic stress disorder. Archives of General Psychiatry, 55, 553-559.
108. Shin, L. M., Orr, S. P., Carson, M. A., Rauch, S. L., Macklin, M. L., Lasko, N. B., et al. (2004). Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female veterans with PTSD. Archives of General Psychiatry, 61(2), 168-176.
109. Shin, L. M., Whalen, P. J., Pitman, R. K., Bush, G., Macklin, M. L., Lasko, N. B., et al. (2001). An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biological Psychiatry, 50(12), 932-942.
110. Shin, L. M., Wright, C. I., Cannistraro, P. A., Wedig, M. M., McMullin, K., Martis, B., et al. (2005). A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Archives of General Psychiatry, 62(3), 273-281.
111. Simeon, D., Guralnik, O., Knutelska, M., Yehuda, R., & Schmeidler, J. (2003). Basal norepinephrine in depersonalization disorder. Psychiatry Research, 121, 93-97.
112. Simeon, D., Knutelska, M., Yehuda, R., Putnam, F., Schmeidler, J., & Smith, L. M. (2007). Hypothalamic-pituitaryadrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biological Psychiatry, 61(8), 966-973.
113. Southwick, S. M., Krystal, J. H., Bremner, J. D., Morgan, C. A., 3rd, Nicolaou, A. L., Nagy, L. M., et al. (1997). Noradrenergic and serotonergic function in posttraumatic stress disorder. Archives of General Psychiatry, 54(8), 749-758.
114. Spiegel, D., Classen, C., & Cardena, E. (2000). New DSM-IV diagnosis of acute stress disorder. American Journal of Psychiatry, 157(11), 1890-1891.
115. Stein, M. B., Koverola, C., Torchia, M. G., & McClarty, B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychological Medicine, 27(4), 951-959.
116. Stein, M. B., Yehuda, R., Koverola, C., & Hanna, C. (1997). Enhanced dexamethasone suppression of plasma cortisol in adult women traumatized by childhood sexual abuse. Biological Psychiatry, 42(8), 680-686.
117. Svec, F. (1985). Glucocorticoid receptor regulation. Life Sciences, 36(25), 2359-2366.
118. Thaller, V., Vrkljan, M., Hotujac, L., & Thakore, J. (1999). The potential role of hypocortisolism in the pathophysiology of PTSD and psoriasis. Collegium Antropologicum, 23(2), 611-619.
119. Vaiva, G., Thomas, P., Ducrocq, F., Fontaine, M., Boss, V., Devos, P., et al. (2004). Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder. Biological Psychiatry, 55(3), 250-254.
120. Wheler, G. H., Brandon, D., Clemons, A., Riley, C., Kendall, J., Loriaux, D. L., et al. (2006). Cortisol production rate in posttraumatic stress disorder. Journal of Clinical Endocrinology and Metabolism, 91(9), 3486-3489.
121. Williams, L. M., Kemp, A. H., Felmingham, K., Barton, M., Olivieri, G., Peduto, A., et al. (2006). Trauma modulates amygdale and medial prefrontal responses to consciously attended fear. Neuroimage, 29(2), 347-257.
122. Woodward, S. H., Kaloupek, D. G., Streeter, C. C., Martinez, C., Schaer, M., & Eliez, S. (2006). Decreased anterior cingulate volume in combat-related PTSD. Biological Psychiatry, 59(7), 582-587.
123. Yamasue, H., Kasai, K., Iwanami, A., Ohtani, T., Yamada, H., Abe, O., et al. (2003). Voxel-based analysis of MRI reveals anterior cingulated gray-matter volume reduction in posstraumatic stress disorder due to terrorism. Proceedings of the National Academy of Sciences in the United States, 100(15), 9039-9043.
124. Yehuda, R. (1997) Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder. Annals of the New York Academy of Sciences 821, 57-75.
125. Yehuda, R., Bell, A., Bierer, L. M., & Schmeidler, J. (2008). Maternal, not paternal, PTSD is related to increased risk for PTSD in offspring of Holocaust survivors. Journal of Psychiatric Research, 42(13), 1104-1111.
126. Yehuda, R., Bierer, L. M., Schmeidler, J., Aferiat, D. H., Breslau, I., & Dolan, S. (2000). Low cortisol and risk for PTSD in adult offspring of holocaust survivors. American Journal of Psychiatry, 157(8), 1252-1259.
127. Yehuda, R., Boisoneau, D., Lowy, M. T., & Giller, E. L. (1995). Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Archives of General Psychiatry, 52(7), 583-593.
128. Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993). Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biological Psychiatry, 34, 18-25.
129. Yehuda, R., Brand, S., & Yang, R. K. (2006). Plasma neuropeptide Y concentrations in combat exposed veterans:Relationship to trauma exposure, recovery from PTSD, and coping. Biological Psychiatry, 59(7), 660-663.
130. Yehuda, R., Golier, J. A., Tischler, L., Harvey, P. D., Newmark, R., Yang, R. K., et al. (2007). Hippocampal volume in aging combat veterans with and without post-traumatic stress disorder: Relation to risk and resilience factors. Journal of Psychiatric Research, 41(5), 435-445.
131. Yehuda, R., Golier, J. A., Yang, R. K., & Tischler, L. (2004). Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biological Psychiatry, 55(11), 1110-1116.
132. Yehuda, R., Halligan, S. L., & Bierer, L. M. (2001). Relationship of parental trauma exposure and PTSD to PTSD, depressive and anxiety disorders in offspring. Journal of Psychiatric Research, 35(5), 261-269.
133. Yehuda, R., Halligan, S. L., & Grossman, R. (2001). Childhood trauma and risk for PTSD: Relationship to intergenerational effects of trauma, parental PTSD and cortisol excretion. Development and Psychopathology, 13(3), 733-753.
134. Yehuda, R., Halligan, S. L., Grossman, R., Golier, J. A., & Wong, C. (2002). The cortisol and glucocorticoid receptor response to low dose dexamethasone administration in aging combat veterans and Holocaust survivors with and without posttraumatic stress disorder. Biological Psychiatry, 52(5), 393-403.
135. Yehuda, R., Halligan, S. L., Golier, J. A., Grossman, R., & Bierer, L. M. (2004). Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology, 29(3), 389-404.
136. Yehuda, R., Harvey, P. D., Buchsbaum, M., Tischler, L., & Schmeidler, J. (2007). Enhanced effects of cortisol administration on working memory in PTSD. Neuropsychopharmacology, 32(12), 2581-2591.
137. Yehuda, R., Kahana, B., Binder-Brynes, K., Southwick, S. M., Mason, J. W., & Giller, E. L. (1995). Low urinary cortisol excretion in Holocaust survivors with posttraumatic stress disorder. American Journal of Psychiatry, 152(7), 982-986.
138. Yehuda, R., & LeDoux, J. (2007). Response variation following trauma: A translational neuroscience approach to understanding PTSD. Neuron Review, 56, 19-32.
139. Yehuda, R., Lowy, M. T., Southwick, S., Shaffer, D., & Giller, E. L. (1991). Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. American Journal of Psychiatry, 148(4), 499-504.
140. Yehuda, R., McFarlane, A. C., & Shalev A. Y. (1998b). Predicting the development of posttraumatic stress disorder from the acute response to a traumatic event. Biological Psychiatry, 44(12), 1305-1313.
141. Yehuda, R., Morris, A., Labinsky, E., Zemelman, S., & Schmeidler, J. (2007). Ten-year follow-up study of cortisol levels in aging Holocaust survivors with and without PTSD. Journal of Traumatic Stress, 20(5), 757-761.
142. Yehuda, R., Southwick, S. M., Krystal, J. H., Bremner, D., Charney, D. S., & Mason, J. W. (1993). Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. American Journal of Psychiatry, 150, 83-86.
143. Yehuda, R., Southwick, S. M., Nussbaum, G., Wahby, V., Giller, E. L., & Mason J. W. (1990). Low urinary cortisol excretion in patients with posttraumatic stress disorder. Journal of Nervous and Mental Disease, 178(6), 366-369.
144. Yehuda, R., Schmeidler, J., Wainberg, M., Binder-Brynes, K., & Duvdevani, T. (1998). Vulnerability to posttraumatic stress disorder in adult offspring of Holocaust survivors. American Journal of Psychiatry, 155(9), 1163-1171.
145. Yehuda, R., Teicher, M. H., Seckl, J. R., Grossman, R. A., Morris, A., & Bierer L. M. (2007). Parental posttraumatic stress disorder as a vulnerability factor for low cortisol trait in offspring of holocaust survivors. Archives of General Psychiatry, 64(9), 1040-1048.
146. Yehuda, R., Teicher, M. H., Trestman, R. L., Levengood, R. A., & Siever L. J. (1996). Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biological Psychiatry, 40(2), 79-88.
147. Yehuda, R., Yang, R. K., Buchsbaum, M. S., & Golier J. A. (2006). Alterations in cortisol negative feedback inhibition as examined using the ACTH response to cortisol administration in PTSD. Psychoneuroendocrinology, 31(4), 447-451.
148. Young, E. A., & Breslau, N. (2004). Cortisol and catecholamines in posttraumatic stress disorder: An epidemiologic community study. Archives of General Psychiatry, 61(4), 394-401.
149. Zangrossi, H., Jr., Viana, M. B., & Graeff, F. G. (1999). Anxiolytic effect of intra-amygdala injection of midazolam an 8-hydroxy-2-(di-n-propylamino) tetralin in the elevated T-maze. European Journal of Pharmacology, 369(3), 267-270.