-
1
-
-
60849097255
-
Gene-expression signatures in breast cancer
-
10.1056/NEJMra0801289, 19228622
-
Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009, 360(8):790-800. 10.1056/NEJMra0801289, 19228622.
-
(2009)
N Engl J Med
, vol.360
, Issue.8
, pp. 790-800
-
-
Sotiriou, C.1
Pusztai, L.2
-
2
-
-
55749115981
-
A genomic approach to identify molecular pathways associated with chemotherapy resistance
-
10.1158/1535-7163.MCT-08-0642, 18852117
-
Riedel RF, et al. A genomic approach to identify molecular pathways associated with chemotherapy resistance. Mol Cancer Ther 2008, 7(10):3141-9. 10.1158/1535-7163.MCT-08-0642, 18852117.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.10
, pp. 3141-3149
-
-
Riedel, R.F.1
-
3
-
-
67651083239
-
Systematizing serendipity for cardiovascular drug discovery
-
10.1161/CIRCULATIONAHA.108.824177, 2756982, 19620524
-
Schlueter PJ, Peterson RT. Systematizing serendipity for cardiovascular drug discovery. Circulation 2009, 120(3):255-63. 10.1161/CIRCULATIONAHA.108.824177, 2756982, 19620524.
-
(2009)
Circulation
, vol.120
, Issue.3
, pp. 255-263
-
-
Schlueter, P.J.1
Peterson, R.T.2
-
4
-
-
65949087244
-
Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses
-
10.1158/0008-5472.CAN-08-3403, 19383916
-
Ebi H, et al. Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses. Cancer Res 2009, 69(9):4027-35. 10.1158/0008-5472.CAN-08-3403, 19383916.
-
(2009)
Cancer Res
, vol.69
, Issue.9
, pp. 4027-4035
-
-
Ebi, H.1
-
5
-
-
60749091249
-
Targeted cancer therapeutics
-
discussion 1267, 10.1158/0008-5472.CAN-08-3836, 19208830
-
Hait WN, Hambley TW. Targeted cancer therapeutics. Cancer Res 2009, 69(4):1263-7. discussion 1267, 10.1158/0008-5472.CAN-08-3836, 19208830.
-
(2009)
Cancer Res
, vol.69
, Issue.4
, pp. 1263-1267
-
-
Hait, W.N.1
Hambley, T.W.2
-
6
-
-
58049221094
-
A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities
-
10.1073/pnas.0806674105, 2592987, 19050079
-
Garman KS, et al. A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci USA 2008, 105(49):19432-7. 10.1073/pnas.0806674105, 2592987, 19050079.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.49
, pp. 19432-19437
-
-
Garman, K.S.1
-
7
-
-
40449099255
-
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
-
10.1158/0008-5472.CAN-07-6013, 18316609
-
Yamashita T, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 2008, 68(5):1451-61. 10.1158/0008-5472.CAN-07-6013, 18316609.
-
(2008)
Cancer Res
, vol.68
, Issue.5
, pp. 1451-1461
-
-
Yamashita, T.1
-
8
-
-
33947204625
-
Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma
-
10.1158/1078-0432.CCR-06-1025, 17317821
-
Jia HL, et al. Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin Cancer Res 2007, 13(4):1133-9. 10.1158/1078-0432.CCR-06-1025, 17317821.
-
(2007)
Clin Cancer Res
, vol.13
, Issue.4
, pp. 1133-1139
-
-
Jia, H.L.1
-
9
-
-
33747029250
-
Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
-
10.1016/j.ccr.2006.06.016, 16904609
-
Budhu A, et al. prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 2006, 10(2):99-111. 10.1016/j.ccr.2006.06.016, 16904609.
-
(2006)
Cancer Cell
, vol.10
, Issue.2
, pp. 99-111
-
-
Budhu, A.1
-
10
-
-
0037391756
-
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
-
10.1038/nm843, 12640447
-
Ye QH, et al. predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003, 9(4):416-23. 10.1038/nm843, 12640447.
-
(2003)
Nat Med
, vol.9
, Issue.4
, pp. 416-423
-
-
Ye, Q.H.1
-
11
-
-
84862962647
-
Large Scale Genome Variation in Health and Disease in: Cytogenetics and Genome Research
-
Nijmegen
-
Kessel AGV. Large Scale Genome Variation in Health and Disease in: Cytogenetics and Genome Research. 2006, Nijmegen.
-
(2006)
-
-
Kessel, A.G.V.1
-
12
-
-
33845876254
-
The Connectivity Map: a new tool for biomedical research
-
10.1038/nrc2044, 17186018
-
Lamb J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 2007, 7(1):54-60. 10.1038/nrc2044, 17186018.
-
(2007)
Nat Rev Cancer
, vol.7
, Issue.1
, pp. 54-60
-
-
Lamb, J.1
-
13
-
-
34548799629
-
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
-
10.1073/pnas.0610292104, 1941805, 17666531
-
Lee JK, et al. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci USA 2007, 104(32):13086-91. 10.1073/pnas.0610292104, 1941805, 17666531.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.32
, pp. 13086-13091
-
-
Lee, J.K.1
-
14
-
-
27344435774
-
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
-
10.1073/pnas.0506580102, 1239896, 16199517
-
Subramanian A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005, 102(43):15545-50. 10.1073/pnas.0506580102, 1239896, 16199517.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.43
, pp. 15545-15550
-
-
Subramanian, A.1
-
15
-
-
79960338041
-
An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors
-
10.1371/journal.pone.0022274, 3137633, 21789246
-
Huang L, et al. An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors. PLoS One 2011, 6(7):e22274. 10.1371/journal.pone.0022274, 3137633, 21789246.
-
(2011)
PLoS One
, vol.6
, Issue.7
-
-
Huang, L.1
-
16
-
-
79960570375
-
A pharmacogenomic method for individualized prediction of drug sensitivity
-
Cohen AL, et al. A pharmacogenomic method for individualized prediction of drug sensitivity. Mol Syst Biol 2011, 513.
-
(2011)
Mol Syst Biol
, pp. 513
-
-
Cohen, A.L.1
-
17
-
-
84870421832
-
Trifluoperazine an antipsychotic agent inhibits cancer stem cell growth and overcomes drug resistance of lung cancer
-
10.1164/rccm.201207-1180OC, 23024022
-
Yeh CT, et al. Trifluoperazine an antipsychotic agent inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. Am J Respir Crit Care Med 2012, 186(11):1180-8. 10.1164/rccm.201207-1180OC, 23024022.
-
(2012)
Am J Respir Crit Care Med
, vol.186
, Issue.11
, pp. 1180-1188
-
-
Yeh, C.T.1
-
18
-
-
84872783025
-
TAZ Expression as a Prognostic Indicator in Colorectal Cancer
-
10.1371/journal.pone.0054211, 3553150, 23372686
-
Yuen HF, et al. TAZ Expression as a Prognostic Indicator in Colorectal Cancer. PLoS One 2013, 8(1):e54211. 10.1371/journal.pone.0054211, 3553150, 23372686.
-
(2013)
PLoS One
, vol.8
, Issue.1
-
-
Yuen, H.F.1
-
19
-
-
84866070620
-
Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma
-
Edris B, et al. Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. Sarcoma 2012, 805614.
-
(2012)
Sarcoma
, pp. 805614
-
-
Edris, B.1
-
20
-
-
80054932086
-
Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach
-
10.1097/JTO.0b013e31822adfb0, 3196823, 21964532
-
Reka AK, et al. Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach. J Thorac Oncol 2011, 6(11):1784-92. 10.1097/JTO.0b013e31822adfb0, 3196823, 21964532.
-
(2011)
J Thorac Oncol
, vol.6
, Issue.11
, pp. 1784-1792
-
-
Reka, A.K.1
-
21
-
-
80052576073
-
Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer
-
10.1371/journal.pone.0024662, 3170379, 21931799
-
Claerhout S, et al. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PLoS One 2011, 6(9):e24662. 10.1371/journal.pone.0024662, 3170379, 21931799.
-
(2011)
PLoS One
, vol.6
, Issue.9
-
-
Claerhout, S.1
-
22
-
-
77956596734
-
From NPC therapeutic target identification to potential treatment strategy
-
10.1158/1535-7163.MCT-09-0966, 20716640
-
Lan MY, et al. From NPC therapeutic target identification to potential treatment strategy. Mol Cancer Ther 2010, 9(9):2511-23. 10.1158/1535-7163.MCT-09-0966, 20716640.
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.9
, pp. 2511-2523
-
-
Lan, M.Y.1
-
23
-
-
84863087650
-
Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug
-
Lee HS, et al. Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. BMC Syst Biol 2012, 80.
-
(2012)
BMC Syst Biol
, pp. 80
-
-
Lee, H.S.1
-
24
-
-
79958754253
-
PREDICT: a method for inferring novel drug indications with application to personalized medicine
-
Gottlieb A, et al. pREDICT: a method for inferring novel drug indications with application to personalized medicine. Mol Syst Biol 2011, 496.
-
(2011)
Mol Syst Biol
, pp. 496
-
-
Gottlieb, A.1
-
25
-
-
68449088145
-
Human disease-drug network based on genomic expression profiles
-
10.1371/journal.pone.0006536, 2715883, 19657382
-
Hu G, Agarwal P. Human disease-drug network based on genomic expression profiles. PLoS One 2009, 4(8):e6536. 10.1371/journal.pone.0006536, 2715883, 19657382.
-
(2009)
PLoS One
, vol.4
, Issue.8
-
-
Hu, G.1
Agarwal, P.2
-
26
-
-
79952213086
-
Using a stem cell-based signature to guide therapeutic selection in cancer
-
10.1158/0008-5472.CAN-10-1735, 3049992, 21169407
-
Shats I, et al. Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Res 2011, 71(5):1772-80. 10.1158/0008-5472.CAN-10-1735, 3049992, 21169407.
-
(2011)
Cancer Res
, vol.71
, Issue.5
, pp. 1772-1780
-
-
Shats, I.1
-
27
-
-
84855381399
-
A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy
-
10.1158/0008-5472.CAN-11-2333, 3251651, 22108825
-
Jin G, et al. A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Res 2012, 72(1):33-44. 10.1158/0008-5472.CAN-11-2333, 3251651, 22108825.
-
(2012)
Cancer Res
, vol.72
, Issue.1
, pp. 33-44
-
-
Jin, G.1
-
28
-
-
84864115444
-
Identifying mechanistic similarities in drug responses
-
10.1093/bioinformatics/bts290, 22592382
-
Zhao C, et al. Identifying mechanistic similarities in drug responses. Bioinformatics 2012, 28(14):1902-10. 10.1093/bioinformatics/bts290, 22592382.
-
(2012)
Bioinformatics
, vol.28
, Issue.14
, pp. 1902-1910
-
-
Zhao, C.1
-
29
-
-
84861150677
-
Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer
-
10.1371/journal.pcbi.1002347, 3276504, 22346740
-
Shigemizu D, et al. Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer. PLoS Comput Biol 2012, 8(2):e1002347. 10.1371/journal.pcbi.1002347, 3276504, 22346740.
-
(2012)
PLoS Comput Biol
, vol.8
, Issue.2
-
-
Shigemizu, D.1
-
30
-
-
79551622693
-
Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping
-
10.1371/journal.pone.0016382, 3031567, 21305029
-
McArt DG, Zhang SD. Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping. PLoS One 2011, 6(1):e16382. 10.1371/journal.pone.0016382, 3031567, 21305029.
-
(2011)
PLoS One
, vol.6
, Issue.1
-
-
McArt, D.G.1
Zhang, S.D.2
-
31
-
-
84870461533
-
FacPad: Bayesian sparse factor modeling for the inference of pathways responsive to drug treatment
-
10.1093/bioinformatics/bts502, 3467747, 22923307
-
Ma H, Zhao H. FacPad: Bayesian sparse factor modeling for the inference of pathways responsive to drug treatment. Bioinformatics 2012, 28(20):2662-70. 10.1093/bioinformatics/bts502, 3467747, 22923307.
-
(2012)
Bioinformatics
, vol.28
, Issue.20
, pp. 2662-2670
-
-
Ma, H.1
Zhao, H.2
-
32
-
-
77950571618
-
Naringenin and 17beta-estradiol coadministration prevents hormone-induced human cancer cell growth
-
Bulzomi P, et al. Naringenin and 17beta-estradiol coadministration prevents hormone-induced human cancer cell growth. IUBMB Life 2010, 62(1):51-60.
-
(2010)
IUBMB Life
, vol.62
, Issue.1
, pp. 51-60
-
-
Bulzomi, P.1
-
33
-
-
3042717657
-
Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells
-
10.1677/jme.0.0320649, 15171706
-
Inoue A, et al. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J Mol Endocrinol 2004, 32(3):649-61. 10.1677/jme.0.0320649, 15171706.
-
(2004)
J Mol Endocrinol
, vol.32
, Issue.3
, pp. 649-661
-
-
Inoue, A.1
-
34
-
-
78650866393
-
MYB suppresses differentiation and apoptosis of human breast cancer cells
-
10.1186/bcr2614, 2949644, 20659323
-
Drabsch Y, Robert RG, Gonda TJ. MYB suppresses differentiation and apoptosis of human breast cancer cells. Breast Cancer Res 2010, 12(4):R55. 10.1186/bcr2614, 2949644, 20659323.
-
(2010)
Breast Cancer Res
, vol.12
, Issue.4
-
-
Drabsch, Y.1
Robert, R.G.2
Gonda, T.J.3
-
35
-
-
33746908103
-
Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
-
10.1158/0008-5472.CAN-05-4269, 16849584
-
Frasor J, et al. Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res 2006, 66(14):7334-40. 10.1158/0008-5472.CAN-05-4269, 16849584.
-
(2006)
Cancer Res
, vol.66
, Issue.14
, pp. 7334-7340
-
-
Frasor, J.1
-
37
-
-
84860868794
-
Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling
-
Guo AJ, et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin Med 2012, 10.
-
(2012)
Chin Med
, pp. 10
-
-
Guo, A.J.1
-
38
-
-
59849083230
-
Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist
-
10.1016/j.febslet.2009.01.030, 19171140
-
Wang J, et al. Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist. FEBS Lett 2009, 583(4):643-7. 10.1016/j.febslet.2009.01.030, 19171140.
-
(2009)
FEBS Lett
, vol.583
, Issue.4
, pp. 643-647
-
-
Wang, J.1
-
39
-
-
1642539199
-
Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol
-
10.1002/jcp.10398, 14603522
-
Hung H. Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol. Journal of Cellular Physiology 2004, 198(2):197-208. 10.1002/jcp.10398, 14603522.
-
(2004)
Journal of Cellular Physiology
, vol.198
, Issue.2
, pp. 197-208
-
-
Hung, H.1
-
40
-
-
38349049189
-
Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary
-
10.1677/JOE-07-0358, 18000302
-
Kim HJ, et al. Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary. J Endocrinol 2007, 195(3):393-405. 10.1677/JOE-07-0358, 18000302.
-
(2007)
J Endocrinol
, vol.195
, Issue.3
, pp. 393-405
-
-
Kim, H.J.1
-
41
-
-
34250889281
-
Estrogen-dependent regulation of Eg5 in breast cancer cells
-
10.1097/CAD.0b013e3280a02f2b, 17581299
-
Planas-Silva MD, Filatova IS. Estrogen-dependent regulation of Eg5 in breast cancer cells. Anticancer Drugs 2007, 18(7):773-9. 10.1097/CAD.0b013e3280a02f2b, 17581299.
-
(2007)
Anticancer Drugs
, vol.18
, Issue.7
, pp. 773-779
-
-
Planas-Silva, M.D.1
Filatova, I.S.2
-
42
-
-
0022220859
-
Therapeutic drug monitoring
-
Edinburgh; New York: Churchill Livingstone
-
Widdop B. Therapeutic drug monitoring. Contemporary issues in clinical biochemistry 1985, Edinburgh; New York: Churchill Livingstone.
-
(1985)
Contemporary issues in clinical biochemistry
-
-
Widdop, B.1
-
43
-
-
0023902246
-
Clinical and endocrine effects of cyproterone acetate in postmenopausal patients with advanced breast cancer
-
10.1016/S0277-5379(98)90011-6, 2968261
-
Willemse PH, et al. Clinical and endocrine effects of cyproterone acetate in postmenopausal patients with advanced breast cancer. Eur J Cancer Clin Oncol 1988, 24(3):417-21. 10.1016/S0277-5379(98)90011-6, 2968261.
-
(1988)
Eur J Cancer Clin Oncol
, vol.24
, Issue.3
, pp. 417-421
-
-
Willemse, P.H.1
-
44
-
-
84871368849
-
BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer
-
10.1158/1535-7163.MCT-12-0447, 23047891
-
Awasthi N, et al. BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer. Mol Cancer Ther 2012, 11(12):2644-53. 10.1158/1535-7163.MCT-12-0447, 23047891.
-
(2012)
Mol Cancer Ther
, vol.11
, Issue.12
, pp. 2644-2653
-
-
Awasthi, N.1
-
45
-
-
84889684034
-
A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography
-
Lee SJ, et al. A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography. Invest New Drugs 2012,
-
(2012)
Invest New Drugs
-
-
Lee, S.J.1
-
46
-
-
79551630554
-
Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program
-
10.1002/pbc.22741, 21298745
-
Kolb EA, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer 2011, 56(4):595-603. 10.1002/pbc.22741, 21298745.
-
(2011)
Pediatr Blood Cancer
, vol.56
, Issue.4
, pp. 595-603
-
-
Kolb, E.A.1
-
47
-
-
73149120253
-
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
-
10.1158/1535-7163.MCT-09-0499, 19996272
-
Carboni JM, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 2009, 8(12):3341-9. 10.1158/1535-7163.MCT-09-0499, 19996272.
-
(2009)
Mol Cancer Ther
, vol.8
, Issue.12
, pp. 3341-3349
-
-
Carboni, J.M.1
-
48
-
-
77953710936
-
High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer
-
Litzenburger BC, et al. High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer. Cancer Research 2009, 69(24):581s-581s.
-
(2009)
Cancer Research
, vol.69
, Issue.24
-
-
Litzenburger, B.C.1
-
49
-
-
84889689307
-
Phase 1 Dose-Escalating Study of Bms-754807 in Japanese Patients with Advanced Solid Tumors
-
Tamura Y, et al. phase 1 Dose-Escalating Study of Bms-754807 in Japanese Patients with Advanced Solid Tumors. Annals of Oncology 2012, 111-112.
-
(2012)
Annals of Oncology
, pp. 111-112
-
-
Tamura, Y.1
-
50
-
-
79551630554
-
Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program
-
10.1002/pbc.22741, 21298745
-
Kolb EA, et al. Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2011, 56(4):595-603. 10.1002/pbc.22741, 21298745.
-
(2011)
Pediatr Blood Cancer
, vol.56
, Issue.4
, pp. 595-603
-
-
Kolb, E.A.1
-
51
-
-
84889678033
-
BMS-754807, an oral dual IGF-1R/insulin receptor (IR) inhibitor: initial results from a Phase 1 dose- and schedule-finding study in combination with carboplatin/paclitaxel in subjects with solid tumors
-
Chu QS, et al. BMS-754807, an oral dual IGF-1R/insulin receptor (IR) inhibitor: initial results from a Phase 1 dose- and schedule-finding study in combination with carboplatin/paclitaxel in subjects with solid tumors. Ejc Supplements 2010, 8(7):131-131.
-
(2010)
Ejc Supplements
, vol.8
, Issue.7
, pp. 131-131
-
-
Chu, Q.S.1
-
52
-
-
84889670538
-
Targeting Type I Insulin-Like Growth Factor Receptor and Insulin Receptor for Cancer Therapy: The Oral Dual Inhibitor Bms-754807 in Clinical Development
-
Desai J, et al. Targeting Type I Insulin-Like Growth Factor Receptor and Insulin Receptor for Cancer Therapy: The Oral Dual Inhibitor Bms-754807 in Clinical Development. Annals of Oncology 2010, 9-9.
-
(2010)
Annals of Oncology
, pp. 9-9
-
-
Desai, J.1
-
53
-
-
0018054267
-
Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons
-
Macdonald RL, Bergey GK. Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons. Trans Am Neurol Assoc 1978, 254-6.
-
(1978)
Trans Am Neurol Assoc
, pp. 254-256
-
-
Macdonald, R.L.1
Bergey, G.K.2
-
54
-
-
42649109021
-
Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors
-
10.1016/j.ctrv.2007.11.003, 18226465
-
Duenas-Gonzalez A, et al. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat Rev 2008, 34(3):206-22. 10.1016/j.ctrv.2007.11.003, 18226465.
-
(2008)
Cancer Treat Rev
, vol.34
, Issue.3
, pp. 206-222
-
-
Duenas-Gonzalez, A.1
-
55
-
-
36749072618
-
Valproic acid as anti-cancer drug
-
10.2174/138161207782360528, 18045192
-
Michaelis M, Doerr HW, Cinatl J. Valproic acid as anti-cancer drug. Curr Pharm Des 2007, 13(33):3378-93. 10.2174/138161207782360528, 18045192.
-
(2007)
Curr Pharm Des
, vol.13
, Issue.33
, pp. 3378-3393
-
-
Michaelis, M.1
Doerr, H.W.2
Cinatl, J.3
-
56
-
-
37049031651
-
Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells
-
10.1016/j.canlet.2007.10.006, 18006146
-
Fortunati N, et al. Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells. Cancer Lett 2008, 259(2):156-64. 10.1016/j.canlet.2007.10.006, 18006146.
-
(2008)
Cancer Lett
, vol.259
, Issue.2
, pp. 156-164
-
-
Fortunati, N.1
-
57
-
-
33645820586
-
Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
-
10.1200/JCO.2005.03.2755, 16505416
-
Oh DS, et al. Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. Journal of Clinical Oncology 2006, 24(11):1656-64. 10.1200/JCO.2005.03.2755, 16505416.
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.11
, pp. 1656-1664
-
-
Oh, D.S.1
-
58
-
-
77957731078
-
Dictionary of pharmacological agents
-
London; Weinheim; New York: Chapman & Hall, 1 livret d'installation d'un cédérom
-
Macdonald F. Dictionary of pharmacological agents. 1997, London; Weinheim; New York: Chapman & Hall, 1 livret d'installation d'un cédérom.
-
(1997)
-
-
Macdonald, F.1
-
59
-
-
0034890377
-
Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin, sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001
-
Munster PN, et al. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin, sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001. Clin Cancer Res 2001, 7(8):2228-36.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.8
, pp. 2228-2236
-
-
Munster, P.N.1
-
60
-
-
84875435418
-
Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
-
10.1038/nchem.1596, 23511419
-
Kitson RR, et al. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem 2013, 5(4):307-14. 10.1038/nchem.1596, 23511419.
-
(2013)
Nat Chem
, vol.5
, Issue.4
, pp. 307-314
-
-
Kitson, R.R.1
-
61
-
-
34547933867
-
Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
-
10.1016/j.jmb.2007.06.065, 17662999
-
Onuoha SC, et al. Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. J Mol Biol 2007, 372(2):287-97. 10.1016/j.jmb.2007.06.065, 17662999.
-
(2007)
J Mol Biol
, vol.372
, Issue.2
, pp. 287-297
-
-
Onuoha, S.C.1
-
62
-
-
84866523199
-
SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line
-
Bellarosa D, et al. SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line. Int J Oncol 2012, 41(4):1486-1494.
-
(2012)
Int J Oncol
, vol.41
, Issue.4
, pp. 1486-1494
-
-
Bellarosa, D.1
-
63
-
-
84866528749
-
Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells
-
10.1007/s10549-012-2171-9, 22825030
-
Fiskus W, et al. Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells. Breast Cancer Research and Treatment 2012, 135(2):433-444. 10.1007/s10549-012-2171-9, 22825030.
-
(2012)
Breast Cancer Research and Treatment
, vol.135
, Issue.2
, pp. 433-444
-
-
Fiskus, W.1
-
64
-
-
84861555689
-
Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells
-
Uehara N, Yoshizawa K, Tsubura A. Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells. Oncology Reports 2012, 28(1):105-110.
-
(2012)
Oncology Reports
, vol.28
, Issue.1
, pp. 105-110
-
-
Uehara, N.1
Yoshizawa, K.2
Tsubura, A.3
-
65
-
-
84355166524
-
Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells
-
10.1016/j.canlet.2011.07.032, 22093617
-
Uehara N, et al. Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Lett 2012, 315(2):112-121. 10.1016/j.canlet.2011.07.032, 22093617.
-
(2012)
Cancer Lett
, vol.315
, Issue.2
, pp. 112-121
-
-
Uehara, N.1
-
66
-
-
80055016793
-
Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer
-
10.1097/FPC.0b013e32834a8639, 21849928
-
Wong NS, et al. Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer. Pharmacogenet Genomics 2011, 21(11):760-768. 10.1097/FPC.0b013e32834a8639, 21849928.
-
(2011)
Pharmacogenet Genomics
, vol.21
, Issue.11
, pp. 760-768
-
-
Wong, N.S.1
-
67
-
-
79958084461
-
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
-
10.1038/bjc.2011.156, 3111195, 21559012
-
Munster PN, et al. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer 2011, 104(12):1828-1835. 10.1038/bjc.2011.156, 3111195, 21559012.
-
(2011)
Br J Cancer
, vol.104
, Issue.12
, pp. 1828-1835
-
-
Munster, P.N.1
-
68
-
-
77649138161
-
Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells
-
3337220, 20049865
-
Zhou Q, et al. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics 2010, 10(5):1029-1039. 3337220, 20049865.
-
(2010)
Proteomics
, vol.10
, Issue.5
, pp. 1029-1039
-
-
Zhou, Q.1
-
69
-
-
78149469566
-
A Phase II Study of the Histone Deacetylase Inhibitor, Vorinostat, in Combination with Trastuzumab in Patients with Advanced Metastatic and/or Local Chest Wall Recurrent HER-2 Amplified Breast Cancer Resistant to Transtuzumab-Containing Therapy: (E1104) a Trial of the Eastern Cooperative Oncology Group
-
Swaby RF, et al. A Phase II Study of the Histone Deacetylase Inhibitor, Vorinostat, in Combination with Trastuzumab in Patients with Advanced Metastatic and/or Local Chest Wall Recurrent HER-2 Amplified Breast Cancer Resistant to Transtuzumab-Containing Therapy: (E1104) a Trial of the Eastern Cooperative Oncology Group. Cancer Research 2009, 69(24):793s-793s.
-
(2009)
Cancer Research
, vol.69
, Issue.24
-
-
Swaby, R.F.1
-
70
-
-
84889631676
-
Preclinical studies in support of the use of vorinostat (SAHA) for the treatment of brain metastases of breast cancer
-
Palmieri D, et al. preclinical studies in support of the use of vorinostat (SAHA) for the treatment of brain metastases of breast cancer. Clinical & Experimental Metastasis 2009, 26(7):905-906.
-
(2009)
Clinical & Experimental Metastasis
, vol.26
, Issue.7
, pp. 905-906
-
-
Palmieri, D.1
-
71
-
-
76649088181
-
Phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy
-
Munster PN, et al. phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy. Journal of Clinical Oncology 2009, 27(15).
-
(2009)
Journal of Clinical Oncology
, vol.27
, Issue.15
-
-
Munster, P.N.1
-
72
-
-
58849126564
-
A Phase II Trial of Vorinostat in Metastatic Breast Cancer (vol 14, pg 7138, 2008)
-
Luu TH, Morgan RJ, Leong L. A Phase II Trial of Vorinostat in Metastatic Breast Cancer (vol 14, pg 7138, 2008). Clinical Cancer Research 2009, 15(1):416-416.
-
(2009)
Clinical Cancer Research
, vol.15
, Issue.1
, pp. 416-416
-
-
Luu, T.H.1
Morgan, R.J.2
Leong, L.3
-
73
-
-
58149242889
-
A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study
-
10.1158/1078-0432.CCR-08-0122, 3543872, 18981013
-
Luu TH, et al. A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study. Clinical Cancer Research 2008, 14(21):7138-7142. 10.1158/1078-0432.CCR-08-0122, 3543872, 18981013.
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.21
, pp. 7138-7142
-
-
Luu, T.H.1
-
74
-
-
2942532642
-
Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view
-
10.2174/0929867043365099, 15180568
-
Vanhaecke T, et al. Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. Current Medicinal Chemistry 2004, 11(12):1629-43. 10.2174/0929867043365099, 15180568.
-
(2004)
Current Medicinal Chemistry
, vol.11
, Issue.12
, pp. 1629-1643
-
-
Vanhaecke, T.1
-
75
-
-
84872785279
-
Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1
-
10.1007/s13277-012-0544-7, 23055198
-
Tavakoli-Yaraki M, et al. Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. Tumour Biol 2013, 34(1):241-9. 10.1007/s13277-012-0544-7, 23055198.
-
(2013)
Tumour Biol
, vol.34
, Issue.1
, pp. 241-249
-
-
Tavakoli-Yaraki, M.1
-
76
-
-
68249138788
-
Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231
-
Nakajima S, et al. Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. Oncology Reports 2009, 22(1):143-8.
-
(2009)
Oncology Reports
, vol.22
, Issue.1
, pp. 143-148
-
-
Nakajima, S.1
-
77
-
-
33644836891
-
Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
-
Alao JP, et al. Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer 2006, 8.
-
(2006)
Mol Cancer
, pp. 8
-
-
Alao, J.P.1
-
78
-
-
16544367723
-
Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells
-
10.1007/BF02980131, 15202563
-
Min KN, et al. Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. Arch Pharm Res 2004, 27(5):554-61. 10.1007/BF02980131, 15202563.
-
(2004)
Arch Pharm Res
, vol.27
, Issue.5
, pp. 554-561
-
-
Min, K.N.1
-
79
-
-
0034901985
-
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo
-
Vigushin DM, et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res 2001, 7(4):971-6.
-
(2001)
Clin Cancer Res
, vol.7
, Issue.4
, pp. 971-976
-
-
Vigushin, D.M.1
|