메뉴 건너뛰기




Volumn 7, Issue SUPPL 5, 2013, Pages

BRCA-Monet: A breast cancer specific drug treatment mode-of-action network for treatment effective prediction using large scale microarray database

Author keywords

Breast Cancer Mode of Action Network (BRCA MoNet); Connectivity Map; Mode of Action (MoA)

Indexed keywords

1 [4 [(5 CYCLOPROPYL 1H PYRAZOL 3 YL)AMINO]PYRROLO[2,1 F][1,2,4]TRIAZIN 2 YL] N (6 FLUORO 3 PYRIDINYL) 2 METHYL 2 PYRROLIDINECARBOXAMIDE; ANTINEOPLASTIC AGENT; ESTRADIOL; PYRAZOLE DERIVATIVE; TRIAZINE DERIVATIVE;

EID: 84889664768     PISSN: None     EISSN: 17520509     Source Type: Journal    
DOI: 10.1186/1752-0509-7-S5-S5     Document Type: Article
Times cited : (7)

References (79)
  • 1
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • 10.1056/NEJMra0801289, 19228622
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009, 360(8):790-800. 10.1056/NEJMra0801289, 19228622.
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 2
    • 55749115981 scopus 로고    scopus 로고
    • A genomic approach to identify molecular pathways associated with chemotherapy resistance
    • 10.1158/1535-7163.MCT-08-0642, 18852117
    • Riedel RF, et al. A genomic approach to identify molecular pathways associated with chemotherapy resistance. Mol Cancer Ther 2008, 7(10):3141-9. 10.1158/1535-7163.MCT-08-0642, 18852117.
    • (2008) Mol Cancer Ther , vol.7 , Issue.10 , pp. 3141-3149
    • Riedel, R.F.1
  • 3
    • 67651083239 scopus 로고    scopus 로고
    • Systematizing serendipity for cardiovascular drug discovery
    • 10.1161/CIRCULATIONAHA.108.824177, 2756982, 19620524
    • Schlueter PJ, Peterson RT. Systematizing serendipity for cardiovascular drug discovery. Circulation 2009, 120(3):255-63. 10.1161/CIRCULATIONAHA.108.824177, 2756982, 19620524.
    • (2009) Circulation , vol.120 , Issue.3 , pp. 255-263
    • Schlueter, P.J.1    Peterson, R.T.2
  • 4
    • 65949087244 scopus 로고    scopus 로고
    • Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses
    • 10.1158/0008-5472.CAN-08-3403, 19383916
    • Ebi H, et al. Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses. Cancer Res 2009, 69(9):4027-35. 10.1158/0008-5472.CAN-08-3403, 19383916.
    • (2009) Cancer Res , vol.69 , Issue.9 , pp. 4027-4035
    • Ebi, H.1
  • 5
    • 60749091249 scopus 로고    scopus 로고
    • Targeted cancer therapeutics
    • discussion 1267, 10.1158/0008-5472.CAN-08-3836, 19208830
    • Hait WN, Hambley TW. Targeted cancer therapeutics. Cancer Res 2009, 69(4):1263-7. discussion 1267, 10.1158/0008-5472.CAN-08-3836, 19208830.
    • (2009) Cancer Res , vol.69 , Issue.4 , pp. 1263-1267
    • Hait, W.N.1    Hambley, T.W.2
  • 6
    • 58049221094 scopus 로고    scopus 로고
    • A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities
    • 10.1073/pnas.0806674105, 2592987, 19050079
    • Garman KS, et al. A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc Natl Acad Sci USA 2008, 105(49):19432-7. 10.1073/pnas.0806674105, 2592987, 19050079.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.49 , pp. 19432-19437
    • Garman, K.S.1
  • 7
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • 10.1158/0008-5472.CAN-07-6013, 18316609
    • Yamashita T, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res 2008, 68(5):1451-61. 10.1158/0008-5472.CAN-07-6013, 18316609.
    • (2008) Cancer Res , vol.68 , Issue.5 , pp. 1451-1461
    • Yamashita, T.1
  • 8
    • 33947204625 scopus 로고    scopus 로고
    • Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma
    • 10.1158/1078-0432.CCR-06-1025, 17317821
    • Jia HL, et al. Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. Clin Cancer Res 2007, 13(4):1133-9. 10.1158/1078-0432.CCR-06-1025, 17317821.
    • (2007) Clin Cancer Res , vol.13 , Issue.4 , pp. 1133-1139
    • Jia, H.L.1
  • 9
    • 33747029250 scopus 로고    scopus 로고
    • Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment
    • 10.1016/j.ccr.2006.06.016, 16904609
    • Budhu A, et al. prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell 2006, 10(2):99-111. 10.1016/j.ccr.2006.06.016, 16904609.
    • (2006) Cancer Cell , vol.10 , Issue.2 , pp. 99-111
    • Budhu, A.1
  • 10
    • 0037391756 scopus 로고    scopus 로고
    • Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning
    • 10.1038/nm843, 12640447
    • Ye QH, et al. predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med 2003, 9(4):416-23. 10.1038/nm843, 12640447.
    • (2003) Nat Med , vol.9 , Issue.4 , pp. 416-423
    • Ye, Q.H.1
  • 11
    • 84862962647 scopus 로고    scopus 로고
    • Large Scale Genome Variation in Health and Disease in: Cytogenetics and Genome Research
    • Nijmegen
    • Kessel AGV. Large Scale Genome Variation in Health and Disease in: Cytogenetics and Genome Research. 2006, Nijmegen.
    • (2006)
    • Kessel, A.G.V.1
  • 12
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: a new tool for biomedical research
    • 10.1038/nrc2044, 17186018
    • Lamb J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 2007, 7(1):54-60. 10.1038/nrc2044, 17186018.
    • (2007) Nat Rev Cancer , vol.7 , Issue.1 , pp. 54-60
    • Lamb, J.1
  • 13
    • 34548799629 scopus 로고    scopus 로고
    • A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
    • 10.1073/pnas.0610292104, 1941805, 17666531
    • Lee JK, et al. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci USA 2007, 104(32):13086-91. 10.1073/pnas.0610292104, 1941805, 17666531.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.32 , pp. 13086-13091
    • Lee, J.K.1
  • 14
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • 10.1073/pnas.0506580102, 1239896, 16199517
    • Subramanian A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005, 102(43):15545-50. 10.1073/pnas.0506580102, 1239896, 16199517.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1
  • 15
    • 79960338041 scopus 로고    scopus 로고
    • An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors
    • 10.1371/journal.pone.0022274, 3137633, 21789246
    • Huang L, et al. An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors. PLoS One 2011, 6(7):e22274. 10.1371/journal.pone.0022274, 3137633, 21789246.
    • (2011) PLoS One , vol.6 , Issue.7
    • Huang, L.1
  • 16
    • 79960570375 scopus 로고    scopus 로고
    • A pharmacogenomic method for individualized prediction of drug sensitivity
    • Cohen AL, et al. A pharmacogenomic method for individualized prediction of drug sensitivity. Mol Syst Biol 2011, 513.
    • (2011) Mol Syst Biol , pp. 513
    • Cohen, A.L.1
  • 17
    • 84870421832 scopus 로고    scopus 로고
    • Trifluoperazine an antipsychotic agent inhibits cancer stem cell growth and overcomes drug resistance of lung cancer
    • 10.1164/rccm.201207-1180OC, 23024022
    • Yeh CT, et al. Trifluoperazine an antipsychotic agent inhibits cancer stem cell growth and overcomes drug resistance of lung cancer. Am J Respir Crit Care Med 2012, 186(11):1180-8. 10.1164/rccm.201207-1180OC, 23024022.
    • (2012) Am J Respir Crit Care Med , vol.186 , Issue.11 , pp. 1180-1188
    • Yeh, C.T.1
  • 18
    • 84872783025 scopus 로고    scopus 로고
    • TAZ Expression as a Prognostic Indicator in Colorectal Cancer
    • 10.1371/journal.pone.0054211, 3553150, 23372686
    • Yuen HF, et al. TAZ Expression as a Prognostic Indicator in Colorectal Cancer. PLoS One 2013, 8(1):e54211. 10.1371/journal.pone.0054211, 3553150, 23372686.
    • (2013) PLoS One , vol.8 , Issue.1
    • Yuen, H.F.1
  • 19
    • 84866070620 scopus 로고    scopus 로고
    • Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma
    • Edris B, et al. Comparative gene expression profiling of benign and malignant lesions reveals candidate therapeutic compounds for leiomyosarcoma. Sarcoma 2012, 805614.
    • (2012) Sarcoma , pp. 805614
    • Edris, B.1
  • 20
    • 80054932086 scopus 로고    scopus 로고
    • Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach
    • 10.1097/JTO.0b013e31822adfb0, 3196823, 21964532
    • Reka AK, et al. Identifying inhibitors of epithelial-mesenchymal transition by connectivity map-based systems approach. J Thorac Oncol 2011, 6(11):1784-92. 10.1097/JTO.0b013e31822adfb0, 3196823, 21964532.
    • (2011) J Thorac Oncol , vol.6 , Issue.11 , pp. 1784-1792
    • Reka, A.K.1
  • 21
    • 80052576073 scopus 로고    scopus 로고
    • Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer
    • 10.1371/journal.pone.0024662, 3170379, 21931799
    • Claerhout S, et al. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PLoS One 2011, 6(9):e24662. 10.1371/journal.pone.0024662, 3170379, 21931799.
    • (2011) PLoS One , vol.6 , Issue.9
    • Claerhout, S.1
  • 22
    • 77956596734 scopus 로고    scopus 로고
    • From NPC therapeutic target identification to potential treatment strategy
    • 10.1158/1535-7163.MCT-09-0966, 20716640
    • Lan MY, et al. From NPC therapeutic target identification to potential treatment strategy. Mol Cancer Ther 2010, 9(9):2511-23. 10.1158/1535-7163.MCT-09-0966, 20716640.
    • (2010) Mol Cancer Ther , vol.9 , Issue.9 , pp. 2511-2523
    • Lan, M.Y.1
  • 23
    • 84863087650 scopus 로고    scopus 로고
    • Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug
    • Lee HS, et al. Rational drug repositioning guided by an integrated pharmacological network of protein, disease and drug. BMC Syst Biol 2012, 80.
    • (2012) BMC Syst Biol , pp. 80
    • Lee, H.S.1
  • 24
    • 79958754253 scopus 로고    scopus 로고
    • PREDICT: a method for inferring novel drug indications with application to personalized medicine
    • Gottlieb A, et al. pREDICT: a method for inferring novel drug indications with application to personalized medicine. Mol Syst Biol 2011, 496.
    • (2011) Mol Syst Biol , pp. 496
    • Gottlieb, A.1
  • 25
    • 68449088145 scopus 로고    scopus 로고
    • Human disease-drug network based on genomic expression profiles
    • 10.1371/journal.pone.0006536, 2715883, 19657382
    • Hu G, Agarwal P. Human disease-drug network based on genomic expression profiles. PLoS One 2009, 4(8):e6536. 10.1371/journal.pone.0006536, 2715883, 19657382.
    • (2009) PLoS One , vol.4 , Issue.8
    • Hu, G.1    Agarwal, P.2
  • 26
    • 79952213086 scopus 로고    scopus 로고
    • Using a stem cell-based signature to guide therapeutic selection in cancer
    • 10.1158/0008-5472.CAN-10-1735, 3049992, 21169407
    • Shats I, et al. Using a stem cell-based signature to guide therapeutic selection in cancer. Cancer Res 2011, 71(5):1772-80. 10.1158/0008-5472.CAN-10-1735, 3049992, 21169407.
    • (2011) Cancer Res , vol.71 , Issue.5 , pp. 1772-1780
    • Shats, I.1
  • 27
    • 84855381399 scopus 로고    scopus 로고
    • A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy
    • 10.1158/0008-5472.CAN-11-2333, 3251651, 22108825
    • Jin G, et al. A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Res 2012, 72(1):33-44. 10.1158/0008-5472.CAN-11-2333, 3251651, 22108825.
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 33-44
    • Jin, G.1
  • 28
    • 84864115444 scopus 로고    scopus 로고
    • Identifying mechanistic similarities in drug responses
    • 10.1093/bioinformatics/bts290, 22592382
    • Zhao C, et al. Identifying mechanistic similarities in drug responses. Bioinformatics 2012, 28(14):1902-10. 10.1093/bioinformatics/bts290, 22592382.
    • (2012) Bioinformatics , vol.28 , Issue.14 , pp. 1902-1910
    • Zhao, C.1
  • 29
    • 84861150677 scopus 로고    scopus 로고
    • Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer
    • 10.1371/journal.pcbi.1002347, 3276504, 22346740
    • Shigemizu D, et al. Using functional signatures to identify repositioned drugs for breast, myelogenous leukemia and prostate cancer. PLoS Comput Biol 2012, 8(2):e1002347. 10.1371/journal.pcbi.1002347, 3276504, 22346740.
    • (2012) PLoS Comput Biol , vol.8 , Issue.2
    • Shigemizu, D.1
  • 30
    • 79551622693 scopus 로고    scopus 로고
    • Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping
    • 10.1371/journal.pone.0016382, 3031567, 21305029
    • McArt DG, Zhang SD. Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping. PLoS One 2011, 6(1):e16382. 10.1371/journal.pone.0016382, 3031567, 21305029.
    • (2011) PLoS One , vol.6 , Issue.1
    • McArt, D.G.1    Zhang, S.D.2
  • 31
    • 84870461533 scopus 로고    scopus 로고
    • FacPad: Bayesian sparse factor modeling for the inference of pathways responsive to drug treatment
    • 10.1093/bioinformatics/bts502, 3467747, 22923307
    • Ma H, Zhao H. FacPad: Bayesian sparse factor modeling for the inference of pathways responsive to drug treatment. Bioinformatics 2012, 28(20):2662-70. 10.1093/bioinformatics/bts502, 3467747, 22923307.
    • (2012) Bioinformatics , vol.28 , Issue.20 , pp. 2662-2670
    • Ma, H.1    Zhao, H.2
  • 32
    • 77950571618 scopus 로고    scopus 로고
    • Naringenin and 17beta-estradiol coadministration prevents hormone-induced human cancer cell growth
    • Bulzomi P, et al. Naringenin and 17beta-estradiol coadministration prevents hormone-induced human cancer cell growth. IUBMB Life 2010, 62(1):51-60.
    • (2010) IUBMB Life , vol.62 , Issue.1 , pp. 51-60
    • Bulzomi, P.1
  • 33
    • 3042717657 scopus 로고    scopus 로고
    • Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells
    • 10.1677/jme.0.0320649, 15171706
    • Inoue A, et al. Transcription factor EGR3 is involved in the estrogen-signaling pathway in breast cancer cells. J Mol Endocrinol 2004, 32(3):649-61. 10.1677/jme.0.0320649, 15171706.
    • (2004) J Mol Endocrinol , vol.32 , Issue.3 , pp. 649-661
    • Inoue, A.1
  • 34
    • 78650866393 scopus 로고    scopus 로고
    • MYB suppresses differentiation and apoptosis of human breast cancer cells
    • 10.1186/bcr2614, 2949644, 20659323
    • Drabsch Y, Robert RG, Gonda TJ. MYB suppresses differentiation and apoptosis of human breast cancer cells. Breast Cancer Res 2010, 12(4):R55. 10.1186/bcr2614, 2949644, 20659323.
    • (2010) Breast Cancer Res , vol.12 , Issue.4
    • Drabsch, Y.1    Robert, R.G.2    Gonda, T.J.3
  • 35
    • 33746908103 scopus 로고    scopus 로고
    • Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome
    • 10.1158/0008-5472.CAN-05-4269, 16849584
    • Frasor J, et al. Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res 2006, 66(14):7334-40. 10.1158/0008-5472.CAN-05-4269, 16849584.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7334-7340
    • Frasor, J.1
  • 37
    • 84860868794 scopus 로고    scopus 로고
    • Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling
    • Guo AJ, et al. Kaempferol as a flavonoid induces osteoblastic differentiation via estrogen receptor signaling. Chin Med 2012, 10.
    • (2012) Chin Med , pp. 10
    • Guo, A.J.1
  • 38
    • 59849083230 scopus 로고    scopus 로고
    • Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist
    • 10.1016/j.febslet.2009.01.030, 19171140
    • Wang J, et al. Kaempferol is an estrogen-related receptor alpha and gamma inverse agonist. FEBS Lett 2009, 583(4):643-7. 10.1016/j.febslet.2009.01.030, 19171140.
    • (2009) FEBS Lett , vol.583 , Issue.4 , pp. 643-647
    • Wang, J.1
  • 39
    • 1642539199 scopus 로고    scopus 로고
    • Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol
    • 10.1002/jcp.10398, 14603522
    • Hung H. Inhibition of estrogen receptor alpha expression and function in MCF-7 cells by kaempferol. Journal of Cellular Physiology 2004, 198(2):197-208. 10.1002/jcp.10398, 14603522.
    • (2004) Journal of Cellular Physiology , vol.198 , Issue.2 , pp. 197-208
    • Hung, H.1
  • 40
    • 38349049189 scopus 로고    scopus 로고
    • Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary
    • 10.1677/JOE-07-0358, 18000302
    • Kim HJ, et al. Estrogen receptor alpha-induced cholecystokinin type A receptor expression in the female mouse pituitary. J Endocrinol 2007, 195(3):393-405. 10.1677/JOE-07-0358, 18000302.
    • (2007) J Endocrinol , vol.195 , Issue.3 , pp. 393-405
    • Kim, H.J.1
  • 41
    • 34250889281 scopus 로고    scopus 로고
    • Estrogen-dependent regulation of Eg5 in breast cancer cells
    • 10.1097/CAD.0b013e3280a02f2b, 17581299
    • Planas-Silva MD, Filatova IS. Estrogen-dependent regulation of Eg5 in breast cancer cells. Anticancer Drugs 2007, 18(7):773-9. 10.1097/CAD.0b013e3280a02f2b, 17581299.
    • (2007) Anticancer Drugs , vol.18 , Issue.7 , pp. 773-779
    • Planas-Silva, M.D.1    Filatova, I.S.2
  • 42
    • 0022220859 scopus 로고
    • Therapeutic drug monitoring
    • Edinburgh; New York: Churchill Livingstone
    • Widdop B. Therapeutic drug monitoring. Contemporary issues in clinical biochemistry 1985, Edinburgh; New York: Churchill Livingstone.
    • (1985) Contemporary issues in clinical biochemistry
    • Widdop, B.1
  • 43
    • 0023902246 scopus 로고
    • Clinical and endocrine effects of cyproterone acetate in postmenopausal patients with advanced breast cancer
    • 10.1016/S0277-5379(98)90011-6, 2968261
    • Willemse PH, et al. Clinical and endocrine effects of cyproterone acetate in postmenopausal patients with advanced breast cancer. Eur J Cancer Clin Oncol 1988, 24(3):417-21. 10.1016/S0277-5379(98)90011-6, 2968261.
    • (1988) Eur J Cancer Clin Oncol , vol.24 , Issue.3 , pp. 417-421
    • Willemse, P.H.1
  • 44
    • 84871368849 scopus 로고    scopus 로고
    • BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer
    • 10.1158/1535-7163.MCT-12-0447, 23047891
    • Awasthi N, et al. BMS-754807, a small-molecule inhibitor of insulin-like growth factor-1 receptor/insulin receptor, enhances gemcitabine response in pancreatic cancer. Mol Cancer Ther 2012, 11(12):2644-53. 10.1158/1535-7163.MCT-12-0447, 23047891.
    • (2012) Mol Cancer Ther , vol.11 , Issue.12 , pp. 2644-2653
    • Awasthi, N.1
  • 45
    • 84889684034 scopus 로고    scopus 로고
    • A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography
    • Lee SJ, et al. A pilot study for the early assessment of the effects of BMS-754807 plus gefitinib in an H292 tumor model by [(18)F]fluorothymidine-positron emission tomography. Invest New Drugs 2012,
    • (2012) Invest New Drugs
    • Lee, S.J.1
  • 46
    • 79551630554 scopus 로고    scopus 로고
    • Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program
    • 10.1002/pbc.22741, 21298745
    • Kolb EA, et al. Initial testing (stage 1) of the IGF-1 receptor inhibitor BMS-754807 by the pediatric preclinical testing program. Pediatr Blood Cancer 2011, 56(4):595-603. 10.1002/pbc.22741, 21298745.
    • (2011) Pediatr Blood Cancer , vol.56 , Issue.4 , pp. 595-603
    • Kolb, E.A.1
  • 47
    • 73149120253 scopus 로고    scopus 로고
    • BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
    • 10.1158/1535-7163.MCT-09-0499, 19996272
    • Carboni JM, et al. BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR. Mol Cancer Ther 2009, 8(12):3341-9. 10.1158/1535-7163.MCT-09-0499, 19996272.
    • (2009) Mol Cancer Ther , vol.8 , Issue.12 , pp. 3341-3349
    • Carboni, J.M.1
  • 48
    • 77953710936 scopus 로고    scopus 로고
    • High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer
    • Litzenburger BC, et al. High IGF-IR Activity in Triple-Negative Breast Cancer Cell Lines Correlates with Sensitivity to IGF-IR Inhibitor BMS-754807 in This Subtype of Human Breast Cancer. Cancer Research 2009, 69(24):581s-581s.
    • (2009) Cancer Research , vol.69 , Issue.24
    • Litzenburger, B.C.1
  • 49
    • 84889689307 scopus 로고    scopus 로고
    • Phase 1 Dose-Escalating Study of Bms-754807 in Japanese Patients with Advanced Solid Tumors
    • Tamura Y, et al. phase 1 Dose-Escalating Study of Bms-754807 in Japanese Patients with Advanced Solid Tumors. Annals of Oncology 2012, 111-112.
    • (2012) Annals of Oncology , pp. 111-112
    • Tamura, Y.1
  • 50
    • 79551630554 scopus 로고    scopus 로고
    • Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program
    • 10.1002/pbc.22741, 21298745
    • Kolb EA, et al. Initial Testing (Stage 1) of the IGF-1 Receptor Inhibitor BMS-754807 by the Pediatric Preclinical Testing Program. Pediatr Blood Cancer 2011, 56(4):595-603. 10.1002/pbc.22741, 21298745.
    • (2011) Pediatr Blood Cancer , vol.56 , Issue.4 , pp. 595-603
    • Kolb, E.A.1
  • 51
    • 84889678033 scopus 로고    scopus 로고
    • BMS-754807, an oral dual IGF-1R/insulin receptor (IR) inhibitor: initial results from a Phase 1 dose- and schedule-finding study in combination with carboplatin/paclitaxel in subjects with solid tumors
    • Chu QS, et al. BMS-754807, an oral dual IGF-1R/insulin receptor (IR) inhibitor: initial results from a Phase 1 dose- and schedule-finding study in combination with carboplatin/paclitaxel in subjects with solid tumors. Ejc Supplements 2010, 8(7):131-131.
    • (2010) Ejc Supplements , vol.8 , Issue.7 , pp. 131-131
    • Chu, Q.S.1
  • 52
    • 84889670538 scopus 로고    scopus 로고
    • Targeting Type I Insulin-Like Growth Factor Receptor and Insulin Receptor for Cancer Therapy: The Oral Dual Inhibitor Bms-754807 in Clinical Development
    • Desai J, et al. Targeting Type I Insulin-Like Growth Factor Receptor and Insulin Receptor for Cancer Therapy: The Oral Dual Inhibitor Bms-754807 in Clinical Development. Annals of Oncology 2010, 9-9.
    • (2010) Annals of Oncology , pp. 9-9
    • Desai, J.1
  • 53
    • 0018054267 scopus 로고
    • Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons
    • Macdonald RL, Bergey GK. Valproic acid: effect on GABA-mediated postsynaptic inhibition in cultured mammalian spinal cord neurons. Trans Am Neurol Assoc 1978, 254-6.
    • (1978) Trans Am Neurol Assoc , pp. 254-256
    • Macdonald, R.L.1    Bergey, G.K.2
  • 54
    • 42649109021 scopus 로고    scopus 로고
    • Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors
    • 10.1016/j.ctrv.2007.11.003, 18226465
    • Duenas-Gonzalez A, et al. Valproic acid as epigenetic cancer drug: preclinical, clinical and transcriptional effects on solid tumors. Cancer Treat Rev 2008, 34(3):206-22. 10.1016/j.ctrv.2007.11.003, 18226465.
    • (2008) Cancer Treat Rev , vol.34 , Issue.3 , pp. 206-222
    • Duenas-Gonzalez, A.1
  • 55
    • 36749072618 scopus 로고    scopus 로고
    • Valproic acid as anti-cancer drug
    • 10.2174/138161207782360528, 18045192
    • Michaelis M, Doerr HW, Cinatl J. Valproic acid as anti-cancer drug. Curr Pharm Des 2007, 13(33):3378-93. 10.2174/138161207782360528, 18045192.
    • (2007) Curr Pharm Des , vol.13 , Issue.33 , pp. 3378-3393
    • Michaelis, M.1    Doerr, H.W.2    Cinatl, J.3
  • 56
    • 37049031651 scopus 로고    scopus 로고
    • Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells
    • 10.1016/j.canlet.2007.10.006, 18006146
    • Fortunati N, et al. Valproic acid is a selective antiproliferative agent in estrogen-sensitive breast cancer cells. Cancer Lett 2008, 259(2):156-64. 10.1016/j.canlet.2007.10.006, 18006146.
    • (2008) Cancer Lett , vol.259 , Issue.2 , pp. 156-164
    • Fortunati, N.1
  • 57
    • 33645820586 scopus 로고    scopus 로고
    • Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers
    • 10.1200/JCO.2005.03.2755, 16505416
    • Oh DS, et al. Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. Journal of Clinical Oncology 2006, 24(11):1656-64. 10.1200/JCO.2005.03.2755, 16505416.
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.11 , pp. 1656-1664
    • Oh, D.S.1
  • 58
    • 77957731078 scopus 로고    scopus 로고
    • Dictionary of pharmacological agents
    • London; Weinheim; New York: Chapman & Hall, 1 livret d'installation d'un cédérom
    • Macdonald F. Dictionary of pharmacological agents. 1997, London; Weinheim; New York: Chapman & Hall, 1 livret d'installation d'un cédérom.
    • (1997)
    • Macdonald, F.1
  • 59
    • 0034890377 scopus 로고    scopus 로고
    • Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin, sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001
    • Munster PN, et al. Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin, sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001. Clin Cancer Res 2001, 7(8):2228-36.
    • (2001) Clin Cancer Res , vol.7 , Issue.8 , pp. 2228-2236
    • Munster, P.N.1
  • 60
    • 84875435418 scopus 로고    scopus 로고
    • Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90
    • 10.1038/nchem.1596, 23511419
    • Kitson RR, et al. Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90. Nat Chem 2013, 5(4):307-14. 10.1038/nchem.1596, 23511419.
    • (2013) Nat Chem , vol.5 , Issue.4 , pp. 307-314
    • Kitson, R.R.1
  • 61
    • 34547933867 scopus 로고    scopus 로고
    • Mechanistic studies on Hsp90 inhibition by ansamycin derivatives
    • 10.1016/j.jmb.2007.06.065, 17662999
    • Onuoha SC, et al. Mechanistic studies on Hsp90 inhibition by ansamycin derivatives. J Mol Biol 2007, 372(2):287-97. 10.1016/j.jmb.2007.06.065, 17662999.
    • (2007) J Mol Biol , vol.372 , Issue.2 , pp. 287-297
    • Onuoha, S.C.1
  • 62
    • 84866523199 scopus 로고    scopus 로고
    • SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line
    • Bellarosa D, et al. SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line. Int J Oncol 2012, 41(4):1486-1494.
    • (2012) Int J Oncol , vol.41 , Issue.4 , pp. 1486-1494
    • Bellarosa, D.1
  • 63
    • 84866528749 scopus 로고    scopus 로고
    • Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells
    • 10.1007/s10549-012-2171-9, 22825030
    • Fiskus W, et al. Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells. Breast Cancer Research and Treatment 2012, 135(2):433-444. 10.1007/s10549-012-2171-9, 22825030.
    • (2012) Breast Cancer Research and Treatment , vol.135 , Issue.2 , pp. 433-444
    • Fiskus, W.1
  • 64
    • 84861555689 scopus 로고    scopus 로고
    • Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells
    • Uehara N, Yoshizawa K, Tsubura A. Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells. Oncology Reports 2012, 28(1):105-110.
    • (2012) Oncology Reports , vol.28 , Issue.1 , pp. 105-110
    • Uehara, N.1    Yoshizawa, K.2    Tsubura, A.3
  • 65
    • 84355166524 scopus 로고    scopus 로고
    • Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells
    • 10.1016/j.canlet.2011.07.032, 22093617
    • Uehara N, et al. Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Lett 2012, 315(2):112-121. 10.1016/j.canlet.2011.07.032, 22093617.
    • (2012) Cancer Lett , vol.315 , Issue.2 , pp. 112-121
    • Uehara, N.1
  • 66
    • 80055016793 scopus 로고    scopus 로고
    • Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer
    • 10.1097/FPC.0b013e32834a8639, 21849928
    • Wong NS, et al. Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer. Pharmacogenet Genomics 2011, 21(11):760-768. 10.1097/FPC.0b013e32834a8639, 21849928.
    • (2011) Pharmacogenet Genomics , vol.21 , Issue.11 , pp. 760-768
    • Wong, N.S.1
  • 67
    • 79958084461 scopus 로고    scopus 로고
    • A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
    • 10.1038/bjc.2011.156, 3111195, 21559012
    • Munster PN, et al. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer 2011, 104(12):1828-1835. 10.1038/bjc.2011.156, 3111195, 21559012.
    • (2011) Br J Cancer , vol.104 , Issue.12 , pp. 1828-1835
    • Munster, P.N.1
  • 68
    • 77649138161 scopus 로고    scopus 로고
    • Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells
    • 3337220, 20049865
    • Zhou Q, et al. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics 2010, 10(5):1029-1039. 3337220, 20049865.
    • (2010) Proteomics , vol.10 , Issue.5 , pp. 1029-1039
    • Zhou, Q.1
  • 69
    • 78149469566 scopus 로고    scopus 로고
    • A Phase II Study of the Histone Deacetylase Inhibitor, Vorinostat, in Combination with Trastuzumab in Patients with Advanced Metastatic and/or Local Chest Wall Recurrent HER-2 Amplified Breast Cancer Resistant to Transtuzumab-Containing Therapy: (E1104) a Trial of the Eastern Cooperative Oncology Group
    • Swaby RF, et al. A Phase II Study of the Histone Deacetylase Inhibitor, Vorinostat, in Combination with Trastuzumab in Patients with Advanced Metastatic and/or Local Chest Wall Recurrent HER-2 Amplified Breast Cancer Resistant to Transtuzumab-Containing Therapy: (E1104) a Trial of the Eastern Cooperative Oncology Group. Cancer Research 2009, 69(24):793s-793s.
    • (2009) Cancer Research , vol.69 , Issue.24
    • Swaby, R.F.1
  • 70
    • 84889631676 scopus 로고    scopus 로고
    • Preclinical studies in support of the use of vorinostat (SAHA) for the treatment of brain metastases of breast cancer
    • Palmieri D, et al. preclinical studies in support of the use of vorinostat (SAHA) for the treatment of brain metastases of breast cancer. Clinical & Experimental Metastasis 2009, 26(7):905-906.
    • (2009) Clinical & Experimental Metastasis , vol.26 , Issue.7 , pp. 905-906
    • Palmieri, D.1
  • 71
    • 76649088181 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy
    • Munster PN, et al. phase II trial of the histone deacetylase inhibitor, vorinostat, to restore hormone sensitivity to the antiestrogen tamoxifen in patients with advanced breast cancer who progressed on prior hormone therapy. Journal of Clinical Oncology 2009, 27(15).
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.15
    • Munster, P.N.1
  • 72
    • 58849126564 scopus 로고    scopus 로고
    • A Phase II Trial of Vorinostat in Metastatic Breast Cancer (vol 14, pg 7138, 2008)
    • Luu TH, Morgan RJ, Leong L. A Phase II Trial of Vorinostat in Metastatic Breast Cancer (vol 14, pg 7138, 2008). Clinical Cancer Research 2009, 15(1):416-416.
    • (2009) Clinical Cancer Research , vol.15 , Issue.1 , pp. 416-416
    • Luu, T.H.1    Morgan, R.J.2    Leong, L.3
  • 73
    • 58149242889 scopus 로고    scopus 로고
    • A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study
    • 10.1158/1078-0432.CCR-08-0122, 3543872, 18981013
    • Luu TH, et al. A Phase II Trial of Vorinostat (Suberoylanilide Hydroxamic Acid) in Metastatic Breast Cancer: A California Cancer Consortium Study. Clinical Cancer Research 2008, 14(21):7138-7142. 10.1158/1078-0432.CCR-08-0122, 3543872, 18981013.
    • (2008) Clinical Cancer Research , vol.14 , Issue.21 , pp. 7138-7142
    • Luu, T.H.1
  • 74
    • 2942532642 scopus 로고    scopus 로고
    • Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view
    • 10.2174/0929867043365099, 15180568
    • Vanhaecke T, et al. Trichostatin A-like hydroxamate histone deacetylase inhibitors as therapeutic agents: toxicological point of view. Current Medicinal Chemistry 2004, 11(12):1629-43. 10.2174/0929867043365099, 15180568.
    • (2004) Current Medicinal Chemistry , vol.11 , Issue.12 , pp. 1629-1643
    • Vanhaecke, T.1
  • 75
    • 84872785279 scopus 로고    scopus 로고
    • Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1
    • 10.1007/s13277-012-0544-7, 23055198
    • Tavakoli-Yaraki M, et al. Induction of apoptosis by Trichostatin A in human breast cancer cell lines: involvement of 15-Lox-1. Tumour Biol 2013, 34(1):241-9. 10.1007/s13277-012-0544-7, 23055198.
    • (2013) Tumour Biol , vol.34 , Issue.1 , pp. 241-249
    • Tavakoli-Yaraki, M.1
  • 76
    • 68249138788 scopus 로고    scopus 로고
    • Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231
    • Nakajima S, et al. Trichostatin A with adenovirus-mediated p53 gene transfer synergistically induces apoptosis in breast cancer cell line MDA-MB-231. Oncology Reports 2009, 22(1):143-8.
    • (2009) Oncology Reports , vol.22 , Issue.1 , pp. 143-148
    • Nakajima, S.1
  • 77
    • 33644836891 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells
    • Alao JP, et al. Histone deacetylase inhibitor, trichostatin A induces ubiquitin-dependent cyclin D1 degradation in MCF-7 breast cancer cells. Mol Cancer 2006, 8.
    • (2006) Mol Cancer , pp. 8
    • Alao, J.P.1
  • 78
    • 16544367723 scopus 로고    scopus 로고
    • Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells
    • 10.1007/BF02980131, 15202563
    • Min KN, et al. Estrogen receptor enhances the antiproliferative effects of trichostatin A and HC-toxin in human breast cancer cells. Arch Pharm Res 2004, 27(5):554-61. 10.1007/BF02980131, 15202563.
    • (2004) Arch Pharm Res , vol.27 , Issue.5 , pp. 554-561
    • Min, K.N.1
  • 79
    • 0034901985 scopus 로고    scopus 로고
    • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo
    • Vigushin DM, et al. Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res 2001, 7(4):971-6.
    • (2001) Clin Cancer Res , vol.7 , Issue.4 , pp. 971-976
    • Vigushin, D.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.