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Volumn 558, Issue , 2014, Pages 159-163

Ethyl pyruvate inhibits HMGB1 phosphorylation and secretion in activated microglia and in the postischemic brain

Author keywords

BV2; Ethyl pyruvate; High mobility group box 1; Middle cerebral artery occlusion; Phosphorylation

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN KINASE C ALPHA; PYRUVIC ACID; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

EID: 84889653010     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.11.006     Document Type: Article
Times cited : (48)

References (21)
  • 3
    • 26444558061 scopus 로고    scopus 로고
    • Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
    • Yu Y.M., Kim J.B., Lee K.W., Kim S.Y., Han P.L., Lee J.K. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 2005, 26:2238-2243.
    • (2005) Stroke , vol.26 , pp. 2238-2243
    • Yu, Y.M.1    Kim, J.B.2    Lee, K.W.3    Kim, S.Y.4    Han, P.L.5    Lee, J.K.6
  • 4
    • 33750604074 scopus 로고    scopus 로고
    • Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
    • Cho I.H., Kim S.W., Kim J.B., Kim T.K., Lee K.W., Han P.L., Lee J.K. Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J. Neurosci. Res. 2006, 84:1505-1511.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 1505-1511
    • Cho, I.H.1    Kim, S.W.2    Kim, J.B.3    Kim, T.K.4    Lee, K.W.5    Han, P.L.6    Lee, J.K.7
  • 5
    • 58049093658 scopus 로고    scopus 로고
    • Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats
    • Yang Z.Y., Ling Y., Yin T., Tao J., Xiong J.X., Wu H.S., Wang C.Y. Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J. Gastroenterol. 2008, 14:4546-4550.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 4546-4550
    • Yang, Z.Y.1    Ling, Y.2    Yin, T.3    Tao, J.4    Xiong, J.X.5    Wu, H.S.6    Wang, C.Y.7
  • 6
    • 67049132380 scopus 로고    scopus 로고
    • Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits
    • Wang Q., Ding Q., Zhou Y., Gou X., Hou L., Chen S., Zhu Z., Xiong L. Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology 2009, 110:1279-1286.
    • (2009) Anesthesiology , vol.110 , pp. 1279-1286
    • Wang, Q.1    Ding, Q.2    Zhou, Y.3    Gou, X.4    Hou, L.5    Chen, S.6    Zhu, Z.7    Xiong, L.8
  • 7
    • 80052669019 scopus 로고    scopus 로고
    • Beneficial effect of ethyl pyruvate through inhibiting high-mobility group box-1 expression and TLR/NF-kB pathway after traumatic brain injury in the rat
    • Su X., Wang H., Zhao J., Pan H., Mao L. Beneficial effect of ethyl pyruvate through inhibiting high-mobility group box-1 expression and TLR/NF-kB pathway after traumatic brain injury in the rat. Mediators Inflamm. 2011, 807142.
    • (2011) Mediators Inflamm. , pp. 807142
    • Su, X.1    Wang, H.2    Zhao, J.3    Pan, H.4    Mao, L.5
  • 9
    • 73949136193 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
    • Shang G.H., Lin D.J., Xiao W., Jia C.Q., Li Y., Wang A.H., Dong L. Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respir. Res. 2009, 10:91.
    • (2009) Respir. Res. , vol.10 , pp. 91
    • Shang, G.H.1    Lin, D.J.2    Xiao, W.3    Jia, C.Q.4    Li, Y.5    Wang, A.H.6    Dong, L.7
  • 10
    • 35748967851 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
    • Bianchi M.E., Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol. Rev. 2007, 220:35-46.
    • (2007) Immunol. Rev. , vol.220 , pp. 35-46
    • Bianchi, M.E.1    Manfredi, A.A.2
  • 11
    • 33751584837 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
    • Youn J.H., Shin J.S. Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J. Immunol. 2006, 177:7889-7897.
    • (2006) J. Immunol. , vol.177 , pp. 7889-7897
    • Youn, J.H.1    Shin, J.S.2
  • 12
    • 58149308833 scopus 로고    scopus 로고
    • Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages
    • Zhang X., Wheeler D., Tang Y., Guo L., Shapiro R.A., Ribar T.J., Means A.R., Billiar T.R., Angus D.C. Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J. Immunol. 2008, 182:5015-5023.
    • (2008) J. Immunol. , vol.182 , pp. 5015-5023
    • Zhang, X.1    Wheeler, D.2    Tang, Y.3    Guo, L.4    Shapiro, R.A.5    Ribar, T.J.6    Means, A.R.7    Billiar, T.R.8    Angus, D.C.9
  • 13
    • 66949144402 scopus 로고    scopus 로고
    • HMGB1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism
    • Oh Y.J., Youn J.H., Ji Y., Lee S.E., Lim K.J., Choi J.E., Shin J.S. HMGB1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism. J. Immunol. 2009, 182:5800-5809.
    • (2009) J. Immunol. , vol.182 , pp. 5800-5809
    • Oh, Y.J.1    Youn, J.H.2    Ji, Y.3    Lee, S.E.4    Lim, K.J.5    Choi, J.E.6    Shin, J.S.7
  • 14
    • 84862779194 scopus 로고    scopus 로고
    • Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion
    • Kim S.W., Jin Y., Shin J.H., Kim I.D., Lee H.K., Park S., Han P.L., Lee J.K. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol. Dis. 2012, 46:147-156.
    • (2012) Neurobiol. Dis. , vol.46 , pp. 147-156
    • Kim, S.W.1    Jin, Y.2    Shin, J.H.3    Kim, I.D.4    Lee, H.K.5    Park, S.6    Han, P.L.7    Lee, J.K.8
  • 15
    • 84881526830 scopus 로고    scopus 로고
    • Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving it from p65
    • Kim S.W., Lee H.K., Shin J.H., Lee J.K. Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving it from p65. Free Radic. Biol. Med. 2013, 65C:468-476.
    • (2013) Free Radic. Biol. Med. , vol.65 C , pp. 468-476
    • Kim, S.W.1    Lee, H.K.2    Shin, J.H.3    Lee, J.K.4
  • 16
    • 77449087688 scopus 로고    scopus 로고
    • Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain
    • Kim S.W., Jeong J.Y., Kim H.J., Seo J.S., Han P.L., Yoon S.H., Lee J.K. Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain. Neurotox. Res. 2010, 17:39-49.
    • (2010) Neurotox. Res. , vol.17 , pp. 39-49
    • Kim, S.W.1    Jeong, J.Y.2    Kim, H.J.3    Seo, J.S.4    Han, P.L.5    Yoon, S.H.6    Lee, J.K.7
  • 17
    • 33745788420 scopus 로고    scopus 로고
    • A novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
    • HMGB1
    • Kim J.B., Choi J.S., Yu Y.M., Nam K., Piao C.S., Kim S.W., Lee M.H., Han P.L., Park J.S., Lee J.K., HMGB1 A novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J. Neurosci. 2006, 26:6413-6421.
    • (2006) J. Neurosci. , vol.26 , pp. 6413-6421
    • Kim, J.B.1    Choi, J.S.2    Yu, Y.M.3    Nam, K.4    Piao, C.S.5    Kim, S.W.6    Lee, M.H.7    Han, P.L.8    Park, J.S.9    Lee, J.K.10
  • 18
    • 80052615268 scopus 로고    scopus 로고
    • Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway
    • Kim S.W., Lim C.M., Kim J.B., Shin J.H., Lee S., Lee M., Lee J.K. Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway. Neurotox. Res. 2011, 20:159-169.
    • (2011) Neurotox. Res. , vol.20 , pp. 159-169
    • Kim, S.W.1    Lim, C.M.2    Kim, J.B.3    Shin, J.H.4    Lee, S.5    Lee, M.6    Lee, J.K.7
  • 19
    • 84855192732 scopus 로고    scopus 로고
    • Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
    • Hu X., Cui B., Zhou X., Xu C., Lu Z., Jiang H. Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol. Biol. Rep. 2009, 39:227-231.
    • (2009) Mol. Biol. Rep. , vol.39 , pp. 227-231
    • Hu, X.1    Cui, B.2    Zhou, X.3    Xu, C.4    Lu, Z.5    Jiang, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.