-
1
-
-
0037125985
-
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
-
Ulloa L., Ochani M., Yang H., Tanovic M., Halperin D., Yang R., Czura C.J., Fink M.P., Tracey K.J. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:12351-12356.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 12351-12356
-
-
Ulloa, L.1
Ochani, M.2
Yang, H.3
Tanovic, M.4
Halperin, D.5
Yang, R.6
Czura, C.J.7
Fink, M.P.8
Tracey, K.J.9
-
2
-
-
2342432453
-
Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia
-
Woo Y.J., Taylor M.D., Cohen J.E., Jayasankar V., Bish L.T., Burdick J., Pirolli T.J., Berry M.F., Hsu H., Grand T. Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia. J. Thorac. Cardiovasc. Surg. 2002, 127:1262-1269.
-
(2002)
J. Thorac. Cardiovasc. Surg.
, vol.127
, pp. 1262-1269
-
-
Woo, Y.J.1
Taylor, M.D.2
Cohen, J.E.3
Jayasankar, V.4
Bish, L.T.5
Burdick, J.6
Pirolli, T.J.7
Berry, M.F.8
Hsu, H.9
Grand, T.10
-
3
-
-
26444558061
-
Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window
-
Yu Y.M., Kim J.B., Lee K.W., Kim S.Y., Han P.L., Lee J.K. Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window. Stroke 2005, 26:2238-2243.
-
(2005)
Stroke
, vol.26
, pp. 2238-2243
-
-
Yu, Y.M.1
Kim, J.B.2
Lee, K.W.3
Kim, S.Y.4
Han, P.L.5
Lee, J.K.6
-
4
-
-
33750604074
-
Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus
-
Cho I.H., Kim S.W., Kim J.B., Kim T.K., Lee K.W., Han P.L., Lee J.K. Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus. J. Neurosci. Res. 2006, 84:1505-1511.
-
(2006)
J. Neurosci. Res.
, vol.84
, pp. 1505-1511
-
-
Cho, I.H.1
Kim, S.W.2
Kim, J.B.3
Kim, T.K.4
Lee, K.W.5
Han, P.L.6
Lee, J.K.7
-
5
-
-
58049093658
-
Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats
-
Yang Z.Y., Ling Y., Yin T., Tao J., Xiong J.X., Wu H.S., Wang C.Y. Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats. World J. Gastroenterol. 2008, 14:4546-4550.
-
(2008)
World J. Gastroenterol.
, vol.14
, pp. 4546-4550
-
-
Yang, Z.Y.1
Ling, Y.2
Yin, T.3
Tao, J.4
Xiong, J.X.5
Wu, H.S.6
Wang, C.Y.7
-
6
-
-
67049132380
-
Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits
-
Wang Q., Ding Q., Zhou Y., Gou X., Hou L., Chen S., Zhu Z., Xiong L. Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits. Anesthesiology 2009, 110:1279-1286.
-
(2009)
Anesthesiology
, vol.110
, pp. 1279-1286
-
-
Wang, Q.1
Ding, Q.2
Zhou, Y.3
Gou, X.4
Hou, L.5
Chen, S.6
Zhu, Z.7
Xiong, L.8
-
7
-
-
80052669019
-
Beneficial effect of ethyl pyruvate through inhibiting high-mobility group box-1 expression and TLR/NF-kB pathway after traumatic brain injury in the rat
-
Su X., Wang H., Zhao J., Pan H., Mao L. Beneficial effect of ethyl pyruvate through inhibiting high-mobility group box-1 expression and TLR/NF-kB pathway after traumatic brain injury in the rat. Mediators Inflamm. 2011, 807142.
-
(2011)
Mediators Inflamm.
, pp. 807142
-
-
Su, X.1
Wang, H.2
Zhao, J.3
Pan, H.4
Mao, L.5
-
8
-
-
70149106605
-
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis
-
Davé S.H., Tilstra J.S., Matsuoka K., Li F., DeMarco R.A., Beer-Stolz D., Sepulveda A.R., Fink M.P., Lotze M.T., Plevy S.E. Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis. J. Leukoc. Biol. 2009, 86:633-643.
-
(2009)
J. Leukoc. Biol.
, vol.86
, pp. 633-643
-
-
Davé, S.H.1
Tilstra, J.S.2
Matsuoka, K.3
Li, F.4
DeMarco, R.A.5
Beer-Stolz, D.6
Sepulveda, A.R.7
Fink, M.P.8
Lotze, M.T.9
Plevy, S.E.10
-
9
-
-
73949136193
-
Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model
-
Shang G.H., Lin D.J., Xiao W., Jia C.Q., Li Y., Wang A.H., Dong L. Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model. Respir. Res. 2009, 10:91.
-
(2009)
Respir. Res.
, vol.10
, pp. 91
-
-
Shang, G.H.1
Lin, D.J.2
Xiao, W.3
Jia, C.Q.4
Li, Y.5
Wang, A.H.6
Dong, L.7
-
10
-
-
35748967851
-
High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity
-
Bianchi M.E., Manfredi A.A. High-mobility group box 1 (HMGB1) protein at the crossroads between innate and adaptive immunity. Immunol. Rev. 2007, 220:35-46.
-
(2007)
Immunol. Rev.
, vol.220
, pp. 35-46
-
-
Bianchi, M.E.1
Manfredi, A.A.2
-
11
-
-
33751584837
-
Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
-
Youn J.H., Shin J.S. Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J. Immunol. 2006, 177:7889-7897.
-
(2006)
J. Immunol.
, vol.177
, pp. 7889-7897
-
-
Youn, J.H.1
Shin, J.S.2
-
12
-
-
58149308833
-
Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages
-
Zhang X., Wheeler D., Tang Y., Guo L., Shapiro R.A., Ribar T.J., Means A.R., Billiar T.R., Angus D.C. Calcium/calmodulin-dependent protein kinase (CaMK) IV mediates nucleocytoplasmic shuttling and release of HMGB1 during lipopolysaccharide stimulation of macrophages. J. Immunol. 2008, 182:5015-5023.
-
(2008)
J. Immunol.
, vol.182
, pp. 5015-5023
-
-
Zhang, X.1
Wheeler, D.2
Tang, Y.3
Guo, L.4
Shapiro, R.A.5
Ribar, T.J.6
Means, A.R.7
Billiar, T.R.8
Angus, D.C.9
-
13
-
-
66949144402
-
HMGB1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism
-
Oh Y.J., Youn J.H., Ji Y., Lee S.E., Lim K.J., Choi J.E., Shin J.S. HMGB1 is phosphorylated by classical protein kinase c and is secreted by a calcium-dependent mechanism. J. Immunol. 2009, 182:5800-5809.
-
(2009)
J. Immunol.
, vol.182
, pp. 5800-5809
-
-
Oh, Y.J.1
Youn, J.H.2
Ji, Y.3
Lee, S.E.4
Lim, K.J.5
Choi, J.E.6
Shin, J.S.7
-
14
-
-
84862779194
-
Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion
-
Kim S.W., Jin Y., Shin J.H., Kim I.D., Lee H.K., Park S., Han P.L., Lee J.K. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol. Dis. 2012, 46:147-156.
-
(2012)
Neurobiol. Dis.
, vol.46
, pp. 147-156
-
-
Kim, S.W.1
Jin, Y.2
Shin, J.H.3
Kim, I.D.4
Lee, H.K.5
Park, S.6
Han, P.L.7
Lee, J.K.8
-
15
-
-
84881526830
-
Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving it from p65
-
Kim S.W., Lee H.K., Shin J.H., Lee J.K. Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving it from p65. Free Radic. Biol. Med. 2013, 65C:468-476.
-
(2013)
Free Radic. Biol. Med.
, vol.65 C
, pp. 468-476
-
-
Kim, S.W.1
Lee, H.K.2
Shin, J.H.3
Lee, J.K.4
-
16
-
-
77449087688
-
Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain
-
Kim S.W., Jeong J.Y., Kim H.J., Seo J.S., Han P.L., Yoon S.H., Lee J.K. Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain. Neurotox. Res. 2010, 17:39-49.
-
(2010)
Neurotox. Res.
, vol.17
, pp. 39-49
-
-
Kim, S.W.1
Jeong, J.Y.2
Kim, H.J.3
Seo, J.S.4
Han, P.L.5
Yoon, S.H.6
Lee, J.K.7
-
17
-
-
33745788420
-
A novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
-
HMGB1
-
Kim J.B., Choi J.S., Yu Y.M., Nam K., Piao C.S., Kim S.W., Lee M.H., Han P.L., Park J.S., Lee J.K., HMGB1 A novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J. Neurosci. 2006, 26:6413-6421.
-
(2006)
J. Neurosci.
, vol.26
, pp. 6413-6421
-
-
Kim, J.B.1
Choi, J.S.2
Yu, Y.M.3
Nam, K.4
Piao, C.S.5
Kim, S.W.6
Lee, M.H.7
Han, P.L.8
Park, J.S.9
Lee, J.K.10
-
18
-
-
80052615268
-
Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway
-
Kim S.W., Lim C.M., Kim J.B., Shin J.H., Lee S., Lee M., Lee J.K. Extracellular HMGB1 released by NMDA treatment confers neuronal apoptosis via RAGE-p38 MAPK/ERK signaling pathway. Neurotox. Res. 2011, 20:159-169.
-
(2011)
Neurotox. Res.
, vol.20
, pp. 159-169
-
-
Kim, S.W.1
Lim, C.M.2
Kim, J.B.3
Shin, J.H.4
Lee, S.5
Lee, M.6
Lee, J.K.7
-
19
-
-
84855192732
-
Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats
-
Hu X., Cui B., Zhou X., Xu C., Lu Z., Jiang H. Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol. Biol. Rep. 2009, 39:227-231.
-
(2009)
Mol. Biol. Rep.
, vol.39
, pp. 227-231
-
-
Hu, X.1
Cui, B.2
Zhou, X.3
Xu, C.4
Lu, Z.5
Jiang, H.6
-
20
-
-
0142137129
-
Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
-
Bonaldi T., Talamo F., Scaffidi P., Ferrera D., Porto A., Bachi A., Rubartelli A., Agresti A., Bianchi M.E. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 2003, 22:5551-5560.
-
(2003)
EMBO J.
, vol.22
, pp. 5551-5560
-
-
Bonaldi, T.1
Talamo, F.2
Scaffidi, P.3
Ferrera, D.4
Porto, A.5
Bachi, A.6
Rubartelli, A.7
Agresti, A.8
Bianchi, M.E.9
-
21
-
-
84860862890
-
Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1)
-
Yang H., Lundbäck P., Ottosson L., Erlandsson-Harris H., Venereau E., Bianchi M.E., Al-Abed Y., Andersson U., Tracey K.J., Antoine D.J. Redox modification of cysteine residues regulates the cytokine activity of high mobility group box-1 (HMGB1). Mol. Med. 2012, 18:250-259.
-
(2012)
Mol. Med.
, vol.18
, pp. 250-259
-
-
Yang, H.1
Lundbäck, P.2
Ottosson, L.3
Erlandsson-Harris, H.4
Venereau, E.5
Bianchi, M.E.6
Al-Abed, Y.7
Andersson, U.8
Tracey, K.J.9
Antoine, D.J.10
|