메뉴 건너뛰기




Volumn 82, Issue , 2014, Pages 117-123

High production of poly-β-hydroxybutyrate (PHB) by an Azotobacter vinelandii mutant altered in PHB regulation using a fed-batch fermentation process

Author keywords

Azotobacter vinelandii; Dissolved oxygen; Fed batch cultures; Fermentation; Mutant; Poly hydroxybutyrate

Indexed keywords

BATCH CELL CULTURE; DISSOLVED OXYGEN; NUTRIENTS; SUGAR (SUCROSE); YEAST;

EID: 84889647940     PISSN: 1369703X     EISSN: 1873295X     Source Type: Journal    
DOI: 10.1016/j.bej.2013.10.020     Document Type: Article
Times cited : (76)

References (45)
  • 1
    • 0033046562 scopus 로고    scopus 로고
    • Metabolic engineering of poly (3-hydroxyalkanoates): from DNA to plastic
    • Madison L., Huisman G. Metabolic engineering of poly (3-hydroxyalkanoates): from DNA to plastic. Microbiol. Mol. Biol. Rev. 2010, 63:21-53.
    • (2010) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 21-53
    • Madison, L.1    Huisman, G.2
  • 3
    • 0142027019 scopus 로고    scopus 로고
    • Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates
    • Aldor I., Keasling J. Process design for microbial plastic factories: metabolic engineering of polyhydroxyalkanoates. Curr. Opin. Biotechnol. 2003, 14:475-483.
    • (2003) Curr. Opin. Biotechnol. , vol.14 , pp. 475-483
    • Aldor, I.1    Keasling, J.2
  • 4
    • 65249103916 scopus 로고    scopus 로고
    • Bacterial polyhydroxyalkanoate granules: biogenesis, structure, and potential use as nano-/micro-beads in biotechnological and biomedical applications
    • Grage K., Jahns A.C., Parlane N., Palanisamy R., Rasiah I.A., Atwood J.A., Rehm B.A.H. Bacterial polyhydroxyalkanoate granules: biogenesis, structure, and potential use as nano-/micro-beads in biotechnological and biomedical applications. Biomacromolecules 2009, 10:660-669.
    • (2009) Biomacromolecules , vol.10 , pp. 660-669
    • Grage, K.1    Jahns, A.C.2    Parlane, N.3    Palanisamy, R.4    Rasiah, I.A.5    Atwood, J.A.6    Rehm, B.A.H.7
  • 5
    • 0032900321 scopus 로고    scopus 로고
    • Factors affecting the economics of polyhydroxyalkanoate production by bacterial fermentation
    • Choi J., Lee S.Y. Factors affecting the economics of polyhydroxyalkanoate production by bacterial fermentation. Appl. Microbiol. Biotechnol. 1999, 51:13-21.
    • (1999) Appl. Microbiol. Biotechnol. , vol.51 , pp. 13-21
    • Choi, J.1    Lee, S.Y.2
  • 6
    • 0028329566 scopus 로고
    • Control of polyhydroxyalkanoate synthesis in Azotobacter vinelandii strain UWD
    • Manchak J., Page W.J. Control of polyhydroxyalkanoate synthesis in Azotobacter vinelandii strain UWD. Microbiology 1994, 140:953-963.
    • (1994) Microbiology , vol.140 , pp. 953-963
    • Manchak, J.1    Page, W.J.2
  • 7
    • 0034736565 scopus 로고    scopus 로고
    • Beta-ketothiolase genes in Azotobacter vinelandii
    • Segura D., Vargas E., Espín G. Beta-ketothiolase genes in Azotobacter vinelandii. Gene 2000, 260:113-120.
    • (2000) Gene , vol.260 , pp. 113-120
    • Segura, D.1    Vargas, E.2    Espín, G.3
  • 8
    • 1642561801 scopus 로고    scopus 로고
    • Azotobacter vinelandii mutants that overproduce poly-β-hydroxybutyrate or alginate
    • Segura D., Guzmán J., Espín G. Azotobacter vinelandii mutants that overproduce poly-β-hydroxybutyrate or alginate. Appl. Microbiol. Biotechnol. 2003, 63:159-163.
    • (2003) Appl. Microbiol. Biotechnol. , vol.63 , pp. 159-163
    • Segura, D.1    Guzmán, J.2    Espín, G.3
  • 9
    • 0036786204 scopus 로고    scopus 로고
    • Expression of the Azotobacter vinelandii poly-β-hydroxybutyrate biosynthetic phbBAC operon is driven by two overlapping promoters and is dependent on the transcriptional activator PhbR
    • Peralta-Gil M., Segura D., Guzmán J., Servin-Gonzalez L., Espín G. Expression of the Azotobacter vinelandii poly-β-hydroxybutyrate biosynthetic phbBAC operon is driven by two overlapping promoters and is dependent on the transcriptional activator PhbR. J. Bacteriol. 2002, 184:5672-5677.
    • (2002) J. Bacteriol. , vol.184 , pp. 5672-5677
    • Peralta-Gil, M.1    Segura, D.2    Guzmán, J.3    Servin-Gonzalez, L.4    Espín, G.5
  • 10
    • 0031688794 scopus 로고    scopus 로고
    • Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-β-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii
    • Segura D., Espín G. Mutational inactivation of a gene homologous to Escherichia coli ptsP affects poly-β-hydroxybutyrate accumulation and nitrogen fixation in Azotobacter vinelandii. J. Bacteriol. 1998, 180:4790-4798.
    • (1998) J. Bacteriol. , vol.180 , pp. 4790-4798
    • Segura, D.1    Espín, G.2
  • 11
    • 51949112803 scopus 로고    scopus 로고
    • Enzyme INtr, NPr and IIANtr are involved in regulation of the poly-β-hydroxybutyrate biosynthetic genes in Azotobacter vinelandii
    • Noguez R., Segura D., Moreno S., Hernández A., Juárez K., Espín G. Enzyme INtr, NPr and IIANtr are involved in regulation of the poly-β-hydroxybutyrate biosynthetic genes in Azotobacter vinelandii. J. Mol. Microbiol. Biotechnol. 2008, 15:244-254.
    • (2008) J. Mol. Microbiol. Biotechnol. , vol.15 , pp. 244-254
    • Noguez, R.1    Segura, D.2    Moreno, S.3    Hernández, A.4    Juárez, K.5    Espín, G.6
  • 12
    • 0342314437 scopus 로고    scopus 로고
    • The GacS sensor kinase regulates alginate and poly-β-hydroxybutyrate production in Azotobacter vinelandii
    • Castañeda M., Guzmán J., Moreno S., Espín G. The GacS sensor kinase regulates alginate and poly-β-hydroxybutyrate production in Azotobacter vinelandii. J. Bacteriol. 2000, 182:2624-2628.
    • (2000) J. Bacteriol. , vol.182 , pp. 2624-2628
    • Castañeda, M.1    Guzmán, J.2    Moreno, S.3    Espín, G.4
  • 14
    • 84863116840 scopus 로고    scopus 로고
    • Optimization of poly(3-hydroxybutyrateco- 3-hydroxyvalerate) production process by using Azohydromonas lata MTCC 2311 by using genetic algorithm on artificial neural network on response surface methodology
    • Zafar M., Kumar S., Kumar S., Dhiman A. Optimization of poly(3-hydroxybutyrateco- 3-hydroxyvalerate) production process by using Azohydromonas lata MTCC 2311 by using genetic algorithm on artificial neural network on response surface methodology. Biocatal. Agric. Biotechnol. 2012, 1:70-79.
    • (2012) Biocatal. Agric. Biotechnol. , vol.1 , pp. 70-79
    • Zafar, M.1    Kumar, S.2    Kumar, S.3    Dhiman, A.4
  • 15
    • 84655176471 scopus 로고    scopus 로고
    • Artificial intelligence based modeling and optimization of poly(3-hydroxybutyrateco- 3-hydroxyvalerate) production process by using Azohydromonas lata MTCC 2311 from cane molasses supplemented with volatile fatty acids: a genetic algorithm paradigm
    • Zafar M., Kumar S., Kumar S., Dhiman A. Artificial intelligence based modeling and optimization of poly(3-hydroxybutyrateco- 3-hydroxyvalerate) production process by using Azohydromonas lata MTCC 2311 from cane molasses supplemented with volatile fatty acids: a genetic algorithm paradigm. Bioresour. Technol. 2012, 104:631-641.
    • (2012) Bioresour. Technol. , vol.104 , pp. 631-641
    • Zafar, M.1    Kumar, S.2    Kumar, S.3    Dhiman, A.4
  • 16
    • 79955611088 scopus 로고    scopus 로고
    • Production of (R)-3-hydroxybutyric acid by fermentation and bioconversion processes with Azohydromonas lata
    • Ugwu C., Tokiwa Y., Ichiba T. Production of (R)-3-hydroxybutyric acid by fermentation and bioconversion processes with Azohydromonas lata. Bioresour. Technol. 2011, 102:6766-6768.
    • (2011) Bioresour. Technol. , vol.102 , pp. 6766-6768
    • Ugwu, C.1    Tokiwa, Y.2    Ichiba, T.3
  • 17
    • 84855739255 scopus 로고    scopus 로고
    • Microbial production of polyhydroxybutyrate with tailor-made properties: an integrated modelling approach and experimental validation
    • Penlogloua G., Chatzidoukasa C., Kiparissidesa C. Microbial production of polyhydroxybutyrate with tailor-made properties: an integrated modelling approach and experimental validation. Biotechnol. Adv. 2012, 30:329-337.
    • (2012) Biotechnol. Adv. , vol.30 , pp. 329-337
    • Penlogloua, G.1    Chatzidoukasa, C.2    Kiparissidesa, C.3
  • 18
    • 0030955605 scopus 로고    scopus 로고
    • Production of poly-β-hydroxybutyrate by Azotobacter vinelandii in a two-stage fermentation process
    • Chen G., Page W. Production of poly-β-hydroxybutyrate by Azotobacter vinelandii in a two-stage fermentation process. Biotechnol. Technique 1997, 11:347-350.
    • (1997) Biotechnol. Technique , vol.11 , pp. 347-350
    • Chen, G.1    Page, W.2
  • 19
    • 33847611475 scopus 로고    scopus 로고
    • Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii
    • Galindo E., Peña C., Nuñez C., Segura D., Espín G. Molecular and bioengineering strategies to improve alginate and polydydroxyalkanoate production by Azotobacter vinelandii. Microb. Cell. Fact. 2007, 6:1-16.
    • (2007) Microb. Cell. Fact. , vol.6 , pp. 1-16
    • Galindo, E.1    Peña, C.2    Nuñez, C.3    Segura, D.4    Espín, G.5
  • 20
    • 72449198564 scopus 로고    scopus 로고
    • Two-stage fermentation process for alginate production by Azotobacter vinelandii mutant altered in poly-β-hydroxybutyrate (PHB) synthesis
    • Mejía M., Segura D., Espín G., Galindo E., Peña C. Two-stage fermentation process for alginate production by Azotobacter vinelandii mutant altered in poly-β-hydroxybutyrate (PHB) synthesis. J. Appl. Microbiol. 2010, 108:55-61.
    • (2010) J. Appl. Microbiol. , vol.108 , pp. 55-61
    • Mejía, M.1    Segura, D.2    Espín, G.3    Galindo, E.4    Peña, C.5
  • 21
    • 34548357146 scopus 로고    scopus 로고
    • The oxygen transfer rate influences the molecular mass of the alginate produced by Azotobacter vinelandii
    • Díaz-Barrera A., Peña C., Galindo E. The oxygen transfer rate influences the molecular mass of the alginate produced by Azotobacter vinelandii. Appl. Microbiol. Biotechnol. 2007, 76:903-910.
    • (2007) Appl. Microbiol. Biotechnol. , vol.76 , pp. 903-910
    • Díaz-Barrera, A.1    Peña, C.2    Galindo, E.3
  • 22
    • 0036851370 scopus 로고    scopus 로고
    • Alginate production by Azotobacter vinelandii mutants altered in poly-β-hydroxybutyrate and alginate biosynthesis
    • Peña C., Miranda L., Segura D., Núñez C., Espín G., Galindo E. Alginate production by Azotobacter vinelandii mutants altered in poly-β-hydroxybutyrate and alginate biosynthesis. Enzyme Microb. Technol. 2002, 29:209-213.
    • (2002) Enzyme Microb. Technol. , vol.29 , pp. 209-213
    • Peña, C.1    Miranda, L.2    Segura, D.3    Núñez, C.4    Espín, G.5    Galindo, E.6
  • 23
    • 0033831612 scopus 로고    scopus 로고
    • Effect of oxygen on formation and structure of Azotobacter vinelandii alginate and its role in protecting nitrogenase
    • Sabra W., Zeng A.P., Lunsdorf H., Deckwer W.D. Effect of oxygen on formation and structure of Azotobacter vinelandii alginate and its role in protecting nitrogenase. Appl. Microbiol. Biotechnol. 2000, 66:4037-4044.
    • (2000) Appl. Microbiol. Biotechnol. , vol.66 , pp. 4037-4044
    • Sabra, W.1    Zeng, A.P.2    Lunsdorf, H.3    Deckwer, W.D.4
  • 24
    • 0343051880 scopus 로고    scopus 로고
    • Poly(3-hydroxybutyrate) production with high polymer content by fed-batch culture of Alcaligenes latus under nitrogen limitation
    • Wang F., Lee S.Y. Poly(3-hydroxybutyrate) production with high polymer content by fed-batch culture of Alcaligenes latus under nitrogen limitation. Appl. Environ. Microbiol. 1997, 63:3703-3706.
    • (1997) Appl. Environ. Microbiol. , vol.63 , pp. 3703-3706
    • Wang, F.1    Lee, S.Y.2
  • 25
    • 0043195843 scopus 로고    scopus 로고
    • Poly(3-hydroxybutyrate) synthesis in fed-batch culture of Ralstonia eutropha with phosphate limitation under different glucose concentrations
    • Shang L., Jiang M., Chang H.N. Poly(3-hydroxybutyrate) synthesis in fed-batch culture of Ralstonia eutropha with phosphate limitation under different glucose concentrations. Biotechnol. Lett. 2003, 25:1415-1419.
    • (2003) Biotechnol. Lett. , vol.25 , pp. 1415-1419
    • Shang, L.1    Jiang, M.2    Chang, H.N.3
  • 26
    • 0031885647 scopus 로고    scopus 로고
    • Production of poly(3-hydroxybutyrate) from starch by Azotobacter chroococcum
    • Kim B.S., Chang H.N. Production of poly(3-hydroxybutyrate) from starch by Azotobacter chroococcum. Biotechnol. Lett. 1998, 20:109-112.
    • (1998) Biotechnol. Lett. , vol.20 , pp. 109-112
    • Kim, B.S.1    Chang, H.N.2
  • 27
    • 0027501493 scopus 로고
    • Growth of Azotobacter vinelandii UWD in fish peptone medium and simplified extraction of poly-β-hydroxybutyrate
    • Page W., Cornish A. Growth of Azotobacter vinelandii UWD in fish peptone medium and simplified extraction of poly-β-hydroxybutyrate. Appl. Microbiol. Microbiol. 1993, 59:4236-4244.
    • (1993) Appl. Microbiol. Microbiol. , vol.59 , pp. 4236-4244
    • Page, W.1    Cornish, A.2
  • 28
    • 65549104453 scopus 로고    scopus 로고
    • Isolation and characterization of Azotobacter vinelandii mutants impaired in alkylresorcinol synthesis: alkylresorcinols are not essential for cysts desiccation resistance
    • Segura D., Vite O., Romero Y., Moreno S., Castañeda M., Espín G. Isolation and characterization of Azotobacter vinelandii mutants impaired in alkylresorcinol synthesis: alkylresorcinols are not essential for cysts desiccation resistance. J. Bacteriol. 2009, 191:3142-3148.
    • (2009) J. Bacteriol. , vol.191 , pp. 3142-3148
    • Segura, D.1    Vite, O.2    Romero, Y.3    Moreno, S.4    Castañeda, M.5    Espín, G.6
  • 29
    • 84894501372 scopus 로고    scopus 로고
    • Biosynthesis of poly-β-hydroxybutyrate (PHB) with a high molecular mass by a mutant strain of Azotobacter vinelandii (OPN)
    • Peña C., López S., García A., Espín G., Romo-Uribe A., Segura D. Biosynthesis of poly-β-hydroxybutyrate (PHB) with a high molecular mass by a mutant strain of Azotobacter vinelandii (OPN). Ann. Microbiol. 2013, 10.1007/s13213-013-0630-0.
    • (2013) Ann. Microbiol.
    • Peña, C.1    López, S.2    García, A.3    Espín, G.4    Romo-Uribe, A.5    Segura, D.6
  • 30
    • 0030699325 scopus 로고    scopus 로고
    • Changes in alginate molecular mass distributions, broth viscosity and morphology of Azotobacter vinelandii cultured in shake flasks
    • Peña C., Campos N., Galindo E. Changes in alginate molecular mass distributions, broth viscosity and morphology of Azotobacter vinelandii cultured in shake flasks. Appl. Microbiol. Biotechnol. 1997, 48:510-515.
    • (1997) Appl. Microbiol. Biotechnol. , vol.48 , pp. 510-515
    • Peña, C.1    Campos, N.2    Galindo, E.3
  • 31
    • 79951943443 scopus 로고    scopus 로고
    • Oxygen transfer rate during the production of alginate by Azotobacter vinelandii under oxygen limited and non oxygen-limited conditions
    • Lozano E., Galindo E., Peña C. Oxygen transfer rate during the production of alginate by Azotobacter vinelandii under oxygen limited and non oxygen-limited conditions. Microb. Cell. Fact. 2011, 10:1-13.
    • (2011) Microb. Cell. Fact. , vol.10 , pp. 1-13
    • Lozano, E.1    Galindo, E.2    Peña, C.3
  • 32
    • 23944459546 scopus 로고    scopus 로고
    • Specific growth rate determines the molecular weight of the alginate produced by Azotobacter vinelandii
    • Priego-Jiménez R., Peña C., Ramírez O.T., Galindo E. Specific growth rate determines the molecular weight of the alginate produced by Azotobacter vinelandii. Biochem. Eng. J. 2005, 25:187-193.
    • (2005) Biochem. Eng. J. , vol.25 , pp. 187-193
    • Priego-Jiménez, R.1    Peña, C.2    Ramírez, O.T.3    Galindo, E.4
  • 33
    • 33747333106 scopus 로고
    • Use of dinitrosalicylic acid reagent for determination of reducing sugars
    • Miller G. Use of dinitrosalicylic acid reagent for determination of reducing sugars. Anal. Chem. 1959, 31:426-428.
    • (1959) Anal. Chem. , vol.31 , pp. 426-428
    • Miller, G.1
  • 35
    • 0015377793 scopus 로고
    • The role of oxygen limitation in the formation of poly-β-hydroxybutyrate during batch and continuous culture of Azotobacter beijerinckii
    • Senior P., Beech G., Ritchie G., Dawes E. The role of oxygen limitation in the formation of poly-β-hydroxybutyrate during batch and continuous culture of Azotobacter beijerinckii. J. Biochem. 1972, 128:1193-1201.
    • (1972) J. Biochem. , vol.128 , pp. 1193-1201
    • Senior, P.1    Beech, G.2    Ritchie, G.3    Dawes, E.4
  • 36
    • 0015887907 scopus 로고
    • The regulation of poly-β-hydroxybutyrate metabolism in Azotobacter beijerinkii
    • Senior P.J., Dawes E.A. The regulation of poly-β-hydroxybutyrate metabolism in Azotobacter beijerinkii. Biochem. J. 1973, 134:225-238.
    • (1973) Biochem. J. , vol.134 , pp. 225-238
    • Senior, P.J.1    Dawes, E.A.2
  • 37
    • 80155150929 scopus 로고    scopus 로고
    • Transcriptional activation of the Azotobacter vinelandii polyhydroxybutyrate biosynthetic genes phbBAC by PhbR and RpoS
    • Hernandez-Eligio A., Castellanos M., Moreno S., Espín G. Transcriptional activation of the Azotobacter vinelandii polyhydroxybutyrate biosynthetic genes phbBAC by PhbR and RpoS. Microbiology 2011, 157:3014-3023.
    • (2011) Microbiology , vol.157 , pp. 3014-3023
    • Hernandez-Eligio, A.1    Castellanos, M.2    Moreno, S.3    Espín, G.4
  • 38
    • 0024318244 scopus 로고
    • Hyperproduction of poly-β -hydroxybutyrate during exponential growth of Azotobacter vinelandii UWD
    • Page W.J., Knosp O. Hyperproduction of poly-β -hydroxybutyrate during exponential growth of Azotobacter vinelandii UWD. Appl. Environ. Microbiol. 1989, 55:1334-1339.
    • (1989) Appl. Environ. Microbiol. , vol.55 , pp. 1334-1339
    • Page, W.J.1    Knosp, O.2
  • 39
    • 0029927341 scopus 로고    scopus 로고
    • Characterization of the genes coding for the putative sigma factor AlgU and its regulators MucA, MucB, MucC, and MucD in Azotobacter vinelandii and evaluation of their roles in alginate biosynthesis
    • Martínez-Salazar J.M., Moreno S., Nájera R., Boucher J.C., Espín G., Soberón-Chávez G., Deretic V. Characterization of the genes coding for the putative sigma factor AlgU and its regulators MucA, MucB, MucC, and MucD in Azotobacter vinelandii and evaluation of their roles in alginate biosynthesis. J. Bacteriol. 1996, 178:1800-1808.
    • (1996) J. Bacteriol. , vol.178 , pp. 1800-1808
    • Martínez-Salazar, J.M.1    Moreno, S.2    Nájera, R.3    Boucher, J.C.4    Espín, G.5    Soberón-Chávez, G.6    Deretic, V.7
  • 40
    • 84879206101 scopus 로고    scopus 로고
    • The acetylation degree of alginates in Azotobacter vinelandii ATCC9046 is determined by the dissolved oxygen and the specific growth rate: studies in glucose-limited chemostat cultivations
    • Castillo M.T., Galindo E., Peña C. The acetylation degree of alginates in Azotobacter vinelandii ATCC9046 is determined by the dissolved oxygen and the specific growth rate: studies in glucose-limited chemostat cultivations. J. Ind. Microbiol. Biotechnol. 2013, 10.1007/s10295-013-1274-6.
    • (2013) J. Ind. Microbiol. Biotechnol.
    • Castillo, M.T.1    Galindo, E.2    Peña, C.3
  • 41
    • 84879023104 scopus 로고    scopus 로고
    • Expression of alginases and alginate polymerase genes in response to oxygen, and their relationship with the alginate molecular weight in Azotobacter vinelandii
    • Flores C., Moreno S., Espín G., Peña C., Galindo E. Expression of alginases and alginate polymerase genes in response to oxygen, and their relationship with the alginate molecular weight in Azotobacter vinelandii. Enzyme Microb. Technol. 2013, 10.1016/j.enzmictec.04.010.
    • (2013) Enzyme Microb. Technol.
    • Flores, C.1    Moreno, S.2    Espín, G.3    Peña, C.4    Galindo, E.5
  • 42
    • 0023416746 scopus 로고
    • Polymer synthesis by microorganisms: technology and economics
    • Byrom D. Polymer synthesis by microorganisms: technology and economics. Trends Biotechnol. 1987, 5:246-250.
    • (1987) Trends Biotechnol. , vol.5 , pp. 246-250
    • Byrom, D.1
  • 43
    • 0002034736 scopus 로고    scopus 로고
    • Production of poly(3-hydroxybutyrate) by high cell density fed-batch culture of Alcaligenes eutrophus with phospate limitation
    • Ryu H.W., Hahn S.K., Chang Y.K., Chang H.N. Production of poly(3-hydroxybutyrate) by high cell density fed-batch culture of Alcaligenes eutrophus with phospate limitation. Biotechnol. Bioeng. 1997, 1:28-32.
    • (1997) Biotechnol. Bioeng. , vol.1 , pp. 28-32
    • Ryu, H.W.1    Hahn, S.K.2    Chang, Y.K.3    Chang, H.N.4
  • 44
    • 0028414108 scopus 로고
    • Production of poly(3-hydroxybutyric acid) by Ralstonia eutropha with glucose concentration control
    • Kim B.S., Lee S.C., Lee S.Y., Chang H.N., Chang Y.K., Woo S.I. Production of poly(3-hydroxybutyric acid) by Ralstonia eutropha with glucose concentration control. Biotechnol. Bioeng. 1994, 43:892-898.
    • (1994) Biotechnol. Bioeng. , vol.43 , pp. 892-898
    • Kim, B.S.1    Lee, S.C.2    Lee, S.Y.3    Chang, H.N.4    Chang, Y.K.5    Woo, S.I.6
  • 45
    • 13344278710 scopus 로고    scopus 로고
    • Increased PHB productivity by high-cell-density fed-batch culture of Alcaligenes latus a growth-associated PHB producer
    • Yamane T., Fukunage M., Lee Y.W. Increased PHB productivity by high-cell-density fed-batch culture of Alcaligenes latus a growth-associated PHB producer. Biotechnol. Bioeng. 1996, 20:197-202.
    • (1996) Biotechnol. Bioeng. , vol.20 , pp. 197-202
    • Yamane, T.1    Fukunage, M.2    Lee, Y.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.