Microbial production of polyhydroxybutyrate with tailor-made properties: An integrated modelling approach and experimental validation

Biotechnology Advances

Volumn 30, Issue 1, 2012, Pages 329-337

  Penloglou, Giannis ^a,b   Chatzidoukas, Christos ^a   Kiparissides, Costas ^a,b  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Centre for Research Technology Hellas   (Greece)

Author keywords

Biopolymers; Kinetic model; Macroscopic model; Metabolic model; PHA; PHB; Polyhydroxyalkanoate; Polyhydroxybutyrate; Polymerization model

Indexed keywords

KINETIC MODEL; MACROSCOPIC MODEL; METABOLIC MODELS; PHA; PHB; POLY-HYDROXYALKANOATE; POLYHYDROXYBUTYRATE; POLYMERIZATION MODEL;

BIOPOLYMERS; MOLECULAR WEIGHT DISTRIBUTION;

OPTIMIZATION;

AMMONIUM SULFATE; BIOPOLYMER; HYDROXYBUTYRIC ACID; POLYHYDROXYALKANOIC ACID; SUCROSE;

BIOACCUMULATION; BIOLOGICAL PRODUCTION; DESIGN; INTEGRATED APPROACH; METABOLISM; MICROBIAL ACTIVITY; MOLECULAR ANALYSIS; NUMERICAL MODEL; POLYMER; POLYMERIZATION;

ALCALIGENACEAE; BIOLOGICAL MODEL; BIOMASS; BIOREACTOR; CHEMISTRY; CULTURE MEDIUM; FERMENTATION; KINETICS; METABOLISM; MOLECULAR WEIGHT; REVIEW;

ALCALIGENACEAE; AMMONIUM SULFATE; BIOMASS; BIOPOLYMERS; BIOREACTORS; CULTURE MEDIA; FERMENTATION; HYDROXYBUTYRATES; KINETICS; MODELS, BIOLOGICAL; MOLECULAR WEIGHT; POLYHYDROXYALKANOATES; SUCROSE;

ALCALIGENES LATUS; BACTERIA (MICROORGANISMS);

EID: 84855739255     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2011.06.021     Document Type: Review

References (25)

1. Anderson A.J., Dawes E.A. Occurrence, metabolism, metabolic role, and industrial uses of bacterial polyhydroxyalkanoates. Microbiol Rev 1990, 54:450-472.
2. Chen G.-Q. A microbial polyhydroxyalkanoates (PHA) based bio- and materials industry. Chem Soc Rev 2009, 8:2434-2446.
3. Choi J., Lee S.Y. Factors affecting the economics of polyhydroxyalkanoate production by bacterial fermentation. Appl Microbiol Biotechnol 1999, 51:13-21.
4. Dias J.M.L., Serafim L.S., Lemos P.C., Reis M.A.M., Oliveira R. Mathematical modelling of a mixed culture cultivation process for the production of polyhydroxybutyrate. Biotechnol Bioeng 2005, 92:209-222.
5. Grothe E., Chisti Y. Poly(β-hydroxybutyric acid) thermoplastic production by Alcaligenes latus: behavior of fed-batch cultures. Bioprocess Eng 2000, 22:441-449.
6. Hong K., Sun S., Tian W., Chen G.Q., Huang W. A rapid method for detecting bacterial polyhydroxyalkanoates in intact cells by Fourier transform infrared spectroscopy. Appl Microbiol Biotechnol 1999, 51:523-526.
7. Johnson K., Kleerebezem R., van Loosdrecht M.C.M. Influence of the C/N ratio on the performance of polyhydroxybutyrate (PHB) producing sequencing batch reactors at short SRTs. Water Res 2010, 44:2141-2152.
8. Kawaguchi Y., Doi Y. Kinetics and mechanism of synthesis and degradation of poly(3-hydroxybutyrate) in Alcaligenes eutrophus. Macromolecules 1992, 25:2324-2329.
9. Khanna S., Srivastava A.K. A simple structured mathematical model for biopolymer (PHB) production. Biotechnol Prog 2005, 21:830-838.
10. Khanna S., Srivastava A.K. Computer simulated fed-batch cultivation for over production of PHB: a comparison of simultaneous and alternate feeding of carbon and nitrogen. Biochem Eng J 2006, 27:197-203.
11. Lee S.Y., Choi J., Wong H.H. Recent advances in polyhydroxyalkanoate production by bacterial fermentation: mini-review. Int J Biol Macromol 1999, 25:31-36.
12. Leef T.A., Srienc F. Metabolic modeling of polyhydroxybutyrate biosynthesis. Biotechnol Bioeng 1998, 57:557-570.
13. Lu J., Tappel R.C., Nomura C.T. Mini-review: biosynthesis of poly(hydroxyalkanoates). J Macromol Sci Part C Polym Rev 2009, 49:226-248.
14. Madison L.L., Huisman G.W. Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic. Microbiol Mol Biol Rev 1999, 63:21-53.
15. Miller G.L. Use of dinitrosalicylic acid reagent for determination of reducing sugar. Anal Chem 1959, 31:426-428.
16. Penloglou G., Roussos A., Chatzidoukas C., Kiparissides C. A combined metabolic/polymerization kinetic model on the microbial production of poly(3-hydroxybutyrate). New Biotechnol 2010, 27:358-367.
17. Philip S., Keshavarz T., Roy I. Polyhydroxyalkanoates: biodegradable polymers with a range of applications. J Chem Technol Biotechnol 2007, 82:233-247.
18. Randriamahefa S., Renard E., Guérin P., Langlois V. Fourier transform infrared spectroscopy for screening and quantifying of PHAs by Pseudomonas grown on sodium octanoate. Biomacromolecules 2003, 4:1092-1097.
19. Somashekara D.M., Rastogi N.K., Ramachandriah T. A simple kinetic model for growth and biosynthesis of polyhydroxyalkanoate in Bacillus flexus. New Biotechnol 2009, 26:92-98.
20. Stewart W.E., Caracotsios M., Sorensen J.P. Parameter estimation from multiresponse data. AiChe J 1992, 38:641-650.
21. Sun Z., Ramsay J.A., Guay M., Ramsay B.A. Fed-batch production of unsaturated medium-chain-length polyhydroxyalkanoates with controlled composition by Pseudomonas putida KT2440. Appl Microbiol Biotechnol 2009, 82:657-662.
22. Tolosa L., Kostov Y., Harms P., Rao G. Noninvasive measurement of dissolved oxygen in shake flasks. Biotechnol Bioeng 2002, 80:594-597.
23. Verlinden R.A.J., Hill D.J., Kenward M.A., Williams C.D., Radecka I. Bacterial synthesis of biodegradable polyhydroxyalkanoates. J Appl Microbiol 2007, 102:1437-1449.
24. Yang Y.-H., Brigham C.J., Budde C.F., Boccazzi P., Willis L.B., Hassan M.A., et al. Optimization of growth media components for polyhydroxyalkanoate (PHA) production from organic acids by Ralstonia eutropha. Appl Microbiol Biotechnol 2010, 87:2037-2045.
25. Wang F., Lee S.Y. Poly(3-hydroxybutyrate) production with high productivity and high polymer content by a fed-batch culture of Alcaligenes latus under nitrogen limitation. Appl Environ Microbiol 1997, 63:3703-3706.